Projects per year
The laboratory for Cell Genetics (Cytogenetics) studies variation in genotype and phenotype, cell division pathways, cell death and genetic changes relevant for the increase of cancer in human. Genotoxicity tests assess the induction of DNA damage, gene mutations, structural and numerical chromosome aberrations. Their predictivity for cancer induction is supported by international studies relating mutations and activation of cancer related genes, and the induction of chromosome aberrations in lymphocytes with increased frequency of cancer. The genotoxicity tests and genotyping performed in the laboratory are used to study the mechanisms of action of mutagens/carcinogens (e.g. indirect mechanisms of genotoxicity by interference with spindle proteins, DNA repair enzymes and cellular trafficking), on development of predictive human genetic susceptibility biomarkers by combining genotyping and integrated phenotyping, on the assessment of potentially more susceptible sub-groups (e.g. stem cells and children) and on the risk of occupational/environmental exposure to newly developed material (e.g. nanotoxicology) Our strategy is a stepwise approach, from fundamental to applied research (including validation), at cellular/molecular level combining cytology with molecular approaches within interlaboratory and international collaborations. In the Developmental and Stem Cell Biology group, we are focusing on: * The role of the Wnt signaling in development and homeostasis by using transgenic mice and gene expression studies * Modeling the embryonic development by differentiating in vitro embryonic stem cell into muscle or neurons * Identifying the signaling pathways involved in some cancers involving the unregulated growth of stem cell, in particular in neural tissue. * Identifying by conserved genomics conserved regulatory elements implicated in limb development In the insect physiology group we concentrate on environmental biology, (eco)toxicology en risk assessment for the use of pesticides en other environment-related compounds, we use the bumble bee Bombus terrestris , which is of major economic and ecologic importance.
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- 32 Finished
OZR3141: Bilateral cooperation in the joint doctoral project: Bench fee for Joint PhD VUB-Universidad Nacional del Nordeste, Barnes Tamara
1/02/17 → 2/02/18
OZR2795: Bilaterale samenwerking ikv gemeenschappelijke onderzoeksproject: Bench fee Joint PhD Jimma University - VUB, Mengistu Damite Chanyalew
13/05/15 → 30/07/20
Project: Policy Based
1/10/12 → 30/09/20
HERC1: Multifoon confocale laser scanning microscoop voor imaging core faciliteit ter ondersteuning van onderzoek van de life sciences campus Jette en campus etterbeek -VUB.
1/12/08 → 30/11/13
Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesisVolders, M. & Fenech, M., 21 Sep 2021, In : Mutation Research - Reviews in Mutation Research. 788, 16 p., 108395.
Research output: Contribution to journal › ArticleOpen Access2 Citations (Scopus)
Kirsch-Volders, M., 5 Jun 2021, In : Mutation Research - Reviews in Mutation Research. 787, 108345.
Research output: Contribution to journal › Article3 Citations (Scopus)
Kirsch-Volders, M., Deo, P., Franzke, B., Stopper, H., Andreassi, M-G., Bolognesi, C., Dhillon, V. S., Laffon, B., Wagner, K-H. & Bonassi, S., 5 Jun 2021, In : Mutation Research - Reviews in Mutation Research. 788, 8 p., 108384.
Research output: Contribution to journal › ArticleOpen Access4 Citations (Scopus)
Kirsch-Volders, M., Bolognesi, C., Ceppi, M., Bruzzone, M. & Fenech, M., 1 Oct 2020, In : Mutation Research. 786, 18 p., 108335.
Research output: Contribution to journal › Article17 Citations (Scopus)
Micronuclei as biomarkers of DNA damage, aneuploidy, inducers of chromosomal hypermutation and as sources of pro-inflammatory DNA in humansFenech, M., Knasmueller, S., Bolognesi, C., Holland, N., Bonassi, S. & Kirsch-Volders, M., 28 Oct 2020, In : Mutation Research. 786, 108342.
Research output: Contribution to journal › Article24 Citations (Scopus)
Micheline Volders (Keynote speaker)24 Oct 2009 → 28 Oct 2009
Activity: Talk or presentation › Talk or presentation at a workshop/seminar
NewGeneris training session for preparation of slides from newborn and maternal full blood for automatic scoring of MN within NewGeneris.Ilse Decordier (Contributor)10 Sep 2009 → 18 Sep 2009
Activity: Other › Research and Teaching at External Organisation
Micheline Volders (Host)2009 → 2013
Activity: Membership › Membership of external research organisation