Projects per year
Organization profile
Organisation profile
The laboratory for Cell Genetics (Cytogenetics) studies variation in genotype and phenotype, cell division pathways, cell death and genetic changes relevant for the increase of cancer in human. Genotoxicity tests assess the induction of DNA damage, gene mutations, structural and numerical chromosome aberrations. Their predictivity for cancer induction is supported by international studies relating mutations and activation of cancer related genes, and the induction of chromosome aberrations in lymphocytes with increased frequency of cancer. The genotoxicity tests and genotyping performed in the laboratory are used to study the mechanisms of action of mutagens/carcinogens (e.g. indirect mechanisms of genotoxicity by interference with spindle proteins, DNA repair enzymes and cellular trafficking), on development of predictive human genetic susceptibility biomarkers by combining genotyping and integrated phenotyping, on the assessment of potentially more susceptible sub-groups (e.g. stem cells and children) and on the risk of occupational/environmental exposure to newly developed material (e.g. nanotoxicology) Our strategy is a stepwise approach, from fundamental to applied research (including validation), at cellular/molecular level combining cytology with molecular approaches within interlaboratory and international collaborations. In the Developmental and Stem Cell Biology group, we are focusing on: * The role of the Wnt signaling in development and homeostasis by using transgenic mice and gene expression studies * Modeling the embryonic development by differentiating in vitro embryonic stem cell into muscle or neurons * Identifying the signaling pathways involved in some cancers involving the unregulated growth of stem cell, in particular in neural tissue. * Identifying by conserved genomics conserved regulatory elements implicated in limb development In the insect physiology group we concentrate on environmental biology, (eco)toxicology en risk assessment for the use of pesticides en other environment-related compounds, we use the bumble bee Bombus terrestris , which is of major economic and ecologic importance.
Keywords
- Cell Genetics
- Developmental Biology
- Physiology
- Insect
- Mouse
- Embryology
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Network
Profiles
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Luc Leyns
- Vrije Universiteit Brussel
- Biology - Undefined, Academic
- Cell Genetics
Person: Researcher, Professor
Projects
- 32 Finished
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OZR3141: Bilateral cooperation in the joint doctoral project: Bench fee for Joint PhD VUB-Universidad Nacional del Nordeste, Barnes Tamara
1/02/17 → 2/02/18
Project: Fundamental
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OZR2795: Bilaterale samenwerking ikv gemeenschappelijke onderzoeksproject: Bench fee Joint PhD Jimma University - VUB, Mengistu Damite Chanyalew
13/05/15 → 30/07/20
Project: Policy Based
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FWOTM656: Trees and water shortage: estimating the vascular factor.
Robert, E., Koedam, N. & Leyns, L.
1/10/12 → 30/09/20
Project: Fundamental
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HERC1: Multifoon confocale laser scanning microscoop voor imaging core faciliteit ter ondersteuning van onderzoek van de life sciences campus Jette en campus etterbeek -VUB.
Bouwens, L., Heimberg, H., Pipeleers, D., Hellemans, K., In 'T Veld, P., Geerts, A., Leyns, L., De Baetselier, P. & Volders, M.
1/12/08 → 30/11/13
Project: Fundamental
Research output
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Hoisted with his own petard: how sex-ratio meiotic drive in Drosophila affinis creates resistance alleles that limit its spread
Ma, W-J., Knoles, E. M., Patch, K. B., Shoaib, M. M. & Unckless, R. L., 16 Feb 2022Research output: Other contribution
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Sex chromosome evolution: The remarkable diversity in the evolutionary rates and mechanisms
Ma, W-J. & Rovatsos, M., 1 Dec 2022, In: Journal of Evolutionary biology. 35, 12, p. 1581-1588 8 p.Research output: Contribution to journal › Article › peer-review
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Simulation of in-ice cosmic ray air shower induced particle cascades
Kockere, S. D., Eijndhoven, N. V., Latif, U. A. & De Vries, K., 24 Aug 2022, In: Phys. Rev. D. 106, 4, 14 p., 043023.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)19 Downloads (Pure) -
Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesis
Volders, M. & Fenech, M., 21 Sep 2021, In: Mutation Research - Reviews in Mutation Research. 788, 16 p., 108395.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Micronuclei, reproduction and child health
Knudsen, L. E. & Kirsch-Volders, M., 5 Jun 2021, In: Mutation Research - Reviews in Mutation Research. 787, 108345.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus)
Activities
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PhD defense Christopher Kariuki - Deciphering the structure and function of select membrane associated proteins in haemoprotozoan parasites (Event)
Remy Loris (Chair), Christopher Kinyanjui Kariuki (Presenter), Stefan Magez (Supervisor), Benoit Stijlemans (Jury), Els Pardon (Jury), Luc Leyns (Jury), Veerle Lejon (Jury) & Sebastian Zoll (Jury)
22 Jun 2022Activity: Membership › Member of PhD committee
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NewGeneris training session for preparation of slides automatic scoring of MN within NewGeneris.
Gina Plas (Contributor)
10 Sep 2009 → 18 Sep 2009Activity: Other › Research and Teaching at External Organisation
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International Association of Environmental Mutagen Societies (IAEMS) (External organisation)
Micheline Volders (Host)
2009 → 2013Activity: Membership › Membership of external research organisation
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NewGeneris Training session for preparation of slides for automatic scoring of MN within NewGeneris.
Micheline Volders (Contributor)
10 Sep 2009 → 18 Sep 2009Activity: Other › Research and Teaching at External Organisation
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Institute Of Occupational Medicine, (External organisation)
Micheline Volders (Member)
2009 → 2012Activity: Membership › Membership of external research organisation