• Paardenstraat 65

    1640 Sint-Genesius-Rode

    Belgium

Organization profile

Organisation profile

Fluorescent pseudomonads are ubiquitous gram-negative bacteria able to thrive in very different environments (plant roots, water, polluted soils, mammal host...). As an example, the type species Pseudomonas aeruginosa is known as a pathogen for man but also as a plant-beneficial micro-organism of the rhizosphere. One of the main factors for the survival of fluorescent pseudomonads such as P. aeruginosa and P. fluorescens, is the existence of a siderophore (pyoverdine)-mediated high-affinity iron transport system which allows these bacteria to compete with micro-organisms for iron and to colonise tissues in which iron is not freely available. Our research programme aims at unravelling the mechanisms involved in siderophore-mediated iron uptake in P. aeruginosa (human pathogen, plant beneficial) and P. fluorescens (plant beneficial), as well as adopt these insights towards applications in medicine and plant biocontrol. Recent experimental evidence indeed suggests that targeted interference with siderophore-mediated iron-uptake represents a promising avenue for the development of novel antibiotics. The study of the interaction of fluorescent pseudomonads with plants aims at the possible development of biocontrol agents against different plant root pathogens. Here we focus on the regulation of the production of antifungal molecules such as phenazines. Finally, we also investigate the potential of these antifungal molecules, and more particularly pyocyanine, to induce systemic resistance in plants against foliar pathogens.

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  • Ovarian stimulation alters the cervical microbiota

    Mackens, S., Vieira-Silva, S., Santos-Ribeiro, S., Centelles-Lodeiro, J., Racca, A., Falony, G., Tito, R., Tournaye, H., Raes, J. & Blockeel, C., Jul 2020, In : Human Reproduction. 35, p. 33-33

    Research output: Contribution to journalMeeting abstract (Journal)

  • Water activity does not shape the microbiota in the human colon.

    Vandeputte, D., Falony, G., D'Hoe, K., Vieira-Silva, S. & Raes, J., Oct 2017, In : Gut. 66, 10, p. 1865-1866 2 p.

    Research output: Contribution to journalLetter

    Open Access
    6 Citations (Scopus)
  • Human gut microbes impact host serum metabolome and insulin sensitivity

    Pedersen, H. K., Gudmundsdottir, V., Nielsen, H. B., Hyotylainen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., Le Chatelier, E., Levenez, F., Doré, J., Mattila, I., Plichta, D. R., Pöhö, P., Hellgren, L. I., Arumugam, M., Sunagawa, S., Vieira-Silva, S. & 14 others, Jørgensen, T., Holm, J. B., Trošt, K., Kristiansen, K., Brix, S., Raes, J., Wang, J., Hansen, T., Bork, P., Brunak, S., Oresic, M., Ehrlich, S. D., Pedersen, O. & MetaHIT Consortium, 21 Jul 2016, In : Nature. 535, 7612, p. 376-381 6 p.

    Research output: Contribution to journalArticle

    796 Citations (Scopus)
  • Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

    Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., Mujagic, Z., Vila, A. V., Falony, G., Vieira-Silva, S., Wang, J., Imhann, F., Brandsma, E., Jankipersadsing, S. A., Joossens, M., Cenit, M. C., Deelen, P., Swertz, M. A., Weersma, R. K., Feskens, E. J. M. & 12 others, Netea, M. G., Gevers, D., Jonkers, D., Franke, L., Aulchenko, Y. S., Huttenhower, C., Raes, J., Hofker, M. H., Xavier, R. J., Wijmenga, C., Fu, J. & LifeLines cohort study, 29 Apr 2016, In : Science. 352, 6285, p. 565-569 5 p.

    Research output: Contribution to journalArticle

    771 Citations (Scopus)
  • Population-level analysis of gut microbiome variation

    Falony, G., Joossens, M., Vieira-Silva, S., Wang, J., Darzi, Y., Faust, K., Kurilshikov, A., Bonder, M. J., Valles-Colomer, M., Vandeputte, D., Tito, R. Y., Chaffron, S., Rymenans, L., Verspecht, C., De Sutter, L., Lima-Mendez, G., D'hoe, K., Jonckheere, K., Homola, D., Garcia, R. & 7 others, Tigchelaar, E. F., Eeckhaudt, L., Fu, J., Henckaerts, L., Zhernakova, A., Wijmenga, C. & Raes, J., 29 Apr 2016, In : Science. 352, 6285, p. 560-564 5 p.

    Research output: Contribution to journalArticle

    855 Citations (Scopus)