Projects per year
Organisation profile
Organisation profile
The Department of Cell Biology (CYTO-VUB) is specialized in molecular and cellular liver research, with a main focus on the (patho)biology of hepatic stellate cells and liver progenitor cells. Prof. A. Geerts contributed to the first paper on isolation, purification and culturing of hepatic stellate cells (1) and is the author of a side scatter activated cell sorting method to purify freshly isolated hepatic stellate cell up to 95 - 100% (2). CYTO-VUB also has long term experience in isolating, purifying and culturing liver sinusoidal endothelial cells and Kupffer cells. The group has the required expertise and know-how to perform molecular and morphological studies on isolated cells and on tissues. Hepatic stellate cells surround the endothelial lining of sinusoids in the liver. They play important roles in : (i) vitamin A metabolism, (ii) formation of extra cellular matrix, (iii) pathogenesis of fibrosis and cirrhosis, (iv) regulation of flow and pressure in the sinusoids, (v) secretion of growth factors and cytokines in normal liver and under physiological and pathological regeneration, (vi) progression of primary or metastatic tumor growth and (vii) neural signal propagation. Besides these classical functions that are attributed to hepatic stellate cells, it appears that a subpopulation of these cells plays a role in formation of the hepatic progenitor cell niches. References: (1) de Leeuw, A. M., S. P. McCarthy, A. Geerts, and D. L. Knook. Purified rat liver fat-storing cells in culture divide and contain collagen. Hepatology 1984, 4:392-403. (2) Geerts, A., T. Niki, P. De Bleser, D. De Craemer, K. Van den Berg, J. M. Lazou, G. Stange, and M. Van De Winkel. Purification of hepatic stellate cells by side scatter activated cell sorting. Hepatology 1998, 27, 590 - 598.
Keywords
- Fibrosis
- Hepatic Stellate Cells
- Histon (de)acetylation
- Stellate cell activation
- Liver Cell Transplantation
- Sinusoidal Cells
- Portal hypertension
- Liver Sinusoidal Cells
- cirrhosis
- Cell Biology
- Cytoskeleton
- Fat-Storing Cells
- NASH / NAFLD
- Intermediate Filaments
- liver stem / progenitor cells
- autophagy
- Flow Cytometry
- Metabolic Syndrome
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Collaborations and top research areas from the last five years
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ADSI143: Interne overdrachten van UZ voor wetenschappelijk onderzoek
van Grunsven, L. & Geerts, A.
2/07/07 → …
Project: Fundamental
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ADSP19: Sponsoring Workshops, Meetings and PhD United activities
van Grunsven, L. & Geerts, A.
2/02/05 → …
Project: Fundamental
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3943320708: Master and Ph. D. Studenten met Abos beurs Opleiding
Geerts, A.
1/10/94 → …
Project: Fundamental
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Research output
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Integration of Cognitive Behavioral Therapy for Insomnia in Best-Practice Care for Patients with Knee Osteoarthritis and Insomnia: A Randomized Controlled Trial Protocol
Labie, C., Runge, N., Mairesse, O., Nijs, J., Malfliet, A., Verschueren, S., Van Assche, D., de Vlam, K., Luyten, F., Bilterys, T., Stat, W. C., De Pourcq, V., Delwiche, B., Huysmans, E. & De Baets, L., 2 Apr 2024, In: Physical Therapy. 104, 4, 30 p., pzad181.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)148 Downloads (Pure) -
CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response
Duchateau, L., Küҫükali, F., De Roeck, A., Wittens, M. M. J., Temmerman, J., Weets, I., Timmers, M., Engelborghs, S., Bjerke, M. & Sleegers, K., Dec 2023, In: Alzheimer's Research & Therapy. 15, 1, 13 p., 195.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)21 Downloads (Pure) -
The interplay between symptoms of insomnia and pain in people with osteoarthritis: A narrative review of the current evidence
De Baets, L., Runge, N., Labie, C., Mairesse, O., Malfliet, A., Verschueren, S., Van Assche, D., de Vlam, K., Luyten, F. P., Coppieters, I., Herrero Babiloni, A., Martel, M. O., Lavigne, G. J. & Nijs, J., Aug 2023, In: Sleep Medicine Reviews. 70, 1, 10 p., 101793.Research output: Contribution to journal › Scientific review › peer-review
Open AccessFile17 Citations (Scopus)360 Downloads (Pure) -
Precision-cut liver slices as a dynamic tool to model liver fibrosis in vitro.
Dewyse, L., De Smet, V., Reynaert, H. & van Grunsven, L. A., 2021, In: Journal of Hepatology. 75, p. S388-S389Research output: Contribution to journal › Meeting abstract (Journal)
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Reduced knee extensor torque production at low to moderate velocities in postmenopausal women with knee osteoarthritis
Rodriguez-Lopez, C., Beckwée, D., Luyten, F. P., Van Assche, D. & Van Roie, E., Nov 2021, In: Scandinavian Journal of Medicine and Science in Sports. 31, 11, p. 2144-2155 12 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus)
Activities
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Untargeted in vitro metabolomics to identify hepatotoxic modes of action
Matthias Cuykx (Speaker), Charlie Beirnaert (Contributor), Robim Marcelino Rodrigues (Contributor), Kris Laukens (Speaker), Tamara Vanhaecke (Contributor) & Adrian Covaci (Speaker)
20 Sept 2018Activity: Talk or presentation › Talk or presentation at a conference
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Epigen meeting
Inge Mannaerts (Speaker)
27 Feb 2014Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Epigen meeting
Leo A Van Grunsven (Participant)
27 Feb 2014Activity: Participating in or organising an event › Participation in workshop, seminar
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EASL The international Liver Congress 2013, Amsterdam, The Netherlands April14-28 2013
Leslie Stradiot (Member)
24 Apr 2013 → 28 Apr 2013Activity: Other › Research and Teaching at External Organisation
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Lineage tracing of Progenitor cells during Liver Regeneration
Jan Best (Speaker)
24 Mar 2010Activity: Talk or presentation › Talk or presentation at a workshop/seminar