Projects per year
Organization profile
Organisation profile
Fluorescent pseudomonads are ubiquitous gram-negative bacteria able to thrive in very different environments (plant roots, water, polluted soils, mammal host...). As an example, the type species Pseudomonas aeruginosa is known as a pathogen for man but also as a plant-beneficial micro-organism of the rhizosphere. One of the main factors for the survival of fluorescent pseudomonads such as P. aeruginosa and P. fluorescens, is the existence of a siderophore (pyoverdine)-mediated high-affinity iron transport system which allows these bacteria to compete with micro-organisms for iron and to colonise tissues in which iron is not freely available. Our research programme aims at unravelling the mechanisms involved in siderophore-mediated iron uptake in P. aeruginosa (human pathogen, plant beneficial) and P. fluorescens (plant beneficial), as well as adopt these insights towards applications in medicine and plant biocontrol. Recent experimental evidence indeed suggests that targeted interference with siderophore-mediated iron-uptake represents a promising avenue for the development of novel antibiotics. The study of the interaction of fluorescent pseudomonads with plants aims at the possible development of biocontrol agents against different plant root pathogens. Here we focus on the regulation of the production of antifungal molecules such as phenazines. Finally, we also investigate the potential of these antifungal molecules, and more particularly pyocyanine, to induce systemic resistance in plants against foliar pathogens.
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Profiles
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Sonja De Meuter
- Vrije Universiteit Brussel
- Vriendenkring VUB - Laboratory expert
- Microbial Interactions
Person: Sympathiser, Administrative/technical staff
Projects
- 7 Finished
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GOA47: Biodiversity and the Metagenome: the Example of Cocoa Fermentation.
1/12/06 → 31/12/10
Project: Fundamental
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IWT220: Gebruik van pyocinen als alternatieve anti-pseudomonasdrug.
1/01/04 → 7/04/08
Project: Fundamental
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OZR570: Utilisation of minitransposons with reporter genes to identify outer membrane proteins in Burkholderia cepacia.
1/01/01 → 31/12/03
Project: Fundamental
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Research output
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Ovarian stimulation alters the cervical microbiota
Mackens, S., Vieira-Silva, S., Santos-Ribeiro, S., Centelles-Lodeiro, J., Racca, A., Falony, G., Tito, R., Tournaye, H., Raes, J. & Blockeel, C., Jul 2020, In : Human Reproduction. 35, p. 33-33Research output: Contribution to journal › Meeting abstract (Journal)
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Water activity does not shape the microbiota in the human colon.
Vandeputte, D., Falony, G., D'Hoe, K., Vieira-Silva, S. & Raes, J., Oct 2017, In : Gut. 66, 10, p. 1865-1866 2 p.Research output: Contribution to journal › Letter
Open Access6 Citations (Scopus) -
Human gut microbes impact host serum metabolome and insulin sensitivity
Pedersen, H. K., Gudmundsdottir, V., Nielsen, H. B., Hyotylainen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., Le Chatelier, E., Levenez, F., Doré, J., Mattila, I., Plichta, D. R., Pöhö, P., Hellgren, L. I., Arumugam, M., Sunagawa, S., Vieira-Silva, S. & 14 others, , 21 Jul 2016, In : Nature. 535, 7612, p. 376-381 6 p.Research output: Contribution to journal › Article
650 Citations (Scopus) -
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., Mujagic, Z., Vila, A. V., Falony, G., Vieira-Silva, S., Wang, J., Imhann, F., Brandsma, E., Jankipersadsing, S. A., Joossens, M., Cenit, M. C., Deelen, P., Swertz, M. A., Weersma, R. K., Feskens, E. J. M. & 12 others, , 29 Apr 2016, In : Science. 352, 6285, p. 565-569 5 p.Research output: Contribution to journal › Article
668 Citations (Scopus) -
Population-level analysis of gut microbiome variation
Falony, G., Joossens, M., Vieira-Silva, S., Wang, J., Darzi, Y., Faust, K., Kurilshikov, A., Bonder, M. J., Valles-Colomer, M., Vandeputte, D., Tito, R. Y., Chaffron, S., Rymenans, L., Verspecht, C., De Sutter, L., Lima-Mendez, G., D'hoe, K., Jonckheere, K., Homola, D., Garcia, R. & 7 others, , 29 Apr 2016, In : Science. 352, 6285, p. 560-564 5 p.Research output: Contribution to journal › Article
729 Citations (Scopus)
Activities
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Pseudomonas genomics and molecular biology (Journal)
Pierre Cornelis (Editor)1 Jan 2008Activity: Publication peer-review and editorial work › Editorial activity
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Societe Francaise de Microbiologie (SFM) (External organisation)
Pierre Cornelis (Member)1 Jan 2006Activity: Membership › Membership of external research organisation
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Transporters and drug resistance
Severine Aendekerk (Keynote speaker)12 Mar 2004Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Transporters and drug resistance
Pierre Cornelis (Organiser)12 Mar 2004Activity: Participating in or organising an event › Participation in workshop, seminar
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Journal of Bacteriology (External organisation)
Pierre Cornelis (Member)2003 → 2005Activity: Membership › Membership of peer-review panel or committee