Organisation profile
Organisation profile
Diabetes mellitus is in many cases a disease state of the pancreatic insulin-producing beta cells, which are either destroyed by an auto-immune assault (type 1 diabetes) or fail to produce and secrete sufficient amounts of insulin under different physiological conditions (type 2 diabetes). Reseach performed within the VUB-unit BIOV is situated within the Diabetes Research Centre (DRC) and has as general aim to better understand how normal beta cells work and how these cells fail during the development of diabetes. Two different aspects of this problem are studied. First, the research unit 'Molecular Pharmacolgy' within BIOV (spokesman F. Schuit) is interested in the molecular mechanisms by which normal beta cells are regulated in their secretory action. We focus on nutrients (glucose) and neutrotransmitters or hormones (glucagon, GLP-1, GIP) or pharmacological tools which mimck or counteract these natural substances. We presently study the signaling pathways of nutrients, and agents which raise cyclic AMP and focus on gene-expression networks that mediate beta-cell regulatory steps. A second part of the BIOV team (Spokesman: Bart Van der Auwera) studies the genetic factors associated with beta cell destruction and development of type I diabetes. This investigation is situated within the framework of the Belgian Diabetes Registry.
Keywords
- biochemistry
Fingerprint
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AII43: Statement of intent for the SPEED BCBC Collaborative Bridging Project (CBP): Secreted Proteins from Endothelal cells for Endocrine Development (SPEED)
Heimberg, H. (Administrative Promotor)
7/10/08 → …
Project: Fundamental
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ADSI146: Internal regularisation.
Heimberg, H. (Administrative Promotor)
14/09/07 → …
Project: Fundamental
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VLIR140: Contribution to Cameroon Diabetes epidemiology by risk analysis in patients and first degree relatives (Cameroon diabetes Epidemiology and Registry (CAMDER) in Kameroen)
Van der Auwera, B. (Administrative Promotor)
28/09/06 → …
Project: Fundamental
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SRP35: SRP (Groeiers): Regenerative therapy in diabetes
Bouwens, L. (Administrative Promotor) & Heimberg, H. (Co-Promotor)
1/03/14 → 28/02/19
Project: Fundamental
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BOR15: UZ-overdracht voor Willy Gepts Fonds. Evaluation of the role of human mesenchymal stem cells in experimental islet transplantation.
Heimberg, H. (Administrative Promotor)
9/01/14 → 9/01/18
Project: Fundamental
Research output
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Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
Baeyens, L., Lemper, M., Leuckx, G., De Groef, S., Bonfanti, P., Stangé, G., Shemer, R., Nord, C., Scheel, D. W., Pan, F. C., Ahlgren, U., Gu, G., Stoffers, D. A., Dor, Y., Ferrer, J., Gradwohl, G., Wright, C. V. E., Van de Casteele, M., German, M. S. & Bouwens, L. & 1 others, , Mar 2020, In: Nature Biotechnology. 38, 3, p. 374-374 1 p., 374.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence
Claudinot, S., Sakabe, J.-I., Oshima, H., Gonneau, C., Mitsiadis, T., Littman, D., Bonfanti, P., Martens, G., Nicolas, M., Rochat, A. & Barrandon, Y., 6 Nov 2020, In: Nature Communications. 11, 1, 5645.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus) -
F-18-PBR111 PET Imaging in Healthy Controls and Schizophrenia: Test-Retest Reproducibility and Quantification of Neuroinflammation: Test - Retest Reproducibility and Quantification of Neuroinflammation
Ottoy, J., De Picker, L., Verhaeghe, J., Deleye, S., Wyffels, L., Kosten, L., Sabbe, B., Coppens, V., Timmers, M., Van Nueten, L., Ceyssens, S., Stroobants, S., Morrens, M. & Staelens, S., 1 Aug 2018, In: Journal of Nuclear Medicine. 59, 8, p. 1267-1274 8 p.Research output: Contribution to journal › Article › peer-review
Open Access47 Citations (Scopus) -
The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages
Scott, C. L., T'Jonck, W., Martens, L., Todorov, H., Sichien, D., Soen, B., Bonnardel, J., De Prijck, S., Vandamme, N., Cannoodt, R., Saelens, W., Vanneste, B., Toussaint, W., De Bleser, P., Takahashi, N., Vandenabeele, P., Henri, S., Pridans, C., Hume, D. A. & Lambrecht, B. N. & 8 others, , 21 Aug 2018, In: IMMUNITY. 49, 2, p. 312-325.e5Research output: Contribution to journal › Article › peer-review
Open Access205 Citations (Scopus) -
De impact van stemmingsstabiliserende geneesmiddelen op cytokineconcen-traties bij patiënten met een bipolaire stoornis: Een systematisch literatuur-onderzoek
Translated title of the contribution :The effect of mood-stabilising drugs on cytokine levels in bipolar disorder: a systematic review Research output: Contribution to journal › Article
Activities
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HbA1c and diagnosis of diabetes
Van Der Auwera, B. (Participant)
31 Mar 2011Activity: Participating in or organising an event › Participation in workshop, seminar
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World Diabetes Congress IDF 2011
Gorus, F. (Keynote speaker)
4 Dec 2011 → 8 Dec 2011Activity: Talk or presentation › Talk or presentation at a conference
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Lecture: complex diseases, complex genetics - the example of autoimmune type 1 diabetes
Van Der Auwera, B. (Keynote speaker)
20 Sept 2010Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Public Health Genomics - Belgian task Force symposium 'How to correctly introduce genme-based knowledge in the belgian health care services?'
Van Der Auwera, B. (Organiser)
7 Feb 2010Activity: Participating in or organising an event › Participation in workshop, seminar
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VLIR-Universitaire Ontwikkelingssamenwerking (UOS) in het kader van het Eigen Initiatieven-Programma 2007 (VLIR-referentie ZEIN2007PR343): Contribution to Cameroon diabetes epidemiology by risk analysis in patients and first degree relatives (CAMDER).
Van Der Auwera, B. (Member)
13 Sept 2010 → 21 Sept 2010Activity: Other › Research and Teaching at External Organisation