Projects per year
Personal profile
Expertise
Bart Neyns obtained his MD (1992) and PhD (2001) from the Vrije Universiteit Brussel (VUB), Brussels. Dr Neyns held a Research Fellowship supported by the National Fund for Scientific Research (NFWO), at the Laboratory of Medical Oncology, VUB (1992–1996). In 1996, he began furthering his training in Internal Medicine and Medical Oncology, at the same institute, obtaining his Specialist Degree in 1999. Dr Neyns subsequently became a Resident at the Department of Internal Medicine/Medical Oncology, VUB (1999–2002). In 2009, Dr Neyns specialized in Medical Oncology. During 2002–2012 and 2012-2019, he was appointed respectively as Head of Clinic and Head of Division at the Department of Medical Oncology, UZ Brussel, before being appointed to his current position as Head of Department at the same department, in May 2019. He currently holds an additional parallel position as Clinical Professor at the Faculty of Medicine and Pharmacy, VUB (since 2007); between 2010 and 2018 he served as a Dermato-Oncology Consultant at the Erasme Hospital Université Libre de Bruxelles (ULB), Brussels. Dr Neyns is the member of seven national and international scientific societies including, the Belgian Medical Society of Medical Oncology ESMO, and ASCO. He has been the recipient of several competitive research grants, and has considerable clinical trial experience as a Principal Investigator for more than fifteen academia sponsored clinical trials for patients with advanced melanoma, glioma and colorectal cancer; including clinical trials with a proprietary autologous dendritic cell therapy (TriMixDC) and first-in-human phase I clinical trials with intratumoral injection of autologous myeloid dendritic cells. Dr Neyns has an extensive publication record as the (co-)author of over hundred forty primary manuscripts published in peer review medical journals (incl. N Engl J Med, Lancet Oncol, and the J Clin Oncol), and has been invited speaker at several international congresses. His current research interests broadly include the immune- and targeted therapy of melanoma and the treatment of patients with malignant glioma with a strong emphasis on conducting academia sponsored trials.
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Collaborations and top research areas from the last five years
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EUAR243: JA PCM: Joint Action Personalised Cancer Medicine
Neyns, B. (Administrative Promotor)
14/01/26 → 13/01/30
Project: Applied
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EUAR240: JANE2: Joint Action on Networks of Expertise on Cancer
Neyns, B. (CoI (Co-Promotor)), Rooman, I. (CoI (Co-Promotor)), Beernaert, K. (CoI (Co-Promotor)), Giron, P. (CoI (Co-Promotor)), De Ridder, M. (CoI (Co-Promotor)), De Becker, A. (CoI (Co-Promotor)), Van Riet, I. (CoI (Co-Promotor)), Hes, F. J. (CoI (Co-Promotor)), Rogiers, A. (CoI (Co-Promotor)), Houbracken, I. (CoI (Co-Promotor)) & Vanderkerken, K. (Administrative Promotor)
1/11/24 → 31/10/28
Project: Applied
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EUAR224: EUnetCCC: The European Comprehensive Cancer Centre Network
Neyns, B. (Administrative Promotor)
1/10/24 → 30/09/28
Project: Applied
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ANI389: Development of a B7-H3 nanoCAR-T cell therapy for recurrent glioblastoma (GlioCAR)
Neyns, B. (Administrative Promotor), Geeraerts, X. (CoI (Co-Promotor)), Tuyaerts, S. (CoI (Co-Promotor)), Breckpot, K. (CoI (Co-Promotor)), Duerinck, J. (CoI (Co-Promotor)) & Smolders, I. (CoI (Co-Promotor))
1/10/24 → 30/09/28
Project: Fundamental
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ANI352: MOTUNE-T therapy: Metabolically Optimized TUNEd T cells as treatment for recurrent glioblastoma
Neyns, B. (Administrative Promotor) & Geeraerts, X. (PI (Promotor, Principal Investigator))
1/10/23 → 1/06/28
Project: Fundamental
Research output
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A randomized phase II clinical trial on intratumoral autologous CD1c (BDCA-1)+/CD141 (BDCA-3)+ myeloid dendritic cells (myDC) plus ipilimumab (IPI) and synthetic adjuvant AS01B combined with low-dose intravenous (IV) nivolumab (NIVO) in advanced pretreated melanoma patients.
Bertels, C., Dirven, I., Vounckx, M., Van Riet, I., De Becker, A. & Neyns, B., 1 Jun 2026, In: Journal of Clinical Oncology. 44, p. 21514-21514 1 p.Research output: Contribution to journal › Meeting abstract (Journal)
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Baseline vs. on-treatment heart failure with preserved ejection fraction (HFpEF) in a real world cardio-oncology clinic: observational analysis of cancer therapy-related cardiovascular toxicity incidence and cancer treatment implications
von Kemp, B., Galloo, X., Roosens, B., Neyns, B., Schots, R., De Ridder, M. & Cosyns, B., 9 Jun 2026, In: Frontiers in Cardiovascular Medicine. 13, 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Discontinuation of combo immunotherapy and outcome of patients with melanoma brain metastases
Mandalà, M., Chen, M. F., Sullivan, R. J., Sergi, M. C., Postow, M., Lawless, A. R., Effiom, D., Peres, T., Lorigan, P. C., Serra-Bellver, P., Dummer, R., Amaral, T., Rasch, M.-L., Giannarelli, D., Vitale, M. G., Helgadottir, H., Robert, C., Ubaldi, M., Johnson, D. B. & Del Vecchio, M. & 25 others, , 4 May 2026, In: Journal for ImmunoTherapy of Cancer. 14, 5, 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Efficacy and safety of regorafenib in patients with advanced pretreated melanoma: results of the RegoMel phase II clinical trial
Dirven, I., Bertels, C., Moreels, Y., Kessels, J. I., Vanlaer, N., Vander Mijnsbrugge, A.-S., Vounckx, M., Dirks, I., Raes, L., Geeraerts, X., Stevens, L., von Kemp, B., Fasolino, G., Awada, G., Janssen, T., Caljon, B., Lefevre, T., Everaert, H., Rogiers, A. & Vandemeulebroucke, J. & 2 others, , Apr 2026, In: ESMO Open. 11, 4, 11 p., 106941.Research output: Contribution to journal › Article › peer-review
Open Access -
Immune Cell Infiltration in Primary and Recurrent Glioblastoma, IDH-Wild Type: Validation of an Immunohistochemistry-Based Scoring System for Research and Clinical Practice
Verlinden, L., Michotte, A., Cools, W., Locy, H., Forsyth, R., Duerinck, J., Neyns, B. & Brock, S., Jan 2026, In: APMIS. Acta pathologica, microbiologica et immunologica Scandinavica. 134, 1, 8 p., e70143.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus)
Datasets
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RNA sequencing human melanoma, glioblastoma and pancreatic adenocarcinoma cell lines
Tuyaerts, S. (Creator), Stevens, L. (Data Manager), Geeraerts, X. (Data Collector) & Neyns, B. (Supervisor), Gene Expression Omnibus (GEO), 21 Aug 2025
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE288221
Dataset
Prizes
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Best Poster Award
Awada, G. (Recipient), Özdemir, I. (Recipient), Schwarze, J. K. (Recipient), Daeninck, E. (Recipient), Gondry, O. (Recipient), Jansen, Y. (Recipient), Seremet, T. (Recipient), Keyaerts, M. (Recipient), Everaert, H. (Recipient) & Neyns, B. (Recipient), 15 Dec 2018
Prize: Prize (including medals and awards)
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Wetenschappelijk Fonds Willy Gepts: A phase I study to assess the safety and feasibility of adjuvant treatment with a KRAS mutation-specific synthetic long peptide vaccine in combination with nivolumab in patients with non-metastatic PDAC (KRAS-vac1)
de Haar-Holleman, A. (Recipient), Neyns, B. (Recipient), Rooman, I. (Recipient), Lefesvre, P. (Recipient) & Breckpot, K. (Recipient), 2023
Prize: Prize (including medals and awards)
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Wetenschappelijk Fonds Willy Gepts: FLT3L expressing HSV-1 derived oncolytic virus plus myeloid dendritic cells as a combination therapy for advanced melanoma patients refractory to immune checkpoint blockade.
Geeraerts, X. (Recipient), Neyns, B. (Recipient) & Tuyaerts, S. (Recipient), 2022
Prize: Prize (including medals and awards)
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Wetenschappelijk Fonds Willy Gepts 2023: Correlation of patient outcome with the neoantigen repertoire, the composition of the tumor microenvironment and neoantigen reactivity of T cells in cerebrospinal fluid for recurrent glioblastoma patients treated with intracerebral immune checkpoint blockade and autologous myeloid dendritic cells (29.067€)
Tuyaerts, S. (Recipient), Neyns, B. (Recipient) & Duerinck, J. (Recipient), 2023
Prize: Prize (including medals and awards)
Activities
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Movub Lentesymposium 2026
Raeymaeckers, S. (Chair), Allemeersch, G.-J. (Participant), Al-Ani, A. (Participant), Al-Awa, A. (Participant), Al-Janabi, M. J. M. (Participant), Al Saadi, M. (Participant), Belsack, D. (Participant), Blockeel, C. (Participant), Bollineni, V. R. (Participant), Boulet, C. (Participant), Breugelmans, M. (Participant), Brussaard, C. (Chair), Bhutia, J. T. (Participant), Cammu, H. (Organiser), Colsoul, O. (Participant), Da'meh, A. (Participant), David, K. (Participant), De Backer, A. (Participant), De Boe, V. R. J. (Participant), De Bondt, A. (Participant), De Leu, N. (Participant), de Mey, J. (Participant), De Mey, J. (Participant), De Munck, F. (Participant), De Ridder, M. (Participant), Devos, H. (Participant), Devroey, D. (Participant), Dewilde, D. (Participant), D'Haese, J. M. G. (Participant), Dhooge, E. (Participant), Diltoer, M. (Participant), Döring, S. (Participant), du Maine, C. M. (Participant), Dumarey, A. (Participant), Engels, B. (Participant), Ernst, C. (Participant), Everaert, H. (Participant), Garkalne, I. (Participant), Goethals, L. (Participant), Gungor, B. (Participant), Hasaerts, D. (Participant), Hubloux, G. (Participant), Hulstaert, T. (Participant), Ilsen, B. (Participant), Janssens, W. P. M. (Participant), Jonckheere, J. (Participant), Kichouh, M. (Participant), Kindt, S. (Participant), Kubincova, M. (Participant), Kumba, C. (Participant), Leeman, M. (Participant), Liebaers, I. (Participant), Leunen, M. (Participant), Leus, A. (Participant), Marchand, J. U. M. (Participant), Marcinkowski, I. (Participant), Marynen, F. (Participant), Mwewa, T. B. (Participant), Neyns, B. (Participant), Nieboer, K. (Participant), Orinx, E. (Participant), Osipowska, E. M. (Participant), Pauwels, A. (Participant), Pauwels, F. (Participant), Poortmans, N. K. N. (Participant), Pouliart, N. (Participant), Raeymaeckers, S. (Chair), Rabbachin, N. (Participant), Reynaert, H. (Participant), Roelandt, T. (Participant), Schiettecatte, A. (Participant), Schoneveld, M. (Participant), Schots, H. (Participant), Siffain, J. (Participant), Smets, D. (Participant), Stadnik, T. (Participant), Stas, A. (Participant), Stevens, G. (Participant), Stijns, J. (Participant), Szucs, E. (Participant), Tanaka, K. (Participant), Thielemans, K. (Participant), Vanbinst, A. (Participant), Van Der Niepen, P. (Participant), Van Eetvelde, E. (Participant), Vanfleteren, P. S. V. (Participant), Vanhoeij, M. (Participant), Van Royen, K. (Participant), Van Vaerenbergh, K. (Participant), Vandenbroucke, F. (Participant), Vanderhasselt, T. (Participant), Vanderlinden, K. (Participant), Vansintejan, J. (Participant), Vercauteren, C. (Participant), Verdam, M. (Participant), Ver Eecke, G. (Participant), Vermoesen, C. (Participant), Verstappen, G. (Participant), Violon, S. (Participant), Tosi, M. (Participant), Scholliers, A. (Participant), von Kemp, K. (Participant), Welch, A. (Participant), Willekens, I. (Participant), Vorsselmans, A. (Participant) & Zeeuws, D. (Participant)
21 Mar 2026Activity: Participating in or organising an event › Participation in conference
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PANSCREEN. PANcreatic cancer SCREENing in indiviuals at high risk of developing pancreatic cancer.
de Haar-Holleman, A. (Participant), Degroote, H. (Contributor), Vandenbroucke, F. (Contributor), Messaoudi, N. (Contributor), Neyns, B. (Contributor), Joris, S. (Contributor), Leemans, G. (Contributor), De Bruyn Carlier, T. M. (Contributor), De Beck, L. (Contributor), Rooman, I. (Contributor), De Cock, D. (Contributor), Cools, W. (Contributor) & Fraioli, M. (Contributor)
13 Feb 2026Activity: Other › Written proposal
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Invited Discussant of abstracts
Neyns, B. (Invited speaker)
20 Oct 2025Activity: Talk or presentation › Talk or presentation at a conference
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BSMO 2025 - 27th Annual Meeting
De Wilde, R. (Participant), Fontaine, C. (Member), Neyns, B. (Participant) & Awada, G. (Participant)
31 Jan 2025 → 1 Feb 2025Activity: Participating in or organising an event › Participation in conference
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ESMO 2025
Aspeslagh, S. (Participant), Awada, G. (Participant), Neyns, B. (Chair), Decoster, L. (Chair), de Haar-Holleman, A. (Participant), Cleo, B. (Participant), Fontaine, C. (Participant) & Joris, S. (Participant)
17 Oct 2025 → 21 Oct 2025Activity: Participating in or organising an event › Participation in conference
Thesis
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FDG PET/CT parameters voor de voorspelling van algemene en progressievrije overleving na pembrolizumab-behandeling bij melanoompatienten
Özdemir, I. ((PhD) Student), Keyaerts, M. (Promotor), Neyns, B. (Promotor) & Everaert, H. (Promotor), 20 Jun 2018Student thesis: Master's Thesis
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Retinal alterations associated with targeted cancer therapy
De Asmundis, C. (Jury), Fasolino, G. ((PhD) Student), Neyns, B. (Promotor) & Raus, P. (Promotor), 4 Dec 2023Student thesis: Master-after-master
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Retrospectieve analyse van de waarde van totaal metabool tumor volume op FDG-PET/CT bij melanoompatiënten behandeld met Pembrolizumab
Calliauw, L. ((PhD) Student), Keyaerts, M. (Promotor), Neyns, B. (Promotor), Everaert, H. (Co-promotor) & Goethals, L. (Co-promotor), 13 Jun 2019Student thesis: Master's Thesis