Projects per year
The main expertise of the research group GEVI is molecular genetics of bacteria that are pathogenic for plants and animals. This laboratory contributed significantly to the present widespread application of the bacterium Agrobacterium tumefaciens, as a tool for routine transformation of plants. Agrobacterium- mediated transformation is used by GEVI for the isolation and study of genes involved in plant morphogenesis. In addition, techniques for the transformation of leguminous crop plants are developed and the expression in plants of lectins with insecticidal activity is optimised. The virulence mechanisms of bacteria (Escherichia coli and Salmonella) pathogenic for humans and domestic animals are studied, by the isolation and analysis of the relevant genes. Several gene clusters, encoding fimbriae involved in the adhesion of pathogenic E. coli to host tissues, were cloned and analysed in detail. New genes involved in the pathogenicity of S.enteritidis for mammals and birds were also identified. Besides providing new insights in these complex interactions, this also leads to the development of more specific diagnostics and improved vaccines for the control of these important pathogens. The controlled expression of viral antigens in attenuated Salmonella vaccine strains, to produce recombinant anti-viral vaccines, is also investigated.
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- 1 Finished
IWT227: Attenuated vaccine for the protection of poultry against avian pathogenic Escherichia coli and Salmonella enterica.
1/09/04 → 31/08/06
Hernalsteens, J-P., Van Lijsebettens, M., Inzé, D., Van Montagu, M. & Depuydt, S., 5 Dec 2020, In : Biotechnology advances. p. 107677 107677.
Research output: Contribution to journal › Scientific review2 Citations (Scopus)
Hernalsteens, J-P., Greve, H. D., Estrozi, L. F., Bacia-Verloop, M., Moriscot, C., Noben, J-P., Schoehn, G. & Lavigne, R., May 2020, In : International Journal of Molecular Sciences. 21, 9, 13 p., 3119.
Research output: Contribution to journal › Article4 Citations (Scopus)
Enzymes Catalyzing the TCA- and Urea Cycle Influence the Matrix Composition of Biofilms Formed by Methicillin-Resistant USA300De Backer, S., Sabirova, J., De Pauw, I., De Greve, H., Hernalsteens, J-P., Goossens, H. & Malhotra-Kumar, S., 29 Oct 2018, In : Microorganisms. 6, 4, 16 p.
Research output: Contribution to journal › Article
Elseviers, J., Yvanoff, C., Hassanzadeh-Ghassabeh, G., Garcia Rodriguez, G., Martens, E., Depicker, A., Martel, A., Haesebrouck, F., Pasmans, F., Hernalsteens, J. P. & De Greve, H., 27 Sep 2018, In : PLoS ONE. 13, 9, e0204222.
Research output: Contribution to journal › Article8 Citations (Scopus)
Hernalsteens, J-P. & Roelants, K., Feb 2017, In : Developmental and Comparative Immunology. 67, p. 395-403 9 p.
Research output: Contribution to journal › Article5 Citations (Scopus)
Research training. The presence of ColV plasmids in avian pathogenic (APEC) Escherichia coli strains was studied to obtain more information on the virulence mechanisms of APEC and to identify the relevant genes for the production of recombinant vaccines.Jean-Pierre Hernalsteens (Member)1 Sep 2002 → 31 May 2003
Activity: Other › Types of External academic engagement - Hosting an academic visitor