Projects per year
Description
sequencing data
Abstract
About half of testicular sperm extraction (TESE) procedures in men with non-obstructive azoospermia (NOA), including men with Klinefelter syndrome (KS), are unsuccessful. To avoid unnecessary invasive surgery, biomarkers for spermatozoa were studied. In addition, markers for spermatogonia in testis tissue were explored. This study aimed to find biomarkers in the semen and/or urine of NOA patients to predict the presence of spermatogonia in the testis. Differentially expressed miRNAs were identified (1) between samples from patients with and without a positive TESE procedure as well as (2) between TESE-negative patients with and without spermatogonia. A total of thirteen upregulated miRNAs (ten in seminal plasma and three in urine) were found in the TESE-negative/spermatogonia-positive group compared to the TESE-negative/spermatogonia-negative group. These miRNAs could be potential biomarkers for spermatogonia; however, more research is necessary to validate their predictive power.
Size
520kb
Date made available | 2023 |
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Publisher | Gene Expression Omnibus (GEO) |
Date of data production | 2023 |
Keywords
- miRNA
- semen
- urine
- NOA
- biomarker
Format
- Format
- tar
- txt
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SRP89: SRP-Groeifinanciering: The spermatogonial stem cell: the key to prevention and treatment of male infertility
1/10/22 → 30/09/27
Project: Fundamental
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FWOTM758: Klinefelter related infertility: getting to know causes
Van Saen, D., Goossens, E., Tournaye, H. & De Schepper, J.
1/10/14 → 1/05/21
Project: Fundamental
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Micro RNA in Semen/Urine from Non-Obstructive Azoospermia Patients as Biomarkers to Predict the Presence of Testicular Spermatozoa and Spermatogonia
Willems, M., Devriendt, C., Olsen, C., Caljon, B., Janssen, T., Gies, I., Vloeberghs, V., Tournaye, H., Saen, D. V. & Goossens, E., 23 Feb 2023, In: Life. 13, 3, 11 p., 616.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)45 Downloads (Pure) -
Unraveling the mechanisms behind testicular fibrosis in Klinefelter men
Willems, M., 2022, 177 p.Research output: Thesis › PhD Thesis
Open AccessFile