Research output per year
Research output per year
Research output
- 40 results
Search results
-
2024
Abstract 3378: Acinar cell susceptibility for tumor development in the pancreas: Targeting the critical regulators for therapy
Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., 15 Mar 2024, In: Cancer Research. 84, 6_supplement, 1 p., 3378.Research output: Contribution to journal › Meeting abstract (Journal)
Open Access -
Acinar cell susceptibility for tumor development in the pancreas: targeting the critical regulators for therapy
Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., Apr 2024, (Accepted/In press).Research output: Unpublished contribution to conference › Poster
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Characterization of the long-term effects of lethal total body irradiation followed by bone marrow transplantation on the brain of C57BL/6 mice
Janssen, P., De Pauw, L., Mambretti, M., Lara, O., Walckiers, J., Mackens, L., Rooman, I., Guillaume, B., De Ridder, M., Ates, G. & Massie, A., 3 Mar 2024, In: International Journal of Radiation Biology. 100, 3, p. 385-398 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Downloads (Pure) -
Compartmentalized role of xCT in supporting pancreatic tumor growth, inflammation and mood disturbance in mice
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Walckiers, J., Pan, Z., Beckers, P., Espinet, E., Sato, H., De Ridder, M., Marks, D. L., Barbé, K., Aerts, J., Hermans, E., Rooman, I. & Massie, A., May 2024, In: Brain, Behavior, and Immunity. 118, p. 275-286 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus) -
Critical regulators of pancreatic acinar cell dedifferentiation: options for therapeutic intervention
Pan, Z., 2024, 152 p.Research output: Thesis › PhD Thesis
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High-resolution and quantitative spatial analysis reveal intra-ductal phenotypic and functional diversification in pancreatic cancer
Michiels, E., Madhloum, H., Van Lint, S., Messaoudi, N., Kunda, R., Martens, S., Giron, P., Olsen, C., Lefesvre, P., Dusetti, N., El Mohajer, L., Tomasini, R., Hawinkels, L. J., Ahsayni, F., Nicolle, R., Arsenijevic, T., Bouchart, C., Van Laethem, J-L. & Rooman, I., Jan 2024, In: Journal of pathology. 262, 1, p. 76-89 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)24 Downloads (Pure) -
Overcoming drug tolerance to enhance the efficacy of EGFR tyrosine kinase inhibitors
Eggermont, C., 2024, 158 p.Research output: Thesis › PhD Thesis
Open AccessFile41 Downloads (Pure) -
Resolution of Acinar Dedifferentiation Regulates Tissue Remodeling in Pancreatic Injury and Cancer Initiation
Baldan, J., Camacho-Roda, J., Ballester, M., Høj, K., Kurilla, A., Maurer, H. C., Arcila-Barrera, S., Lin, X., Pan, Z., Castro, J. L., Mayorca-Guiliani, A. E., Rift, C. V., Hasselby, J., Bouwens, L., Lefebvre, V., David, C. J., Parnas, O., DelGiorno, K. E., Erler, J. T., Rooman, I. & 1 others, , Sep 2024, In: Gastroenterology. 167, 4, p. 718-732.e18 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
ROBO1 Drives Gemcitabine Resistance in Pancreatic Cancer
Mader, S., Rooman, I., Rodriguez Aznar, E., Soubeyran, P., Dusetti, N. & Bousquet Vaysse, C., 17 Jun 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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ROBO1 Drives Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma
Mader, S., Soubeyran, P., Dusetti, N., Bousquet Vaysse, C., Rodriguez Aznar, E. & Rooman, I., 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Spatial Characterization of B7H3 Expression in PDAC reveals increased Expression in Basal-like Tumor Ducts and αSMA-positive Stromal Cells
De Man, V., Michiels, E., Messaoudi, N., Olsen, C., Giron, P. & Rooman, I., 18 Apr 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Spatial transcriptomic analysis of human Pancreatic Basal Cells reveals PTGES as a potential target for the Basal-Like subtype of Pancreatic Ductal Adenocarcinoma.
Van den Bossche, J-L., Van der Vliet, M., Coolens, K., Michiels, E., Houbracken, I., Baldan, J. & Rooman, I., 18 Apr 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Spatial transcriptomic analysis reveals PTGES as a conserved potential therapeutic target for basal cells in Pancreatic Ductal Adenocarcinoma.
Van der Vliet, M., Van den Bossche, J-L. & Rooman, I., 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Spatial transcriptomic and single cell sequencing data reveals PTGES as a conserved potential therapeutic target for basal cells in pancreatic cancer.
Van der Vliet, M. & Rooman, I., 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Unravel acinar cell subpopulation with propensity for cancer initiation
Baldan, J., Scheele, C., Jacquemin, P. & Rooman, I., 23 Oct 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Unravel proliferative acinar cell subpopulation with propensity for cancer initiation.
Baldan, J., Scheele, C., Jacquemin, P. & Rooman, I., 29 Nov 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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2023
Axon guidance genes control hepatic artery development
Gannoun, L., De Schrevel, C., Belle, M., Dauguet, N., Achouri, Y., Loriot, A., Vanderaa, C., Cordi, S., Dili, A., Heremans, Y., Rooman, I., Leclercq, I. A., Jacquemin, P., Gatto, L. & Lemaigre, F. P., 15 Aug 2023, In: Development. 150, 16, 15 p., dev201642.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)12 Downloads (Pure) -
Heterotopia of salivary gland tissue in the pancreas
Martens, S., Coolens, K., Olsen, C., Lefesvre, P. & Rooman, I., Dec 2023, In: Diagnostic pathology. 18, 1, 6 p., 98.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)27 Downloads (Pure) -
Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress
Pan, Z., Van den Bossche, J-L., Rodriguez-Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., 21 Aug 2023, In: Cell & Death Disease. 14, 8, 10 p., 536.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)23 Downloads (Pure) -
Systemic deletion of xCT in mice attenuates peripheral inflammation and inflammation-related mood disturbances in a pancreatic cancer model
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Sato, H., De Ridder, M., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 21 Apr 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Systemic deletion of xCT in mice attenuates peripheral inflammation and inflammation-related mood disturbances in a pancreatic cancer model
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Sato, H., De Ridder, M., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 6 Jun 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
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System xc- (xCT) prevents ferroptosis in pancreatic acinar cells as a first step in acinar-to-ductal metaplasia
Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., Nov 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
File84 Downloads (Pure) -
System xc- prevents ferroptosis in pancreatic acinar cells as a first step in acinar-to-ductal metaplasia
Pan, Z. & Rooman, I., Apr 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Tackling pancreatic cancer from different angles: compartmentalized role of xCT in supporting tumor growth and inflammation-related comorbidities in mice
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Walckiers, J., Pan, Z., Beckers, P., Espinet, E., Sato, H., De Ridder, M., Marks, D. L., Barbé, K., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 13 Nov 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
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2022
Spatial heterogeneity of mutant KRAS expression in the context of pancreatic cancer subtypes
Michiels, E., Rooman, I., Messaoudi, N., Giron, P., Olsen, C., Frederix, K. & Lefesvre, P., 6 Nov 2022.Research output: Unpublished contribution to conference › Poster
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Spatial heterogeneity of mutant KRAS expression in the context of pancreatic cancer subtypes
Michiels, E., Messaoudi, N., Rooman, I., Giron, P., Olsen, C., Lefesvre, P. & Frederix, K., 29 Sep 2022.Research output: Unpublished contribution to conference › Poster
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Spatial Heterogeneity of Mutant KRAS Expression in the Context of Pancreatic Cancer Subtypes
Rooman, I., 5 Nov 2022.Research output: Unpublished contribution to conference › Poster
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Targeting system xc- in a mouse pancreatic cancer model reduces tumor growth, neuroinflammation and mood disturbances
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Njemini, R., Sato, H., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 9 May 2022, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Targeting system xc- in a mouse pancreatic cancer model reduces tumor growth, neuroinflammation and mood disturbances
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Njemini, R., Sato, H., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 9 May 2022, Targeting system xc- in a mouse pancreatic cancer model reduces tumor growth, neuroinflammation and mood disturbances.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book)
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2021
Discovery and 3D imaging of deltaNp63-expressing cells in the human pancreatic duct that share characteristics with an aggressive molecular subtype of pancreatic cancer: poster and video abstract
Rooman, I., 5 May 2021.Research output: Unpublished contribution to conference › Poster
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Discovery and 3D imaging of deltaNp63-expressing cells in the human pancreatic duct that share characteristics with the aggressive molecular subtype of pancreatic cancer: Poster Discussion Session for Top Abstracts
Rooman, I., 9 Jun 2021.Research output: Unpublished contribution to conference › Poster
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MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Kurokawa, M., Goyama, S., Bouwens, L., Jacquemin, P., Houbracken, I. & Rooman, I., 21 Mar 2021, Biorxiv, 40 p.Research output: Working paper › Preprint
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Robo1 supports actin rich structures in pancreatic tumor cells with particular effects on Rhoa activity at adherens junctions
Sklyarova, T. & Rooman, I., Oct 2021, In: United European Gastroenterology Journal. 9, p. 108-109 2 p.Research output: Contribution to journal › Meeting abstract (Journal)
Open AccessFile130 Downloads (Pure) -
Setting up a PDXO platform for pancreatic cancer with spatial omics characterization
Michiels, E. & Rooman, I., 5 Oct 2021.Research output: Unpublished contribution to conference › Poster
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Setting up a PDXO platform of pancreatic cancer with spatial-omics characterization
Michiels, E. & Rooman, I., 21 Sep 2021.Research output: Unpublished contribution to conference › Poster
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2020
A novel basal DeltaNP63 (P40)-expressing pancreatic cell type undergoes expansion and reorganization in chronic pancreatitis
Martens, S., Van Bulck, M., Coolens, K., Esni, F., Leuckx, G., Heimberg, H., Bouwens, L., Jacquemin, P., Spagnoli, F., Real, F. X., in 't Veld, P., Lesfevre, P. & Rooman, I., Oct 2020, In: United European Gastroenterology Journal. 8, p. 123-124 2 p.Research output: Contribution to journal › Meeting abstract (Journal)
Open AccessFile252 Downloads (Pure) -
2019
In vivo investigation of a potential regulator of pancreatic acinar dedifferentiation
Michiels, E., Backx, E. & Rooman, I., 25 Jun 2019, (Unpublished).Research output: Unpublished contribution to conference › Poster
File37 Downloads (Pure) -
2018
Drug Repurposing as a Source of Innovative Therapies in Pancreatic Cancer
Pantziarka, P., Capistrano, R., Bouche, G. & Rooman, I., 2018.Research output: Unpublished contribution to conference › Poster
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2016
Role of the microenvironment in chronic pancreatitis and pancreatic cancer
Pinho, A. V., Apte, M. V., Wilson, J. S. & Rooman, I., 1 Mar 2016, In: Cancer Forum. 40, 1, p. 11-15 5 p.Research output: Contribution to journal › Scientific review › peer-review
1 Citation (Scopus) -
2003
Proliferation and differentiation of adult rat pancreatic exocrine cells
Rooman, I., 2003, In: Verhandelingen - Koninklijke Academie voor Geneeskunde van België. 65, p. 117-125Research output: Contribution to journal › Scientific review
2 Citations (Scopus)