Projects per year
Personal profile
Expertise
Neurochemical and neuropharmacological research is strongly dependent on the availability of sensitive analysis methods for neurotransmitters, neuromodulators and drugs in biological samples. The development of new, faster and sensitive analysis methods remains challenging for the bioanalyst due to the very low concentrations of these compounds in small sample volumes, in addition to the need for higher throughput.
The research group has ample experience in the development of miniaturized LC methods, coupled to fluorescence, electrochemical or tandem mass spectrometric (MS/MS) detection, for the quantification of neurotransmitters and neuromodulators in microdialysis samples. In addition, we have a large experience in the development and validation of analytical methods for the determination of drugs in drug products and biological samples with capillary electrophoresis, LC-UV, LC-fluorescence and LC-MS/MS.
The main research topics are:
- Nano LC tandem mass spectrometry for quantification of neuropeptides in microdialysis samples
- Metabolite profiling for the discovery and analysis of biomarkers of drug resistant epilepsy
- Miniaturized (enantioselective) LC methods for quantification of neuro- and gliotransmitters in biological samples
- Miniaturized LC methods for quantification of drug in biological samples
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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HERC74: Ultrahigh Pressure Liquid Chromatograph - Triple Quadrupole Mass Spectrometer for targeted analysis in complex matrices
Van Eeckhaut, A. (Administrative Promotor), Vander Heyden, Y. (CoI (Co-Promotor)), Mangelings, D. (CoI (Co-Promotor)), Tommelein, E. (CoI (Co-Promotor)) & De Waele, E. (CoI (Co-Promotor))
1/05/26 → 30/04/30
Project: Fundamental
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OZR4464: Ultrahigh Pressure Liquid Chromatograph - Triple Quadrupole Mass Spectrometer for targeted analysis in complex matrices
Van Eeckhaut, A. (Administrative Promotor), Mangelings, D. (CoI (Co-Promotor)), Tommelein, E. (CoI (Co-Promotor)), De Waele, E. (CoI (Co-Promotor)) & Vander Heyden, Y. (CoI (Co-Promotor))
1/05/26 → 30/04/30
Project: Fundamental
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FWOSB173: Understanding experienced person-centred maternity care and the pharmacology of ADHD medication during pregnancy and lactation.
De Hondt, L. (Mandate), Tommelein, E. (Administrative Promotor), Crunelle, C. (CoI (Co-Promotor)), Van Eeckhaut, A. (CoI (Co-Promotor)) & De Bundel, D. (CoI (Co-Promotor))
1/11/24 → 31/10/28
Project: Fundamental
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FWOAL1076: Achiral and chiral targeted brain metabolomics in volume-limited samples: quest for broad coverage, sensitivity and throughput using chemical derivatization and miniaturized liquid chromatography tandem mass spectrometry.
Van Eeckhaut, A. (Administrative Promotor) & Vander Heyden, Y. (Co-Promotor)
1/01/23 → 31/12/26
Project: Fundamental
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SRP85: SRP-Onderzoekszwaartepunt: Translating the biology of cognitive function to improve diagnosis and treatment of brain disorders
Smolders, I. (Administrative Promotor), De Bundel, D. (Co-Promotor), Van Eeckhaut, A. (Co-Promotor), Engelborghs, S. (Co-Promotor), Massie, A. (Co-Promotor), Nagels, G. (Co-Promotor) & Van Schependom, J. (Co-Promotor)
1/10/22 → 30/09/29
Project: Fundamental
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Chemogenetic astrocyte modulation reduces spontaneous hippocampal discharges and metabolite changes in an epilepsy mouse model
Nestor, L., Van Den Herrewegen, Y., Dyer, M., Bossuyt, J., Hendrix, E., Buckinx, A., Bournons, S., Viaene, J., Vander Heyden, Y., Van de Casteele, M., Van Eeckhaut, A., Smolders, I. & De Bundel, D., Feb 2026, In: Epilepsia. 67, 2, p. 934-949 16 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Comparison of two chiral derivatization reagents for the enantioselective analysis of amino acids through UHPLC-MS/MS
Lella, C., Hennecke, U. (Contributor), Vander Heyden, Y. (Contributor) & Van Eeckhaut, A. (Contributor), 21 May 2026.Research output: Unpublished contribution to conference › Poster
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Comparison of two chiral derivatization reagents for the enantioselective analysis of amino acids through UHPLC-MS/MS
Lella, C., Hennecke, U. (Contributor), Vander Heyden, Y. (Contributor) & Van Eeckhaut, A. (Contributor), Jul 2026.Research output: Unpublished contribution to conference › Poster
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Development of Novel Highly Sensitive Immunoassays Targetting the Microtubule Binding Region of Tau in Cerebrospinal Fluid
Cloet, J., Van Eeckhaut, A. & Bjerke, M., 12 Jul 2026.Research output: Unpublished contribution to conference › Poster
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Effects of different Extraction Methods and Arginine Modification on the Physicochemical Properties and Biological Activities of Fungal and Slime Mold Melanins
Lai, T. N. B., Nguyen Ngoc, A. T., Dang Nguyen, A. V., Tran, Y. T. H., Doan, L. H., Mangelings, D., Vander Heyden, Y., Van Eeckhaut, A. & Tran, H. T. M., Dec 2026, In: Applied Food Research. 6, 2, 13 p., 102275.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Neuroprotective data
Nguyen, D. T. (Data Curator), Nguyen Vo, L. P. (Data Curator), Mangelings, D. (Project Member), Van Eeckhaut, A. (Project Leader), Vander Heyden, Y. (Project Leader) & Tran, H. (Project Leader), Zenodo, 17 Apr 2025
Dataset
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Antioxidant, neuroprotective, and neuroblastoma cells (SH-SY5Y) differentiation effects of melanins and arginine-modified melanins from Daedaleopsis tricolor and Fomes fomentarius.
Nguyen, H. A. T. (Creator), Phu Ho, T. (Creator), Mangelings, D. (Creator), Van Eeckhaut, A. (Creator), Vander Heyden, Y. (Creator) & Tran, H. (Creator), Zenodo, 2024
Dataset
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Metabolomics data - "Chemogenetic astrocyte modulation reduces spontaneous hippocampal discharges and metabolite changes in an epilepsy mouse model"
Nestor, L. (Creator), Van Den Herrewegen, Y. (Creator), Dyer, M. (Creator), Bossuyt, J. (Creator), Hendrix, E. (Creator), Buckinx, A. (Creator), Bournons, S. (Creator), Viaene, J. (Creator), Vander Heyden, Y. (Creator), Van De Casteele, M. (Creator), Van Eeckhaut, A. (Creator), Smolders, I. (Creator) & De Bundel, D. (Creator), Zenodo, 2025
Dataset
Prizes
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Project grant Wetenschappelijk Fonds Willy Gepts (WFWG)
Custers, M.-L. (Recipient), Van Eeckhaut, A. (Recipient) & Smolders, I. (Recipient), 1 Dec 2021
Prize: Prize (including medals and awards)
Activities
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A polyamide-based 3D-printed sorbent in a validated sample pretreatment for the analysis of amino acids in mice plasma
Verding, P. (Speaker), Kroll, D. M. (Contributor), Belka, M. (Contributor), Baczek, T. (Contributor), Vander Heyden, Y. (Contributor), Van Eeckhaut, A. (Contributor) & Mangelings, D. (Contributor)
6 Jul 2026 → 9 Jul 2026Activity: Talk or presentation › Talk or presentation at a conference
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Porous polyamide 3D-printed devices for extraction of hydrophilic compounds
Kroll, D. M. (Speaker), Verding, P. (Contributor), Mangelings, D. (Contributor), Vander Heyden, Y. (Contributor), Van Eeckhaut, A. (Contributor), Baron, G. (Contributor) & Baczek, T. (Contributor)
15 Jun 2025 → 19 Jun 2025Activity: Talk or presentation › Talk or presentation at a conference
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Optimization of a liquid chromatography tandem mass spectrometry method for the enantioselective analysis of amino acids using a chiral derivatization reagent
Lella, C. (Speaker), Nestor, L. (Contributor), Hennecke, U. (Contributor), Vander Heyden, Y. (Contributor) & Van Eeckhaut, A. (Contributor)
12 Sept 2025Activity: Talk or presentation › Talk or presentation at a conference
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Development of an untargeted brain metabolomics method using supercritical fluid chromatography-mass spectrometry
Bilal, S. (Speaker), Van Eeckhaut, A. (Contributor), Vander Heyden, Y. (Contributor) & Mangelings, D. (Contributor)
12 Sept 2025Activity: Talk or presentation › Talk or presentation at a conference
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Novel 3D-printed sorbents compared to an optimized protein precipitation protocol for the extraction of neurologically relevant amino acids from mice plasma
Verding, P. (Speaker), Kroll, D. M. (Contributor), Belka, M. (Contributor), Baczek, T. (Contributor), Vander Heyden, Y. (Contributor), Van Eeckhaut, A. (Contributor) & Mangelings, D. (Contributor)
31 Mar 2025 → 1 Apr 2025Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Analytical Challenges for the Determination of Alpha-Synuclein in the Context of Parkinson Disease.
Napp, A. ((PhD) Student), Fillet, M. (Promotor), Servais, A.-C. (Promotor), Hubert (Jury), Garraux (Jury), Merville (Jury), Lipka (Jury) & Van Eeckhaut, A. (Jury), 15 Oct 2018Student thesis: Doctoral Thesis
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Applicability of cerebral open flow microperfusion and microdialysis to quantify a brain-penetrating nanobody mice
Brock, A. R. ((PhD) Student), Smolders, I. (Promotor) & Van Eeckhaut, A. (Promotor), Custers, M.-L. (Advisor), 1 Jul 2021Student thesis: Master's Thesis
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A quest to increase sensitivity for the LC-MC/MS analysis of peptides from the neuromedin family
Del'Haye, G. ((PhD) Student), Van Eeckhaut, A. (Promotor), Vander Heyden, Y. (Promotor) & Mangelings, D. (Promotor), Bongaerts, J. (Co-promotor), 2021Student thesis: Master's Thesis
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Bepaling van de plasmastabiliteit van een synthetisch peptide en preliminair onderzoek naar het minimaliseren van peptide-adsorptie tijdens microdialyse
Van den Borre, L. ((PhD) Student), Van Eeckhaut, A. (Promotor), Caveliers, V. (Jury) & Doktorova, T. (Jury), 10 Jun 2015Student thesis: Master's Thesis
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Bioanalysis and model based treatment optimization for preclinical and clinical studies of peritoneal carcinomatosis from ovarian cancer.
Xie, F. ((PhD) Student), Van Bocxlaer, J. (Promotor), Vermeulen, A. (Promotor), Colin, P. (Promotor), Boussery, K. (Jury), Remaut, K. (Jury), Vervaet, C. (Jury), Ceelen, MD, W. (Jury), Van Eeckhaut, A. (Jury) & Jose Perez Ruixo, J. (Jury), 28 Aug 2019Student thesis: Doctoral Thesis