Projects per year
Personal profile
Expertise
Neurochemical and neuropharmacological research is strongly dependent on the availability of sensitive analysis methods for neurotransmitters, neuromodulators and drugs in biological samples. The development of new, faster and sensitive analysis methods remains challenging for the bioanalyst due to the very low concentrations of these compounds in small sample volumes, in addition to the need for higher throughput.
The research group has ample experience in the development of miniaturized LC methods, coupled to fluorescence, electrochemical or tandem mass spectrometric (MS/MS) detection, for the quantification of neurotransmitters and neuromodulators in microdialysis samples. In addition, we have a large experience in the development and validation of analytical methods for the determination of drugs in drug products and biological samples with capillary electrophoresis, LC-UV, LC-fluorescence and LC-MS/MS.
The main research topics are:
- Nano LC tandem mass spectrometry for quantification of neuropeptides in microdialysis samples
- Metabolite profiling for the discovery and analysis of biomarkers of drug resistant epilepsy
- Miniaturized (enantioselective) LC methods for quantification of neuro- and gliotransmitters in biological samples
- Miniaturized LC methods for quantification of drug in biological samples
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ANI176: Chemogenetic interrogation of neuromedin U involvement in stress-induced psychopathology.
De Bundel, D., Smolders, I. & Van Eeckhaut, A.
1/01/17 → 31/12/19
Project: Fundamental
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FWOTM824: Chemogenetic modulation of astrocytes in temporal lobe epilepsy.
Smolders, I., De Bundel, D., Van Eeckhaut, A. & Van Den Herrewegen, Y.
1/10/16 → 30/09/20
Project: Fundamental
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OZR2983: Onderzoek naar de functie van neuromedine U in de stressrespons
Smolders, I., De Bundel, D. & Van Eeckhaut, A.
1/10/16 → 30/09/17
Project: Fundamental
Research output
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Accelerated HF-rTMS Modifies SERT Availability in the Subgenual Anterior Cingulate Cortex: A Canine [11C] DASB Study on the Serotonergic System
Xu, Y., Kappen, M., Peremans, K., De Bundel, D., Van Eeckhaut, A., Van Laeken, N., De Vos, F., Dobbeleir, A., Saunders, J. H. & Baeken, C., 10 Mar 2022, In : Journal of Clinical Medicine. 11, 6, 12 p., 1531.Research output: Contribution to journal › Article
Open AccessFile17 Downloads (Pure) -
Assessment of gliotransmitter concentrations upon chemogenetic modulation of astroglia in mouse hippocampus
Nestor, L., Sahu, S., De Bundel, D., Van Eeckhaut, A. & Smolders, I., 9 May 2022, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid
Custers, M-L., Nestor, L., De Bundel, D., Van Eeckhaut, A. & Smolders, I., 13 May 2022, In : Pharmaceutics. 14, 5, 20 p., 1051.Research output: Contribution to journal › Article
Open AccessFile9 Downloads (Pure) -
Fabrication of a molecularly imprinted monolithic column via the epitope approach for the selective capillary microextraction of neuropeptides in human plasma
LEI, X., Huang, T., Wu, X., Mangelings, D., Van Eeckhaut, A., Bongaerts, J., Terryn, H. & Vander Heyden, Y., 1 Jun 2022, In : Talanta. 243, 9 p., 123397.Research output: Contribution to journal › Article
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Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for Epileptogenesis
Aourz, N., Van Leuven, F., Allaoui, W., Van Eeckhaut, A., De Bundel, D. & Smolders, I., 16 Mar 2022, In : ACS Chemical Neuroscience. 13, 6, p. 796-805 10 p.Research output: Contribution to journal › Article
Prizes
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Project grant Wetenschappelijk Fonds Willy Gepts (WFWG)
Marie-Laure Custers (Recipient), Ann Van Eeckhaut (Recipient) & Ilse Smolders (Recipient), 1 Dec 2021
Prize: Prize (including medals and awards)
Activities
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PhD day C4N
Marie-Laure Custers (Speaker), Maria Bjerke (Contributor), Ann Van Eeckhaut (Contributor), Ilse Smolders (Contributor)16 Dec 2021Activity: Talk or presentation › Talk or presentation at a conference
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Scientific Research Section
Marie-Laure Custers (Speaker), Maria Bjerke (Contributor), Ann Van Eeckhaut (Contributor), Ilse Smolders (Contributor)24 Sep 2021Activity: Talk or presentation › Talk or presentation at a conference
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Separations (Journal)
Ann Van Eeckhaut (Editor)2021 → 2023Activity: Publication peer-review and editorial work › Editorial activity
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PhD day C4N
Marie-Laure Custers (Speaker), Yessica Wouters (Contributor), Tom Jaspers (Contributor), Bart De Strooper (Contributor), Maarten Dewilde (Contributor), Ann Van Eeckhaut (Contributor), Ilse Smolders (Contributor)3 Dec 2020Activity: Talk or presentation › Talk or presentation at a conference
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Targeted metabolomics of the brain – the quest for sensitivity, selectivity and throughput.
Ann Van Eeckhaut (Invited speaker), Jana Bongaerts (Contributor), Marie-Laure Custers (Contributor), Liam Nestor (Contributor), Anouk Pierre (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor)29 Jan 2020 → 31 Jan 2020Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Analysis of poliovirus with capillary electrophoresis
Author: Halewyck, H., Vander Heyden, Y., Thys, B., Rombaut, B., De Paepe, K., Steurbaut, S., Van Eeckhaut, A., Adams, E., Delaunay, N. & Maes, P., 18 May 2016Supervisor: Vander Heyden, Y. (Promotor), Rombaut, B. (Promotor), Thys, B. (Promotor), De Paepe, K. (Jury), Steurbaut, S. (Jury), Van Eeckhaut, A. (Jury), Adams, E. (External person) (Jury), Delaunay, N. (External person) (Jury) & Maes, P. (External person) (Jury)
Student thesis: Doctoral Thesis
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Analytical Challenges for the Determination of Alpha-Synuclein in the Context of Parkinson Disease.
Author: Napp, A., Fillet, M., Servais, A., Hubert, , Garraux, , Merville, , Lipka, & Van Eeckhaut, A., 15 Oct 2018Student thesis: Doctoral Thesis
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Analytical method transfer of capillary electrophoretic methods: development of guidelines to overcome interinstrumental differences.
Author: De Cock, B., Vander Heyden, Y., Mangelings, D., Massie, A., Van Eeckhaut, A., Puttemans, F., Van Schepdael, A. & Ramautar, R., 18 Apr 2018Supervisor: Vander Heyden, Y. (Promotor), Mangelings, D. (Promotor), Massie, A. (Jury), Van Eeckhaut, A. (Jury), Puttemans, F. (Jury), Van Schepdael, A. (External person) (Jury) & Ramautar, R. (External person) (Jury)
Student thesis: Doctoral Thesis
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Apport de différents outils chromatographiques couplés à la spectrométrie de masse pour la quantification de biomarqueurs peptidiques
Author: Mansion, F., Fillet, M. & Van Eeckhaut, A., 2012Supervisor: Van Eeckhaut, A. (Jury) & Fillet, M. (External person) (Promotor)
Student thesis: Doctoral Thesis
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Astrocytic endothelin-1 and cerebral hypoperfusion in multiple sclerosis
Author: Hostenbach, S., Kooijman, R., D'Haeseleer, M., De Keyser, J., De Bundel, D., Versijpt, J., Bissay, V., Van Eeckhaut, A., Hupperts, R. & Hellings, N., 16 Jul 2020Supervisor: Kooijman, R. (Promotor), D'Haeseleer, M. (Promotor), De Keyser, J. (Promotor), De Bundel, D. (Jury), Versijpt, J. (Jury), Van Eeckhaut, A. (Jury), Bissay, V. (Jury), Hupperts, R. (External person) (Jury) & Niels, H. (External person) (Jury)
Student thesis: Doctoral Thesis