Pharmaceutical and Pharmacological Sciences

Projects

Projects per year 1993 2015 2016 2018 2019 2020 2021 2022 2023 2024 2028

• 67 Active
• 119 Finished

Projects per year

Search results

• Active

  BASGO40: OZR Basisfinanciering voor Grote Onderzoeksgroepen - In Vitro Toxicology and Dermato-Cosmetology (IVTD)

  Vanhaecke, T.

  1/01/25 → 31/12/25

  Project: Fundamental

• FWOAL1171: Role of Panx1 channels and Cx43 hemichannels as new therapeutic targets in the paracrine signalling circuit between hepatic stellate cells and hepatocellular carcinoma cells established in metabolic dysfunction-associated steatohepatitis.

  Vinken, M.

  1/01/25 → 31/12/27

  Project: Fundamental

• ANI409: Evaluating the therapeutic potential of psilocybin in a preclinical model of Alzheimer’s disease

  De Bundel, D.

  1/01/25 → 31/12/27

  Project: Fundamental

• FWOAL1157: BacTyriAL: Development of a new therapy for hypertyrosinemia using in vitro re-engineered bacterial tyrosine ammonia lyase enzymes

  De Kock, J.

  1/12/24 → 31/12/28

  Project: Fundamental

• FWOSB173: Understanding experienced person-centred maternity care and the pharmacology of ADHD medication during pregnancy and lactation.

  De Hondt, L., Tommelein, E., Crunelle, C., Van Eeckhaut, A. & De Bundel, D.

  1/11/24 → 31/10/28

  Project: Fundamental

• OZR4354: OZR opvangmandaat aspirant Annika Drees

  Vinken, M. & Drees, A. H.

  1/11/24 → 31/10/25

  Project: Fundamental

• FWOSB171: Optimization of nanobodies targeting pannexin1 channels for the treatment of cholestasis.

  Peeters, D. & Vinken, M.

  1/11/24 → 31/10/28

  Project: Fundamental

• OZR4353: OZR opvangmandaat aspirant Vicente Efrain Saavedra Alarcón

  Aerts, J. & Alarcón, V. E. S.

  1/11/24 → 31/10/25

  Project: Fundamental

• IRP27: TumorScope: Digital health research on data, AI and legal challenges at the VUB and UZB

  Vranken, W., Vandemeulebroucke, J., Cornu, P., Quinn, P., Van Dooren, S., Duerinck, J., Olsen, C. & Forsyth, R.

  1/11/24 → 30/04/27

  Project: Fundamental

• FWOSB174: Development and testing of a new approach methodology for the prediction of human risk following exposure to mixtures of toxic chemicals

  Callewaert, E. & Vinken, M.

  1/11/24 → 31/10/28

  Project: Fundamental

• FWOTM1217: Noradrenergic modulation of contextual memory encoding through hippocampal astrocyte α1A receptors.

  Dyer, M. & De Bundel, D.

  1/10/24 → 30/09/27

  Project: Fundamental

• FWOTM1243: Testing of de novo generated nanobodies raised against connexin43 as novel therapeutics for the treatment of inflammatory liver disease

  Van Campenhout, R., Vinken, M., Devoogdt, N. & De Groof, T.

  1/10/24 → 30/09/27

  Project: Fundamental

• ANI389: Development of a B7-H3 nanoCAR-T cell therapy for recurrent glioblastoma (GlioCAR)

  Neyns, B., Geeraerts, X., Tuyaerts, S., Breckpot, K., Duerinck, J. & Smolders, I.

  1/10/24 → 30/09/28

  Project: Fundamental

• EUAR201: VICT3R: Developing and implementing VIrtual Control groups To reducE animal use in toxicology Research

  Vinken, M.

  1/09/24 → 29/02/28

  Project: Applied

• HERC67: Exploiting plasma etching processes for micro/nanotexturing of metal surfaces to enable novel chemical, analytical, optical, and medical applications

  De Malsche, W., Stiens, J., Hellemans, K., Vander Heyden, Y., Peeters, E., Hennecke, U., Ferranti, F., Maes, D. & Schelkens, P.

  1/05/24 → 30/04/28

  Project: Fundamental

  • metal surfaces 100%
  • plasma etching 91%
  • masks 51%
  • metals 31%
  • etching 30%

• HERC66: 3D-CELLMAP: Unveiling complex cellular interactions in tissues through 3D super-resolution protein multiplex imaging

  Movahedi, K., Rooman, I., Sermon, K., De Bundel, D., Fioravanti, A., Staels, W., Magez, S., Breckpot, K., De Kock, J., Laoui, D., Goyvaerts, C., Smolders, I., Van Ginderachter, J., Marcelino Rodrigues, R., De Leu, N., van Grunsven, L., Hernot, S., Peeters, E., Vanhaecke, T., De Veirman, K., Ruytinx, J., Van Schependom, J., Kortekaas, I. & Goossens, E.

  1/05/24 → 31/05/28

  Project: Fundamental

  • Tissue 100%
  • Imaging techniques 89%
  • Proteins 86%
  • Microscopic examination 50%
  • Multiplexing 48%

• OZR4288: Financiering MZW OZR: RAPTOR: Rapid Analysis and production of Proteins for clinical Translation using biacORe and bioreactOR systems.

  Devoogdt, N., Hernot, S., De Groof, T., Ballet, S., Stijlemans, B., Massie, A., Rooman, I., Keyaerts, M., Raes, G., De Kock, J., Breckpot, K., De Veirman, K. & Caveliers, V.

  24/04/24 → 24/04/28

  Project: Fundamental

  • bioreactors 100%
  • translation (genetics) 88%
  • Bioreactors 49%
  • Proteins 37%
  • proteins 34%

• OZR4299: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UHasselt, MEERT Jessy

  De Bundel, D.

  22/04/24 → 21/04/28

  Project: Fundamental

• FWOAL1134: Sodium channelopathies as a possible cause of Primary Focal Hyperhidrosis

  Bosmans, F.

  1/01/24 → 31/12/27

  Project: Fundamental

• IOFPOC61: EVOStAR: a strategic applicability and business plan roadmap for EVOZymes-based therapeutics.

  De Kock, J. & Vanhaecke, T.

  1/01/24 → 30/06/25

  Project: Applied

  • therapeutics 100%
  • inherited metabolic diseases 69%
  • enzymes 38%
  • business development 34%
  • business planning 33%

• IOFPOC60: ESCAPE - Enhanced nanoformulation based on layer-by-layer polyelectrolyte submicroparticles conjugated with cationic peptides

  Aerts, J. & Allard, S.

  1/01/24 → 31/12/25

  Project: Applied

  • Messenger RNA 100%
  • 1-methylpseudouridine 85%
  • Vaccines 81%
  • Nucleosides 80%
  • Nucleoside 70%

• FWOTM1203: BacTyriAL: Development of a new therapy for hereditary tyrosinemia type 1 using in vitro re-engineered bacterial tyrosine ammonia lyase enzymes

  Salvi, N. & De Kock, J.

  1/11/23 → 31/10/27

  Project: Fundamental

  • L-tyrosine ammonia-lyase 100%
  • Tyrosinemias 73%
  • Enzymes 26%
  • In Vitro Techniques 21%
  • Therapeutics 7%

• FWOTM1196: ExplorAKUre: Exploring genetically engineered tyrosine ammonia lyases as an mRNA-based therapy for alkaptonuria

  Desmet, L. & De Kock, J.

  1/11/23 → 31/10/27

  Project: Fundamental

  • L-tyrosine ammonia-lyase 100%
  • Alkaptonuria 78%
  • Messenger RNA 27%
  • Therapeutics 7%

• FWOTM1194: The prophylactic and therapeutic effects of butyrate in a preclinical maternal immune activation model for neurodevelopmental disorders

  Meert, J. D. & De Bundel, D.

  1/11/23 → 31/10/27

  Project: Fundamental

  • Butyrates 100%
  • Neurodevelopmental Disorders 93%
  • Therapeutic Uses 65%
  • Mothers 50%

• FWOSB150: Role of cellular communication mediated by pannexin1 channels in non-alcoholic fatty liver disease induced by microgravity and radiation: testing of a pharmacological countermeasure for the protection of astronauts.

  Cools, B. & Vinken, M.

  1/11/23 → 31/10/27

  Project: Fundamental

  • Astronauts 100%
  • Weightlessness 93%
  • Non-alcoholic Fatty Liver Disease 78%
  • Radiation 54%
  • Communication 54%

• FOD176: Physicochemical characterization and genotoxicity assessment of nanomaterials applied in the food chain using new approach methodologies

  Vanhaecke, T. & Sevenants, L.

  18/09/23 → 17/09/25

  Project: Fundamental

• VLIR423: REVALUATION OF ANDEAN ANCESTRAL KNOWLEDGE ON MEDICINAL HERBS THROUGH THE DEVELOPMENT OF A PHYTOTHERAPEUTIC PRODUCT

  Vander Heyden, Y.

  1/09/23 → 31/08/25

  Project: Fundamental

• VLAIM5: Innovation mandate Spin-off: EVOZymes Development Platform

  Neuckermans, J., De Kock, J. & Vanhaecke, T.

  1/08/23 → 31/07/25

  Project: Applied

  • business planning 100%
  • in vivo studies 70%
  • animal models 56%
  • dosage 33%

• BOR85: Brussels Research on Breastfeeding, Lactation and Technology

  Tommelein, E. & Smolders, I.

  1/07/23 → 30/09/24

  Project: Fundamental

  • candidiasis 100%
  • teats 68%
  • mastitis 53%
  • breast feeding 49%
  • breasts 47%

• AIIFUND104: An animal-free approach for human safety testing of food additives

  Vinken, M.

  11/04/23 → 30/04/25

  Project: Fundamental

  • Food additives 100%
  • Safety testing 86%
  • food additives 63%
  • Animals 53%
  • liver 21%

• FWOAL1076: Achiral and chiral targeted brain metabolomics in volume-limited samples: quest for broad coverage, sensitivity and throughput using chemical derivatization and miniaturized liquid chromatography tandem mass spectrometry.

  Van Eeckhaut, A. & Vander Heyden, Y.

  1/01/23 → 31/12/26

  Project: Fundamental

  • Metabolome 100%
  • Metabolomics 97%
  • Liquid Chromatography 92%
  • Liquid Chromatography Mass Spectrometry (LCMS) 91%
  • Mass Spectrometry 79%

• FWOAL1070: The role of pannexin1 channels in non-alcoholic steatohepatitis: therapeutic and diagnostic relevance.

  Vinken, M.

  1/01/23 → 31/12/26

  Project: Fundamental

  • Fatty Liver 100%
  • Liver 82%
  • Adverse Outcome Pathways 77%
  • Single-Domain Antibodies 69%
  • acute course 67%

• ANI370: In-depth characterization of the dynamics of the functional latent reservoir in long- term cART-treated people living with HIV-1 from Belgium

  Aerts, J. & Allard, S.

  1/01/23 → 31/12/26

  Project: Fundamental

  • Belgium 100%
  • Proviruses 80%
  • HIV 76%
  • HIV-1 64%
  • Acquired Immunodeficiency Syndrome 51%

• FOD143: The development of an Integrated Approach to Testing and Assessment (IATA) for genotoxicity

  Vanhaecke, T.

  1/12/22 → 30/11/26

  Project: Fundamental

• FWOSB134: Development and application of a human stem cell-derived, etiology-based anti-MAFLD drug discovery platform targeting the thyroid hormone receptor axis

  Vanhaecke, T., Boeckmans, J., Marcelino Rodrigues, R. & Gatzios, A.

  1/11/22 → 31/10/26

  Project: Fundamental

  • methamidophos 100%
  • Non-alcoholic Fatty Liver Disease 98%
  • Thyroid Hormone Receptors 91%
  • Drug Discovery 86%
  • Phospholipases 67%

• SRP85: SRP-Onderzoekszwaartepunt: Translating the biology of cognitive function to improve diagnosis and treatment of brain disorders

  Smolders, I., De Bundel, D., Van Eeckhaut, A., Engelborghs, S., Massie, A., Nagels, G. & Van Schependom, J.

  1/10/22 → 30/09/27

  Project: Fundamental

  • Brain Diseases 100%
  • Cognition 94%
  • Cognitive Dysfunction 61%
  • Multiple Sclerosis 26%
  • Epilepsy 25%

• SRP86: SRP-Groeifinanciering: Unravelling host-pathogen-immune interactions in infectious diseases: the good, the bad and the ugly

  Allard, S. & Aerts, J.

  1/10/22 → 30/09/27

  Project: Fundamental

  • Communicable Diseases 100%
  • Host-Pathogen Interactions 95%
  • Pandemics 23%
  • Vaccines 21%
  • Allergy and Immunology 15%

• VLIR418: Levodopa-rich biomass of slime molds and puffballs and their melanins for treatment of Parkinson’s disease and Alzheimer’s disease

  Van Eeckhaut, A.

  1/09/22 → 31/08/27

  Project: Fundamental

  • L-dopa 100%
  • Parkinson disease 97%
  • Melanin 89%
  • Alzheimer disease 88%
  • melanin 78%

• OZR4032: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - MUST (Uganda), TUYIRINGIRE Naasson

  Vander Heyden, Y.

  3/03/22 → 2/03/26

  Project: Fundamental

  • Uganda 100%

• EUAR77: VORTEXLC : Vortex enhanced liquid chromatography for HbA1c monitoring based diabetes management in a globalized setting

  De Malsche, W., Ottevaere, H. & Weets, I.

  1/03/22 → 28/02/26

  Project: Applied

  • Raman spectroscopy 100%
  • Hemoglobins 60%
  • Substrates 52%
  • performance 32%
  • Nanostructures 20%

• AIIFUND87: Study Abroad Program Ministry of National Education - Turkey: Ph.D. Batuhan Yildiz

  Vinken, M. & Yildiz, B.

  1/02/22 → 31/12/25

  Project: Policy Based

  • RNA Sequencing 100%
  • Phalloidin 96%
  • Activation Analysis 81%
  • Apolipoprotein 73%
  • studies abroad 69%

• FOD119: An Interdisciplinary strategy to identify medical devices as a source of allergic or pyrogenic reactions

  Vanhaecke, T.

  17/01/22 → 16/01/26

  Project: Fundamental

  • Equipment and Supplies 100%
  • Budgets 95%
  • Odorants 88%
  • Hypersensitivity 68%
  • Cosmetics 43%

• FWOAL1042: Investigating the role of astrocytes and noradrenaline as critical regulators of neuronal circuit excitability.

  De Bundel, D.

  1/01/22 → 31/12/25

  Project: Fundamental

  • Norepinephrine 100%
  • Astrocytes 93%
  • Brain 24%
  • Neurotransmitter Agents 14%
  • Epilepsy 14%

• FWOAL1047: Can food additives cause liver damage? A mechanistic in vitro modelling study.

  Vinken, M.

  1/01/22 → 31/12/25

  Project: Fundamental

  • Adverse Outcome Pathways 100%
  • Liver 55%
  • Chemical and Drug Induced Liver Injury 39%
  • Parenteral 38%
  • mitochondria 38%

• FWOAL1041: Combination of Molecular Dynamics and Quantitative Structure Enantioselective Relationships (QSER) models to elucidate enantiorecognition mechanisms on polysaccharide and antibiotic based chiral selectors

  Mangelings, D., Vanommeslaeghe, K. & Vander Heyden, Y.

  1/01/22 → 31/12/25

  Project: Fundamental

  • Polysaccharide 100%
  • Enantiomer 91%
  • Antimicrobial Agent 82%
  • Molecular Dynamics 73%
  • Pharmaceutical 61%

• IOFCOFUN1: IOF strategic cofinancing

  Thienpont, H., Westbroek, P., Ivcevic, A., Thumfart, J., Leiva, C. L., Outsios, G., Chichevaliev, S., Mampay, M., Teixeira-Costa, L., Mihajlovic, M., Parvez, M. S., Chen, Y., Hyder-Rahman, N., Oddo, L., Bussooa, A., Sharma, R., Rawat, P., Egberts, E., Gaba, E., Eze, C. T., Helvacıoğlu Akyüz, S. & Ogembo, V.

  15/12/21 → 15/12/25

  Project: Applied

• OZR3923: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UGent, DE BOEVER Sybren

  Vinken, M.

  17/11/21 → 16/11/25

  Project: Fundamental

• FWOTM1078: PiKachU: Development of human phenylalanine ammonia lyase (PAL) enzymes to treat phenylketonuria (PKU) using directed protein evolution

  Nulmans, I. & De Kock, J.

  1/11/21 → 31/10/25

  Project: Fundamental

  • Phenylalanine Ammonia-Lyase 100%
  • Phenylketonurias 71%
  • Human Development 60%
  • Enzymes 30%
  • Proteins 20%

• FWOTM1061: Chemogenetic modulation of CX3CR1+ cells in a mouse model of drug-resistant limbic epilepsy.

  Bossuyt, J. & Smolders, I.

  1/11/21 → 31/10/25

  Project: Fundamental

  • Designer Drugs 100%
  • Microglia 84%
  • Drug Resistant Epilepsy 71%
  • Astrocytes 57%
  • Neurosciences 55%

• OZR3898: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UGent, MAERTEN Amy

  Vinken, M.

  13/10/21 → 12/10/25

  Project: Fundamental