DescriptionEvery language has an alphabet, and the redox language of the cell is no exception. The letters of this alphabet are oxidants, such as H2O2, H2S, and HOCl, and reductants, like NADH and NADPH. The mitochondria, endoplasmic reticulum, and lysosomes use this alphabet to form and exchange messages that control proteostatic processes, including biogenesis, protein folding, trafficking, and degradation. The nucleus also speaks this language, and upon relay of redox input, adapts transcription in order to translate the received messages to appropriate cellular responses. Redox miscommunication, on the other hand, has been shown to be involved in several pathological processes, including the development of cancer and neurodegenerative diseases, as well as ageing. New biochemical insights, including the elucidation of the proteins involved in redox signaling and their mechanisms, have led to a more thorough, yet still incomplete, understanding of the redox language. Further elucidation of the oxidative and reductive “letters” of the redox alphabet, their intracellular metabolism, trafficking, and the proteins involved in their signaling will open new chapters in the development of redox therapeutics for human diseases. Our objectives for this Special Issue of Antioxidants are to highlight the recent developments in methodological tools and reagents that enable us to monitor cellular redox events, including their contribution to the exciting conceptual advances in our understanding of the cellular redox lexicon in the context of cell biology, physiological processes, life span, disease pathogenesis, and signalling.
|Period||21 Mar 2021|
|Type of journal||Journal|