Research output per year
Research output per year
Laarbeeklaan 101
1090 Jette
Belgium
NEGE will focus on the research of mitochondrial diseases and of genetic malformations of the brain.
Deficiencies of oxidative phosphorylation are at the basis of a heterogeneous group of hereditary disorders, better known as mitochondrial cytopathies. The incidence was long underestimated, but the morbidity and mortality of these conditions have an important impact on public health.
Hundreds of proteins involved in the formation and functioning of these five enzymatic complexes are under dual genetic control, but there is no unambiguous correlation between phenotype and genotype. Although many mitochondrial and nuclear mutations have been identified during the last thirty years, these aspects hypothesize the confirmation of clinical diagnosis via biochemical and molecular research in a large patient population.
With the development of new and expanding existing analytical methods, this research group wants to detect the causal underlying mechanisms of isolated and combined complex deficiencies.
Hereditary brain deprivations such as lissencephaly, polymicrogyria and heterotopy are a major cause of mental and motor disability, severe epilepsy, learning disorders and autism. The etiology and repetition risk are largely unknown and the Treatment is purely symptomatic. The work of the research group is aimed at identifying new genes involved in the development of brain defects and the Genotype-phenotype correlations to optimize diagnostics and genetic counseling. The study of the function of new genes involved in the development of brain defects gives the opportunity to further elucidate the mechanisms underlying normal brain development.
Person: Researcher, Physician, Master's Programme, Advanced Master's Programme
Person: Researcher, Professor
Person: Researcher, Professor
Person: Researcher, Professor
Person: Researcher, Physician, PhD, Advanced Master's Programme, Doctoral student
Research output: Contribution to journal › Meeting abstract (Journal)
Research output: Unpublished contribution to conference › Poster
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Kathelijn Keymolen (Participant), Katrien Stouffs (Participant), Ileen Slegers (Participant), Boglarka Krisztina Bansagi (Participant), Veronik Hutse (Participant), Kim Van Berkel (Participant), Stefanie Rosa Van de Voorde (Participant), Sophie Uyttebroeck (Participant), Annelore Van Der Kelen (Participant) & Thomy de Ravel (Participant)
Activity: Participating in or organising an event › Participation in conference
Niels Vandewalle (Organiser), Heleen Hanssens (Organiser), Hamide Yildirim (Organiser), Arne Wyns (Organiser), Lien Ann Van Hemelrijck (Organiser), Catharina Muylaert (Organiser), Charlotte Janssens (Organiser) & Michiel De Coster (Organiser)
Activity: Participating in or organising an event › Participation in conference
Robbe Heestermans (Speaker), Wouter De Brouwer (Contributor), Ken Maes (Contributor), Isabelle Vande Broek (Contributor), Freya Vaeyens (Contributor), Catharina Olsen (Contributor), Toon Janssen (Contributor), Ann De Becker (Contributor), Marleen Bakkus (Contributor), Henri Schots (Contributor) & Ivan Van Riet (Contributor)
Activity: Talk or presentation › Talk or presentation at a conference
Hamide Yildirim (Participant)
Activity: Participating in or organising an event › Participation in workshop, seminar
Hamide Yildirim (Speaker)
Activity: Talk or presentation › Talk or presentation at a conference