Projects per year
Organization profile
Organisation profile
The laboratory for Cell Genetics (Cytogenetics) studies variation in genotype and phenotype, cell division pathways, cell death and genetic changes relevant for the increase of cancer in human. Genotoxicity tests assess the induction of DNA damage, gene mutations, structural and numerical chromosome aberrations. Their predictivity for cancer induction is supported by international studies relating mutations and activation of cancer related genes, and the induction of chromosome aberrations in lymphocytes with increased frequency of cancer. The genotoxicity tests and genotyping performed in the laboratory are used to study the mechanisms of action of mutagens/carcinogens (e.g. indirect mechanisms of genotoxicity by interference with spindle proteins, DNA repair enzymes and cellular trafficking), on development of predictive human genetic susceptibility biomarkers by combining genotyping and integrated phenotyping, on the assessment of potentially more susceptible sub-groups (e.g. stem cells and children) and on the risk of occupational/environmental exposure to newly developed material (e.g. nanotoxicology) Our strategy is a stepwise approach, from fundamental to applied research (including validation), at cellular/molecular level combining cytology with molecular approaches within interlaboratory and international collaborations. In the Developmental and Stem Cell Biology group, we are focusing on: * The role of the Wnt signaling in development and homeostasis by using transgenic mice and gene expression studies * Modeling the embryonic development by differentiating in vitro embryonic stem cell into muscle or neurons * Identifying the signaling pathways involved in some cancers involving the unregulated growth of stem cell, in particular in neural tissue. * Identifying by conserved genomics conserved regulatory elements implicated in limb development In the insect physiology group we concentrate on environmental biology, (eco)toxicology en risk assessment for the use of pesticides en other environment-related compounds, we use the bumble bee Bombus terrestris , which is of major economic and ecologic importance.
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Profiles
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Merel Fabre
- Vrije Universiteit Brussel
- Amphibian Evolution Lab
- Cell Genetics
- Ecology and Systematics
- General Botany and Nature Management
- Biology - Management Assistant
- Physics - Administrative Assistant
Person: Researcher, Administrative/technical staff
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Ann Pauwels
- Vrije Universiteit Brussel
- Biology - Education/Research Officer
- Cell Genetics
Person: Researcher, Administrative/technical staff
Projects
- 32 Finished
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OZR3141: Bilateral cooperation in the joint doctoral project: Bench fee for Joint PhD VUB-Universidad Nacional del Nordeste, Barnes Tamara
1/02/17 → 2/02/18
Project: Fundamental
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OZR2795: Bilaterale samenwerking ikv gemeenschappelijke onderzoeksproject: Bench fee Joint PhD Jimma University - VUB, Mengistu Damite Chanyalew
13/05/15 → 30/07/20
Project: Policy Based
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FWOTM656: Trees and water shortage: estimating the vascular factor.
Robert, E., Koedam, N. & Leyns, L.
1/10/12 → 30/09/20
Project: Fundamental
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HERC1: Multifoon confocale laser scanning microscoop voor imaging core faciliteit ter ondersteuning van onderzoek van de life sciences campus Jette en campus etterbeek -VUB.
Bouwens, L., Heimberg, H., Pipeleers, D., Hellemans, K., In 'T Veld, P., Geerts, A., Leyns, L., De Baetselier, P. & Volders, M.
1/12/08 → 30/11/13
Project: Fundamental
Research output
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Polycomb group RING finger protein 5 influences several developmental signaling pathways during the in vitro differentiation of mouse embryonic stem cells
Meng, Y., Liu, Y., Dakou, E., Gutierrez, G. J. & Leyns, L., 1 May 2020, In : Development, Growth & Differentiation. 62, 4, p. 232-242 11 p.Research output: Contribution to journal › Article
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Loss of Emp2 compromises cardiogenic differentiation in mouse embryonic stem cells.
Liu, Y., Dakou, E., Meng, Y. & Leyns, L., 26 Mar 2019, In : Biochemical and Biophysical Research Communications. 511, 1, p. 173-178 6 p.Research output: Contribution to journal › Article
Open Access2 Citations (Scopus) -
Natural Histogel-Based Bio-Scaffolds for Sustaining Angiogenesis in Beige Adipose Tissue
Di Somma, M., Schaafsma, W., Grillo, E., Vliora, M., Dakou, E., Corsini, M., Ravelli, C., Ronca, R., Sakellariou, P., Vanparijs, J., Castro, B. & Mitola, S., 18 Nov 2019, In : Cells. 8, 11, 1457.Research output: Contribution to journal › Article
1 Citation (Scopus) -
MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis
Stijlemans, B., Brys, L., Korf, H., Bieniasz-Krzywiec, P., Sparkes, A., Vansintjan, L., Leng, L., Vanbekbergen, N., Mazzone, M., Caljon, G., Van Den Abbeele, J., Odongo, S., De Trez, C., Magez, S., Van Ginderachter, J. A., Beschin, A., Bucala, R. & De Baetselier, P., Sep 2016, In : PLoS Pathogens. 12, 9, p. e1005862Research output: Contribution to journal › Article
10 Citations (Scopus) -
Amorphous silica nanoparticles alter microtubule dynamics and cell migration
Gonzalez, L., De Santis Puzzonia, M., Ricci, R., Aureli, F., Guarguaglini, G., Cubadda, F., Leyns, L., Cundari, E. & Volders, M., 2015, In : Nanotoxicology. 9, 6, p. 729-736Research output: Contribution to journal › Article
10 Citations (Scopus)
Activities
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NewGeneris training session for preparation of slides automatic scoring of MN within NewGeneris.
Ilse Decordier (Contributor)10 Sep 2009 → 18 Sep 2009Activity: Other › Research and Teaching at External Organisation
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Identification of novel genes involved in the induction and anterior-posterior patterning of mesoderm during mouse embryonic development.
Eleni Dakou (Speaker)3 Dec 2009Activity: Talk or presentation › Talk or presentation at a conference
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Annual Meeting of the Environmental Mutagen Society
Micheline Volders (Keynote speaker)24 Oct 2009 → 28 Oct 2009Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Annual Meeting of the Environmental Mutagen Soc
Micheline Volders (Keynote speaker)24 Oct 2009 → 28 Oct 2009Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Training session for the preparation of slides for automatic scoring of MN
Ilse Decordier (Contributor)10 Sep 2009 → 18 Oct 2009Activity: Other › Research and Teaching at External Organisation