Reproduction and Genetics

Research output

Research output per year 1973 2021

• 15610 Citations
• 66 h-Index
• 576 Article
• 117 Meeting abstract (Journal)
• 103 Meeting abstract (Book)
• 60 Conference paper
• 142 More
  • 49 Poster
  • 21 Chapter
  • 21 Unpublished abstract
  • 19 Editorial
  • 14 Scientific review
  • 6 Comment/debate
  • 3 Book
  • 3 Letter
  • 2 Other scientific journal contribution
  • 1 Other
  • 1 Special issue
  • 1 Other contribution
  • 1 PhD Thesis

Research output per year

Research output per year

Search results

• 2000

  Developmental outcome of children born after ICSI compared to children born after IVF at 2 years old.

  Bonduelle, M-L., Heurckmans, N., De Ketelaere, V., Derde, M-P., Liebaers, I. & Van Steirteghem, A., 2000, In : Unknown Journal.

  Research output: Contribution to journal › Editorial

• Embryo implantation after biopsy of one or two cells from cleavage-stage embryos with a view to preimplantation genetic diagnosis

  Van de Velde, H., De Vos, A., Sermon, K., Staessen, C., De Rycke, M., Van Assche, E., Lissens, W., Vandervorst, M., Van Ranst, H., Liebaers, I. & Van Steirteghem, A., Dec 2000, In : Prenatal Diagnosis. 20, 13, p. 1030-1037 8 p.

  Research output: Contribution to journal › Article

  • Preimplantation Diagnosis 100%
  • Embryo Implantation 90%
  • Embryonic Structures 58%
  • Biopsy 43%
  • Pregnancy Rate 25%

• Mutations in the gene encoding the latency-associated peptide of TGF-beta 1 cause camurati engelmann disease

  Janssens, K., Gershoni-Baruch, R., Guanabens, N., Migone, N., Ralston, S., Bonduelle, M-L., Lissens, W., Van Maldergem, L., Vanhoenacker, F., Verbruggen, L. & Van Hul, W., Nov 2000, In : Nat Genet. 26, November, p. 273-275 3 p.

  Research output: Contribution to journal › Article

  • Camurati-Engelmann Syndrome 100%
  • Transforming Growth Factor beta1 74%
  • Peptides 35%
  • Transforming Growth Factor beta 33%
  • Mutation 31%
  168 Citations (Scopus)

• Soluble HLA-DR antigen levels in serum correlate with rheumatoid arthritis disease activity and the presence of disease-associated epitopes.

  Verbruggen, L., Dumarey, N., Van De Velde, H., Rebmann, V., Flament, J., Van Waeyenberge, C., Grosse-Wilde, H. & Demanet, C., 2000, In : Tissue Antigens. 56, p. 436-440 5 p.

  Research output: Contribution to journal › Article

  • HLA-DR Antigens 100%
  • Epitopes 79%
  • Rheumatoid Arthritis 76%
  • Serum 41%
  • Antibodies 25%
  18 Citations (Scopus)

• The Brussels' expererience of more than 5 years of clinical preimplantation genetic diaglosis

  Vandervorst, M., Staessen, C., Sermon, K., De Vos, A., Van De Velde, H., Van Assche, E., Bonduelle, M-L., Vanderfaeillie, A., Lissens, W., Tournaye, H., Devroey, P., Van Steirteghem, A. & Liebaers, I., 2000, In : Hum Reprod Update. 6, July-August, p. 364-373 10 p.

  Research output: Contribution to journal › Article

  • Preimplantation Diagnosis 100%
  • Embryonic Structures 35%
  • Pregnancy 34%
  • Parturition 30%
  • Sex Chromosomes 18%
  63 Citations (Scopus)

• The Brussels' experience of more than 5 years of clinical preimplantation genetic diagnosis

  Vandervors, M., Staessen, C., Sermon, K., De Vos, A., Van de Velde, H., Van Assche, E., Bonduelle, M., Vanderfaellie, A., Lissens, W., Tournaye, H., Devroey, P., Van Steirteghem, A. & Liebaers, I., 6 Sep 2000, In : Human Reproduction Update. 6, 4, p. 364-73 10 p., x.

  Research output: Contribution to journal › Article

  • Preimplantation Diagnosis 100%
  • Embryonic Structures 35%
  • Pregnancy 34%
  • Parturition 30%
  • Sex Chromosomes 18%

• The paramedical task during teh follow-up of pregnancies and babies born after assisted fertilization.

  Buysse, A., Bonduelle, M-L., Liebaers, I. & Van Steirteghem, A., 2000, In : Unknown Journal.

  Research output: Contribution to journal › Editorial
• 1999

  Cerebral palsy and pyruvate dehydrogenase deficiency: identification of two new mutations in the E1alpha gene

  Lissens, W., Vreken, P., Barth, P. G., Wijburg, F. A., Ruitenbeek, W., Wanders, R. J., Seneca, S., Liebaers, I. & De Meirleir, L., 1999, In : European Journal of Pediatrics. 158, 10, p. 853-857 5 p.

  Research output: Contribution to journal › Article

  • Pyruvate Dehydrogenase Complex Deficiency Disease 100%
  • Cerebral Palsy 62%
  • Mutation 33%
  • Microcephaly with spastic quadriplegia 29%
  • Hypocalcemia 27%
  20 Citations (Scopus)

• Cerebral palsy and pyruvate dehydrogenase deficiency: identification od two new mutations in the Ela gene.

  Lissens, W., Vreken, P., Barth, P. G., Wijburg, F. A., Ruitenbeek, W., Wanders, R. J. A., Seneca, S., Liebaers, I. & De Meirleir, L., 1999, In : Unknown Journal.

  Research output: Contribution to journal › Article

• Clinical experience of sex determination by fluorescent in-situ hybridization for preimplantation genetic diagnosis.

  Staessen, C., Van Assche, E., Joris, H., Bonduelle, M-L., Vandervorst, M., Liebaers, I. & Van Steirteghem, A., Apr 1999, In : Molecular Human Reproduction. 5, April, p. 382-390 9 p.

  Research output: Contribution to journal › Article

  • Preimplantation Diagnosis 100%
  • Fluorescence In Situ Hybridization 72%
  • Blastomeres 71%
  • Embryonic Structures 58%
  • Diploidy 14%
  69 Citations (Scopus)

• Clinical experience with PID and ICSI in 'Genetics in Human reproduction'

  Van Assche, E., Van Steirteghem, A., Liebaers, I., Bonduelle, M-L., Devroey, P., Graumann, S. (ed.), Hildt, E. (ed.), Joris, C., Lissens, W., Nagy, P., Sermon, K., Staessen, C. & Vandervorst, M., 1999, In book Genetics in human reproduction, E. Hildt, S. Graumann (eds), p3-15, 1999..

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Electieve terugplaatsing van één embryo: evenveel zwangerschappen en geen tweelingen meer!

  De Sutter, P., Coetsier, T., Blockeel, C., De Vries, M., Peters, N., Van Der Elst, J. & Dhont, M., 1999, -.

  Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book)

• Fluorescent PCR and automated fragment analysis in preimplantaion gentic diagnosis for 21-hydroxylase deficiency in congenital adrenal hyperplasia.

  Van De Velde, H., Sermon, K., De Vos, A., Lissens, W., Joris, H., Vandervorst, M., Van Steirteghem, A. & Liebaers, I., Jul 1999, In : Molecular Human Reproduction. 5, July, p. 691-696 6 p.

  Research output: Contribution to journal › Article

  • Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 100%
  • Preimplantation Diagnosis 97%
  • Congenital Adrenal Hyperplasia 93%
  • Steroid 21-Hydroxylase 51%
  • Polymerase Chain Reaction 41%
  27 Citations (Scopus)

• Genetics in human reproduction.

  Liebaers, I., Sermon, K., Staessen, C., Joris, H., Lissens, W., Van Assche, E., Nagy, P., Bonduelle, M-L., Devroey, P. & Van Steirteghem, A., 1999, E. Hildt S. Graumann p. 3-15.

  Research output: Book/Report › Book › Specialist

• High frequency of BRCA1/2 germline mutations in 42 Belgian families with a small number of symptomatic subjects

  Goelen, G., Teugels, E., Bonduelle, M-L., Neyns, B. & De Greve, J., Apr 1999, In : Journal of Medical Genetics. 36, April, p. 304-308 5 p.

  Research output: Contribution to journal › Article

  • Germ-Line Mutation 100%
  • Mutation 49%
  • BRCA1 Gene 40%
  • Counseling 25%
  • Ovarian Neoplasms 17%
  28 Citations (Scopus)

• In female infertility current practice.

  Van Steirteghem, A., De Vos, A., Staessens, C., Verheyen, G. & Bonduelle, M-L., 1999, In : Unknown Journal.

  Research output: Contribution to journal › Article

• Molecular analysis of the cystic fibrosis gene reveals a high frequency of the intron 8 splice variant 5T in Egyptian males with congenital bilateral absence of the vas deferens

  Lissens, W., Mahmoud, K. Z., El-Gindi, E., Abdel-Sattar, A., Seneca, S., Van Steirteghem, A. & Liebaers, I., Jan 1999, In : Molecular Human Reproduction. 5, 1, p. 10-13 4 p.

  Research output: Contribution to journal › Article

  • Congenital bilateral aplasia of vas deferens 100%
  • Cystic Fibrosis 59%
  • Introns 58%
  • Cystic Fibrosis Transmembrane Conductance Regulator 54%
  • Genes 24%
  33 Citations (Scopus)

• Preimplanation genetic diagnosis of B-thalassemia: comparison of fluorescent and conventional polymerase chain reaction.

  De Rycke, M., Van De Velde, H., Sermon, K., Lissens, W., De Vos, A., Abramowics, M. J. & Van Steirteghem, A., 1999, In : Hum Reprod. 14, p. 189 1 p.

  Research output: Contribution to journal › Meeting abstract (Journal)

• Preimplantation diagnosis for fragile X-syndrome based on the detection of the non-expanded paternal and maternal CGG

  Sermon, K., Seneca, S., Vanderfaeillie, A., Lissens, W., Joris, H., Vandervorst, M., Van Steirteghem, A. & Liebaers, I., Dec 1999, In : Prenat Diagn. 19, December, p. 1223-1230 8 p.

  Research output: Contribution to journal › Article

  • Preimplantation Diagnosis 100%
  • Fragile X Syndrome 93%
  • Intellectual Disability 68%
  • Trinucleotide Repeats 49%
  • Mothers 46%
  66 Citations (Scopus)

• Preimplantation genetic diagnosis and sperm analysis by fluorescence insitu hybridisation for the most common reciprocal translocation t(11;22)

  Van Assche, E., Staessen, C., Vegetti, W., Bonduelle, M-L., Vandervorst, M., Van Steirteghem, A. & Liebaers, I., Jul 1999, In : Molecular Human Reproduction. 5, July, p. 682-690 9 p.

  Research output: Contribution to journal › Article
  102 Citations (Scopus)

• Preimplantation genetic diagnosis of Marfan syndrome with the use of fluorescent polymerase chain reaction and the automated laser fluorescent DNA sequencer.

  Sermon, K., Lissens, W., Messiaen, L., Bonduelle, M-L., Vandervorst, M., Van Steirteghem, A. & Liebaers, I., Jan 1999, In : Fertil Steril. 71, January, p. 163-166 4 p.

  Research output: Contribution to journal › Article
  36 Citations (Scopus)

• The influence of the social context on the meaning of sperm donation

  Pennings, G., Baetens, P., Kristoffersen, I., Devroey, P., Van Steirteghem, A. & Stuy, J., 1999, Human Reproduction 14, Abstracts of the 15th annual meeting of the European Society of Human Reproduction and Embryology, June 27-30, Tours (France), pp. 251-252., 1999.

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper
• 1998

  A rare variant of neuronal ceroid lipofuscinosis

  Vanderstraeten, V., Ceuterick, C., Haan, J., Martin, J. J., Keymolen, K., Hasaerts, D. & De Meirleir, L., 1998, In : Acta Neurologica Belgica. 98, p. supplement 1 p.

  Research output: Contribution to journal › Meeting abstract (Journal)

  • Neuronal Ceroid-Lipofuscinoses 100%

• Fluorescent PCR and automated fragment analysis for the clinical application of preimplantation genetic diagnosis of myotonic dystrophy (Steinert's disease)

  Sermon, K., De Vos, A., Van de Velde, H., Seneca, S., Lissens, W., Joris, H., Vandervorst, M., Van Steirteghem, A. & Liebaers, I., Aug 1998, In : Molecular Human Reproduction. 4, 8, p. 791-796 6 p.

  Research output: Contribution to journal › Article

  • Preimplantation Diagnosis 100%
  • Myotonic Dystrophy 92%
  • Polymerase Chain Reaction 42%
  • Myotonia 21%
  • Trinucleotide Repeats 19%
  88 Citations (Scopus)

• Motile organisms in the epididymis ?

  Pierard, D., Janssenswillen, C., Tournaye, H., Devroey, P. & Van Steirteghem, A., 1998, In : Human Reproduction. 13, p. 2335-2336 2 p.

  Research output: Contribution to journal › Article

• Preimplantation diagnosis for Huntington's disease (HD): clinical application and analysis of the HD expansion in affected embryos

  Sermon, K., Goossens, V., Seneca, S., Lissens, W., De Vos, A., Vandervorst, M., Van Steirteghem, A. & Liebaers, I., Dec 1998, In : Prenat Diagn. 18, December, p. 1427-1436 10 p.

  Research output: Contribution to journal › Article
  117 Citations (Scopus)

• Prenatal diagnosis by chorionic villus sampling in multiple pregancies prior to fetal reduction

  Decatte, L., Camus, M., Bonduelle, M-L., Liebaers, I. & Foulon, W., May 1998, In : Am J Perinatol. 15, May, p. 339-343 5 p.

  Research output: Contribution to journal › Article

  • Multifetal Pregnancy Reduction 100%
  • Chorionic Villi Sampling 92%
  • Prenatal Diagnosis 65%
  • Fetus 51%
  • Multiple Pregnancy 32%

• Ultrastructure of gametes after intracytoplasmic sperm injection

  Bourgain, C., Nagy, Z. P., De Zutter, H., Van Ranst, H., Nogueira, D. & Van Steirteghem, A. C., Apr 1998, In : Human Reproduction. 13, Suppl 1, p. 107-116 10 p.

  Research output: Contribution to journal › Article

  • Intracytoplasmic Sperm Injections 100%
  • Germ Cells 83%
  • Oocytes 78%
  • Metaphase 20%
  • Vacuoles 19%
  36 Citations (Scopus)
• 1997

  Birth defects in infants conceived by intracytoplasmic sperm injection : an alternative interpretation

  Bonduelle, M-L., Devroey, P., Liebaers, I. & Van Steirteghem, A., 1997, In : Br Med J. 315, p. 1260-1266 7 p.

  Research output: Contribution to journal › Article

  184 Citations (Scopus)

• Familiale colonkanker

  Neyns, B., Teugels, E., Goelen, G., Bonduelle, M-L. & De Greve, J., 1997, Unknown Journal.

  Research output: Contribution to specialist/vulgarizing publication › Article › Specialist

• How to counsel in osteopathia striata with cranial sclerosis

  Keymolen, K., Bonduelle, M-L., De Maeseneer, M. & Liebaers, I., Aug 1997, In : Genet Couns. 8, 3, p. 207-211

  Research output: Contribution to journal › Article

  7 Citations (Scopus)

• Microsurgical epididymal sperm aspiration with motile trophozoite cells but no spermatozoa

  Janssenswillen, C., Tournaye, H., Pierard, D., Devroey, P. & Van Steirteghem, A., 1997, In : Hum Reprod. 12, 10, p. 2217-2219 3 p.

  Research output: Contribution to journal › Article

  • Sperm Retrieval 100%
  • Trophozoites 85%
  • Azoospermia 83%
  • Spermatozoa 61%
  • Trichomonas Infections 30%
  3 Citations (Scopus)

• Oocyte donation

  De Saedeleer, V., Baetens, P., Pennings, G., Devroey, P., Van Steirteghem, A. & Kristoffersen, I., 1997, Human Reproduction, Vol. 12, Abstract Book, Oxford University Press, Edinburgh, p. 22-25.

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper

• Transfection of a transdominant negative c-jun mutant (tam 67) induces massive apoptotic cell death through a bystander effect in NIH-OVCAR3 epithelial ovarian cancer cells

  Neyns, B., De Rycke, M., Teugels, E., Petrova-Benedict, R., Bourgain, C., Birrer, M. & De Greve, J., 1997, Acta Clinica Belgica, 136, p. 52-56.

  Research output: Contribution to specialist/vulgarizing publication › Article › Specialist
• 1996

  Cystic fibrosis and infertility caused by congenital bilateral absence of the vas deferens and related clinical entities.

  Lissens, W., Mercier, B., Tournaye, H., Bonduelle, M-L., Férec, C., Seneca, S., Devroey, P., Silber, S., Van Steirteghem, A. & Liebaers, I., 1996, In : Human Reproduction. 4, suppl, p. 55-78 24 p.

  Research output: Contribution to journal › Article

  • Congenital bilateral aplasia of vas deferens 100%
  • Cystic Fibrosis 59%
  • Infertility 56%
  • Cystic Fibrosis Transmembrane Conductance Regulator 38%
  • Regulator Genes 21%
  71 Citations (Scopus)
• 1995

  Gene deletions and point mutations leading to type 1 antithrombin deficiency in six Belgian kindreds

  Jochmans, K., Lissens, W., Capel, P., Chatelain, B., Meeus, P., Osselaer, J. C., Vermylen, J., De Waele, M. & Liebaers, I., 1995, In : Thrombosis and Haemostasis. 73, p. 1250 1 p.

  Research output: Contribution to journal › Meeting abstract (Journal)

• Sleep apnoea in babies born after in vitro fertilization

  Audiens, H., Denayer, E., Najafi, N., Troch, E., Bonduelle, M-L., Ramet, J. & Vandenplas, Y., Jun 1995, In : European Journal of Pediatrics. 154, 6, p. 454-457 4 p.

  Research output: Contribution to journal › Article

  • Sleep Apnea Syndromes 100%
  • Fertilization in Vitro 99%
  • Twins 44%
  • Central Sleep Apnea 23%
  • Apnea 17%
  5 Citations (Scopus)

• The influence of the site of sperm deposition and mode of oolemma breakage at intracytoplasmic sperm injection on fertilization and embryo development rates

  Nagy, Z. P., Liu, J., Joris, H., Bocken, G., Desmet, B., Van Ranst, H., Vankelecom, A., Devroey, P. & Van Steirteghem, A. C., Dec 1995, In : Human Reproduction. 10, 12, p. 3171-3177 7 p.

  Research output: Contribution to journal › Article

  • Intracytoplasmic Sperm Injections 100%
  • Suction 95%
  • Fertilization 91%
  • Oocytes 78%
  • Spermatozoa 78%
• 1993

  Efficiency of polymerase chain reaction assay for cystic fibrosis in single human blastomeres according to the presence or absence of nuclei

  Liu, J., Lissens, W., Devroey, P., Liebaers, I. & Van Steirteghem, A. C., Apr 1993, In : Fertility and Sterility. 59, 4, p. 815-9 5 p.

  Research output: Contribution to journal › Article

  • Blastomeres 100%
  • Cystic Fibrosis 71%
  • Polymerase Chain Reaction 43%
  • Microscopy 33%
  • Fluorescence Microscopy 24%

• Polymerase chain reaction analysis of the cystic fibrosis delta F508 mutation in human blastomeres following oocyte injection of a single sperm from a carrier

  Liu, J., Lissens, W., Devroey, P., Van Steirteghem, A. & Liebaers, I., Sep 1993, In : Prenatal Diagnosis. 13, 9, p. 873-80 8 p.

  Research output: Contribution to journal › Article

  • Blastomeres 100%
  • Cystic Fibrosis 71%
  • Oocytes 68%
  • Spermatozoa 67%
  • Embryonic Structures 49%
• 1992

  A serine to proline substitution (S1255P) in the second nucleotide binding fold of the cystic fibrosis gene

  Lissens, W., Bonduelle, M., Malfroot, A., Dab, I. & Liebaers, I., Sep 1992, In : Human Molecular Genetics. 1, 6, p. 441-2 2 p.

  Research output: Contribution to journal › Article

• Efficiency and accuracy of polymerase-chain-reaction assay for cystic fibrosis allele delta F508 in single cell

  Liu, J., Lissens, W., Devroey, P., Van Steirteghem, A. & Liebaers, I., 1992, In : Lancet (British edition). 339, 8803, p. 1190-2 3 p.

  Research output: Contribution to journal › Article

  • Cystic Fibrosis 100%
  • Spermatozoa 75%
  • Alleles 74%
  • Polymerase Chain Reaction 60%
  • Blastomeres 56%
• 1991

  Beta-glucuronidase activity in mouse oocytes, mouse preimplantation embryos, and human gametes

  Van Blerk, M., Lissens, W., Nijs, M., Van der Linden, M., Van Steirteghem, A. C. & Liebaers, I., Aug 1991, In : Prenatal Diagnosis. 11, 8, p. 509-12 4 p.

  Research output: Contribution to journal › Article

  • Glucuronidase 100%
  • Blastocyst 92%
  • Germ Cells 80%
  • Oocytes 75%
  • Spermatozoa 45%

• Mild cystic fibrosis in child homozygous for G542 non-sense mutation in CF gene

  Bonduelle, M., Lissens, W., Liebaers, I., Malfroot, A. & Dab, I., 20 Jul 1991, In : Lancet. 338, July, 1 p., 189.

  Research output: Contribution to journal › Article

  • Cystic Fibrosis 100%
  • Mutation 57%
  • Child 44%
  • Genes 41%
  10 Citations (Scopus)
• 1988

  Chorionic gonadotrophin-beta mRNA, a trophoblast marker, is expressed in human 8-cell embryos derived from tripronucleate zygotes

  Bonduelle, M. L., Dodd, R., Liebaers, I., Van Steirteghem, A., Williamson, R. & Akhurst, R., 1988, In : Human Reproduction. 3, 7, p. 909-14 6 p.

  Research output: Contribution to journal › Article

  • Zygote 100%
  • Trophoblasts 87%
  • Chorionic Gonadotropin 86%
  • Embryonic Structures 65%
  • Fertilization 57%
• 1987

  Hormonal changes during a spontaneous attack of hypokalemic periodic paralysis

  De Keyser, J., Malfait, R., Van Steirteghem, A., Ebinger, G. & Smitz, J., 1987, In : Eur Neurol. 26, p. 60-64 5 p.

  Research output: Contribution to journal › Article

  • Hypokalemic Periodic Paralysis 100%
  • Growth Hormone 59%
  • Insulin 42%
  • Potassium Chloride 39%
  • Aldosterone 32%
  1 Citation (Scopus)
• 1985

  Demonstration of human alpha-L-fucosidase polymorphism by means of monoclonal antibodies

  Lissens, W., Vrijsen, R., Sijens, R., Liebaers, I. & Boeye, A., 1985, In : Biochim Biophys Acta. 831, October, p. 281-287 7 p.

  Research output: Contribution to journal › Article

  • alpha-L-fucosidase 100%
  • polymorphism 70%
  • monoclonal antibodies 58%
  • antibodies 42%
  • placenta 26%
• 1973

  Séparation des isoenzymes de l'hexosaminidase dans les leucocytes et les cultures de fibroblastes et cellules amniotiques normales: mise en évidence de trois fractions

  Liebaers, I., Vamos, E. & Mandelbaum, I. M., 1973, In : Comptes rendus des seances de la Societe de biologie et de ses filiales. 167, 6, p. 1068-73 6 p.

  Research output: Contribution to journal › Article