Projects per year
Organisation profile
Organisation profile
The department FAFY is mainly developing research activities in the following domains: 1. The use of hepatocytes in culture and co-culture as a model for toxicity and biotransformation studies of xenobiotics: - Evaluation of the iso-enzyme pattern of hepatocytes in culture and co-culture; - Detoxification mechanisms of hepatocytes in cultures and co-cultures; - Biotransformation and toxicity of isobutene; - Biotransformation and toxicity of anti-epileptic drugs. 2. Dermato-cosmetics: - Efficiency measurements of dermato-cosmetic products; - Evaluation and standardisation of new and existing methodology for efficiency measurements of dermato-cosmetic products.
Keywords
- Pharmacology
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Collaborations and top research areas from the last five years
Profiles
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Joeri Aerts
- Vrije Universiteit Brussel
- Pharmaceutical and Pharmacological Sciences
- Neuro-Aging & Viro-Immunotherapy
Person: Researcher, Professor
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Fardine Ameli
- Vrije Universiteit Brussel
- Pharmaceutical and Pharmacological Sciences - Doctoral scholarschip
- Department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling
- Faculty of Medicine and Pharmacy
Person: Researcher, PhD, Doctoral student
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Najat Aourz
- Vrije Universiteit Brussel
- Pharmaceutical and Pharmacological Sciences - Undefined, Education Coordinator
- Experimental Pharmacology
Person: Guest professor, Administrative/technical staff
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Gamze Ates
- Vrije Universiteit Brussel
- Pharmaceutical and Pharmacological Sciences - postdoctoral researcher
- Neuro-Aging & Viro-Immunotherapy
Person: Researcher, Professor
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BASGO40: OZR Basisfinanciering voor Grote Onderzoeksgroepen - In Vitro Toxicology and Dermato-Cosmetology (IVTD)
1/01/25 → 31/12/25
Project: Fundamental
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ANI409: Evaluating the therapeutic potential of psilocybin in a preclinical model of Alzheimer’s disease
1/01/25 → 31/12/27
Project: Fundamental
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FWOAL1157: BacTyriAL: Development of a new therapy for hypertyrosinemia using in vitro re-engineered bacterial tyrosine ammonia lyase enzymes
1/12/24 → 31/12/28
Project: Fundamental
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FWOSB171: Optimization of nanobodies targeting pannexin1 channels for the treatment of cholestasis.
1/11/24 → 31/10/28
Project: Fundamental
Research output
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ASPIS definition of new approach methodologies
Colbourne, J. K., Escher, S. E., Lee, R., Vinken, M., Van De Water, B. & Freedman, J. H., 30 Jan 2025, (Accepted/In press) In: Environmental Toxicology and Chemistry.Research output: Contribution to journal › Article › peer-review
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Design and synthesis of cyclic lipidated peptides derived from the C-terminus of Cx43 for hemichannel inhibition and cardiac endothelium targeting
Iaculli, D., Montgomery, J., Lamouroux, A., Caufriez, A., Gozalbes, R., Vinken, M., Molica, F., Kwak, B. R. & Ballet, S., 1 Dec 2025, In: RSC Medicinal Chemistry. 15 p.Research output: Contribution to journal › Article › peer-review
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Development of a triple cell co-culture spheroid model for cholestatic drug-induced liver injury prediction
Sanz-Serrano, J., Matyjasiak, J., Drees, A. H., Avirvarei, A-C., Rodrigues, P., Olaizola, P., Banales, J. M. & Vinken, M., 2025, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Dose-Limiting Toxicities of Paclitaxel in Breast Cancer Patients: Studying Interactions Between Pharmacokinetics, Physical Activity, and Body Composition—A Protocol for an Observational Cohort Study
Nys, L. D., Barzegar-Fallah, A., Lanckmans, K., Steurbaut, S., Beckwée, D., Haar-Holleman, A. D., Provyn, S., Gasthuys, E., Casteele, S. V., Sutter, P-J. D., Vermeulen, A., Bocxlaer, J. V., Wuyts, S. C. M. & Adriaenssens, N., Jan 2025, In: Cancers. 17, 1, 13 p., 50.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Energy and protein nutrition adequacy in general wards among intensive care unit survivors: A systematic review and meta‐analysis
Rosseel, Z., Cortoos, PJ., Leemans, L., Zanten, A. R. H. V., Ligneel, C. & Waele, E. D., Jan 2025, In: Journal of Parenteral and Enteral Nutrition. 49, 1, p. 18-32 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure)
Activities
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Presentation "Effects of altered microgravity and cosmic radiation on the liver"
Mathieu Vinken (Invited speaker)
18 Mar 2025Activity: Talk or presentation › Talk or presentation at a conference
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VICT3R webinar "Standard for exchange of non-clinical data (SEND)"
Mathieu Vinken (Chair)
14 Jan 2025Activity: Participating in or organising an event › Participation in workshop, seminar
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EUROTOX2025
Mathieu Vinken (Organiser)
14 Sep 2025 → 17 Sep 2025Activity: Participating in or organising an event › Participation in conference
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13th World Congress on Alternatives and Animal Use in the Life Sciences
Mathieu Vinken (Chair)
31 Aug 2025 → 4 Sep 2025Activity: Participating in or organising an event › Participation in conference
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ASPIS working group meeting
Mathieu Vinken (Chair)
21 Jan 2025Activity: Participating in or organising an event › Participation in workshop, seminar
Equipment
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Seahorse platform: the Agilent Seahorse Flux Analyser with integrated normalization system
Ann Massie (Infrastructure coordinator)
Pharmaceutical and Pharmacological SciencesFacility/equipment: Equipment › no e-resource/single sited
Datasets
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Gene expression profiling of Fah- and Hgd-deficient mouse livers upon short-term nitisinone discontinuation
Neuckermans, J. (Creator), Claes, P. (Researcher), Heymans, A. (Researcher), Colemonts-Vroninks, H. (Project Member), Martens, G. (Project Member), Vanhaecke, T. (Supervisor) & De Kock, J. (Supervisor), NCBI Gene Expression Omnibus, 4 Apr 2023
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE225001
Dataset
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Additional file 1 of Incorporating ‘reason for use’ into the prescribing process of medication: a survey on the opinion of patients in Flanders, Belgium
Peeters, M. (Creator), Iturrospe, E. (Creator), Jans, D. (Creator), van Nuijs, A. L. N. (Creator) & De Loof, H. (Creator), figshare.ars, 1 Oct 2022
DOI: 10.6084/m9.figshare.21256851
Dataset
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"Transcriptomics analysis of in vitro NASH models unveils potential adverse effect of elafibranor"
Marcelino Rodrigues, R. (Creator), NCBI Gene Expression Omnibus, 22 Mar 2022
DOI: doi:10.3390/cells11050893
Dataset
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Modelling the enantiorecognition of structurally diverse pharmaceuticals on O-substituted polysaccharide-based stationary phases
De Gauquier, P. (Creator), Peeters, J. (Creator), Vanommeslaeghe, K. (Creator), Vander Heyden, Y. (Creator) & Mangelings, D. (Creator), Zenodo, 2024
DOI: https://doi.org/10.5281/zenodo.14289039
Dataset
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Testosterone-Producing and Cytotypic Human Testicular Organoids with Bicompartmental Architecture Derived from Adult Testicular Tissue of Transgender Women
Baert, Y. (Creator), Madureira Silva, S. (Creator), Chalmel, F. (Creator) & Goossens, E. (Creator), VUB Institutional Data Repository, 17 Jan 2025
Dataset