Projects per year
Personal profile
Expertise
Neurochemical and neuropharmacological research is strongly dependent on the availability of sensitive analysis methods for neurotransmitters, neuromodulators and drugs in biological samples. The development of new, faster and sensitive analysis methods remains challenging for the bioanalyst due to the very low concentrations of these compounds in small sample volumes, in addition to the need for higher throughput.
The research group has ample experience in the development of miniaturized LC methods, coupled to fluorescence, electrochemical or tandem mass spectrometric (MS/MS) detection, for the quantification of neurotransmitters and neuromodulators in microdialysis samples. In addition, we have a large experience in the development and validation of analytical methods for the determination of drugs in drug products and biological samples with capillary electrophoresis, LC-UV, LC-fluorescence and LC-MS/MS.
The main research topics are:
- Nano LC tandem mass spectrometry for quantification of neuropeptides in microdialysis samples
- Metabolite profiling for the discovery and analysis of biomarkers of drug resistant epilepsy
- Miniaturized (enantioselective) LC methods for quantification of neuro- and gliotransmitters in biological samples
- Miniaturized LC methods for quantification of drug in biological samples
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Projects
- 13 Finished
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ANI176: Chemogenetic interrogation of neuromedin U involvement in stress-induced psychopathology.
De Bundel, D., Smolders, I. & Van Eeckhaut, A.
1/01/17 → 31/12/19
Project: Fundamental
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FWOTM824: Chemogenetic modulation of astrocytes in temporal lobe epilepsy.
Smolders, I., De Bundel, D., Van Eeckhaut, A. & Van Den Herrewegen, Y.
1/10/16 → 30/09/20
Project: Fundamental
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OZR2983: Onderzoek naar de functie van neuromedine U in de stressrespons
Smolders, I., De Bundel, D. & Van Eeckhaut, A.
1/10/16 → 30/09/17
Project: Fundamental
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HERC36: advanced Metabolomics Platform consisting of two complementary LC-MS/MS analyzers
Martens, G., Van Eeckhaut, A., Smolders, I., De Bundel, D., De Kock, J., Rogiers, V., Marcelino Rodrigues, R., Menu, E., Vander Heyden, Y., van Grunsven, L., Mortier, A., Vanhaecke, T. & Mangelings, D.
1/05/16 → 30/04/20
Project: Applied
Research output
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Applicability of cerebral open flow microperfusion and microdialysis to quantify a brain-penetrating nanobody in mice
Custers, M-L., Wouters, Y., Jaspers, T., Bundel, D. D., Dewilde, M., Eeckhaut, A. V. & Smolders, I., Sep 2021, In : Analytica Chimica Acta. 1178, 338803.Research output: Contribution to journal › Article
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Feasibility study on exhaled-breath analysis by untargeted Selected-Ion Flow-Tube Mass Spectrometry in children with cystic fibrosis, asthma, and healthy controls: comparison of data pretreatment and classification techniques.
Segers, K., Slosse, A., Viaene, J., Bannier, M. A. G. E., Van de Kant, K. D. G., Dompeling, E., Van Eeckhaut, A., Vercammen, J. & Vander Heyden, Y., 1 Apr 2021, In : Talanta. 225, 122080.Research output: Contribution to journal › Article
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Mass spectrometry based metabolomics of volume-restricted in-vivo brain samples: Actual status and the way forward
van Mever, M., Segers, K., Mangelings, D., Hankemeier, T., Vander Heyden, Y., Van Eeckhaut, A. & Ramautar, R., 10 Jun 2021, In : TrAC. Trends in Analytical Chemistry. 143, 116365.Research output: Contribution to journal › Article
Open Access -
"+ Flash presentation" A comparative study of Unispray and Electrospray for the ionization of neuropeptides in LC-MS/MS.
Bongaerts, J., Van Wanseele, Y., Van Oudenhove, L., Segers, K., Van Hulle, M., De Bundel, D., Smolders, I., Mangelings, D., Vander Heyden, Y. & Van Eeckhaut, A., 2020.Research output: Unpublished contribution to conference › Poster
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"+ Flash Presentation" Optimization of an untargeted LC-MS method for metabolite profiling of restricted-volume plasma samples.
Segers, K., Frederickx, K. Y., Grech, J., Bongaerts, J., Mangelings, D., Vander Heyden, Y. & Van Eeckhaut, A., 2020.Research output: Unpublished contribution to conference › Poster
Activities
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Separations (Journal)
Ann Van Eeckhaut (Editor)2021 → 2023Activity: Publication peer-review and editorial work › Editorial activity
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Targeted metabolomics of the brain – the quest for sensitivity, selectivity and throughput.
Ann Van Eeckhaut (Invited speaker), Jana Bongaerts (Contributor), Marie-Laure Custers (Contributor), Liam Nestor (Contributor), Anouk Pierre (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor)29 Jan 2020 → 31 Jan 2020Activity: Talk or presentation › Talk or presentation at a conference
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CHEMOGENETIC MODULATION OF ASTROCYTES IN A MODEL FOR TEMPORAL LOBE EPILEPSY
Yana Van Den Herrewegen (Presenter), An Buckinx (Contributor), Ann Van Eeckhaut (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor)20 May 2019Activity: Talk or presentation › Talk or presentation at a conference
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The synthetic ghrelin receptor agonist MK0677 increases mesolimbic/mesocortical dopamine release following local administration in the ventral tegmental area without affecting anxiety or cued fear extinction
Anouk Pierre (Speaker), Andries Van Schuerbeek (Speaker), Wissal Allaoui (Speaker), Eva-Maria Fritz (Contributor), Nicolas Singewald (Contributor), tom beckers (Contributor), Ann Van Eeckhaut (Speaker), Ilse Smolders (Speaker), Dimitri De Bundel (Speaker)21 May 2019Activity: Talk or presentation › Talk or presentation at a conference
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CE-MS-based profiling of cationic plasma metabolomics from a mouse model for acute epileptic seizures.
Karen Segers (Speaker), W. Zhang (Contributor), Debby Mangelings (Contributor), T. Hankemeier (Contributor), Dimitri De Bundel (Contributor), Yvan Vander Heyden (Contributor), Ilse Smolders (Contributor), Rawi Ramautar (Contributor), Ann Van Eeckhaut (Contributor)20 May 2019Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Analysis of poliovirus with capillary electrophoresis
Author: Halewyck, H., Vander Heyden, Y., Thys, B., Rombaut, B., De Paepe, K., Steurbaut, S., Van Eeckhaut, A., Adams, E., Delaunay, N. & Maes, P., 18 May 2016Supervisor: Vander Heyden, Y. (Promotor), Rombaut, B. (Promotor), Thys, B. (Promotor), De Paepe, K. (Jury), Steurbaut, S. (Jury), Van Eeckhaut, A. (Jury), Adams, E. (External person) (Jury), Delaunay, N. (External person) (Jury) & Maes, P. (External person) (Jury)
Student thesis: Doctoral Thesis
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Analytical Challenges for the Determination of Alpha-Synuclein in the Context of Parkinson Disease.
Author: Napp, A., Fillet, M., Servais, A., Hubert, , Garraux, , Merville, , Lipka, & Van Eeckhaut, A., 15 Oct 2018Student thesis: Doctoral Thesis
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Analytical method transfer of capillary electrophoretic methods: development of guidelines to overcome interinstrumental differences.
Author: De Cock, B., Vander Heyden, Y., Mangelings, D., Massie, A., Van Eeckhaut, A., Puttemans, F., Van Schepdael, A. & Ramautar, R., 18 Apr 2018Supervisor: Vander Heyden, Y. (Promotor), Mangelings, D. (Promotor), Massie, A. (Jury), Van Eeckhaut, A. (Jury), Puttemans, F. (Jury), Van Schepdael, A. (External person) (Jury) & Ramautar, R. (External person) (Jury)
Student thesis: Doctoral Thesis
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Apport de différents outils chromatographiques couplés à la spectrométrie de masse pour la quantification de biomarqueurs peptidiques
Author: Mansion, F., Fillet, M. & Van Eeckhaut, A., 2012Supervisor: Van Eeckhaut, A. (Jury) & Fillet, M. (External person) (Promotor)
Student thesis: Doctoral Thesis
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Astrocytic endothelin-1 and cerebral hypoperfusion in multiple sclerosis
Author: Hostenbach, S., Kooijman, R., D'Haeseleer, M., De Keyser, J., De Bundel, D., Versijpt, J., Bissay, V., Van Eeckhaut, A., Hupperts, R. & Hellings, N., 16 Jul 2020Supervisor: Kooijman, R. (Promotor), D'Haeseleer, M. (Promotor), De Keyser, J. (Promotor), De Bundel, D. (Jury), Versijpt, J. (Jury), Van Eeckhaut, A. (Jury), Bissay, V. (Jury), Hupperts, R. (External person) (Jury) & Niels, H. (External person) (Jury)
Student thesis: Doctoral Thesis