Projects per year
Personal profile
Expertise
Neurochemical and neuropharmacological research is strongly dependent on the availability of sensitive analysis methods for neurotransmitters, neuromodulators and drugs in biological samples. The development of new, faster and sensitive analysis methods remains challenging for the bioanalyst due to the very low concentrations of these compounds in small sample volumes, in addition to the need for higher throughput.
The research group has ample experience in the development of miniaturized LC methods, coupled to fluorescence, electrochemical or tandem mass spectrometric (MS/MS) detection, for the quantification of neurotransmitters and neuromodulators in microdialysis samples. In addition, we have a large experience in the development and validation of analytical methods for the determination of drugs in drug products and biological samples with capillary electrophoresis, LC-UV, LC-fluorescence and LC-MS/MS.
The main research topics are:
- Nano LC tandem mass spectrometry for quantification of neuropeptides in microdialysis samples
- Metabolite profiling for the discovery and analysis of biomarkers of drug resistant epilepsy
- Miniaturized (enantioselective) LC methods for quantification of neuro- and gliotransmitters in biological samples
- Miniaturized LC methods for quantification of drug in biological samples
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FWOAL1076: Achiral and chiral targeted brain metabolomics in volume-limited samples: quest for broad coverage, sensitivity and throughput using chemical derivatization and miniaturized liquid chromatography tandem mass spectrometry.
Van Eeckhaut, A. & Vander Heyden, Y.
1/01/23 → 31/12/26
Project: Fundamental
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Research output
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Improving the LC-MS/MS analysis of neuromedin U-8 and neuromedin S by minimizing their adsorption behavior and optimizing UHPLC and MS parameters
Bongaerts, J., De Bundel, D., Smolders, I., Mangelings, D., Vander Heyden, Y. & Van Eeckhaut, A., 10 May 2023, In: Journal of Pharmaceutical and Biomedical Analysis. 228, 11 p., 115306.Research output: Contribution to journal › Article › peer-review
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Prognostic value of left ventricular global constructive work in patients with cardiac amyloidosis
Geers, J., Luchian, M-L., Motoc, A., De Winter, J., Roosens, B., Bjerke, M., Van Eeckhaut, A., Wittens, M. M. J., Demeester, S., Forsyth, R., de Ravel, T., Bissay, V., Schots, R., Verbrugge, F. H., Weytjens, C., Weets, I., Cosyns, B. & Droogmans, S., Mar 2023, In: The International Journal of Cardiovascular Imaging. 39, 3, p. 585-593 9 p.Research output: Contribution to journal › Article › peer-review
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Accelerated HF-rTMS Modifies SERT Availability in the Subgenual Anterior Cingulate Cortex: A Canine [11C] DASB Study on the Serotonergic System
Xu, Y., Kappen, M., Peremans, K., De Bundel, D., Van Eeckhaut, A., Van Laeken, N., De Vos, F., Dobbeleir, A., Saunders, J. H. & Baeken, C., 10 Mar 2022, In: Journal of Clinical Medicine. 11, 6, 12 p., 1531.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)42 Downloads (Pure) -
Assessment of gliotransmitter concentrations upon chemogenetic modulation of astroglia in mouse hippocampus
Nestor, L., Sahu, S., De Bundel, D., Van Eeckhaut, A. & Smolders, I., 9 May 2022, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid
Custers, M-L., Nestor, L., De Bundel, D., Van Eeckhaut, A. & Smolders, I., 13 May 2022, In: Pharmaceutics. 14, 5, 20 p., 1051.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)33 Downloads (Pure)
Prizes
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Project grant Wetenschappelijk Fonds Willy Gepts (WFWG)
Custers, Marie-Laure (Recipient), Van Eeckhaut, Ann (Recipient) & Smolders, Ilse (Recipient), 1 Dec 2021
Prize: Prize (including medals and awards)
Activities
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DA-PBA 2022: 12th International Symposium on Drug Analysis & 32nd International Symposium on Pharmaceutical and Biomedical Analysis
Marie-Laure Custers (Speaker), Maria Bjerke (Contributor), Ann Van Eeckhaut (Contributor) & Ilse Smolders (Contributor)
13 Sep 2022Activity: Talk or presentation › Talk or presentation at a conference
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Peptide quantification at the picomolar level in volume-limited biological samples: obstacles to tackle
Ann Van Eeckhaut (Speaker)
14 Sep 2022Activity: Talk or presentation › Talk or presentation at a conference
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Separations (Journal)
Ann Van Eeckhaut (Editor)
2021 → 2023Activity: Publication peer-review and editorial work › Editorial activity
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Scientific Research Section
Marie-Laure Custers (Speaker), Maria Bjerke (Contributor), Ann Van Eeckhaut (Contributor) & Ilse Smolders (Contributor)
24 Sep 2021Activity: Talk or presentation › Talk or presentation at a conference
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PhD day C4N
Marie-Laure Custers (Speaker), Maria Bjerke (Contributor), Ann Van Eeckhaut (Contributor) & Ilse Smolders (Contributor)
16 Dec 2021Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Analytical Challenges for the Determination of Alpha-Synuclein in the Context of Parkinson Disease.
Author: Napp, A., Fillet, M., Servais, A., Hubert, , Garraux, , Merville, , Lipka, & Van Eeckhaut, A., 15 Oct 2018Student thesis: Doctoral Thesis
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Bepaling van de plasmastabiliteit van een synthetisch peptide en preliminair onderzoek naar het minimaliseren van peptide-adsorptie tijdens microdialyse
Author: Van den Borre, L., Van Eeckhaut, A., Caveliers, V. & Doktorova, T., 10 Jun 2015Student thesis: Master's Thesis
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Bioanalysis and model based treatment optimization for preclinical and clinical studies of peritoneal carcinomatosis from ovarian cancer.
Author: Xie, F., Van Bocxlaer, J., Vermeulen, A., Colin, P., Boussery, K., Remaut, K., Vervaet, C., Ceelen, MD, W., Van Eeckhaut, A. & Jose Perez Ruixo, J., 28 Aug 2019Student thesis: Doctoral Thesis
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Chiral Separations with Cyclodextrin Mediated Capillary Electrophoresis
Author: Van Eeckhaut, A. & Michotte, Y., 2004Supervisor: Michotte, Y. (Promotor)
Student thesis: Doctoral Thesis
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Determination of the in vitro stability of Neuromedin U analogues in human plasma via HPLC-UV
Author: Contryn, J., Van Eeckhaut, A. & Caveliers, V., 15 Jun 2017Student thesis: Master's Thesis