Projects per year
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
-
BASGO23: OZR Basisfinanciering voor Grote Onderzoeksgroepen - GRAD
1/01/24 → 31/12/25
Project: Fundamental
-
FWOAL1071: Liver and brain organoids to model human pluripotent stem cell tumorigenesis
1/01/23 → 31/12/26
Project: Fundamental
-
OZRMETH9: The Genetic Component to Infertility and Early Developmental Failure
1/01/23 → 31/12/29
Project: Fundamental
-
FWOAL1040: The impact of chromosomal abnormalities in hPSC-derived retinal pigmented epithelial cells
1/01/22 → 31/12/25
Project: Fundamental
Research output
-
Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight
Spits, C., Mertens, J., Belva, F., van Montfoort, A. PA., Regin, M., Zambelli, F., Seneca, S., Couvreu De Deckersberg, E., Bonduelle, M-L., Tournaye, H., Stouffs, K., Barbé, K., Smeets, B., Van De Velde, H., Sermon, K. & Blockeel, C., 9 Feb 2024, In: Nature Communications. 15, 1, 16 p., 1232 .Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)6 Downloads (Pure) -
De Novo Cancer Mutations Frequently Associate with Recurrent Chromosomal Abnormalities during Long-Term Human Pluripotent Stem Cell Culture
Delbany, D. A., Ghosh, M. S., Krivec, N., Huyghebaert, A., Regin, M., Duong, M. C., Lei, Y., Sermon, K., Olsen, C. & Spits, C., 21 Aug 2024, In: Cells. 13, 16, 12 p., 1395.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
Krivec, N., Couvreu De Deckersberg, E., Lei, Y., Al Delbany, D., Regin, M., Verhulst, S., van Grunsven, L. A., Sermon, K. & Spits, C., 21 Nov 2024, In: Cell Death and Disease. 15, 14 p., 852.Research output: Contribution to journal › Article › peer-review
Open Access -
Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research
Krivec, N., Ghosh, M. & Spits, C., 9 Jan 2024, In: Stem Cell Reports. 19, p. 11-27 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)1 Downloads (Pure) -
Liver organoids to study if aneuploidy primes human pluripotent stem-cell derived hepatocytes for oncogenic transformation
Huyghebaert, A., Al Delbany, D., Ghosh, M., Kazemzadeh Dastjerd, M., Krivec, N., van Grunsven, L. A. & Spits, C., 29 Nov 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
Datasets
-
Mitochondrial DNA variants segregate during human preimplantation development into genetically different cell lineages that are maintained postnatally
Spits, C. (Creator), Open Science Framework, 7 Jan 2025
Dataset
-
-
De Novo Cancer Mutations Frequently Associate with Recurrent Chromosomal Abnormalities during Long-Term Human Pluripotent Stem Cell Culture
Al Delbany, D. (Creator), Ghosh, M. (Creator), Krivec, N. (Creator), Huyghebaert, A. (Creator), Regin, M. (Creator), Duong, C. M. (Creator), Lei, Y. (Creator), Sermon, K. (Creator), Olsen, C. (Creator) & Spits, C. (Creator), OSF, 2024
Dataset
-
SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss
Spits, C. (Creator) & Lei, Y. (Creator), Open Science Framework, 2024
DOI: DOI 10.17605/OSF.IO/HPAXC
Dataset
-
Modeling of myogenesis using human embryonic stem cells reveals myotonic dystrophy type 1 specific misregulated cellular processes
Spits, C. (Creator), Gene Expression Omnibus (GEO), 2022
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE160916
Dataset
Activities
-
Regulators of cell fate decisions in human pre-implantation embryos (Event)
Luc Leyns (Jury), Marius Regin (Presenter), Karen Sermon (Supervisor) & Claudia Spits (Supervisor)
28 Mar 2024Activity: Membership › Member of PhD committee
-
KU Leuven (External organisation)
Johan De Mey (Chair), Eveline Peeters (Member), Gerard Clarke (Member), Joost Smolders (Member), Joao Sabino (Member), Claudia Spits (Member), Marie Beatrice D'Hooghe (Supervisor), Jeroen Raes (Supervisor) & Lindsay Devolder (Supervisor)
21 Nov 2022Activity: Membership › Member of PhD committee
-
Shifting the context of differentiation: chromosomal abnormalities in pluripotent stem cells (Event)
Luc Leyns (Jury), Alexander Scott Keller (Presenter), Claudia Spits (Supervisor) & Mieke Geens (Supervisor)
14 Jul 2021Activity: Membership › Member of PhD committee
-
Aneuploidy induces proteotoxic stress and autophagy-mediated apoptosis in human preimplantation embryos
Marius Regin (Speaker), Edouard Couvreu De Deckersberg (Contributor), Yves Guns (Contributor), Pieter Verdyck (Contributor), Greta Verheyen (Contributor), Hilde Van De Velde (Contributor), Claudia Spits (Contributor) & Karen Sermon (Contributor)
1 Jul 2021Activity: Talk or presentation › Talk or presentation at a conference
-
Mitochondrial DNA mosaicism in early human development
Joke Mertens (Speaker), Marius Regin (Contributor), Neelke De Munck (Contributor), Edouard Couvreu De Deckersberg (Contributor), Christophe Blockeel (Contributor), Herman Tournaye (Contributor), Hilde Van De Velde (Contributor), Karen Sermon (Contributor) & Claudia Spits (Contributor)
17 Sep 2021Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
Thesis
-
(R)evolution in preimplantation genetic diagnosis : development and clinical application of different approaches to preimplantation genetic diagnosis for monogenic disorders.
Author: Spits, C., Liebaers, I., Sermon, K., De Rycke, M., Van Schravendijk, C., Van Der Auwera, B., Geraedts, J., Harper, J., Santalo Pedro, J., De Paepe, A., Legius, E. & Timmerman, V., 4 Dec 2006Supervisor: Liebaers, I. (Promotor), Sermon, K. (Co-promotor), De Rycke, M. (Co-promotor), Van Schravendijk, C. (Jury), Van Der Auwera, B. (Jury), Geraedts, J. (External person) (Jury), Harper, J. (External person) (Jury), Santalo Pedro, J. (External person) (Jury), De Paepe, A. (External person) (Jury), Legius, E. (External person) (Jury) & Timmerman, V. (External person) (Jury)
Student thesis: Doctoral Thesis