Projects per year
Organization profile
Organisation profile
Our team wants to find ways to generate new insulin-producing, glucose-regulated "beta" cells that can be used for transplantation in diabetes patients and ways to regenerate beta cells in the pancreas. We study rodent experimental models as well as human cells. The first aim is based on tissue engineering starting from: 1. Exocrine pancreatic cells: reprogramming of adult exocrine cells to endocrine cells, or transdifferentiation in culture. 2. Embryonic stem cells: directed differentiation by mimicking the embryonic environment in culture. Cell differentiation is driven in these models by addition of extracellular agents like growth factors, cytokines, hormones and extracellular matrix components. These studies include the phenotypic and functional characterization of the obtained (human) beta cells and their transplantation in animal models. The second aim is based on experimental animal models: 1. Pancreatic duct ligation, a "neogenesis" model that has been developed in our group and mimicks pancreatitis; it is the model that induces the most robust expansion of the beta cell mass. 2. Diabetic mice. In both models, we want to discover the progenitor cells from which new beta cells can be regenerated, and the extracellular factors that regulate the associated events (cell proliferation, differentiation, migration).
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Profiles
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Emmy De Blay
- Vrije Universiteit Brussel
- Basic (bio-) Medical Sciences - Education/Research Officer
- Cell Differentiation
Person: Researcher, Administrative/technical staff
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Céline Moens
- Vrije Universiteit Brussel
- Faculty of Medicine and Pharmacy
- Basic (bio-) Medical Sciences - Academic
- Cell Differentiation
Person: Researcher, PhD
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BRGIMP11: BRIDGE: Diatype : Personalized medicine in diabetes: towards an etiology-based diagnosis and better patient care
1/01/18 → 31/03/22
Project: Applied
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AII62: Transdifferentiation on human exocrine acinar cells to endocrine beta cells by STAT3 and MAPK signalling.
1/07/10 → 30/06/12
Project: Fundamental
Research output
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Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease
Martens, S., Coolens, K., Van Bulck, M., Arsenijevic, T., Casamitjana, J., Fernandez Ruiz, A., El Kaoutari, A., Martinez de Villareal, J., Madhloum, H., Esni, F., Heremans, Y., Leuckx, G., Heimberg, H., Bouwens, L., Jacquemin, P., De Paep, D. L., In't Veld, P., D'Haene, N., Bouchart, C., Dusetti, N. & 6 others, , 30 Jul 2021, In : Gut.Research output: Contribution to journal › Article
Open AccessFile2 Citations (Scopus) -
Dynamic regulation of expression of KRAS and its effectors determines the ability to initiate tumorigenesis in pancreatic acinar cells
Assi, M., Achouri, Y., Loriot, A., Dauguet, N., Dahou, H., Baldan, J., Libert, M., Fain, J. S., Guerra, C., Bouwens, L., Barbacid, M., Lemaigre, F. P. & Jacquemin, P., May 2021, In : Cancer Research. 81, 10, p. 2679-2689 11 p.Research output: Contribution to journal › Article
5 Citations (Scopus) -
Fractionated Radiation Severely Reduces the Number of CD8+ T Cells and Mature Antigen Presenting Cells Within Lung Tumors
Reijmen, E., De Mey, S., De Mey, W., Gevaert, T., De Ridder, K., Locy, H., Martens, S., De Blay, E., Bouwens, L., Debie, P., Breckpot, K., De Grève, J., De Ridder, M. & Goyvaerts, C., 1 Sep 2021, In : International Journal of Radiation Oncology, Biology, Physics. 111, 1, p. 272-283 12 p.Research output: Contribution to journal › Article
8 Citations (Scopus) -
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Kurokawa, M., Goyama, S., Bouwens, L., Jacquemin, P., Houbracken, I. & Rooman, I., Sep 2021, In : Cell Death and Differentiation. 28, 9, p. 2601-2615 15 p.Research output: Contribution to journal › Article
Open AccessFile6 Citations (Scopus)24 Downloads (Pure) -
Peroxiredoxin-I sustains inflammation during pancreatitis
Buckens, H., Pirenne, S., Achouri, Y., Baldan, J., Dahou, H., Bouwens, L., Lemaigre, F. P., Jacquemin, P. & Assi, M., 2021, In : Cellular and molecular gastroenterology and hepatology. 12, 2, p. 741-743 3 p.Research output: Contribution to journal › Article
Open Access3 Citations (Scopus)
Activities
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Presentatie en verdediging laboratoriumstage 2
Isabelle Houbracken (Examiner)19 Jun 2019Activity: Other
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3rd joint meeting of the EASD Islet Study Group and Beta-Cell Workshop in Oxford, UK
Isabelle Houbracken (Participant)1 Apr 2019 → 3 Apr 2019Activity: Participating in or organising an event › Participation in conference
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FWO SB mock defence postdoctoral fellows (Event)
Isabelle Houbracken (Referee)19 Apr 2019Activity: Publication peer-review and editorial work › Editorial activity
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SID-In Kortrijk
Isabelle Houbracken (Advisor)24 Jan 2019 → 25 Jan 2019Activity: Participating in or organising an event › Participating in or organizing a school event
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Scientific Reports - Nature (Journal)
Isabelle Houbracken (Peer reviewer)2019 → …Activity: Publication peer-review and editorial work › Editorial activity