Research output per year
Research output per year
Personal profile
Expertise
The preservation and transplantation of spermatogonial stem cells (SSCs) is a potential strategy to circumvent sterility: frozen-thawed SSCs can be transplanted back into the cured patient to restore spermatogenesis. For almost 20 years, the research group BITE performed pioneering work to develop this strategy towards a clinical application. For patients at high risk of losing their SSCs, the cryopreservation of SSCs is a valuable clinical tool to preserve their fertility. The research group BITE developed optimal protocols to cryopreserve either testicular cell suspensions or testicular tissue containing SSCs. These protocols are now being used in clinical fertility preservation programs. The UZ Brussel started in 2002 to store testicular tissue of young boys who are at high risk of losing their spermatogonia. In order to harvest their testicular tissue, these young boys need to undergo a testicular tissue biopsy. Although the biopsy procedure itself does not have a high complication rate, little is known about its effects on the long-term. BITE studies the effect of a testicular biopsy on the later pubertal development and fertility.
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Collaborations and top research areas from the last five years
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Research output
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A 20-year overview of fertility preservation in boys: new insights gained through a comprehensive international survey
Duffin, K., Neuhaus, N., Andersen, C. Y., Barraud-Lange, V., Braye, A., Eguizabal, C., Feraille, A., Ginsberg, J. P., Gook, D., Goossens, E., Jahnukainen, K., Jayasinghe, Y., Keros, V., Kliesch, S., Lane, S., Mulder, C., Orwig, K. E., Ans, M. M. V. P., Poirot, C., Rimmer, M. & 8 others, , 16 Feb 2024, In: Human reproduction open. 2024, 2, 11 p., hoae010.Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (Scopus) -
Testis development and fertility potential in Klinefelter syndrome
Braye, A. & Goossens, E., 1 Apr 2024, In: Médecine de la Reproduction. 26, 2, p. 182-192 11 p.Research output: Contribution to journal › Article › peer-review
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Gonadal development and function after immature testicular tissue banking as part of high-risk gonadotoxic treatment
Braye, A., Delgouffe, E., van der Werff Ten Bosch, J., Gies, I., Ferster, A. & Goossens, E., Aug 2023, In: Pediatric Blood & Cancer. 70, 8, 11 p., e30370.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)10 Downloads (Pure) -
Immature testicular tissue banking for fertility preservation in (pre) pubertal boys: patient enrolment and follow-up
Braye, A., 2023, Brussel: Crazy Copy Center Productions. 141 p.Research output: Thesis › PhD Thesis
Open AccessFile273 Downloads (Pure) -
Spermatogenesis after gonadotoxic childhood treatment: follow-up of 12 patients
Delgouffe, E., Braye, A., Vloeberghs, V., Mateizel, I., Ernst, C., Ferster, A., Devalck, C., Tournaye, H., Gies, I. & Goossens, E., 2023, In: Human reproduction open. 2023, 3, 8 p., hoad029.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)37 Downloads (Pure)
Datasets
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20-year overview of fertility preservation in boys
Goossens, E. (Creator), Duffin, K. (Data Manager), Neuhaus, N. (Data Manager), Andersen, C. (Data Collector), Barraud-Lange, V. (Data Collector), Braye, A. (Data Collector), Eguizabal, C. (Data Collector), Feraille, A. (Data Collector), Ginsberg, J. (Creator), Gook, D. (Data Collector), Jahnukainen, K. (Data Collector), Jaysinghe, Y. (Data Collector), Keros, V. (Data Collector), Kliesch, S. (Data Collector), Lane, S. (Data Collector), Mulder, C. (Data Collector), Orwig, K. E. (Data Collector), Van Pelt, A. (Data Collector), Poirot, C. (Data Collector), Rimmer, M. (Data Collector), Rives, N. (Data Collector), Sadri-Ardekani, H. (Data Collector), Safrai, M. (Data Collector), Schlatt, S. (Data Collector), Stukenborg, J. (Data Collector), Van De Wetering, M. (Data Collector), Wyns, C. (Data Collector) & Mitchell, R. (Project Manager), Zenodo, 13 Dec 2024
DOI: https://doi.org/10.5281/zenodo.14437763
Dataset
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Patient follow-up (<18 years)
Goossens, E. (Creator), Braye, A. (Creator) & Delgouffe, E. (Creator), VUB Institutional Data Repository, 2024
Dataset
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Patient follow-up (≥18 years)
Goossens, E. (Creator), Braye, A. (Creator) & Delgouffe, E. (Creator), VUB Institutional Data Repository, 2024
Dataset
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Testicular Tissue Banking for Fertility Preservation in Young Boys: Which Patients Should Be Included?
Delgouffe, E. (Creator), Goossens, E. (Creator) & Braye, A. (Related person), Zenodo, 10 Dec 2024
DOI: 10.3389/fendo.2022.854186, https://zenodo.org/records/14361127
Dataset
Prizes
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2018 International Society of Andrology Travel Award
Braye, Aude (Recipient), 2018
Prize: Prize (including medals and awards)
Activities
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Research Group Reproduction, Genetics and Development (GRAD) - Cluster Monthly meetings
Hamide Yildirim (Organiser), Wafaa Essahib (Organiser), Aude Braye (Organiser) & Laure Degroote (Organiser)
2023 → …Activity: Participating in or organising an event › Participating in or organizing a school event
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Reproduction, Genetics and Regenerative medicine (RGRG)-Cluster Monthly meetings
Hamide Yildirim (Organiser), Wafaa Essahib (Organiser), Nazli Akin (Organiser) & Aude Braye (Organiser)
2022 → …Activity: Participating in or organising an event › Participating in or organizing a school event
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LSM PhD day 2021
Aude Braye (Participant)
30 Mar 2021Activity: Participating in or organising an event › Participation in workshop, seminar
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ESHRE Webinar Series: Fertility preservation in breast cancer patients
Aude Braye (Participant)
25 Feb 2021 → 25 Mar 2021Activity: Participating in or organising an event › Participation in workshop, seminar
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Fertility Preservation in Boys: Recent Developments and New Insights
Aude Braye (Speaker)
30 Mar 2021Activity: Talk or presentation › Talk or presentation at a workshop/seminar
Thesis
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Long-term culture of human testicular cells: characterization before optimization
Author: Braye, A., Baert, Y. & Goossens, E., 2014Supervisor: Baert, Y. (Advisor) & Goossens, E. (Promotor)
Student thesis: Master's Thesis