Projects per year
Organization profile
Organisation profile
A decreased beta cell mass or the incapability of the beta cell mass to compensate for increased insulin needs, results in an absolute or relative deficiency of insulin defining type I and type II diabetes, respectively. Our research group aims to compensate the reduced beta cell mass in diabetes by transplantation or in situ differentiation and expansion of beta- and pre-beta cells. We therefore investigate mechanisms to generate new, fully functional beta cells by: - Differentiation of endogenous progenitor/stem cells - regeneration of the beta cell mass - Protection and profileration of existing beta cells - Transdifferentiation of pancreatic non-beta cells to beta cells Our research is performed within the collaborative framework of the JDRF Center for Beta Cell Therapy in Diabetes and the Beta Cell Biology Consortium.
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Profiles
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Nico De Leu
- UZBrussel
- Vrije Universiteit Brussel
- Clinical sciences - Academic
- Internal medicine - endocrinology - UZB Physician
- Beta Cell Neogenesis
Person: Researcher, Professor, Physician
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Yves Heremans
- Vrije Universiteit Brussel
- Basic (bio-) Medical Sciences - Academic
- Pathology/molecular and cellular medicine - Head of Department
- Beta Cell Neogenesis
Person: Researcher, Administrative/technical staff
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Gunter Leuckx
- Vrije Universiteit Brussel
- Pathology/molecular and cellular medicine - Technical Expert
- Beta Cell Neogenesis
Person: Researcher, Administrative/technical staff
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Willem Staels
- UZBrussel
- Vrije Universiteit Brussel
- Clinical sciences - Academic
- Pediatrics - UZB Physician
- Pathology/molecular and cellular medicine - Academic
- Beta Cell Neogenesis
Person: Researcher, Professor, Physician
Projects
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FWOSB94: Microvascular remodeling for beta(-like) cell differentiation, regeneration and transplantation
1/11/20 → 31/10/22
Project: Fundamental
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BRGIMP11: BRIDGE: Diatype : Personalized medicine in diabetes: towards an etiology-based diagnosis and better patient care
1/01/18 → 31/12/21
Project: Applied
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AIIFUND48: EFSD/JDRF/lilly European Programme in Type 1 Diabetes Research Grant : Does pregnancy induce changes in Urinary C-peptide Creatinine Ratio (UCPCR) in women with Type 1 diabetes?
Baeyens, L.
1/11/18 → 31/01/20
Project: Fundamental
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fwotm766: Insulin-producing cells in Drosophila, mouse and man: A multidisciplinary approach to study and treat diabetes.
Heimberg, H., Callaerts, P. & Bussche, L.
1/10/15 → 30/06/16
Project: Fundamental
Research output
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Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?
Bourgeois, S., Sawatani, T., Van Mulders, A., De Leu, N., Heremans, Y., Heimberg, H., Cnop, M. & Staels, W., 19 Jan 2021, In : Cells. 10, 1, 24 p., 191.Research output: Contribution to journal › Article
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Evidence of tissue repair in human donor pancreas after prolonged duration of stay in intensive care.
Smeets, S., Stange, G., Leuckx, G., Roelants, L., Cools, W., De Paep, D. L., Ling, Z., De Leu, N. & In 'T Veld, P., Mar 2020, In : Diabetes. 69, 3, p. 401-412 12 p.Research output: Contribution to journal › Article
3 Citations (Scopus) -
Inflammation enables pancreatic acinar cells to overcome resistance to oncogenic Kras by increasing its expression and plasma membrane localization.
Assi, M. N., Lodewyckx, J-N., Achouri, Y., Gerard, C., Dauguet, N., Houbracken, I., Heremans, Y., Tyteca, D., Rooman, I., Bouwens, L., Lemaigre, F. & Jacquemin, P., May 2020, In : MOLECULAR CANCER RESEARCH. 18, 5, p. 36-36Research output: Contribution to journal › Meeting abstract (Journal)
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Insulitis and lymphoid structures in the islets of Langerhans of a 66-year-old patient with long-standing type 1 diabetes
Smeets, S., Staels, W., Stange, G., Gillard, P., De Leu, N. & In 'T Veld, P., 24 Aug 2020, In : Virchows Archiv. 2020, 6 p.Research output: Contribution to journal › Article
Open AccessFile4 Downloads (Pure) -
Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta-cells
Berthault, C., Staels, W. & Scharfmann, R., Dec 2020, In : Molecular Metabolism. 42, 101060.Research output: Contribution to journal › Article
1 Citation (Scopus)
Activities
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Manipulating VEGF-A signaling for beta cell (re)generation and transplantation
Nico De Leu (Speaker)2 Oct 2018Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Prize best oral presentation fTALES
Willem Staels (Speaker)5 Jun 2018Activity: Talk or presentation › Talk or presentation at a workshop/seminar
File -
VEGF-A, islet endothelial cells and beta cell (re)generation
Nico De Leu (Speaker)2 Jun 2017Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Joint Meeting of The Islet Study Group & Beta Cell Workshop
Willem Staels (Participant)3 May 2015 → 7 May 2015Activity: Participating in or organising an event › Participation in conference
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Annual meeting of the JDRF Center for Beta Cell Therapy in Diabetes.
Willem Staels (Participant)11 Dec 2014 → 12 Dec 2014Activity: Participating in or organising an event › Participation in conference