Experimental in vitro toxicology and dermato-cosmetology

2022

Adverse outcome pathway from activation of the AhR to breast cancer-related death

Benoit, L., Jornod, F., Zgheib, E., Tomkiewicz, C., Koual, M., Coustillet, T., Barouki, R., Audouze, K., Vinken, M. & Coumoul, X., 9 Jun 2022, In : Environment International. 165, 107323.

Research output: Contribution to journal › Article

Open Access

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Adverse Outcome Pathways as Versatile Tools in Liver Toxicity Testing

Arnesdotter, E., Gijbels, E., dos Santos Rodrigues, B., Vilas-Boas, V. & Vinken, M., 22 Feb 2022, In : Methods in Molecular Biology: In Silico Methods for Predicting Drug Toxicity. 2425, p. 521-535 15 p.

Research output: Contribution to journal › Article

Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks

Hoffmann, S., Aiassa, E., Angrish, M., Beausoleil, C., Bois, F. Y., Ciccolallo, L., Craig, P. S., de Vries, R. B. M., Dorne, J. L. C. M., Druwe, I. L., Edwards, S. W., Eskes, C., Georgiadis, M., Hartung, T., Kienzler, A., Kristjansson, E. A., Lam, J., Martino, L., Meek, B., Morgan, R. L. & 19 others, Munoz-Guajardo, I., Noyes, P. D., Parmelli, E., Piersma, A., Rooney, A., Sena, E., Sullivan, K., Tarazona, J., Terron, A., Thayer, K., Turner, J., Verbeek, J., Verloo, D., Vinken, M., Watford, S., Whaley, P., Wikoff, D., Willett, K. & Tsaioun, K., 28 Feb 2022, (Accepted/In press) In : ALTEX.

Research output: Contribution to journal › Article

Assessing safety without animal testing: the road ahead

Daston, G., Mahony, C., Thomas, R. S. & Vinken, M., 26 May 2022, In : Toxicological Sciences. 187, 2, p. 214-218 5 p.

Research output: Contribution to journal › Article

Connexin-based channels in the liver.

Van Campenhout, R., Leroy, K., Cooreman, A., Tabernilla Garcia, A., Cogliati, B., Kadam, P. & Vinken, M., 27 Apr 2022, (Accepted/In press) In : Comprehensive Physiology.

Research output: Contribution to journal › Article

Correction to: Toxicogenomics directory of chemically exposed human hepatocytes

Grinberg, M., Stöber, R. M., Edlund, K., Rempel, E., Godoy, P., Reif, R., Widera, A., Madjar, K., Schmidt-Heck, W., Marchan, R., Sachinidis, A., Spitkovsky, D., Hescheler, J., Carmo, H., Arbo, M. D., van de Water, B., Wink, S., Vinken, M., Rogiers, V., Escher, S. & 21 others, Hardy, B., Mitic, D., Apic, G., Myatt, G., Waldmann, T., Mardinoglu, A., Damm, G., Seehofer, D., Nüssler, A., Weiss, T. S., Oberemm, A., Lampen, A., Schaap, M. M., Luijten, M., van Steeg, H., Thasler, W. E., Kleinjans, J. C. S., Stierum, R. H., Leist, M., Rahnenführer, J. & Hengstler, J. G., 2022, In : Archives of Toxicology. 96, 3, p. 945-946 2 p.

Research output: Contribution to journal › Article

Open Access

COVID-19 through adverse outcome pathways: building networks to better understand the disease: report of the 3rd CIAO AOP design workshop

Clerbaux, L-A., Amigó, N., Amorim, M. J., Bal-Price, A., Leite, S. B., Beronius, A., Bezemer, G. F. G., Bostroem, A-C., Carusi, A., Coecke, S., Concha, R., Daskalopoulos, E. P., Debernardi, F., Edrosa, E., Edwards, S. W., Filipovska, J., Garcia-Reyero, N., Gavins, F. N. E., Halappanavar, S., Hargreaves, A. J. & 38 others, Hogberg, H., Huynh, M. T., Jacobson, D., Josephs-Spaulding, J., Kim, Y. J., Kong, H. J., Krebs, C. E., Lam, A., Landesmann, B., Racanelli Layton, A., Lee, Y. O., Macmillan, D. S., Mantovani, A., Margiotta-Casaluci, L., Martens, M., Masereeuw, R., Mayasich, S. A., Mei, L. M., Mortensen, H., Munoz Pineiro, A., Nymark, P., Ohayon, E., Manoj Ojasi, J., Paini, A., Parissis, N., Parvatam, S., Pistollato, F., Sachana, M., Birkelund Sørli, J., Sullivan, K. M., Sund, J., Tanabe, S., Tsaioun, K., Vinken, M., Viviani, L., Waspe, J., Willett, C. & Wittwehr, C., 11 Apr 2022, In : ALTEX. 39, 2, p. 322-335 14 p.

Research output: Contribution to journal › Article

Open Access

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1 Citation (Scopus)

16 Downloads (Pure)

Development of a robust high-throughput screening system for the evaluation of human homogentisate 1,2-dioxygenase missense variants in the context of rare disease alkaptonuria

Lequeue, S., Neuckermans, J., Vanhaecke, T. & De Kock, J., 2022, (Unpublished).

Research output: Unpublished contribution to conference › Poster

Effects of drugs formerly proposed for COVID-19 treatment on connexin43 hemichannels.

Cooreman, A., Caufriez, A., Tabernilla Garcia, A., Van Campenhout, R., Leroy, K., Kadam, P., Sanz-Serrano, J., dos Santos Rodrigues, B., Annaert, P. & Vinken, M., 30 Apr 2022, In : International Journal of Molecular Sciences. 23, 16 p., 5018.

Research output: Contribution to journal › Article

Open Access

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Effects of drugs formerly suggested for COVID-19 repurposing on pannexin1 channels.

Caufriez, A., Tabernilla Garcia, A., Van Campenhout, R., Cooreman, A., Leroy, K., Sanz-Serrano, J., Kadam, P., dos Santos Rodrigues, B., Lamouroux, A., Ballet, S. & Vinken, M., 19 May 2022, In : International Journal of Molecular Sciences. 23, 10, 21 p., 5664.

Research output: Contribution to journal › Article

Open Access

End-user engineering of ontology-based knowledge bases

Sanctorum, A., Riggio, J., Maushagen, J., Sepehri, S., Arnesdotter, E., Delagrange, M., De Kock, J., Vanhaecke, T., Debruyne, C. & De Troyer, O., 29 Jun 2022, In : Behaviour & Information Technology.

Research output: Contribution to journal › Article

Evaluating micellar liquid chromatographic methods on octadecyl particle-based and monolithic columns to predict the skin permeation of drug and cosmetic molecules

Grooten, Y., Marcelis, Q., Mangelings, D. & Vander Heyden, Y., 25 Jan 2022, In : Journal of Chromatography. A. 1663, 10 p., 462753.

Research output: Contribution to journal › Article

Expérimentation animale à Bruxelles: la plate-forme sur les alternatives améliorée

Van Mulders, M., Liodo Missigba, N. M. A., Mertens, B. & Rogiers, V., 16 Jan 2022, SUDINFO.

Research output: Contribution to specialist/vulgarizing publication › Editorial › Vulgarizing

Flanders and Brussels join forces to tackle animal testing

Van Mulders, M., Liodo Missigba, N. M. A., Mertens, B. & Rogiers, V., 16 Jan 2022, The Brussels times magazine.

Research output: Contribution to specialist/vulgarizing publication › Editorial › Vulgarizing

From NAFLD to MAFLD: Aligning translational in vitro research to clinical insights

Gatzios, A., Rombaut, M., Buyl, K., De Kock, J., Rodrigues, R., Rogiers, V., Vanhaecke, T. & Boeckmans, J., 13 Jan 2022, In : Biomedicines. 10, 1, 19 p., 161.

Research output: Contribution to journal › Article

Open Access

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Light triggered nanoscale biolistics for efficient intracellular delivery of functional macromolecules in mammalian cells

Fraire, J. C., Shaabani, E., Sharifiaghdam, M., Rombaut, M., Hinnekens, C., Hua, D., Ramon, J., Raes, L., Bolea-Fernandez, E., Brans, T., Vanhaecke, F., Borghgraef, P., Huang, C., Sauvage, F., Vanhaecke, T., De Kock, J., Xiong, R., De Smedt, S. & Braeckmans, K., Dec 2022, In : Nature Communications. 13, 1, 16 p., 1996.

Research output: Contribution to journal › Article

Open Access

Meer alternatieven voor dierenproeven

Van Mulders, M., Liodo Missigba, N. M. A., Mertens, B. & Rogiers, V., 16 Jan 2022, Kabinet Minister Weyts.

Research output: Other contribution

Metabolic Signature of Ethanol-Induced Hepatotoxicity in HepaRG Cells by Liquid Chromatography–Mass Spectrometry-Based Untargeted Metabolomics

Iturrospe, E., Silva, K. M. D., Robeyns, R., Lavoir, M. V. D., Boeckmans, J., Vanhaecke, T., Nuijs, A. L. N. V. & Covaci, A., 1 Apr 2022, In : Journal of Proteome Research. 21, 4, p. 1153-1166 14 p.

Research output: Contribution to journal › Article

Mitochondria as target of hepatotoxicity and drug-induced liver injury: molecular mechanisms and detection methods

Mihajlovic, M. & Vinken, M., 18 Mar 2022, In : International Journal of Molecular Sciences. 23, 6, 39 p., 3315.

Research output: Contribution to journal › Article

Open Access

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25 Downloads (Pure)

Nieuw kennisplatform moet alternatieven voor dierenproeven bevorderen: «We blijven gaan voor maximale daling van aantal dierenproeven»

Van Mulders, M., Mertens, B. & Rogiers, V., 17 Jan 2022, Metro (Nederlandse ed.).

Research output: Contribution to specialist/vulgarizing publication › Article › Vulgarizing

"Œuvrer à moins de souffrance animale en science est un devoir éthique"

Van Mulders, M., Rogiers, V. & Mertens, B., 25 Mar 2022, La Libre Belgique.

Research output: Contribution to specialist/vulgarizing publication › Article › Vulgarizing

Publisher Correction: Light triggered nanoscale biolistics for efficient intracellular delivery of functional macromolecules in mammalian cells (Nature Communications, (2022), 13, 1, (1996), 10.1038/s41467-022-29713-7)

Fraire, J. C., Shaabani, E., Sharifiaghdam, M., Rombaut, M., Hinnekens, C., Hua, D., Ramon, J., Raes, L., Bolea-Fernandez, E., Brans, T., Vanhaecke, F., Borghgraef, P., Huang, C., Sauvage, F., Vanhaecke, T., De Kock, J., Xiong, R., De Smedt, S. & Braeckmans, K., 26 Apr 2022, In : Nature Communications. 13, 1, 1 p., 2385.

Research output: Contribution to journal › Comment/debate

Open Access

RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies

Van Mulders, M., Everaert, M., Liodo Missigba, N. M. A., Mertens, B. & Rogiers, V., 22 Jun 2022, In : Frontiers in Pharmacology.

Research output: Contribution to journal › Article

RE-Place heeft reeds 170 alternatieve methoden voor dierproeven opgelijst

Van Mulders, M., Liodo Missigba, N. M. A., Mertens, B. & Rogiers, V., 16 Jan 2022, Kabinet Minister Clerfayt.

Research output: Other contribution

RE-Place project: Reducing animal research through alternative methods

Van Mulders, M., Mertens, B. (ed.) & Rogiers, V. (ed.), 16 Mar 2022, Biovox.

Research output: Contribution to specialist/vulgarizing publication › Article › Vulgarizing

Resmetirom reduces lipid load, restores THRB expression and prevents cell damage in a human stem cell based in vitro MAFLD model.

Gatzios, A., Rodrigues, R., De Kock, J., Verhoeven, A., Sepehri, S., Buyl, K., Rombaut, M., Rogiers, V., Boeckmans, J. & Vanhaecke, T., 10 Jun 2022, Resmetirom reduces lipid load, restores THRB expression and prevents cell damage in a human stem cell based in vitro MAFLD model.. 3rd European Fatty Liver Conference, p. 49-49 1 p.

Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book)

Study of the antioxidant activity of Pistacia atlantica Desf. Gall extracts and evaluation of the responsible compounds

Ben Ahmed, Z., Hefied, F., Yousfi, M., Demeyer, K. & Vander Heyden, Y., Feb 2022, In : Biochemical Systematics and Ecology. 100, 10 p., 104358.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Systematic comparison of experimental and human obstructive cholestasis reveals conservation of canonical pathway activation and biomarkers relevant for cholestatic liver disease

Gijbels, E., De Muynck, K., Vanderborght, B., Meese, T., Van Nieuwerburgh, F., Vanlander, A., Berrevoet, F., Hendrikx, B., Hoorens, A., Van Vlierberghe, H., Vinken, M. & Devisscher, L., 22 Feb 2022, (Accepted/In press) In : Genes&Diseases.

Research output: Contribution to journal › Article

The Rise of Three Rs Centres and Platforms in Europe

Neuhaus, W., Reininger-Gutmann, B., Rinner, B., Plasenzotti, R., Wilflingseder, D., De Kock, J., Vanhaecke, T., Rogiers, V., Jírová, D., Kejlová, K., Knudsen, L. E., Nielsen, R. N., Kleuser, B., Kral, V., Thöne-Reineke, C., Hartung, T., Pallocca, G., Leist, M., Hippenstiel, S., Lang, A. & 45 others, Retter, I., Krämer, S., Jedlicka, P., Ameli, K., Fritsche, E., Tigges, J., Buettner, M., Bleich, A., Baumgart, N., Baumgart, J., Meinhardt, M. W., Spanagel, R., Chourbaji, S., Kränzlin, B., Seeger, B., von Köckritz-Blickwede, M., Sánchez-Morgado, J. M., Galligioni, V., Ruiz-Pérez, D., Movia, D., Prina-Mello, A., Ahluwalia, A., Chiono, V., Gutleb, A. C., Schmit, M., van Golen, B., van Weereld, L., Kienhuis, A., van Oort, E., van der Valk, J., Smith, A., Roszak, J., Stępnik, M., Sobańska, Z., Olsson, I. A. S., Franco, N. H., Sevastre, B., Kandarova, H., Capdevila, S., Johansson, J., Cederroth, C. R., Sandström, J., Ragan, I., Bubalo, N. & Spielmann, H., Mar 2022, In : ATLA. Alternatives to Laboratory Animals. 50, 2, p. 90-120 31 p.

Research output: Contribution to journal › Article

Open Access

Transcriptomics reveals discordant lipid metabolism effects between in vitro models exposed to elafibranor and liver samples of NAFLD patients after bariatric surgery

Boeckmans, J., Gatzios, A., Heymans, A., Rombaut, M., Rogiers, V., De Kock, J., Vanhaecke, T. & Rodrigues, R., 1 Mar 2022, In : Cells. 11, 5, 16 p., 893.

Research output: Contribution to journal › Article

Open Access

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Vlaams-Brussels platform rond alternatieven voor dierproeven geoptimaliseerd

Van Mulders, M., Liodo Missigba, N. M. A., Mertens, B. & Rogiers, V., 16 Jan 2022, HLN.

Research output: Contribution to specialist/vulgarizing publication › Editorial › Vulgarizing

Vlaams en Brussels Gewest zoeken samen naar alternatieven dierenproeven

Van Mulders, M., Rogiers, V. & Mertens, B., 16 Jan 2022, BRUZZ.

Research output: Contribution to specialist/vulgarizing publication › Blog › Vulgarizing

2021

A jigsaw-Based End-User Tool for the Development of Ontology-Based Knowledge Bases

Sanctorum, A., Riggio, J., Sepehri, S., Arnesdotter, E., Vanhaecke, T. & De Troyer, O., 2021, End-User Development. IS-EUD 2021. . Fogli, D., Tetteroo, D., Barricelli, B. R., Borsci, S., Markopoulos, P. & Papadopoulos, G. A. (eds.). Springer, p. 169-184 16 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 12724 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Conference paper

Open Access

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15 Downloads (Pure)

An exploratory approach for an oriented development of an untargeted hydrophilic interaction liquid chromatography-mass spectrometry platform for polar metabolites in biological matrices

Iturrospe, E., Da Silva, K. M., Talavera Andújar, B., Cuykx, M., Boeckmans, J., Vanhaecke, T., Covaci, A. & van Nuijs, A. L. N., 25 Jan 2021, In : Journal of Chromatography. A. 1637, 14 p., 461807.

Research output: Contribution to journal › Article

8 Citations (Scopus)

A novel prediction model to evaluate genotoxicity based on a gene signature in metabolically competent human HepaRG (TM) cells

Thienpont, A., Verhulst, S., van Grunsven, L., Rogiers, V., Vanhaecke, T. & Mertens, B., Sep 2021, In : Toxicology Letters. 350, p. S66-S66

Research output: Contribution to journal › Meeting abstract (Journal)

An Overview of Current Practices for Regulatory Risk Assessment with Lessons Learnt from Cosmetics in The European Union

Arnesdotter, E., Rogiers, V., Vanhaecke, T. & Vinken, M., 15 Sep 2021, In : Critical reviews in toxicology. 51, 5, p. 395-471 23 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

4 Downloads (Pure)

A robust, mechanistically based in silico structural profiler for hepatic cholestasis

Firman, J. W., Pestana, C. B., Rathman, J. F., Vinken, M., Yang, C. & Cronin, M. T. D., 15 Feb 2021, In : Chemical Research in Toxicology. 34, 2, p. 641-655 15 p.

Research output: Contribution to journal › Article

Open Access

File

4 Citations (Scopus)

25 Downloads (Pure)

Biomarkers of cholestasis

Pieters, A., Gijbels, E., Cogliati, B., Annaert, P., Devisscher, L. & Vinken, M., Apr 2021, In : Biomarkers in Medicine. 15, 6, p. 437-454 18 p.

Research output: Contribution to journal › Article

Open Access

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4 Citations (Scopus)

35 Downloads (Pure)

Bosentan alters endo- and exogenous bile salt disposition in sandwich-cultured human hepatocytes

Oorts, M., Van Brantegem, P., Deferm, N., Chatterjee, S., Dreesen, E., Cooreman, A., Vinken, M., Richert, L. & Annaert, P., 1 Oct 2021, In : Journal of Pharmacology and Experimental Therapeutics. 379, 1, p. 20-32 13 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Open Access

File

1 Citation (Scopus)

33 Downloads (Pure)

Corrigendum to: Impact of the Revised European Tobacco Product Directive on the Quality of E-cigarette Refill Liquids in Belgium

Barhdadi, S., Moens, G., Canfyn, M., Vanhee, C., Desmedt, B., Courselle, P., Rogiers, V., Vanhaecke, T. & Deconinck, E., 7 Jan 2021, In : Nicotine & tobacco research. 23, 1, p. 322-323 2 p.

Research output: Contribution to journal › Article

Open Access