Projects per year
Organization profile
Organisation profile
Peptides are naturally occurring molecules composed of a small number of amino acids. They control many vital functions in the organism, such as blood pressure, pain, memory, appetite, growth, ..., which make them very interesting as potential therapeutics. However, their rapid degradation and their poor oral bioavailability limits their application as drugs. Our team develops methods to make these active peptides more stable, so that their life time in the body is prolonged. Moreover, methods are developed to modify their structure into small organic molecules which can be taken orally. Present targets are opioid peptides for pain therapy, radio labelled peptides for tumour diagnosis and tumour therapy, enzyme inhibitors for the treatment of liver pathology and growth hormone release inhibitory peptides. The strategy which is used to design the new compounds is based on the knowledge of the three dimensional structure of the peptides and of their analogs. This is studied by spectroscopic methods and by computer- assisted molecular modelling. Their preparation requires the use of advanced organic synthesis techniques.
Keywords
- Organic Synthesis
- Biorganic Compounds
- Peptide Hormones
- FTECR
- Enzyme Inhibitors
- NMR
- Enzyme Immibitors
- Fab-Ms
- HPLC/MS
- GCMS
Fingerprint
Network
Profiles
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Thomas Barlow
- Vrije Universiteit Brussel
- Chemistry - postdoctoral researcher, Academic
- Organic Chemistry
Person: Researcher, Administrative/technical staff
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Jolien Bertouille
- Vrije Universiteit Brussel
- Chemistry - doctoral student
- Faculty of Sciences and Bioengineering Sciences
- Organic Chemistry
Person: Researcher, PhD, Doctoral student
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Anne Caufriez
- Vrije Universiteit Brussel
- Experimental in vitro toxicology and dermato-cosmetology
- Organic Chemistry
- Pharmaceutical and Pharmacological Sciences - Academic, Doctoral scholarschip
- Faculty of Medicine and Pharmacy
Person: Researcher, PhD, Doctoral student
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Thibault Cauwenbergh
- Vrije Universiteit Brussel
- Chemistry - Mandate assistant, Academic
- Organic Chemistry
- Faculty of Sciences and Bioengineering Sciences
Person: Researcher, PhD, Doctoral student
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OZR3843: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UGent, AERSSENS Dorien
4/11/20 → 3/11/24
Project: Fundamental
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OZR3900: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - CY (FR), LOZADA Camille
1/10/19 → 30/09/23
Project: Fundamental
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VLW62: Conformationally constrained amino acids and opoid peptides : synthesis, chiral analysis and biological activities.
11/12/00 → 11/12/03
Project: Fundamental
Research output
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Second generation Spautin-1 analogues targeting EGFR-mutant non-small cell lung cancer cells
Elsocht, M., Giron, P., De Grève, J. & Ballet, S., 1 Jan 2023, In: Bioorganic & Medicinal Chemistry Letters. 79, 129066.Research output: Contribution to journal › Article › peer-review
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Antimicrobial Activity of a Repurposed Harmine-Derived Compound on Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates
Breine, A., Van Gysel, M., Elsocht, M., Whiteway, C., Philippe, C., Quinet, T., Valcek, A., Wouters, J., Ballet, S. & Van der Henst, C., 24 Jan 2022, In: Frontiers in Cellular and Infection Microbiology. 11, 9 p., 789672.Research output: Contribution to journal › Article › peer-review
Open Access -
A Quantum Chemical Deep-Dive into the pi-pi Interactions of 3-Methylindole and Its Halogenated Derivatives-Towards an Improved Ligand Design and Tryptophan Stacking
Van Lommel, R., Bettens, T., Barlow, T. M. A., Bertouille, J., Ballet, S. & De Proft, F., Aug 2022Research output: Other contribution
Open Access1 Citation (Scopus) -
A study of the ability of PHA accumulation and the differential genes expression in the moderate thermophile Schlegelella thermodepolymerans
Moanis, R., Gansemans, Y., Naandam, Y., Van Nieuwerburgh, F., Hennecke, U. & Peeters, E., 30 Jun 2022.Research output: Unpublished contribution to conference › Poster
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A transcriptomic study of the thermophilic polyhydroxyalkanoate-producing bacterium Schlegelella thermodepolymerans (Poster)
Moanis, R., Gansemans, Y., Van Nieuwerburgh, F., Hennecke, U., Peeters, E. & Mostafa, M., 8 Dec 2022.Research output: Unpublished contribution to conference › Poster
Activities
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Invited talk: "Extreme halophiles as next-generation cell factories for the production of bioplastics"
Brendan Schroyen (Contributor), Chloé Vanden Haute (Contributor), Niko Van den Brande (Contributor), Ulrich Hennecke (Contributor) & Eveline Peeters (Speaker)
1 Jun 2022Activity: Talk or presentation › Talk or presentation at a conference
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Selected talk "A transcriptomic study of the thermophilic polyhydroxyalkanoate producing bacterium Schlegelella thermodepolymerans"
Radwa Moanis (Speaker), Yannick Gansemans (Contributor), Filip Van Nieuwerburgh (Contributor), Ulrich Hennecke (Contributor) & Eveline Peeters (Contributor)
14 Sep 2022Activity: Talk or presentation › Talk at an external academic organisation
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22e GFPP-BPGM5
Anne Caufriez (Participant)
29 May 2022 → 3 Jun 2022Activity: Participating in or organising an event › Participation in conference
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Chemistry (Organisational unit)
Tom Bettens (Presenter), Frank De Proft (Supervisor), Mercedes Alonso Giner (Supervisor), Paul Geerlings (Supervisor), Ulrich Hennecke (Chair), Wim Versées (Jury), Freija De Vleeschouwer (Jury), Andreas Dreuw (Jury), Célia Fonseca Guerra (Jury) & Christophe Morell (Jury)
13 Dec 2021Activity: Membership › Member of PhD committee
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Development of Generic G Protein Peptidomimetics Able to Stabilize Active State Gs Protein-Coupled Receptors for Application in Drug Discovery
Steven Ballet (Speaker)
15 Nov 2021 → 17 Nov 2021Activity: Talk or presentation › Talk or presentation at a conference
Equipment
Datasets
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YbiB: a Novel Interactor of the GTPase ObgE
Deckers, B. (Creator), Peeters, E. (Creator), Ballet, S. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Zenodo, 8 Nov 2022
Dataset
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CCDC 2056208: Experimental Crystal Structure Determination
Van Lommel, R. (Creator), Bock, J. (Creator), Hennecke, U. (Creator) & De Proft, F. (Creator), Cambridge Crystallographic Data Centre, 2021
DOI: 10.5517/ccdc.csd.cc270n97
Dataset
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CCDC 2056212: Experimental Crystal Structure Determination
Van Lommel, R. (Creator), Bock, J. (Creator), Hennecke, U. (Creator) & De Proft, F. (Creator), Cambridge Crystallographic Data Centre, 2021
DOI: 10.5517/ccdc.csd.cc270nfc
Dataset
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CCDC 2056213: Experimental Crystal Structure Determination
Van Lommel, R. (Creator), Bock, J. (Creator), Hennecke, U. (Creator) & De Proft, F. (Creator), Cambridge Crystallographic Data Centre, 2021
DOI: 10.5517/ccdc.csd.cc270ngd
Dataset
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CCDC 2056210: Experimental Crystal Structure Determination
Van Lommel, R. (Creator), Bock, J. (Creator), Hennecke, U. (Creator) & De Proft, F. (Creator), Cambridge Crystallographic Data Centre, 2021
DOI: 10.5517/ccdc.csd.cc270nc9
Dataset