Projects per year
Organisation profile
About us
The Structural Biology Brussels Lab, headed by Jan Steyaert was founded by Lode Wyns in the seventies at the Vrije Universiteit Brussel and is one of the Flanders Institute for Biotechnology departments. The understanding of the function of a protein, from its structure to its dynamics, remains the central theme of the lab. Our multidisciplinary team of about 40 researchers is housed in new laboratory facilities and combines extensive expertise in biophysics and molecular biology. We master genetic engineering, protein purification, enzymology, calorimetry, crystallography, surface plasmon resonance, atomic force microscopy and now also NMR. Major esearch interests include Aggregating proteins and Amyloidosis, Membrane proteins, Protein assemblies, Redox regulation, RNA modification, Nanomodulators, Cell surface fillaments & Adhesion, Urinary tract infections, Enterotoxigenic E. coli, Molecular reognition and Toxin-Anti Toxin systems. Translational research is intrinsic to our programs, with possible applications in medicine.
Keywords
- X-ray crystallography
- Protein Chemistry
- Molecular Microbiology
- Structural Biology
- NMR
- Enzyme kinetics
- Antibody Engineering
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Collaborations and top research areas from the last five years
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FWOTM1122: Characterizing mutations in hnRNPA2 to identify pathogenic mechanisms in degenerative disorders
Tompa, P. (Administrative Promotor), Maes, D. (Co-Promotor) & Duran Armenta, L. F. (Mandate)
1/11/22 → 31/10/26
Project: Fundamental
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OZR3940: Cofinanciering OZR FWO Hercules MZW: A platform for next-generation comprehensive proteome analysis: liquid chromatography trapped-ion-mobility time- of-flight (LC-timsTOF) mass spectrometry
Eeltink, S. (Administrative Promotor), Desmet, G. (Co-Promotor), Steyaert, J. (Co-Promotor), Peeters, E. (Co-Promotor), Stijlemans, B. (Co-Promotor), Magez, S. (Co-Promotor), De Trez, C. (Co-Promotor), De Vos, J. (Co-Promotor) & Meston, D. (Co-Promotor)
16/03/22 → 16/03/25
Project: Fundamental
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OZR3822: Backup mandate Research Council: Exploring prion-like nucleation of liquid-liquid phase separation of hnRNPA2 in Amyotrophic Lateral Sclerosis
Tompa, P. (Administrative Promotor) & Duran Armenta, L. F. (Mandate)
1/11/21 → 31/10/22
Project: Fundamental
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OZR3906: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, PEREZ CHAVEZ Israel
Messens, J. (Administrative Promotor)
1/10/21 → 30/09/25
Project: Fundamental
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OZRIFTM7: Nanobodies to recognize non-canonical DNA structures and regulate their formation in vivo
Loris, R. (Administrative Promotor) & Pevec, M. (Mandate)
1/10/21 → 13/08/26
Project: Fundamental
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DNA binding and dimerization of the SOG1 NAC domain are functionally linked with its ability to undergo liquid-liquid phase separation.
Mignon, K., Van der Eecken, R., Galle, M., Demulder, M., Van Lindt, J., De Veylder, L., De Greve, H. & Loris, R., 20 Jan 2026, In: Nucleic Acids Res.. 54, 2, 16 p., gkaf1522.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)8 Downloads (Pure) -
Combining evolution and protein language models for an interpretable cancer driver mutation prediction with D2Deep
Tzavella, K., Diaz, A., Olsen, C. & Vranken, W., 1 Jan 2025, In: Briefings in Bioinformatics. 26, 1, 13 p., bbae664.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)32 Downloads (Pure) -
Microfluidic handling and separation tools for intracellular structure analysis
Gómez Piedrafita, E., Bihi, I., Ezeriņa, D., Messens, J. & De Malsche, W., 2025, (Unpublished). 1 p.Research output: Unpublished contribution to conference › Poster
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Novel antigen-binding chimeric proteins and methods and uses thereof
Steyaert, J. (Inventor), Pardon, E. (Inventor), Uchanski, T. (Inventor) & Vranken, W. (Inventor), 2025, Patent No. EP3704160B1Research output: Patent
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Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams
Schenck, S., Laeremans, T., Steyaert, J. & Brunner, J., Dec 2025, In: Nature Communications. 16, 1, 14 p., 4172.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)4 Downloads (Pure)
Activities
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Structural Biology Brussels (Organisational unit)
Goes, L. (Chair)
13 Nov 2023 → …Activity: Membership › Member of PhD committee
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Trends in PED, new IDP ensembles and future applications
Lazar, T. (Invited speaker)
3 Jul 2023Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Universidad Nacional de San Martin (External organisation)
Lazar, T. (Contributor)
Mar 2023 → Apr 2023Activity: Membership › Membership of external research organisation
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Will the widespread use of AI-based structure prediction impact conformational ensemble use and ensemble generation?
Lazar, T. (Speaker)
5 Jul 2023Activity: Talk or presentation › Talk or presentation at a conference
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1st Motif Biology Meeting: The Past, Present, and Future of Short Linear Motif Research
Lazar, T. (Participant)
22 Jun 2023 → 23 Jun 2023Activity: Participating in or organising an event › Participation in conference
Datasets
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YbiB: a Novel Interactor of the GTPase ObgE
Deckers, B. (Creator), Vercauteren, S. (Creator), De Kock, V. (Creator), Martin, C. (Creator), Lazar, T. (Creator), Herpels, P. (Creator), Dewachter, L. (Creator), Verstraeten, N. (Creator), Peeters, E. (Creator), Ballet, S. (Creator), Michiels, J. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Zenodo, 8 Nov 2022
Dataset
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Human ganglioside-induced differentiation-associated protein 1 (GDAP1) missense mutant H123R, construct GDAP1∆302-358
Loris, R. (Creator) & Muruganandam, G. (Creator), Small Angle Scattering Biological Data Bank, 2022
https://www.sasbdb.org/data/SASDND6/
Dataset
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Human ganglioside-induced differentiation-associated protein 1 (GDAP1) missense mutant R120W, construct GDAP1∆302-358
Loris, R. (Supervisor) & Muruganandam, G. (Creator), Small Angle Scattering Biological Data Bank, 2022
https://www.sasbdb.org/data/SASDNE6/
Dataset
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Mouse cysteine sulphinic acid decarboxylase (CSAD)
Loris, R. (Supervisor) & Muruganandam, G. (Creator), Small Angle Scattering Biological Data Bank, 2021
Dataset
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Dimeric human ganglioside-induced differentiation-associated protein 1, construct GDAP1∆303-358
Loris, R. (Supervisor) & Muruganandam, G. (Creator), Small Angle Scattering Biological Data Bank, 2021
Dataset