Projects per year
Organization profile
Organisation profile
The Department of Cell Biology (CYTO-VUB) is specialized in molecular and cellular liver research, with a main focus on the (patho)biology of hepatic stellate cells and liver progenitor cells. Prof. A. Geerts contributed to the first paper on isolation, purification and culturing of hepatic stellate cells (1) and is the author of a side scatter activated cell sorting method to purify freshly isolated hepatic stellate cell up to 95 - 100% (2). CYTO-VUB also has long term experience in isolating, purifying and culturing liver sinusoidal endothelial cells and Kupffer cells. The group has the required expertise and know-how to perform molecular and morphological studies on isolated cells and on tissues. Hepatic stellate cells surround the endothelial lining of sinusoids in the liver. They play important roles in : (i) vitamin A metabolism, (ii) formation of extra cellular matrix, (iii) pathogenesis of fibrosis and cirrhosis, (iv) regulation of flow and pressure in the sinusoids, (v) secretion of growth factors and cytokines in normal liver and under physiological and pathological regeneration, (vi) progression of primary or metastatic tumor growth and (vii) neural signal propagation. Besides these classical functions that are attributed to hepatic stellate cells, it appears that a subpopulation of these cells plays a role in formation of the hepatic progenitor cell niches. References: (1) de Leeuw, A. M., S. P. McCarthy, A. Geerts, and D. L. Knook. Purified rat liver fat-storing cells in culture divide and contain collagen. Hepatology 1984, 4:392-403. (2) Geerts, A., T. Niki, P. De Bleser, D. De Craemer, K. Van den Berg, J. M. Lazou, G. Stange, and M. Van De Winkel. Purification of hepatic stellate cells by side scatter activated cell sorting. Hepatology 1998, 27, 590 - 598.
Keywords
- Fibrosis
- Hepatic Stellate Cells
- Histon (de)acetylation
- Stellate cell activation
- Liver Cell Transplantation
- Sinusoidal Cells
- Portal hypertension
- Liver Sinusoidal Cells
- cirrhosis
- Cell Biology
- Cytoskeleton
- Fat-Storing Cells
- NASH / NAFLD
- Intermediate Filaments
- liver stem / progenitor cells
- autophagy
- Flow Cytometry
- Metabolic Syndrome
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Network
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ADSI143: Interne overdrachten van UZ voor wetenschappelijk onderzoek
van Grunsven, L. & Geerts, A.
2/07/07 → …
Project: Fundamental
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ADSP19: Sponsoring Workshops, Meetings and PhD United activities
van Grunsven, L. & Geerts, A.
2/02/05 → …
Project: Fundamental
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3943320708: Master and Ph. D. Studenten met Abos beurs Opleiding
Geerts, A.
1/10/94 → …
Project: Fundamental
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Research output
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Precision-cut liver slices as a dynamic tool to model liver fibrosis in vitro.
Dewyse, L., De Smet, V., Reynaert, H. & van Grunsven, L. A., 2021, In: Journal of Hepatology. 75, p. S388-S389Research output: Contribution to journal › Meeting abstract (Journal)
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Reduced knee extensor torque production at low to moderate velocities in postmenopausal women with knee osteoarthritis
Rodriguez-Lopez, C., Beckwée, D., Luyten, F. P., Van Assche, D. & Van Roie, E., Nov 2021, In: Scandinavian Journal of Medicine and Science in Sports. 31, 11, p. 2144-2155 12 p.Research output: Contribution to journal › Article › peer-review
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A mood state-specific interaction between kynurenine metabolism and inflammation is present in bipolar disorder
van den Ameele, S., van Nuijs, A. L., Lai, F. Y., Schuermans, J., Verkerk, R., van Diermen, L., Coppens, V., Fransen, E., de Boer, P., Timmers, M., Sabbe, B. & Morrens, M., Feb 2020, In: Bipolar Disorders. 22, 1, p. 59-69 11 p.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
Amyloid-beta(1-43) cerebrospinal fluid levels and the interpretation of APP, PSEN1 and PSEN2 mutations
BELNEU Consortium, 11 Sep 2020, In: Alzheimer's Research & Therapy. 12, 1, 108.Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus) -
Immune and Neuroendocrine Trait and State Markers in Psychotic Illness: Decreased Kynurenines Marking Psychotic Exacerbations
De Picker, L., Fransen, E., Coppens, V., Timmers, M., de Boer, P., Oberacher, H., Fuchs, D., Verkerk, R., Sabbe, B. & Morrens, M., 17 Jan 2020, In: Frontiers in Immunology. 10, 12 p., 2971.Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus)
Activities
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Untargeted in vitro metabolomics to identify hepatotoxic modes of action
Matthias Cuykx (Speaker), Charlie Beirnaert (Contributor), Robim Marcelino Rodrigues (Contributor), Kris Laukens (Speaker), Tamara Vanhaecke (Contributor) & Adrian Covaci (Speaker)
20 Sep 2018Activity: Talk or presentation › Talk or presentation at a conference
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Epigen meeting
Leo A Van Grunsven (Participant)
27 Feb 2014Activity: Participating in or organising an event › Participation in workshop, seminar
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Epigen meeting
Inge Mannaerts (Speaker)
27 Feb 2014Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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EASL The international Liver Congress 2013, Amsterdam, The Netherlands April14-28 2013
Leslie Stradiot (Member)
24 Apr 2013 → 28 Apr 2013Activity: Other › Research and Teaching at External Organisation
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EASL monothematic conference on signaling in the liver
Elke Van Rossen (Participant)
18 Feb 2010 → 20 Feb 2010Activity: Participating in or organising an event › Participation in conference