Projects per year
Organization profile
Organisation profile
The Structural Biology Brussels Lab, headed by Jan Steyaert was founded by Lode Wyns in the seventies at the Vrije Universiteit Brussel and is one of the Flanders Institute for Biotechnology departments. The understanding of the function of a protein, from its structure to its dynamics, remains the central theme of the lab. Our multidisciplinary team of about 40 researchers is housed in new laboratory facilities and combines extensive expertise in biophysics and molecular biology. We master genetic engineering, protein purification, enzymology, calorimetry, crystallography, surface plasmon resonance, atomic force microscopy and now also NMR. Major esearch interests include Aggregating proteins and Amyloidosis, Membrane proteins, Protein assemblies, Redox regulation, RNA modification, Nanomodulators, Cell surface fillaments & Adhesion, Urinary tract infections, Enterotoxigenic E. coli, Molecular reognition and Toxin-Anti Toxin systems. Translational research is intrinsic to our programs, with possible applications in medicine.
Fingerprint
Network
Profiles
-
Eva Beke
- Vrije Universiteit Brussel
- Department of Bio-engineering Sciences - Technical Assistant
- Structural Biology Brussels - Technical staff
- Structural Biology Brussels
Person: Researcher, Administrative/technical staff
-
Lieven Buts
- Vrije Universiteit Brussel
- Department of Bio-engineering Sciences - postdoctoral researcher
- Structural Biology Brussels - Academic
- Structural Biology Brussels
Person: Researcher
-
Nele Buys
- Vrije Universiteit Brussel
- Department of Bio-engineering Sciences - Administration
- Structural Biology Brussels - Technical staff
- Structural Biology Brussels
Person: Researcher, Administrative/technical staff
-
Maia De Kerpel
- Vrije Universiteit Brussel
- Department of Bio-engineering Sciences - pre-doctoral researcher
- Structural Biology Brussels - Technical specialist
- Structural Biology Brussels
Person: Researcher, Administrative/technical staff
-
Luis Fernando Duran Armenta
- Vrije Universiteit Brussel
- Faculty of Sciences and Bioengineering Sciences
- Structural Biology Brussels - Academic
Person: Researcher, PhD
-
OZR3941: Cofinanciering OZR FWO Hercules MZW: SPECY-SORT: SPEctral flow CYtometer and cell SORTer
Laoui, D., Van Ginderachter, J., Movahedi, K., De Veirman, K., Magez, S., De Trez, C., Stijlemans, B., Raes, G., Devoogdt, N., Messens, J., Brunner, J., Remaut, H. K., Fioravanti, A., Peeters, E. & Van der Henst, C.
16/03/22 → 16/03/25
Project: Fundamental
-
OZR3940: Cofinanciering OZR FWO Hercules MZW: A platform for next-generation comprehensive proteome analysis: liquid chromatography trapped-ion-mobility time- of-flight (LC-timsTOF) mass spectrometry
Eeltink, S., Desmet, G., Steyaert, J., Peeters, E., Stijlemans, B., Magez, S., De Trez, C., De Vos, J. & Meston, D.
16/03/22 → 16/03/25
Project: Fundamental
-
OZR3906: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, PEREZ CHAVEZ Israel
1/10/21 → 30/09/25
Project: Fundamental
-
OZRIFTM7: Nanobodies to recognize non-canonical DNA structures and regulate their formation in vivo
1/10/21 → 30/09/25
Project: Fundamental
-
Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor
Zarkadas, E., Pebay-Peyroula, E., Thompson, M. J., Schoehn, G., Uchański, T., Steyaert, J., Chipot, C., Dehez, F., Baenziger, J. E. & Nury, H., 20 Apr 2022, In : Neuron. 110, 8, p. 1358-1370.e5Research output: Contribution to journal › Article
-
Degron masking outlines degronons, co-degrading functional modules in the proteome
Guha Roy, M., Lazar, T., Macossay Castillo, M. & Tompa, P., May 2022, In : Communications Biology. 5, 445.Research output: Contribution to journal › Article
Open Access -
F/YGG-motif is an intrinsically disordered nucleic-acid binding motif
Van Lindt, J., Lazar, T., Pakravan, D., Demulder, M., Meszaros, A., Van Den Bosch, L., Maes, D. & Tompa, P., 1 May 2022, In : RNA Biology. 19, 1, p. 622-635 14 p.Research output: Contribution to journal › Article
Open Access -
Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives
Kostyuk, A. I., Tossounian, M-A., Panova, A. S., Thauvin, M., Raevskii, R. I., Ezeriņa, D., Wahni, K., Van Molle, I., Sergeeva, A. D., Vertommen, D., Gorokhovatsky, A. Y., Baranov, M. S., Vriz, S., Messens, J., Bilan, D. S. & Belousov, V. V., 10 Jan 2022, In : Nature Communications. 13, 1, 17 p., 171.Research output: Contribution to journal › Article
Open Access1 Citation (Scopus) -
Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies
Keown, J. R., Zhu, Z., Carrique, L., Fan, H., Walker, A. P., Serna Martin, I., Pardon, E., Steyaert, J., Fodor, E. & Grimes, J. M., 11 Jan 2022, In : Nature Communications. 13, 1, 11 p., 251.Research output: Contribution to journal › Article
Activities
-
Structural Biology Brussels (Organisational unit)
Anke Breine (Chair), Aline D'Hondt (Chair)16 Mar 2022 → 31 Aug 2023Activity: Membership › Work on academic committees and working groups
-
The dynamic redox language of the cell – peroxiredoxin mediated signaling
Joris Messens (Speaker)15 Jun 2021Activity: Talk or presentation › Talk or presentation at a conference
-
Redox in motion
Joris Messens (Speaker)29 Mar 2021Activity: Talk or presentation › Talk or presentation at a conference
-
Prokaryote toxin-antitoxin modules: complex regulation of an unclear biological function
Remy Loris (Speaker)7 Apr 2021Activity: Talk or presentation › Talk at an external academic organisation
File -
Department of Bio-engineering Sciences (Organisational unit)
Eveline Peeters (Chair), Inge Van Molle (Jury), Kim Roelants (Jury), Remy Loris (Supervisor), Henri De Greve (Supervisor), Tanel Tenson (Jury), Jan Michiels (Jury)2 Sep 2021Activity: Membership › Member of PhD committee