• Pleinlaan 2

    1050 Brussels

    Belgium

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Organization profile

Organisation profile

A decreased beta cell mass or the incapability of the beta cell mass to compensate for increased insulin needs, results in an absolute or relative deficiency of insulin defining type I and type II diabetes, respectively. Our research group aims to compensate the reduced beta cell mass in diabetes by transplantation or in situ differentiation and expansion of beta- and pre-beta cells. We therefore investigate mechanisms to generate new, fully functional beta cells by: - Differentiation of endogenous progenitor/stem cells - regeneration of the beta cell mass - Protection and profileration of existing beta cells - Transdifferentiation of pancreatic non-beta cells to beta cells Our research is performed within the collaborative framework of the JDRF Center for Beta Cell Therapy in Diabetes and the Beta Cell Biology Consortium.

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