Projects per year
Organization profile
Organisation profile
As part of the Oncology Research Center, the Laboratory for Medical & Molecular Oncology (LMMO) at the VUB Faculty of Medicine engages in several major research initiatives: to study pancreatic cancer biology (Prof. Dr. Ilse Rooman), to study cancer immunotherapy including autologous dendritic cell therapies (Prof. Dr. Bart Neyns) and to advance targeted therapies for cancer in genomically defined patients (personalized medicine, Prof. Emeritus Dr. Jacques De Grève)
PROJECTS ROOMAN LAB
The role of axon guidance genes in pancreatic cancer
The SLIT ligand-ROBO receptor pathway presents frequent mutations in pancreatic cancer. We study the biology in pancreatic tumor cells and their interaction with the stroma.
Molecular characterization of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma can be subdivided in different molecular tumor subtypes. Our study aims at pragmatic subtyping and studying subtype-specific biomarkers.
Exocrine cell differentiation in pancreatitis and pancreatic cancer
Exocrine cells are the cells of origin for tumor formation. We study changes in exocrine cell differentiation, in particular those of acinar cells, that might predispose for tumor development.
Drug repurposing in pancreatic cancer
We investigate the effects of non-cancer drugs for their potential tumor inhibitory effects.
The above research is underpinned by advanced microscopic techniques, and advanced pancreatic (tumor) cell modelling in vitro (cell lines, primary cells, organoids) and in mice (genetically engineered mouse models, patient derived xenografts).
PROJECTS NEYNS LAB
Targeted Therapies (BRAF/MEK-inhibitors) (Dr. G. Awada)
- TraMel-WT (PI Prof. Dr. B. Neyns): trial of Trametinib in patients with advanced pretreated BRAFV600 wild-type Melanoma
- Combi-R2 (PI Prof. Dr. B. Neyns): Dabrafenib/Trametinib/Hydroxychloroquine for advanced pretreated BRAF V600 mutant melanoma
Myeloid Dendritic Cell Therapy (MYDC) (Dr. JK. Schwarze)
- myDCTV (PI Prof. Dr. B. Neyns): intratumoral injection of autologous CD1c/CD141 (BDCA-1/BDCA-3)+ myDC plus Talimogene Laherparepvec (T-VEC)
- myDAvlpNi (PI Prof. Dr. B. Neyns): intratumoral injection of autologous CD1c/CD141 (BDCA-1/BDCA-3)+ myDC, Avelumab, and Ipilimumab plus systemic Nivolumab
Checkpoint Inhibitors (Prof. Dr. B. Neyns)
- GlitipNi: intra-tumoral Ipilimumab plus intravenous Nivolumab following the resection of recurrent Glioblastoma
- LuSCID: Lung cancer treated with SBRT, Checkpoint Inhibitors and myeloid Dendritic cells
PARP Inhibition in HRD Solid Tumors (Dr. S. Joris)
- Precision 2 Study: Olaparib: efficacy of olaparib in advanced cancers occurring in patients with germline mutations or somatic tumor mutations in homologous recombination genes
- Whole exome sequencing on index patients in families with breast and pancreatic cancer
EGFR-Targeted Therapy (Prof. Dr. L. Decoster)
- Afatinib: a prospective explorative open label Phase II study of Afatinib in the treatment of advanced cancers carrying a EGFR, HER2 or HER3 mutation
- G-OncoCOACH (geriatric assessment): randomized study to investigate the effect of GA-directed interventions coordinated by the geriatric team and patient coaching versus interventions coordinated by oncologists in older adults with cancer treated with systemic therapy
Fingerprint
Network
Profiles
-
Sandrine Aspeslagh
- UZBrussel
- Vrije Universiteit Brussel
- Laboratory of Molecular and Medical Oncology
- Clinical sciences - Academic, Undefined
- Medical Oncology - UZB Physician
Person: Researcher, Professor, Physician
-
Gil Awada
- UZBrussel
- Vrije Universiteit Brussel
- Laboratory of Molecular and Medical Oncology
- Clinical sciences - Academic
- Faculty of Medicine and Pharmacy
- Internal medicine - endocrinology - UZB Physician
Person: Researcher, PhD, Physician, Advanced Master's Programme
-
Katarina Coolens
- Vrije Universiteit Brussel
- Laboratory of Molecular and Medical Oncology
- Basic (bio-) Medical Sciences - doctoral student
- Faculty of Medicine and Pharmacy
Person: Researcher, PhD
-
Lore Decoster
- UZBrussel
- Vrije Universiteit Brussel
- Clinical sciences - Academic
- Medical Oncology - UZB Physician
- Laboratory of Molecular and Medical Oncology
Person: Researcher, Professor, Physician, Guest professor
Projects
-
FWOODYS12: De-convolution of tumour biology in the post-genomic era: focus on pancreatic cancer
1/10/16 → 1/10/21
Project: Fundamental
-
ANI172: Effects of transcutaneous vagal nerve stimulation on radiation-induced inflammation and prognosis of patients with lung cancer.
De Grève, J. & Gidron, Y.
1/10/16 → 30/09/20
Project: Fundamental
-
Research output
-
5-Year outcomes of the prospective and randomized cistcert study comparing steroid withdrawal to replacement of cyclosporine with everolimus in de novo kidney transplant patients
Pipeleers, L., Abramowicz, D., Broeders, N., Lemoine, A., Peeters, P., Van Laecke, S., Weekers, L. E., Sennesael, J., Wissing, K. M., Geers, C. & Bosmans, J-L., Feb 2021, In : Transplant International. 34, 2, p. 313-326 14 p.Research output: Contribution to journal › Article
-
A Comprehensive Analysis of Baseline Clinical Characteristics and Biomarkers Associated with Outcome in Advanced Melanoma Patients Treated with Pembrolizumab
Awada, G., Jansen, Y., Schwarze, J. K., Tijtgat, J., Hellinckx, L., Gondry, O., Vermeulen, S., Warren, S., Schats, K., van Dam, P-J., Kockx, M., Keyaerts, M., Everaert, H., Seremet, T., Rogiers, A. & Neyns, B., 2 Jan 2021, In : Cancers. 13, 2, p. 1-18 18 p., 168.Research output: Contribution to journal › Article
-
Addressing disparities and challenges in underserved patient populations with metastatic breast cancer in Europe
Vrdoljak, E., Gligorov, J., Wierinck, L., Conte, P., De Grève, J., Meunier, F., Palmieri, C., Travado, L., Walker, A., Wiseman, T., Wuerstlein, R., Alba, E., Biurrún, C., D'Antona, R., Sola-Morales, O., Ubaysi, C., Ventura, R. & Cardoso, F., Feb 2021, In : Breast. 55, p. 79-90 12 p.Research output: Contribution to journal › Article
-
Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin
Espinet, E., Gu, Z., Imbusch, C. D., Giese, N. A., Buscher, M., Safavi, M., Weisenburger, S., Klein, C., Vogel, V., Falcone, M., Insua-Rodriguez, J., Reitberger, M., Thiel, V., Kossi, S. O., Muckenhuber, A., Sarai, K., Lee, A. Y., Backx, E., Zarei, S., Gaida, M. M. & 18 others, , Mar 2021, In : Cancer discovery. 11, 3, p. 638-659 22 p.Research output: Contribution to journal › Article
-
Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio
Vinh - Hung, V., Everaert, H., Gorobets, O., Van Parijs, H., Verfaillie, G., Vanhoeij, M., Storme, G., Fontaine, C., Lamote, J., Perrin, J., Farid, K., Nguyen, N. P., Verschraegen, C. & De Ridder, M., 10 Mar 2021, In : Breast Cancer.Research output: Contribution to journal › Article
Activities
-
Avondseminarie Heelkunde - Wat verwachten huisartsen van een chirurg ?
Brecht De Cooman (Participant), Nicolas De Sutter (Participant), Hannah Van Rompaey (Participant), Bram Van Hove (Participant), Jaro Van Zande (Participant), Julie Tuypens (Participant), Tobias Kristiaan Van De Winkel (Participant), Lisa Edith D Ramaut (Participant), Wim Jonckheere (Participant), Marian Vanhoeij (Organiser), Ward Patrick M Janssens (Participant), Yanina Jansen (Participant), Guy Verfaillie (Participant), Erik Debing (Participant), Yannick Kenneth Vancampenhout (Participant), Tjeerd Arnaldo Jager (Participant), Nicole Pouliart (Participant), Vleugels Tom (Participant), Tom Danau (Participant), Nouredin Messaoudi (Participant), Bart Willaert (Participant), Thomas Rose (Participant), Marc Krick (Participant), Marc Duinslaeger (Participant)10 Mar 2021Activity: Participating in or organising an event › Participation in workshop, seminar
-
Symposium Medische Wereld
Maria Filomena Cuevas Y Bretones (Participant), Kathelijn Keymolen (Participant), Mary-Louise Bonduelle (Participant), Jacques De Grève (Participant), Melissa Sys (Participant), Kim Van Berkel (Participant)9 May 2020Activity: Participating in or organising an event › Participation in conference
-
Melanomen
Guy Verfaillie (Speaker), Valerie Vandersleyen (Speaker), Bart Neyns (Speaker)19 Feb 2019Activity: Talk or presentation › Talk or presentation at a workshop/seminar
-
Nanobody-mediated imaging of the immune checkpoint LAG-3
Quentin Lecocq (Speaker), Katty Zeven (Contributor), Yannick De Vlaeminck (Contributor), Sandrina Martens (Contributor), Sam Massa (Contributor), Cleo Goyvaerts (Contributor), Geert Raes (Contributor), Marleen Keyaerts (Contributor), Karine Breckpot (Contributor), Nick Devoogdt (Contributor)18 Oct 2019Activity: Talk or presentation › Talk or presentation at a conference
-
Single domain antibody-mediated imaging of the mouse immune checkpoint LAG-3
Quentin Lecocq (Speaker), Yannick De Vlaeminck (Contributor), Katty Zeven (Contributor), Sandrina Martens (Contributor), Geert Raes (Contributor), Nick Devoogdt (Contributor), Marleen Keyaerts (Contributor), Karine Breckpot (Contributor)23 Apr 2019Activity: Talk or presentation › Talk or presentation at a conference