Experimental in vitro toxicology and dermato-cosmetology

Research output

Research output per year 1981 2021

• 6690 Citations
• 39 h-Index
• 333 Article
• 140 Poster
• 42 Meeting abstract (Book)
• 38 Chapter
• 50 More
  • 10 Unpublished abstract
  • 8 Editorial
  • 6 Meeting abstract (Journal)
  • 5 Conference paper
  • 5 Scientific review
  • 4 Book
  • 3 Special issue
  • 2 Other
  • 2 Other scientific journal contribution
  • 2 Other contribution
  • 1 Other report
  • 1 Unpublished paper
  • 1 Comment/debate

Research output per year

Research output per year

Search results

• 2019

  RE-Place: an online tool to gather New Approach Methodologies (NAMs).

  Liodo Missigba, N. M. A., Van Mulders, M., Rogiers, V. & Mertens, B., 20 May 2019.

  Research output: Unpublished contribution to conference › Poster

• RE-Place: a project to collect expertise on New Approach Methodologies in one central database

  Van Mulders, M., Liodo Missigba, N. M. A., Mertens, B. & Rogiers, V., 25 Oct 2019.

  Research output: Unpublished contribution to conference › Poster

• RE-PLace: a project to collect the available Belgian expertise on New Approach Methodologies in one central database

  Van Mulders, M., Liodo Missigba, N. M. A., Mertens, B. & Rogiers, V., 21 Nov 2019.

  Research output: Unpublished contribution to conference › Poster

• System xc- deficiency extends life-span and prevents age-related hippocampal dysfunction in mice

  Verbruggen, L., Bentea, E. M., Villers, A., Lara, O., Ates, G., De Bundel, D., Sato, H., Ris, L. & Massie, A., 2 May 2019, Front. Neurosci. Conference Abstract: 13th National Congress of the Belgian Society for Neuroscience, May 24, 2019, Royal Academy Brussels. 1 p.

  Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research

  • Longevity
  • Synaptic Transmission
  • Glutamic Acid
  • Recognition (Psychology)
  • Hippocampus

• Technological advancements for the development of stem cell-based models for hepatotoxicity testing

  Natale, A., Vanmol, K., Arslan, A., Van Vlierberghe, S., Dubruel, P., Van Erps, J., Thienpont, H., Buzgo, M., Boeckmans, J., De Kock, J., Vanhaecke, T., Rogiers, V. & Marcelino Rodrigues, R., Jul 2019, In : Archives of Toxicology. 93, 7, p. 1789-1805 17 p.

  Research output: Contribution to journal › Article

  • Stem cells
  • Hepatocytes
  • Liver
  • Stem Cells
  • Scaffolds (biology)
  4 Citations (Scopus)

• The effect of NTBC on the metabolic and neurocognitive profile in hereditary tyrosinemia type 1 (HT1) mouse models

  Colemonts-Vroninks, H., Yildirim, H., Martens, G., Vanhaecke, T., De Bundel, D. & De Kock, J., 25 Jun 2019.

  Research output: Unpublished contribution to conference › Poster

• The role and therapeutic potential of connexins, pannexins and their channels in Parkinson’s disease

  Ahmadian, E., Eftekhari, A., Samiei, M., Maleki Dizaj, S. & Vinken, M., 16 Mar 2019, In : Cellular Signalling. 58, p. 111-118 8 p.

  Research output: Contribution to journal › Article

  • Connexins
  • Parkinson Disease
  • Neurodegenerative Diseases
  • Pathologic Processes
  • Therapeutics
  5 Citations (Scopus)

• The use of social media in scientific research and creative thinking.

  Busquet, F. & Vinken, M., 29 Apr 2019, In : Toxicology in Vitro. 59, p. 51-54 4 p.

  Research output: Contribution to journal › Article

  • Creativity
  • Social Media
  • Social sciences
  • Congresses
  • Education

• Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor

  Boeckmans, J., Buyl, K., Natale, A., Vandenbempt, V., Branson, S., De Boe, V., Rogiers, V., De Kock, J., Marcelino Rodrigues, R. & Vanhaecke, T., 1 Aug 2019, In : Data in Brief. 25, p. 104093 6 p., 104093.

  Research output: Contribution to journal › Article

  Open Access

  • 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid
  • Fatty Liver
  • In Vitro Techniques
  • Multipotent Stem Cells
  • Peroxisome Proliferator-Activated Receptors
  1 Citation (Scopus)

• What is understood by “animal-free research”?

  Oredsson, S., Coecke, S., van der Valk, J. & Vinken, M., Jun 2019, In : Toxicology in Vitro. 57, p. 143-144 2 p.

  Research output: Contribution to journal › Article
  1 Citation (Scopus)
• 2018

  A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment

  Ates, G., Mertens, B., Heymans, A., Verschaeve, L., Milushev, D., Vanparys, P., Roosens, N. H., De Keersmaecker, SCJ., Rogiers, V. & Doktorova Tatyana, Y., 1 Apr 2018, In : Archives of Toxicology. 92, 4, p. 1593-1608 16 p.

  Research output: Contribution to journal › Article

  • Toxicogenetics
  • Mutagens
  • Cells
  • Genes
  • Hazards
  10 Citations (Scopus)

• A training game for family physician students: educational project report

  Van Rossem, I., Devroey, D., De Paepe, K., Puttemans, F., Petit, P., Schol, S., Deridder, S. & Vandevoorde, J., 21 Sep 2018, EURACT Medical Education Conference 2018: Family medicine education in the real world: from theory into practice. Degryse, J. (ed.). p. 8-8 1 p.

  Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research

  • family physician
  • simulation
  • student
  • Clinical Practice
  • education

• Characterization of hepatocyte-based in vitro systems for reliable toxicity testing

  Vinken, M. & Hengstler, J., 1 Oct 2018, In : Archives of Toxicology. 92, 10, p. 2981-2986 6 p.

  Research output: Contribution to journal › Article

  • Hepatocytes
  • Toxicity
  • Testing
  • In Vitro Techniques
  • Stem cells
  14 Citations (Scopus)

• Chemical characterization of electronic cigarette refills (e-liquids) in Belgium

  Barhdadi, S., Canfyn, M., Moens, G., Vanhee, C., Desmedt, B., Courselle, P., Rogiers, V., Vanhaecke, T. & Deconinck, E., 12 Sep 2018.

  Research output: Unpublished contribution to conference › Poster

• Comment to ‘Letter to the editor: Human-based systems: Mechanistic NASH modelling just around the corner?’

  Boeckmans, J., Natale, A., Buyl, K., De Kock, J., Rogiers, V., Vanhaecke, T. & Marcelino Rodrigues, R., Nov 2018, In : Pharmacological Research. 137, 31475, p. 282-283 2 p.

  Research output: Contribution to journal › Comment/debate
  1 Citation (Scopus)

• Development and testing of a repeated dose toxicity ontology model for chemical risk assessment purposes: liver effects as a case study

  Gustafson, E., Klaric, M., Kienhuis, A., Van De Water, B., Cronin, M., Kramer, N., Kroese, D., Daston, G., Yang, C., Desprez, B. & Vinken, M., 2018.

  Research output: Unpublished contribution to conference › Poster

• DEvelopment of a high-throughput bacterial inhbition assay for human 4-hydroxyphenylpyruvate dioxygenase in the context of tyrosinemia type 1

  Neukermans, J., Mertens, A., Schwaneberg, U., De Kock, J. & Vanhaecke, T., 2018.

  Research output: Unpublished contribution to conference › Poster

• Development of a high-throughput bacterial inhibition assay for human 4-hydroxyphenylpyruvate dioxygenase in the context of tyrosinemia type 1

  Neuckermans, J., 2018, (Unpublished).

  Research output: Unpublished contribution to conference › Poster

• Development of a micellar liquid chromatography method to predict the skin permeability of pharmaceutical compounds.

  Grooten, Y., Marcelis, Q., Mangelings, D. & Vander Heyden, Y., 2018.

  Research output: Unpublished contribution to conference › Poster

  • Liquid chromatography
  • Skin
  • Pharmaceutical Preparations

• Development of an in vitro model for drug hepatoxicity screening through 3D printing of gelatin-based scaffolds for HepG2 support

  Carpentier, N., Natale, A., Vanhaecke, T. & Van Vlierberghe, S., 28 May 2018.

  Research output: Unpublished contribution to conference › Poster

• Development of a sophisticated 3D-nanoscaffold to differentiate human skin cells towards hepatic-like cells

  Natale, A., Van Erps, J., Thienpont, H., Rogiers, V., Vanhaecke, T. & Marcelino Rodrigues, R., 2018.

  Research output: Unpublished contribution to conference › Unpublished abstract

• elafibranor reduces characteristics of metabolically- and drug-induced fatty liver disease in human skin stem cell-derived hepatic cells

  Boeckmans, J., Vandenbempt, V., Buyl, K., Natale, A., Rogiers, V., De Kock, J., Vanhaecke, T. & Marcelino Rodrigues, R., 2018.

  Research output: Unpublished contribution to conference › Poster

• Elafibranor reduces the expression of pannexin1 and CCL5 in a human-relevant skin stem cell-based model of non-alcoholic steatohepatitis (NASH)

  Boeckmans, J., Natale, A., Buyl, K., De Kock, J., Rogiers, V., Vanhaecke, T. & Marcelino Rodrigues, R., 20 Mar 2018.

  Research output: Unpublished contribution to conference › Poster

• Elafibranor reduces the expression of pannexin1 and CCL5 in a human-relevant skin stem cell-based model of non-alcoholic steatohepatitis (NASH)

  Boeckmans, J., Natale, A., Buyl, K., De Kock, J., Rogiers, V., Marcelino Rodrigues, R. & Vanhaecke, T., 22 Mar 2018.

  Research output: Unpublished contribution to conference › Poster

• Elafibranor restores lipogenic gene expression in a human skin stem cell-derived non-alcoholic fatty liver disease (NAFLD) model

  Boeckmans, J., Natale, A., Buyl, K., De Kock, J., Rogiers, V., Vanhaecke, T. & Marcelino Rodrigues, R., 2018, Elafibranor restores lipogenic gene expression in a human skin stem cell-derived non-alcoholic fatty liver disease (NAFLD) model. p. 354-355 2 p.

  Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research

• Elafibranor restores lipogenic gene expression in a human skin stem cell-derived non-alcoholic fatty liver disease (NAFLD) model

  Boeckmans, J., Natale, A., Buyl, K., De Kock, J., Rogiers, V., Vanhaecke, T. & Marcelino Rodrigues, R., 26 Feb 2018.

  Research output: Unpublished contribution to conference › Poster

• Elafibranor reverts lipogenic and inflammatory responses in a human skin stem cell-based model of non-alcoholic steatohepatitis (NASH)

  Boeckmans, J., Natale, A., Buyl, K., De Kock, J., Rogiers, V., Vanhaecke, T. & Marcelino Rodrigues, R., 2018.

  Research output: Unpublished contribution to conference › Poster

• Engineering of a potent nitisinone-insensitive HPD enzyme by directed protein evolution.

  Neuckermans, J., Mertens, A., De Kock, J. & Schwaneberg, U., 25 Apr 2018, (Unpublished).

  Research output: Unpublished contribution to conference › Poster

• Evaluation of 3D-culture methods for the hepatic differentiation of human skin-derived stem cells

  Natale, A., Vanmol, K., Arslan, A., Van Vlierberghe, S., Dubruel, P., Van Erps, J., Thienpont, H., De Kock, J., Rogiers, V., Marcelino Rodrigues, R. & Vanhaecke, T., 10 Oct 2018, In : Toxicology Letters. 295, p. S111-S111 1 p.

  Research output: Contribution to journal › Meeting abstract (Journal)

• Evaluation of innovative 3D-culture methods for the differentiation of human skin-derived stem cells towards hepatic cells

  Natale, A., Vanhaecke, T., De Kock, J., Boeckmans, J., Arslan, A., Vanmol, K., Van Erps, J., Van Vlierberghe, S., Dubruel, P. & Marcelino Rodrigues, R., 22 Mar 2018.

  Research output: Unpublished contribution to conference › Poster

• Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes

  Chaudhari, U., Nemade, H., Sureshkumar, P., Vinken, M., Ates, G., Rogiers, V., Hescheler, J., Hengstler, J. & Sachinidis, A., 20 Jan 2018, In : Archives of Toxicology. 92, 1, p. 371-381 11 p.

  Research output: Contribution to journal › Article

  • Functional assessment
  • Triclosan
  • Stem cells
  • Cosmetics
  • triclocarban
  14 Citations (Scopus)

• Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model

  Crespo Yanguas, S., da Silva, T. C., Alves Pereira, I. V., Maes, M., Willebrords, J., Shestopalov, V. I., Goes, B., Sayuri Nogueira, M., de Castro, I. A., Romualdo, G. R., Barbisan, L. F., Gijbels, E., Vinken, M. & Cogliati, B., 1 Aug 2018, In : Archives of Toxicology. 92, 8, p. 2607-2627 21 p.

  Research output: Contribution to journal › Article

  Open Access

  • Anatomic Models
  • Ablation
  • Liver
  • Liver Cirrhosis
  • Carbon Tetrachloride
  5 Citations (Scopus)

• Genetic ablation of pannexin1 counteracts liver fibrosis in mice

  Crespo Yanguas, S., da Silva, T. C., Alves Pereira, I. V., Maes, M., Willebrords, J., Shestopalov, V. I., Goes, B., Romualdo, G. R., Barbisan, L. F., Gijbels, E., Vinken, M. & Cogliati, B., 20 Mar 2018, (Unpublished).

  Research output: Unpublished contribution to conference › Poster

  • Hepatic Stellate Cells
  • Liver Cirrhosis
  • Inflammasomes
  • Carbon Tetrachloride
  • Knockout Mice

• Human-based systems: Mechanistic NASH modelling just around the corner?

  Boeckmans, J., Natale, A., Buyl, K., Rogiers, V., De Kock, J., Vanhaecke, T. & Marcelino Rodrigues, R., 1 Aug 2018, In : Pharmacological Research. 134, p. 257-267 11 p.

  Research output: Contribution to journal › Article

  • Fatty Liver
  • Drug Development
  • Pharmaceutical Preparations
  • Diet Therapy
  • Non-alcoholic Fatty Liver Disease
  13 Citations (Scopus)

• Human skin-derived mesenchymal stromal cells do not rescue hereditary tyrosinemia type 1 mice after permanent nitisinone withdrawal

  Colemonts-Vroninks, H., Laeremans, H., Claes, P., Neuckermans, J., Verhulst, S., van Grunsven, L. A., Martens, G., De Bundel, D., Vanhaecke, T. & De Kock, J., Sep 2018, p. S37-S219.

  Research output: Unpublished contribution to conference › Poster

  Open Access

• Identification of Flavouring Substances of Genotoxic Concern Present in E-Cigarette refills

  Barhdadi, S., Mertens, B., Van Bossuyt, M., Canfyn, M. C., Courselle, P., Rogiers, V., Deconinck, E. & Vanhaecke, T., 2018.

  Research output: Unpublished contribution to conference › Poster

• Identification of potential genotoxic flavouring substances in e-cigarette refills using insilico tools

  Barhdadi, S., Mertens, B., Van Bossuyt, M., Canfyn, M. C., Rogiers, V., Deconinck, E. & Vanhaecke, T., 2018.

  Research output: Unpublished contribution to conference › Poster

• Identification of some bioactive metabolites in a fractionated methanol extract from Ipomoea aquatica (aerial parts) through TLC, HPLC, LC-ESI-QTOF-MS and LC-SPE-NMR fingerprints analyses

  Demeyer, K., Hefny Gad Hussein, M., Vander Heyden, Y., Mangelings, D. & Pieters, L., 2018, In : Phytochemical Analysis. 29, p. 5-15 11 p.

  Research output: Contribution to journal › Article

• Identification of some Bioactive Metabolites in a Fractionated Methanol Extract from Ipomoea aquatica (Aerial Parts) through TLC, HPLC, UPLC-ESI-QTOF-MS and LC-SPE-NMR Fingerprints Analyses.

  Hefny Gad Hussein, M., Tuenter, E., El-Sawi, N., Younes, S., El-Ghadban, E-M., Demeyer, K., Pieters, L., Vander Heyden, Y. & Mangelings, D., 2018, In : Phytochemical Analysis. 29, 1, p. 5-15 11 p.

  Research output: Contribution to journal › Article

  • Ipomoea
  • Thin layer chromatography
  • High performance liquid chromatography
  • Liquid chromatography
  • Ipomoea aquatica
  5 Citations (Scopus)

• Improvement of hepatic differentiation of human skin-derived stem cells by 3D-scaffolds and fluidics

  Natale, A., Vanmol, K., Arslan, A., Van Vlierberghe, S., Dubruel, P., Van Erps, J., Thienpont, H., Boeckmans, J., De Kock, J., Rogiers, V., Marcelino Rodrigues, R. & Vanhaecke, T., 2018.

  Research output: Unpublished contribution to conference › Unpublished abstract

• Improvement of hepatic differentiation of human skin-derived stem cells by 3D-scaffolds and fluidics

  Natale, A., Boeckmans, J., De Kock, J., Arslan, A., Vanmol, K., Van Vlierberghe, S., Dubruel, P., Vanhaecke, T., Rogiers, V. & Marcelino Rodrigues, R., 26 Oct 2018.

  Research output: Unpublished contribution to conference › Poster

• Influence of 3D-scaffolds and fluidics on the hepatic differentiation of human skin-derived precursors

  Natale, A., Boeckmans, J., De Kock, J., Arslan, A., Vanmol, K., Van Vlierberghe, S., Dubruel, P., Van Erps, J., Vanhaecke, T., Marcelino Rodrigues, R. & Rogiers, V., 15 Oct 2018, (Unpublished).

  Research output: Unpublished contribution to conference › Other

• Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents.

  Walrave, L., Pierre, A., Albertini, G., Aourz, N., De Bundel, D., Van Eeckhaut, A., Vinken, M., Giaume, C., Leybaert, L. & Smolders, I., Aug 2018, In : Glia. 66, 8, p. 1788-1804 17 p.

  Research output: Contribution to journal › Article

  • TAT-Gap19 peptide
  • Connexin 43
  • Anticonvulsants
  • Rodentia
  • Seizures
  15 Citations (Scopus)

• In vitro assessment of hepatotoxicity by metabolomics: a review

  Cuykx, M., Marcelino Rodrigues, R., Laukens, K., Vanhaecke, T. & Covaci, A., 1 Oct 2018, In : Archives of Toxicology. 92, 10, p. 3007-3029 23 p.

  Research output: Contribution to journal › Scientific review

  • Metabolomics
  • Metabolites
  • Hepatocytes
  • Biomarkers
  • Citric Acid Cycle
  14 Citations (Scopus)

• In vitro evaluation of a potential drug against fatty liver disease using a disease model based on human skin-derived stem cells

  Boeckmans, J., Vandenbempt, V., Buyl, K., Natale, A., Rogiers, V., De Kock, J., Vanhaecke, T. & Marcelino Rodrigues, R., 2018.

  Research output: Unpublished contribution to conference › Poster

• In-vitro metabolomics to evaluate toxicity of particulate matter under environmentally realistic conditions

  Sanchez-Soberon, F., Cuykx, M., Serra, N., Linares, V., Belles, M., Covaci, A. & Schuhmacher, M., Oct 2018, In : Chemosphere. 209, p. 137-146 10 p.

  Research output: Contribution to journal › Article
  9 Citations (Scopus)

• In vitro Phase I and Phase II metabolism of the new designer benzodiazepine cloniprazepam using liquid chromatography coupled to quadrupole time-of-flight mass spectrometry

  Mortele, O., Vervliet, P., Gys, C., Degreef, M., Cuykx, M., Maudens, K., Covaci, A., van Nuijs, A. L. N. & Lai, F. Y., 10 May 2018, In : Journal of Pharmaceutical and Biomedical Analysis. 153, p. 158-167 10 p.

  Research output: Contribution to journal › Article
  20 Citations (Scopus)

• In vitro prediction of drug-induced cholestatic liver injury: a challenge for the toxicologist

  Vinken, M., 24 Mar 2018, In : Archives of Toxicology. 92, 5, p. 1909-1912 4 p., 4.

  Research output: Contribution to journal › Article
  11 Citations (Scopus)

• In Vivo Introduction of Transgenes into Mouse Sciatic Nerve Cells Using Viral Vectors

  Van Hameren, G., Gonzalez, S., Fernando, R. N., Perrin-Tricaud, C. & Tricaud, N., 2018, In : Methods in Molecular Biology. 1791, p. 263-276 14 p.

  Research output: Contribution to journal › Article

  • Sciatic Nerve
  • Transgenes
  • Axons
  • Schwann Cells
  • Peripheral Nerves
  1 Citation (Scopus)

• Mass spectrometric identification of in vitro-generated metabolites of two emerging organophosphate flame retardants: V6 and BDP

  Alves, A., Erratico, C., Lucattini, L., Cuykx, M., Ballesteros-Gomez, A., Leonards, P. E. G., Voorspoels, S. & Covaci, A., Dec 2018, In : Chemosphere. 212, p. 1047-1057 11 p.

  Research output: Contribution to journal › Article
  4 Citations (Scopus)