Projects per year
Organisation profile
Organisation profile
The Structural Biology Brussels Lab, headed by Jan Steyaert was founded by Lode Wyns in the seventies at the Vrije Universiteit Brussel and is one of the Flanders Institute for Biotechnology departments. The understanding of the function of a protein, from its structure to its dynamics, remains the central theme of the lab. Our multidisciplinary team of about 40 researchers is housed in new laboratory facilities and combines extensive expertise in biophysics and molecular biology. We master genetic engineering, protein purification, enzymology, calorimetry, crystallography, surface plasmon resonance, atomic force microscopy and now also NMR. Major esearch interests include Aggregating proteins and Amyloidosis, Membrane proteins, Protein assemblies, Redox regulation, RNA modification, Nanomodulators, Cell surface fillaments & Adhesion, Urinary tract infections, Enterotoxigenic E. coli, Molecular reognition and Toxin-Anti Toxin systems. Translational research is intrinsic to our programs, with possible applications in medicine.
Keywords
- X-ray crystallography
- Protein Chemistry
- Molecular Microbiology
- Structural Biology
- NMR
- Enzyme kinetics
- Antibody Engineering
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Collaborations and top research areas from the last five years
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FWOTM1122: Characterizing mutations in hnRNPA2 to identify pathogenic mechanisms in degenerative disorders
Tompa, P., Maes, D. & Duran Armenta, L. F.
1/11/22 → 31/10/26
Project: Fundamental
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OZR3940: Cofinanciering OZR FWO Hercules MZW: A platform for next-generation comprehensive proteome analysis: liquid chromatography trapped-ion-mobility time- of-flight (LC-timsTOF) mass spectrometry
Eeltink, S., Desmet, G., Steyaert, J., Peeters, E., Stijlemans, B., Magez, S., De Trez, C., De Vos, J. & Meston, D.
16/03/22 → 16/03/25
Project: Fundamental
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OZRIFTM7: Nanobodies to recognize non-canonical DNA structures and regulate their formation in vivo
1/10/21 → 30/09/25
Project: Fundamental
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OZR3906: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, PEREZ CHAVEZ Israel
1/10/21 → 30/09/25
Project: Fundamental
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OZR3904: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, SHEN Tzu-Keng
30/07/21 → 29/07/25
Project: Fundamental
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Analysis of the inter-domain orientation of tandem RRM domains with diverse linkers: connecting experimental with AlphaFold2 predicted models
Roca-Martínez, J., Kang, H-S., Sattler, M. & Vranken, W., 1 Mar 2024, In: NAR genomics and bioinformatics. 6, 1, 16 p., lqae002.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Biophysical characterization of the Plasmodium falciparum circumsporozoite protein's N-terminal domain
Geens, R., Stanisich, J., Beyens, O., D'Hondt, S., Thiberge, J-M., Ryckebosch, A., De Groot, A., Magez, S., Vertommen, D., Amino, R., De Winter, H., Volkov, A. N., Tompa, P. & Sterckx, Y. G-J., Jan 2024, In: Protein Science : A Publication of the Protein Society. 33, 1, 14 p., e4852.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Conformational dynamics of α-1 acid glycoprotein (AGP) in cancer: A comparative study of glycosylated and unglycosylated AGP
Dixit, B., Vranken, W. & Ghysels, A., Feb 2024, In: Proteins. 92, 2, p. 246-264 19 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Data-driven probabilistic definition of the low energy conformational states of protein residues
Gavalda-Garcia, J., Bickel, D., Roca-Martinez, J., Raimondi, D., Orlando, G. & Vranken, W., Sep 2024, In: NAR genomics and bioinformatics. 6, 3, 13 p., lqae082.Research output: Contribution to journal › Article › peer-review
Open Access -
DisProt in 2024: improving function annotation of intrinsically disordered proteins
Aspromonte, M. C., Nugnes, M. V., Quaglia, F., Bouharoua, A., DisProt Consortium, Lazar, T., Tompa, P., Piovesan, D. & Tosatto, S. C. E., 5 Jan 2024, In: Nucleic Acids Research. 52, 1, p. 434-441 8 p., gkad928.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus)
Activities
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LEUCALS Launch Event
Tamas Lazar (Participant)
11 May 2023Activity: Participating in or organising an event › Participation in conference
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Will the widespread use of AI-based structure prediction impact conformational ensemble use and ensemble generation?
Tamas Lazar (Speaker)
5 Jul 2023Activity: Talk or presentation › Talk or presentation at a conference
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1st Motif Biology Meeting: The Past, Present, and Future of Short Linear Motif Research
Tamas Lazar (Participant)
22 Jun 2023 → 23 Jun 2023Activity: Participating in or organising an event › Participation in conference
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Trends in PED, new IDP ensembles and future applications
Tamas Lazar (Invited speaker)
3 Jul 2023Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Universidad Nacional de San Martin (External organisation)
Tamas Lazar (Contributor)
Mar 2023 → Apr 2023Activity: Membership › Membership of external research organisation
Datasets
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YbiB: a Novel Interactor of the GTPase ObgE
Deckers, B. (Creator), Vercauteren, S. (Creator), De Kock, V. (Creator), Martin, C. (Creator), Lazar, T. (Creator), Herpels, P. (Creator), Dewachter, L. (Creator), Verstraeten, N. (Creator), Peeters, E. (Creator), Ballet, S. (Creator), Michiels, J. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Zenodo, 8 Nov 2022
Dataset
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Protein ambiguity
Lazar, T. (Creator), Roca Martinez, J. (Researcher), Pancsa, R. (Creator) & Vranken, W. (Supervisor), Frontiers in Molecular Biosciences, 3 Aug 2022
DOI: 10.3389/fmolb.2022.959956, https://bitbucket.org/bio2byte/protein_ambiguity/src/master/
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMT).
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMT/pdb
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMU)
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMU/pdb
Dataset
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Crystal structure of the LRR-Roc-COR domain of the Chlorobium tepidum Roco protein
Versées, W. (Project Leader), Deyaert, E. (Creator) & Singh, R. K. (Researcher), Protein Data Bank in Europe, 26 Dec 2018
DOI: 10.2210/pdb6HLU/pdb
Dataset