Projects per year
Organisation profile
Organisation profile
The Structural Biology Brussels Lab, headed by Jan Steyaert was founded by Lode Wyns in the seventies at the Vrije Universiteit Brussel and is one of the Flanders Institute for Biotechnology departments. The understanding of the function of a protein, from its structure to its dynamics, remains the central theme of the lab. Our multidisciplinary team of about 40 researchers is housed in new laboratory facilities and combines extensive expertise in biophysics and molecular biology. We master genetic engineering, protein purification, enzymology, calorimetry, crystallography, surface plasmon resonance, atomic force microscopy and now also NMR. Major esearch interests include Aggregating proteins and Amyloidosis, Membrane proteins, Protein assemblies, Redox regulation, RNA modification, Nanomodulators, Cell surface fillaments & Adhesion, Urinary tract infections, Enterotoxigenic E. coli, Molecular reognition and Toxin-Anti Toxin systems. Translational research is intrinsic to our programs, with possible applications in medicine.
Keywords
- X-ray crystallography
- Protein Chemistry
- Molecular Microbiology
- Structural Biology
- NMR
- Enzyme kinetics
- Antibody Engineering
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Collaborations and top research areas from the last five years
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FWOTM1122: Characterizing mutations in hnRNPA2 to identify pathogenic mechanisms in degenerative disorders
Tompa, P., Maes, D. & Duran Armenta, L. F.
1/11/22 → 31/10/26
Project: Fundamental
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OZR3940: Cofinanciering OZR FWO Hercules MZW: A platform for next-generation comprehensive proteome analysis: liquid chromatography trapped-ion-mobility time- of-flight (LC-timsTOF) mass spectrometry
Eeltink, S., Desmet, G., Steyaert, J., Peeters, E., Stijlemans, B., Magez, S., De Trez, C., De Vos, J. & Meston, D.
16/03/22 → 16/03/25
Project: Fundamental
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OZR3906: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, PEREZ CHAVEZ Israel
1/10/21 → 30/09/25
Project: Fundamental
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OZRIFTM7: Nanobodies to recognize non-canonical DNA structures and regulate their formation in vivo
1/10/21 → 30/09/25
Project: Fundamental
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OZR3904: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, SHEN Tzu-Keng
30/07/21 → 29/07/25
Project: Fundamental
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C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1
Van Nerom, M., Ahmed, J., Lazar, T., Van Lindt, J., Pancsa, R., Maes, D. & Tompa, P., 31 Mar 2023, In: BIORXIV. 2023, 46 p.Research output: Contribution to journal › Article
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DisProt in 2024: improving function annotation of intrinsically disordered proteins
Aspromonte, M. C., Nugnes, M. V., Quaglia, F., Bouharoua, A., DisProt Consortium, Lazar, T., Tompa, P., Piovesan, D. & Tosatto, S. C. E., Oct 2023, (E-pub ahead of print) In: Nucleic Acids Research. gkad928.Research output: Contribution to journal › Article › peer-review
Open Access -
ELM - The Eukaryotic Linear Motif resource - 2024 update
Kumar, M., Michael, S., Alvardo-Valverde, J., Zeke, A., Lazar, T., Glavina, J., Nagy-Kanta, E., Mac Donagh, J., Dobson-Kalman, Z., Pascarelli, S., Palopoli, N., Dobson, L., Suarez, C. F., Van Roey, K., Krystkowiak, I., Griffin, J. E., Nagpal, A., Bhardwaj, R., Diella, F., Mészáros, B. & 5 others, , Nov 2023, (E-pub ahead of print) In: Nucleic Acids Research. gkad1058.Research output: Contribution to journal › Article › peer-review
Open Access -
Helicobacter pylori attachment-blocking antibodies protect against duodenal ulcer disease
Bugaytsova, J. A., Moonens, K., Piddubnyi, A., Schmidt, A., Edlund, J. O., Lisiutin, G., Brännström, K., Chernov, Y. A., Thorel, K., Tkachenko, I., Sharova, O., Vikhrova, I., Butsyk, A., Shubin, P., Chyzhma, R., Johansson, D. X., Marcotte, H., Sjöström, R., Shevtsova, A., Bylund, G. & 37 others, , 24 May 2023, In: BIORXIV.Research output: Contribution to journal › Article
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In Silico Structural Analysis Exploring Conformational Folding of Protein Variants in Alzheimer’s Disease
Efraimidis, E. O., Krokidis, M. G., Exarchos, T. P., Lazar, T. & Vlamos, P., 31 Aug 2023, In: International Journal of Molecular Sciences. 24, 17, 13543.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure)
Activities
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1st Motif Biology Meeting: The Past, Present, and Future of Short Linear Motif Research
Tamas Lazar (Participant)
22 Jun 2023 → 23 Jun 2023Activity: Participating in or organising an event › Participation in conference
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Trends in PED, new IDP ensembles and future applications
Tamas Lazar (Invited speaker)
3 Jul 2023Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Will the widespread use of AI-based structure prediction impact conformational ensemble use and ensemble generation?
Tamas Lazar (Speaker)
5 Jul 2023Activity: Talk or presentation › Talk or presentation at a conference
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Universidad Nacional de San Martin (External organisation)
Tamas Lazar (Contributor)
Mar 2023 → Apr 2023Activity: Membership › Membership of external research organisation
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LEUCALS Launch Event
Tamas Lazar (Participant)
11 May 2023Activity: Participating in or organising an event › Participation in conference
Datasets
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YbiB: a Novel Interactor of the GTPase ObgE
Deckers, B. (Creator), Vercauteren, S. (Creator), De Kock, V. (Creator), Martin, C. (Creator), Lazar, T. (Creator), Herpels, P. (Creator), Dewachter, L. (Creator), Verstraeten, N. (Creator), Peeters, E. (Creator), Ballet, S. (Creator), Michiels, J. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Zenodo, 8 Nov 2022
Dataset
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Protein ambiguity
Lazar, T. (Creator), Roca Martinez, J. (Researcher), Pancsa, R. (Creator) & Vranken, W. (Supervisor), Frontiers in Molecular Biosciences, 3 Aug 2022
DOI: 10.3389/fmolb.2022.959956, https://bitbucket.org/bio2byte/protein_ambiguity/src/master/
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMT).
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMT/pdb
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMS).
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMS/pdb
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMU)
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMU/pdb
Dataset