Projects per year
Organisation profile
Organisation profile
The In Vivo Cellular and Molecular Imaging (ICMI) Core Facility is specialized in nuclear and optical imaging of small animals. The lab is equipped with a myriad of multi-modality cameras and ex vivo analysis techniques to study tracer biodistribution, pharmacokinetics, dosimetry, and therapeutic efficacy of radiopharmaceuticals. The lab is situated in a biosafety level 2 environment with direct access to the animalarium.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
Projects
- 4 Active
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HERC73: Upgrade of confocal FLIM microscope with two-photon excitation and detection modules
1/01/25 → 31/01/28
Project: Fundamental
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FWOSB194: NAIROBI: iNjectable suprAmolecular peptIde hydRogels for cOntrolled release of BioactIves
Robberechts, I., Martin, C., Ballet, S. & Hernot, S.
1/11/24 → 31/10/28
Project: Fundamental
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HERC66: 3D-CELLMAP: Unveiling complex cellular interactions in tissues through 3D super-resolution protein multiplex imaging
Movahedi, K., Rooman, I., Sermon, K., De Bundel, D., Fioravanti, A., Staels, W., Magez, S., Breckpot, K., De Kock, J., Laoui, D., Goyvaerts, C., Smolders, I., Van Ginderachter, J., Marcelino Rodrigues, R., De Leu, N., van Grunsven, L., Hernot, S., Peeters, E., Vanhaecke, T., De Veirman, K., Ruytinx, J., Van Schependom, J., Kortekaas, I. & Goossens, E.
1/05/24 → 31/05/28
Project: Fundamental
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IOF3030: Advance Imaging -Advancing imaging technologies and associated applications in life sciences, healthcare, medical research and beyond.
Hernot, S., Kuijk, M., Ingelberts, H., Van Eetvelde, E., Stijns, J. & Stroet, M.
1/01/24 → 31/12/28
Project: Applied
Research output
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Bimodal PET/fluorescence imaging with Nanobody tracers: comparison of MOMIP platforms
Saliën, J., Floru, S., Vizier, R., Delalieux, S., Bridoux, J., Goncalves, V., Denat, F. & Hernot, S., 14 Mar 2025.Research output: Unpublished contribution to conference › Poster
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Breaking the Nanosecond Barrier: Antibody-Based Tumor Imaging with Extended-Lifetime Fluorescent Tracers – A Promise for Enhanced Multiplexing
Mateusiak, L., Chazeau, E., Al-Sabea, H., Samuelsen Fosse, V., Kleinmanns, K., Goze, C., McCormack, E., Lapauw, T., Van Den Dries, T., Ingelberts, H., Denat, F. & Hernot, S., 12 Mar 2025.Research output: Unpublished contribution to conference › Poster
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Cetuximab enhances tumor-to-background ratio during Nanobody-based fluorescence guided surgery in dogs with EGFR-expressing tumors
Herreira do Valle, N. C., Debacker, J., De Cock, H., Pollenus, S., Hernot, S. & de Rooster, H., 14 Mar 2025.Research output: Unpublished contribution to conference › Poster
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Evaluation of a single domain antibody targeting uPAR for molecular imaging of atherosclerosis in ApoE-/-mice
Dumas, L., Raes, F., Adoumou-Limoune, B., André, C., Bezot, M., Bacot, S., Ahmadi, M., N'guessan, E., Mateusiak, L., Ghezzi, C., Hernot, S. & Broisat, A., 2025.Research output: Unpublished contribution to conference › Poster
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Fluorescent Imaging with Single-Domain Antibodies labeled with Next-Generation FNIR-Tag-Dyes
Chigoho, D. M., Stroet, M., Floru, S., Schnermann, M. J. & Hernot, S., 15 Mar 2025.Research output: Unpublished contribution to conference › Poster
Activities
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Towards contrast between tissue biomarkers with single-wavelength dyes: A first NIR-I in vivo FLT multiplex study using the VUB tauCAMTM
Simone Janssen (Speaker), Thomas Van Den Dries (Contributor), Sevada Sahakian (Contributor), Thomas Lapauw (Contributor), Sam Floru (Contributor), Lukasz Mateusiak (Contributor), Irina Okkelman (Contributor), Marcus Stroet (Contributor), Jeroen De Geeter (Contributor), Ruslan Dmitriev (Contributor), Maarten Kuijk (Contributor), Hilde de Rooster (Contributor), Hans Ingelberts (Contributor) & Sophie Hernot (Speaker)
31 Mar 2025Activity: Talk or presentation › Talk or presentation at a conference
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Near-Infrared azaBODIPY Based Probe with Extended Lifetime to Unlock the Potential of Fluorescence Lifetime Imaging In Vivo
Elisa Chazeau (Speaker), Hassan Al-Sabea (Contributor), Simone Janssen (Contributor), Lukasz Mateusiak (Contributor), Thomas Van Den Dries (Contributor), Thomas Lapauw (Contributor), Hans Ingelberts (Contributor), Marcus Stroet (Contributor), Sophie Hernot (Contributor), Anthony Romieu (Contributor), Christine Goze (Contributor) & Frank Denat (Contributor)
12 Mar 2025Activity: Talk or presentation › Talk or presentation at a conference
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Near-Infrared azaBODIPY Based Probe with Extended Lifetime to Unlock the Potential of Fluorescence Lifetime Imaging In Vivo
Elisa Chazeau (Speaker), Hassan Al-Sabea (Contributor), Simone Janssen (Contributor), Lukasz Mateusiak (Contributor), Thomas Van Den Dries (Contributor), Thomas Lapauw (Contributor), Hans Ingelberts (Contributor), Marcus Stroet (Contributor), Sophie Hernot (Contributor), Anthony Romieu (Contributor), Christine Goze (Contributor) & Franck Denat (Contributor)
12 Mar 2025Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Educational talk: Tracer Design: Enhancing Intraoperative Imaging for Precision Surgery.
Sophie Hernot (Speaker)
11 Mar 2025Activity: Talk or presentation › Talk or presentation at a conference
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Imaging with Nanobody-based bimodal PET/fluorescence tracers for improved clinical decision making
Jelena Saliën (Speaker), Sam Floru (Contributor), Romane Vizier (Contributor), Marcus Stroet (Contributor), Jessica Bridoux (Contributor), Sophie Hernot (Contributor), Victor Goncalves (Contributor) & Franck Denat (Contributor)
May 2025Activity: Talk or presentation › Talk or presentation at a conference
Equipment
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Intravital imaging as tool to bridge the gap between macroscopic in vivo imaging and microscopic tissue analysis.
Sophie Hernot (Scientific coordinator)
In Vivo Cellular and Molecular ImagingFacility/equipment: Equipment › no e-resource/single sited
Datasets
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Generation and Characterization of Novel Pan-Cancer Anti-uPAR Fluorescent Nanobodies as Tools for Image-Guided Surgery
Mateusiak, L. (Creator), Floru, S. (Researcher), De Groof, T. (Researcher), Wouters, J. (Researcher), Declerck, N. (Researcher), Debie, P. (Researcher), Janssen, S. (Researcher), Zeven, K. (Researcher), Puttemans, J. (Researcher), Vincke, C. (Researcher), Breckpot, K. (Project Member), Devoogdt, N. (Project Member) & Hernot, S. (Supervisor), Zenodo, 26 Mar 2025
DOI: https://zenodo.org/records/15089920
Dataset
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Fluorescent Nanobodies for enhanced guidance in digestive tumors and liver metastasis surgery
Mateusiak, L. (Creator), Hakuno, S. (Researcher), de Jonge-Muller, E. (Researcher), Floru, S. (Researcher), Sier, C. F. M. (Supervisor), Hawinkels, L. J. (Supervisor) & Hernot, S. (Supervisor), Zenodo, 27 Mar 2025
DOI: https://zenodo.org/records/15096527
Dataset
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Dataset related to article "Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting"
Movahedi, K. (Creator), Allavena, P. (Creator), Erreni, M. (Creator), Debie, P. (Creator), Mantovani, A. (Creator), D'Autilia, F. (Creator), Doni, A. (Creator), van Leeuwen, F. W. B. (Creator), Avigni, R. (Creator), Arnouk, S. (Creator), Vincke, C. (Creator), Van Ginderachter, J. (Creator), Anselmo, A. (Creator), Parente, R. (Creator), Hernot, S. (Creator), Garlanda, C. (Creator) & Bolli, E. (Creator), Zenodo, 4 Dec 2023
DOI: 10.5281/zenodo.10254683, https://zenodo.org/records/10254683
Dataset