Projects per year
Description
Here, we mapped the immune compartment in the bone marrow and spleen of the immunocompetent 5T33MM Multiple Myeloma mouse model, using scRNA-seq analysis. This revealed distinct cell types as well as their dynamics in both naive mice and at various disease stages of MM, illustrating the evolving immune landscape during MM progression.
Abstract
Here, we mapped the immune compartment in the bone marrow and spleen of the immunocompetent 5T33MM Multiple Myeloma mouse model, using scRNA-seq analysis. This revealed distinct cell types as well as their dynamics in both naive mice and at various disease stages of MM, illustrating the evolving immune landscape during MM progression.
format
Gene Expression Omnibus (NCBI GEO)
| Date made available | 14 Nov 2024 |
|---|---|
| Publisher | NCBI Gene Expression Omnibus |
Keywords
- Multiple Myeloma progression
- 5T33MM immune microenvironment
- Single-cell RNA-sequencing
- Human-mouse comparison
- Anti-CD40 agonist therapy
Format
- Format
- csv
- tar
Projects
- 1 Finished
-
ANI323: Personalized tumor-derived dendritic cell therapy to overcome residual disease in multiple myeloma
1/11/22 → 31/10/23
Project: Fundamental
Research output
- 1 Article
-
A single-cell transcriptomic map of the murine and human multiple myeloma immune microenvironment across disease stages
Verheye, E., Kancheva, D., Satilmis, H., Vandewalle, N., Fan, R., Bardet, P., Clappaert, E., Verstaen, K., De Becker, A., Vanderkerken, K., De Veirman, K. & Laoui, D., 7 Nov 2024, In: Journal of Hematology & Oncology. 17, 107, 22 p., 107.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus)