Projects per year
Personal profile
Expertise
Bart Neyns obtained his MD (1992) and PhD (2001) from the Vrije Universiteit Brussel (VUB), Brussels. Dr Neyns held a Research Fellowship supported by the National Fund for Scientific Research (NFWO), at the Laboratory of Medical Oncology, VUB (1992–1996). In 1996, he began furthering his training in Internal Medicine and Medical Oncology, at the same institute, obtaining his Specialist Degree in 1999. Dr Neyns subsequently became a Resident at the Department of Internal Medicine/Medical Oncology, VUB (1999–2002). In 2009, Dr Neyns specialized in Medical Oncology. During 2002–2012 and 2012-2019, he was appointed respectively as Head of Clinic and Head of Division at the Department of Medical Oncology, UZ Brussel, before being appointed to his current position as Head of Department at the same department, in May 2019. He currently holds an additional parallel position as Clinical Professor at the Faculty of Medicine and Pharmacy, VUB (since 2007); between 2010 and 2018 he served as a Dermato-Oncology Consultant at the Erasme Hospital Université Libre de Bruxelles (ULB), Brussels. Dr Neyns is the member of seven national and international scientific societies including, the Belgian Medical Society of Medical Oncology ESMO, and ASCO. He has been the recipient of several competitive research grants, and has considerable clinical trial experience as a Principal Investigator for more than fifteen academia sponsored clinical trials for patients with advanced melanoma, glioma and colorectal cancer; including clinical trials with a proprietary autologous dendritic cell therapy (TriMixDC) and first-in-human phase I clinical trials with intratumoral injection of autologous myeloid dendritic cells. Dr Neyns has an extensive publication record as the (co-)author of over hundred forty primary manuscripts published in peer review medical journals (incl. N Engl J Med, Lancet Oncol, and the J Clin Oncol), and has been invited speaker at several international congresses. His current research interests broadly include the immune- and targeted therapy of melanoma and the treatment of patients with malignant glioma with a strong emphasis on conducting academia sponsored trials.
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Collaborations and top research areas from the last five years
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ANI389: Development of a B7-H3 nanoCAR-T cell therapy for recurrent glioblastoma (GlioCAR)
Neyns, B., Geeraerts, X., Tuyaerts, S., Breckpot, K., Duerinck, J. & Smolders, I.
1/10/24 → 30/09/28
Project: Fundamental
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ANI352: MOTUNE-T therapy: Metabolically Optimized TUNEd T cells as treatment for recurrent glioblastoma
1/10/23 → 30/09/27
Project: Fundamental
Research output
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1667P Psychological issues and neurocognitive functioning in long-term advanced cancer survivors treated with immune checkpoint blockade
Vanlaer, N., Dirven, I., Vounckx, M., Kessels, J., Neyns, B. & Rogiers, A., Sep 2024, In: Annals of Oncology. 35, 1 p., S1004.Research output: Contribution to journal › Meeting abstract (Journal)
Open Access -
1667P Psychological issues and neurocognitive functioning in long-term advanced cancer survivors treated with immune checkpoint blockade
Vanlaer, N., Dirven, I., Vounckx, M., Kessels, J., Neyns, B. & Rogiers, A., 15 Sep 2024.Research output: Unpublished contribution to conference › Poster
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Activation of PD-1K78A CAR transduced T-cells via clinical grade anti-PD-1 monoclonal antibodies
Schaukens, J., De Vlaeminck, Y., Geeraerts, X., Stevens, L., Breckpot, K., Neyns, B. & Tuyaerts, S., 15 May 2024.Research output: Unpublished contribution to conference › Poster
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An interpretable deep learning approach for lesion detection and segmentation on whole-body [18F]FDG PET/CT
Dirks, I., Keyaerts, M., Neyns, B. & Vandemeulebroucke, J., 2 Apr 2024, Proc. SPIE 12926, Medical Imaging 2024: Image Processing. SPIE, Vol. 12926. 10 p. 1292617. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 12926).Research output: Chapter in Book/Report/Conference proceeding › Conference paper
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A randomized phase II clinical trial of stereotactic body radiation therapy (SBRT) and systemic pembrolizumab with or without intratumoral avelumab/ipilimumab plus CD1c (BDCA-1)+/CD141 (BDCA-3)+ myeloid dendritic cells in solid tumors
Vounckx, M., Tijtgat, J., Stevens, L., Dirven, I., Ilsen, B., Vandenbroucke, F., Raeymaeckers, S., Vekens, K., Forsyth, R., Geeraerts, X., Van Riet, I., Schwarze, J. K., Tuyaerts, S., Decoster, L., De Ridder, M., Dufait, I. & Neyns, B., 2 Jul 2024, In: Cancer Immunol Immunother. 73, 9, 8 p., 167.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Prizes
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Best Poster Award
Awada, Gil (Recipient), Özdemir, Ibrahim (Recipient), Schwarze, Julia Katharina (Recipient), Daeninck, Emma (Recipient), Gondry, Odrade (Recipient), Jansen, Y. (Recipient), Seremet, T. (Recipient), Keyaerts, Marleen (Recipient), Everaert, Hendrik (Recipient) & Neyns, Bart (Recipient), 15 Dec 2018
Prize: Prize (including medals and awards)
Activities
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A phase I clinical trial on intracranial administration of autologous myeloid dendritic cells (myDC) in combination with ipilimumab and nivolumab in patients with recurrent glioblastoma (rGB).
Wietse Geens (Speaker), Julia Katharina Schwarze (Contributor), Cleo Bertels (Contributor), Jens Tijtgat (Contributor), Gil Awada (Contributor), F Vaeyens (Contributor), Louise Cras (Contributor), Anne Vanbinst (Contributor), Hendrik Everaert (Contributor), Alex Michotte (Contributor), Toon Janssen (Contributor), Ben Caljon (Contributor), Thomas Cauwenbergh (Contributor), Michaël Bruneau (Contributor), Ramses Forsyth (Contributor) & Bart Neyns (Contributor)
26 Mar 2022Activity: Talk or presentation › Talk or presentation at a conference
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Prognostic value of 0-(2-[18F]-fluoroethyl)-L-tyrosine PET in patients with recurrent glioblastoma.
Wietse Geens (Speaker), Stephanie Du Four (Contributor), S VAN LAERE (Contributor), Julia Katharina Schwarze (Contributor), Gil Awada (Contributor), Michaël Bruneau (Contributor), Jens Tijtgat (Contributor), Hendrik Everaert (Contributor), Bart Neyns (Contributor) & Johnny Duerinck (Contributor)
26 Mar 2022Activity: Talk or presentation › Talk or presentation at a conference
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A phase I clinical trial on intracranial administration of autologous myeloid dendritic cells (myDC) in combination with ipilimumab and nivolumab in patients with recurrent glioblastoma (rGB).
Wietse Geens (Speaker), Julia Katharina Schwarze (Contributor), Cleo Bertels (Contributor), Jens Tijtgat (Contributor), Gil Awada (Contributor), F Vaeyens (Contributor), Louise Cras (Contributor), Anne Vanbinst (Contributor), Hendrik Everaert (Contributor), Alex Michotte (Contributor), Toon Janssen (Contributor), Ben Caljon (Contributor), Thomas Cauwenbergh (Contributor), Michaël Bruneau (Contributor), Ramses Forsyth (Contributor), Sandra Tuyaerts (Contributor), Bart Neyns (Contributor) & Johnny Duerinck (Contributor)
26 Mar 2022Activity: Talk or presentation › Talk or presentation at a conference
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Human relevant models for drug research and development
Fien Meeus (Speaker), Robin Maximilian Awad (Contributor), Nick Devoogdt (Contributor), Sandra Tuyaerts (Contributor), Cleo Goyvaerts (Contributor), Yannick De Vlaeminck (Contributor), Bart Neyns (Contributor) & Karine Breckpot (Contributor)
8 Oct 2021Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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Intracranial administration of CTLA-4 and PD-1 immune checkpoint blocking monoclonal antibodies in recurrent glioblastoma (rGB): a multi-cohort adaptive phase I clinical trial
Julia Katharina Schwarze (Speaker), Wietse Geens (Contributor), Jens Tijtgat (Contributor), Gil Awada (Contributor), Anne-Marie Van Binst (Contributor), Hendrik Everaert (Contributor), Laura Seynaeve (Contributor), Alex Michotte (Contributor), Michaël Bruneau (Contributor), I VAN RIET (Contributor), Sandra Tuyaerts (Contributor), Johnny Duerinck (Contributor) & Bart Neyns (Contributor)
16 Sep 2021 → 21 Sep 2021Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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FDG PET/CT parameters voor de voorspelling van algemene en progressievrije overleving na pembrolizumab-behandeling bij melanoompatienten
Author: Özdemir, I., Keyaerts, M., Neyns, B. & Everaert, H., 20 Jun 2018Student thesis: Master's Thesis
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Retinal alterations associated with targeted cancer therapy
Author: De Asmundis, C., Fasolino, G., Neyns, B. & Raus, P., 4 Dec 2023Student thesis: Master-after-master
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Retrospectieve analyse van de waarde van totaal metabool tumor volume op FDG-PET/CT bij melanoompatiënten behandeld met Pembrolizumab
Author: Calliauw, L., Keyaerts, M., Neyns, B., Everaert, H. & Goethals, L., 13 Jun 2019Student thesis: Master's Thesis