The design and validation of new culture systems, ovarian follicles and unripe egg cells. This research project hopes to establish practical, applicable strategies for fertility clinics. Core motivation - Fundamental research into in-vitro culture systems for ovarian follicles and egg cells and fundamental mechanic research into the effects of xenobiotic substances upon egg cell in vitro egg cell development - Fundamental and pre-clinical research into in-vitro maturation of unripe egg cells from small antral follicles - Clinical activities: 1) cryopreservation of gonadal tissue for female patients to avoid sterility, or with other words, preservation of fertility during cancer treatment 2) in vitro maturation (IVM) of oocytes from small follicles