Projects per year
Organization profile
Organisation profile
The Structural Biology Brussels Lab, headed by Jan Steyaert was founded by Lode Wyns in the seventies at the Vrije Universiteit Brussel and is one of the Flanders Institute for Biotechnology departments. The understanding of the function of a protein, from its structure to its dynamics, remains the central theme of the lab. Our multidisciplinary team of about 40 researchers is housed in new laboratory facilities and combines extensive expertise in biophysics and molecular biology. We master genetic engineering, protein purification, enzymology, calorimetry, crystallography, surface plasmon resonance, atomic force microscopy and now also NMR. Major esearch interests include Aggregating proteins and Amyloidosis, Membrane proteins, Protein assemblies, Redox regulation, RNA modification, Nanomodulators, Cell surface fillaments & Adhesion, Urinary tract infections, Enterotoxigenic E. coli, Molecular reognition and Toxin-Anti Toxin systems. Translational research is intrinsic to our programs, with possible applications in medicine.
Keywords
- X-ray crystallography
- Protein Chemistry
- Molecular Microbiology
- Structural Biology
- NMR
- Enzyme kinetics
- Antibody Engineering
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Network
Profiles
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Tamas Lazar
- Vrije Universiteit Brussel
- Structural Biology Brussels - postdoctoral researcher
- https://structuralbiology.brussels - postdoctoral researcher
Person: Researcher
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FWOTM1122: Characterizing mutations in hnRNPA2 to identify pathogenic mechanisms in degenerative disorders
Tompa, P., Maes, D. & Duran Armenta, L. F.
1/11/22 → 31/10/26
Project: Fundamental
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OZR3940: Cofinanciering OZR FWO Hercules MZW: A platform for next-generation comprehensive proteome analysis: liquid chromatography trapped-ion-mobility time- of-flight (LC-timsTOF) mass spectrometry
Eeltink, S., Desmet, G., Steyaert, J., Peeters, E., Stijlemans, B., Magez, S., De Trez, C., De Vos, J. & Meston, D.
16/03/22 → 16/03/25
Project: Fundamental
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OZR3941: Cofinanciering OZR FWO Hercules MZW: SPECY-SORT: SPEctral flow CYtometer and cell SORTer
Laoui, D., Van Ginderachter, J., Movahedi, K., De Veirman, K., Magez, S., De Trez, C., Stijlemans, B., Raes, G., Devoogdt, N., Messens, J., Brunner, J., Remaut, H. K., Fioravanti, A., Peeters, E. & Van der Henst, C.
16/03/22 → 16/03/25
Project: Fundamental
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OZRIFTM7: Nanobodies to recognize non-canonical DNA structures and regulate their formation in vivo
1/10/21 → 30/09/25
Project: Fundamental
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OZR3906: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, PEREZ CHAVEZ Israel
1/10/21 → 30/09/25
Project: Fundamental
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The dynamics of single-cell nanomotion behaviour of Candida albicans in a microfluidic chip during antifungal treatment
Radonicic, V., Yvanoff, C., Villalba, M. I., Devreese, B., Kasas, S. & Willaert, R., 2023, (Submitted).Research output: Unpublished contribution to conference › Poster
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YbiB: a novel interactor of the GTPase ObgE
Deckers, B., Vercauteren, S., De Kock, V., Martin, C., Lazar, T., Herpels, P., Dewachter, L., Verstraeten, N., Peeters, E., Ballet, S., Michiels, J., Galicia, C. & Versées, W., 2 Mar 2023, In: Nucleic Acids Research. 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor
Zarkadas, E., Pebay-Peyroula, E., Thompson, M. J., Schoehn, G., Uchański, T., Steyaert, J., Chipot, C., Dehez, F., Baenziger, J. E. & Nury, H., 20 Apr 2022, In: Neuron. 110, 8, p. 1358-1370.e5 13 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C
Killer, M., Finocchio, G., Mertens, H. D. T., Svergun, D. I., Pardon, E., Steyaert, J. & Löw, C., 2022, In: Frontiers in molecular biosciences. 9, p. 1-15 15 p., 917725.Research output: Contribution to journal › Article › peer-review
Open Access -
Degron masking outlines degronons, co-degrading functional modules in the proteome
Guha Roy, M., Lazar, T., Macossay Castillo, M. & Tompa, P., May 2022, In: Communications Biology. 5, 1, 445.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus)
Activities
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Making the invisible visible – Mechanistical insights on biosensor functioning
Joris Messens (Speaker)
9 Oct 2022Activity: Talk or presentation › Talk or presentation at a conference
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II. PhasAGE-VIB International Conference “Biomolecular condensates in biology and disease”
Peter Tompa (Organiser), Tamas Lazar (Organiser), Mark Edward Lackey (Organiser), Junaid Ahmed (Organiser), Joris Van Lindt (Organiser), Luis Fernando Duran Armenta (Organiser), Anna Bratek-Skicki (Organiser), Nazanin Farahi (Organiser), Attila Meszaros (Organiser), Kevin Muwonge (Organiser), Giorgio Russo (Organiser), Ludo Van Den Bosch (Organiser), Sandra Macedo-Ribeiro (Organiser) & Rita Vilaca (Organiser)
11 Dec 2022 → 12 Dec 2022Activity: Participating in or organising an event › Participation in conference
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Structural Biology Brussels (Organisational unit)
Anke Breine (Chair) & Aline D'Hondt (Chair)
16 Mar 2022 → 31 Aug 2023Activity: Membership › Work on academic committees and working groups
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Department of Bio-engineering Sciences (Organisational unit)
Joris Messens (Member)
2022Activity: Membership › Member of PhD committee
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SFRR-E conference
Joris Messens (Chair)
26 Aug 2022Activity: Participating in or organising an event › Participation in conference
Datasets
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Protein ambiguity
Lazar, T. (Creator), Roca Martinez, J. (Researcher), Pancsa, R. (Creator) & Vranken, W. (Supervisor), Frontiers in Molecular Biosciences, 3 Aug 2022
DOI: 10.3389/fmolb.2022.959956, https://bitbucket.org/bio2byte/protein_ambiguity/src/master/
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMS).
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMS/pdb
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMT).
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMT/pdb
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMU)
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMU/pdb
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMV)
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 Jun 2018
DOI: 10.2210/pdb6EMV/pdb
Dataset