Projects per year
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Collaborations and top research areas from the last five years
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FWOTM1142: Deciphering the involvement of iron metabolism in beta cell differentiation, maturation, and function.
Staels, W. (Administrative Promotor), De Leu, N. (Co-Promotor), Heimberg, H. (Co-Promotor) & Van Mulders, A. (Mandate)
1/11/22 → 31/10/26
Project: Fundamental
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OZR3838: Backup mandate Research Council: Uncovering the role of iron metabolism in beta cell differentiation, maturation, and function.
Staels, W. (Administrative Promotor) & Van Mulders, A. (Mandate)
1/11/21 → 31/10/22
Project: Fundamental
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GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection
Degroote, L., Chrzanowski, J. (Contributor), Lemaitre, P. (Contributor), Wouters, A. (Contributor), Bourgeois, S. (Contributor), Van Mulders, A. (Contributor), Pierreux, J. (Contributor), Coenen, S. (Contributor), Willems, L. (Contributor), Leuckx, G. (Contributor), Viaene, M. (Contributor), Packbier, M. (Contributor), Douros, J. D. (Contributor), Yang, B. (Contributor), Heremans, Y. (Contributor), Mathieu, C. (Contributor), Staels, W. (Contributor), Gysemans, C. (Contributor) & De Leu, N. (Contributor), 18 Jun 2026, (Unpublished). 1 p.Research output: Unpublished contribution to conference › Unpublished abstract
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GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection
Degroote, L., Chrzanowski, J., Lemaitre, P., Wouters, A., Bourgeois, S., Mulders, A. V., Pierreux, J., Coenen, S., Willems, L., Leuckx, G., Viaene, M., Packbier, M., Douros, J. D., Yang, B., Heremans, Y., Mathieu, C., Staels, W., Gysemans, C. & Leu, N. D., 18 May 2026, In: Diabetologia. 69, 8, p. 2307-2322 16 p.Research output: Contribution to journal › Article › peer-review
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GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection
Degroote, L., Chrzanowski, J. (Contributor), Lemaitre, P. (Contributor), Wouters, A. (Contributor), Bourgeois, S. (Contributor), Van Mulders, A. (Contributor), Pierreux, J. (Contributor), Coenen, S. (Contributor), Willems, L. (Contributor), Leuckx, G. (Contributor), Viaene, M. (Contributor), Packbier, M. (Contributor), Douros, J. D. (Contributor), Yang, B. (Contributor), Heremans, Y. (Contributor), Mathieu, C. (Contributor), Staels, W. (Contributor), Gysemans, C. (Contributor) & De Leu, N. (Contributor), 17 Jun 2026, (Unpublished). 1 p.Research output: Unpublished contribution to conference › Poster
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Iron deficiency induces maturation-dependent loss of pancreatic β-cells
Van Mulders, A., Willems, L., Coenen, S., Bourgeois, S., Yi, X., Tong, Y., Leuckx, G., Heremans, Y., Pierreux, J., Degroote, L., Sawatani, T., Vinci, C., Ates, G., Massie, A., Carlotti, F., de Koning, E., Mandrup-Poulsen, T., Zelinsky, C., Goderis, S. & Ghesquière, B. & 4 others, , 16 Feb 2026, In: NATURE COMMUNICATIONS. 17, 1, 21 p., 2826.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
NEUROG3 regulates δ-cell function and its expression in adult reflects δ-cell enrichment rather than progenitor reactivation
Coenen, S., Kellens, Y., Heremans, Y., Van Mulders, A., Pierreux, J., Degroote, L., Willems, L., Bourgeois, S., De Leu, N. & Staels, W., 17 Jun 2026, (Unpublished).Research output: Unpublished contribution to conference › Poster
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European Islet Study Group 2026
Degroote, L. (Participant), Willems, L. (Participant), Coenen, S. (Participant), Van Mulders, A. (Participant), Bourgeois, S. (Participant), Pierreux, J. (Participant) & Staels, W. (Participant)
17 Jun 2026 → 19 Jun 2026Activity: Participating in or organising an event › Participation in conference
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GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection
Degroote, L. (Speaker), Chrzanowski, J. (Contributor), Lemaitre, P. (Contributor), Wouters, A. (Contributor), Bourgeois, S. (Contributor), Van Mulders, A. (Contributor), Pierreux, J. (Contributor), Coenen, S. (Contributor), Willems, L. (Contributor), Leuckx, G. (Contributor), Viaene, M. (Contributor), Packbier, M. (Contributor), Douros, J. D. (Contributor), Yang, B. (Contributor), Heremans, Y. (Contributor), Mathieu, C. (Contributor), Staels, W. (Contributor), Gysemans, C. (Contributor) & De Leu, N. (Contributor)
18 Jun 2026Activity: Talk or presentation › Talk or presentation at a conference
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Inter University Initiative Young Researchers In Metabolism
Degroote, L. (Participant), Coenen, S. (Participant), Willems, L. (Participant) & Van Mulders, A. (Participant)
22 Oct 2025Activity: Participating in or organising an event › Participation in conference
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Targeting system xc- to simultaneously tackle the metabolic and neurological comorbidities of diet-induced obesity
Walckiers, J. (Speaker), Dalmas, E. (Contributor), Vanonckelen, O. (Contributor), Mackens, L. (Contributor), Van Mulders, A. (Contributor), Dreessen, T. (Contributor), Staels, W. (Contributor), De Leu, N. (Contributor), Ates, G. (Contributor) & Massie, A. (Contributor)
20 Oct 2025Activity: Talk or presentation › Talk or presentation at a conference
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Combination therapy of low-dose anti-CD3 with GLP1-E2 delays and reduces type 1 diabetes in non-obese diabetic mice
Degroote, L. (Speaker), Bourgeois, S. (Contributor), Van Mulders, A. (Contributor), Pierreux, J. (Contributor), Willems, L. (Contributor), Coenen, S. (Contributor), Heremans, Y. (Contributor), Staels, W. (Contributor) & De Leu, N. (Contributor)
22 Oct 2025Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Modulating islet vascularization to promote beta cell regeneration
Van Mulders, A. ((PhD) Student) & De Leu, N. (Promotor), De Leu, N. (Promotor), 2021Student thesis: Master's Thesis
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Surface coating of alginate encapsulated human islets with RGD-motifs prevents clustering of the capsules, reduces fibrotic overgrowth and improves implantation of human islets in a pilot study in type 1 diabetic patients
Van Mulders, A. ((PhD) Student), Hellemans, K. (Promotor), 2019Student thesis: Master's Thesis