Projects per year
Personal profile
Expertise
I am an experienced scientist and project manager with hands on experience in Radiochemistry, Protein, peptide and small molecule chemistry. In the last ten years I have been involved in different projects for the development of probes for Imaging and Therapy. I had a major role in the successful translation of two PET probes to the clinic that are now in Phase II.
I have contributed and obtained several projects funding, including a EU-Horizon 2020 research and innovation programme (PET3D - PET Imaging in Drug Design and Development) where I had the opportunity to collaborate with researchers within Academia and Industry recognized in the field of PET Imaging. In the last years I have been promotor of several PhD and master students.
Education/Academic qualification
Chemistry , Distinction , University of Lisbon
1 Nov 2004 → 28 Feb 2009
Award Date: 21 Jul 2009
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Collaborations and top research areas from the last five years
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Projects
- 6 Finished
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EU514: PET Imaging in Drug Design and Development (PET3D)
Caveliers, V., Xavier, C., Hernot, S., Devoogdt, N. & Bridoux, J.
1/06/16 → 31/05/20
Project: Fundamental
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ANI130: Clinical translation of 177Lu-anti-HER2 nanobody for targeted radionuclide therapy of HER2 positieve cancer.
1/01/15 → 31/12/16
Project: Fundamental
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FWOAL780: Site-specific functionalization of Nanobodies as probes for Molecular Imaging and Therapy - Theranostic tool
Muyldermans, S., Xavier, C. & Devoogdt, N.
1/01/15 → 31/12/18
Project: Fundamental
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GOA74: Nanobody Translational Molecular Imaging
Lahoutte, T., Caveliers, V., Devoogdt, N., Xavier, C., TCHOUATE GAINKAM Lea, O., D'Huyvetter, M., Hernot, S., Keyaerts, M., Vaneycken, I. & Van Hove, C.
1/01/10 → 31/12/12
Project: Fundamental
Research output
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Phase I Study of [68Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)
Gondry, O., Xavier, C., Raes, L., Heemskerk, J., Devoogdt, N., Everaert, H., Breckpot, K., Lecocq, Q., Decoster, L., Fontaine, C., Schallier, D., Aspeslagh, S., Vaneycken, I., Raes, G., Van Ginderachter, J. A., Lahoutte, T., Caveliers, V. & Keyaerts, M., Sep 2023, In: Journal of Nuclear Medicine. 64, 9, p. 1378-1384 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)1 Downloads (Pure) -
Assessment of repeatability and uptake quantification of (68)GaNOTA-anti-HER2 sdAb PET/CT in patients with locally advanced or metastatic breast cancer
Gondry, O., Xavier, C., Waelput, W., Al Dabssi, O., Vanhoeij, M., Aspeslagh, S., Joris, S., Fontaine, C., Verfaillie, G., De Greve, J., Glorieus, K., Luyten, I., Vandenbroucke, F., Bourgeois, S., Thyparambil, S., Devoogdt, N., Vaneycken, I., Cousaert, J., Caveliers, V., Everaert, H. & 3 others, , 15 Feb 2022, In: Cancer Research. 82, 4, p. P3-02-05Research output: Contribution to journal › Meeting abstract (Journal)
Open Access -
Repeatability of 68GaNOTA-anti-HER2 sdAb in 20 breast cancer patients.
Gondry, O., Xavier, C., De Geeter, F., Al dabssi, O., Glorieus, K., Aspeslagh, S., Joris, S., Fontaine, C., Verfaillie, G., De Grève, J., Vanhoeij, M., Luyten, I., Heemskerk, J., Bourgeois, S., Raes, L. A. J., Devoogdt, N., Vaneycken, I., Cousaert, J., Caveliers, V., Everaert, H. & 2 others, , Mar 2022.Research output: Unpublished contribution to conference › Unpublished abstract
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68Ga-Labeling: Laying the Foundation for an Anti-Radiolytic Formulation for NOTA-sdAb PET Tracers
Baudhuin, H., Cousaert, J., Vanwolleghem, P., Raes, G., Caveliers, V., Keyaerts, M., Lahoutte, T. & Xavier, C., 1 Jan 2021, In: Pharmaceuticals. 14, 5, 16 p., 448.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)33 Downloads (Pure) -
Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality
Baudhuin, H., Puttemans, J., Hanssens, H., Vanwolleghem, P., Hernot, S., Raes, G., Xavier, C., Lahoutte, T. & Debie, P., May 2021, In: Pharmaceuticals. 14, 5, 19 p., 407.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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Best Poster Award
Xavier, Catarina (Recipient), 20 Apr 2012
Prize: Prize (including medals and awards)
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Certificat of Young Speaker Award
Lecocq, Quentin (Recipient), Broos, K. (Recipient), Bridoux, Jessica (Recipient), Raes, Geert (Recipient), Xavier, Catarina (Recipient), Devoogdt, Nick (Recipient), Keyaerts, Marleen (Recipient) & Breckpot, Karine (Recipient), 1 Feb 2019
Prize: Prize (including medals and awards)
File -
ESMI presentation award for best oral presentation
Bridoux, Jessica (Recipient), Broos, K. (Recipient), Lecocq, Quentin (Recipient), Crauwels, M. (Recipient), Martin, Charlotte (Recipient), Cleeren, F. (Recipient), Kondrashov, M. (Recipient), Ballet, Steven (Recipient), Bormans, G. (Recipient), Schou, M. (Recipient), Elmore, C. (Recipient), Raes, Geert (Recipient), Breckpot, Karine (Recipient), Muyldermans, Serge (Recipient), Devoogdt, Nick (Recipient), Keyaerts, Marleen (Recipient), Caveliers, Vicky (Recipient) & Xavier, Catarina (Recipient), 17 Jan 2020
Prize: Prize (including medals and awards)
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Knowledge for Growth 2018 Ghent - poster award
Broos, K. (Recipient), Lecocq, Quentin (Recipient), Bridoux, Jessica (Recipient), Raes, Geert (Recipient), Xavier, Catarina (Recipient), Keyaerts, Marleen (Recipient), Devoogdt, Nick (Recipient) & Breckpot, Karine (Recipient), 18 May 2018
Prize: Prize (including medals and awards)
Activities
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Using the site-specific radiolabeling of a PD-L1 nanobody via maleimide–cysteine chemistry to develop a PET-tracer as screening tool for personalized oncology treatment
Dora Mugoli Chigoho (Speaker), Jessica Bridoux (Speaker), Catarina Xavier (Speaker), Vicky Caveliers (Speaker), Marleen Keyaerts (Speaker), Nick Devoogdt (Speaker), Karine Breckpot (Speaker), Robin Maximilian Awad (Speaker) & Quentin Lecocq (Speaker)
7 May 2022Activity: Talk or presentation › Talk or presentation at a conference
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Noninvasive imaging and inhibition of human programmed death ligand 1 (PD-L1) using nanobody K2 to improve cancer immunotherapy
Robin Maximilian Awad (Contributor), Dora Mugoli Chigoho (Contributor), Katrijn Broos (Contributor), Quentin Lecocq (Contributor), Katty Zeven (Contributor), Thomas Ertveldt (Contributor), Lien De Beck (Contributor), Hannelore Ceuppens (Contributor), Yannick De Vlaeminck (Contributor), Cleo Goyvaerts (Contributor), Steve Schoonooghe (Contributor), Vicky Caveliers (Contributor), Catarina Xavier (Contributor), Jessica Bridoux (Contributor), Geert Raes (Contributor), Marleen Keyaerts (Contributor), Nick Devoogdt (Contributor) & Karine Breckpot (Speaker)
25 Oct 2021 → 26 Oct 2021Activity: Talk or presentation › Talk or presentation at a conference
File -
2020-74
Tony Lahoutte (Supervisor), Vicky Caveliers (Contributor), Catarina Xavier (Contributor), Jessica Bridoux (Contributor) & Herlinde Dierick (Contributor)
2020Activity: Other
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Immuno-PET imaging using the hPD-L1 Nanobody: Radiolabelling strategies
Jessica Bridoux (Speaker), Katrijn Broos (Contributor), Quentin Lecocq (Contributor), Maxine Crauwels (Contributor), Charlotte Martin (Contributor), Frederik Cleeren (Contributor), Mikhail Krivoshapov (Speaker), Steven Ballet (Speaker), G. Bormans (Speaker), Geert Raes (Speaker), Karine Breckpot (Speaker), Serge Muyldermans (Speaker), Magnus Schou (Speaker), Chad Elmore (Speaker), Nick Devoogdt (Speaker), Vicky Caveliers (Speaker), Marleen Keyaerts (Speaker) & Catarina Xavier (Speaker)
14 Jan 2020Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
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Tackling a shortage of PET scientists and improving healthcare
Jessica Bridoux, Vicky Caveliers & Catarina Xavier
1/10/17
1 Media contribution
Press/Media: Research
Thesis
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Conversion of Nanobodies to Fluorescent probes with conserved size and functionality
Author: Nguyen, T. N. H., Xavier, C., Muyldermans, S. & Pauw, De, P., 5 Sep 2014Student thesis: Master's Thesis
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Development and preclinical evaluation of novel SPECT and PET tracers for cell death imaging
Author: Elvas, F. & Xavier, C., 29 May 2017Student thesis: Doctoral Thesis
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Development of a radioimmunotracer: Gallium-68 labelled hPD-L1 nanobody for PET imaging
Author: Bridoux, J., Chigoho, D. M., Xavier, C. & Fransen, P., 31 Jan 2020Student thesis: Master's Thesis
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Effect of different characteristics of radiometal labelled nanobodies on the kidney retention
Author: Crauwels, M., Xavier, C., Muyldermans, S. & Devoogdt, N., 26 Oct 2020Student thesis: Doctoral Thesis
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New Approaches for development of 68Ga-Labelled Biomolecules for PET-Imaging based on a Siderophore Scaffold
Author: Kaeopookum, P., Xavier, C. & Decristoforo, C., Sep 2019Student thesis: Doctoral Thesis