Projects per year
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Dive into the research topics where Claudia Spits is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Projects
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FWOTM1016: The impact of recurrent chromosomal abnormalities on growth advantage and differentiation capacity of human pluripotent stem cells
Krivec, N., Spits, C. & Sermon, K.
1/11/20 → 31/10/22
Project: Fundamental
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OZR3565: Seahorse platform: the Agilent Seahorse Flux Analyser with integrated normalization system
Massie, A., Stiens, J., Van Ginderachter, J., Vanommeslaeghe, K., Vinken, M., Menu, E., Spits, C. & Njemini, R.
1/05/20 → 30/04/24
Project: Fundamental
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HERC53: Seahorse platform: the Agilent Seahorse Flux Analyser with integrated normalization system
Massie, A., Stiens, J., Van Ginderachter, J., Vanommeslaeghe, K., Vinken, M., Menu, E., Spits, C. & Njemini, R.
1/05/20 → 30/04/24
Project: Fundamental
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FWOTM968: The search for the origin of chromosomal abnormalities in human preimplantation embryos
Sermon, K., Spits, C. & Regin, M.
1/10/19 → 31/10/21
Project: Fundamental
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FWOSB55: A roadmap to the safe introduction of hESC in the clinic: the case of genetic mosaicism in hESC-derived retinal cells
Couvreu De Deckersberg, E., Spits, C. & Sermon, K.
1/01/19 → 31/12/22
Project: Fundamental
Research output
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Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm
Dziedzicka, D., Tewary, M., Keller, A., Tilleman, L., Prochazka, L., Östblom, J., Couvreu De Deckersberg, E., Markouli, C., Franck, S., Van Nieuwerburgh, F., Spits, C., Zandstra, P. W., Sermon, K. & Geens, M., 2021, In : Scientific Reports. 11, 1, 14 p., 6137.Research output: Contribution to journal › Article
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MSH2 knock-down shows CTG repeat stability and concomitant upstream demethylation at the DMPK locus in myotonic dystrophy type 1 human embryonic stem cells
Franck, S., Barbé, L., Ardui, S., De Vlaeminck, Y., Allemeersch, J., Dziedzicka, D., Spits, C., Vanroye, F., Hilven, P., Duqué, G., Vermeesch, J. R., Gheldof, A. & Sermon, K., 6 Jan 2021, In : Human Molecular Genetics. 29, 21, p. 3566-3577 12 p.Research output: Contribution to journal › Article
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Sustained intrinsic WNT and BMP4 activation impairs hESC differentiation to definitive endoderm and drives the cells towards extra-embryonic mesoderm
Markouli, C., Couvreu De Deckersberg, E., Dziedzicka, D. A., Regin, M., Franck, S., Keller, A. S., Gheldof, A., Geens, M., Sermon, K. & Spits, C., 15 Apr 2021, In : Scientific Reports - Nature. 11Research output: Contribution to journal › Article
Open Access -
243rd ENMC international workshop: Developing guidelines for management of reproductive options for families with maternally inherited mtDNA disease, Amsterdam, the Netherlands, 22-24 March 2019.
Poulton, J., Steffann, J., Burgstaller, J., McFarland, R., Arbeithuber, B., Bengoa, J., Chan, S., Chiaratti, M., Crouch, M., Dimond, R., Enriques, JA., Gorman, G., Hyslop, L., Johnston, I., Kitto, J., Maguire, A., Mitalipov, S., Otterloo, V., Sallevelt, S., Smeets, H. & 7 others, , 2019, In : Neuromuscular Disorders. 29, p. 725-733 9 p.Research output: Contribution to journal › Article
4 Citations (Scopus) -
Detection of Heteroplasmic Variants in the Mitochondrial Genome through Massive Parallel Sequencing
Mertens, J., Zambelli, F., Daneels, D., Caljon, B., Sermon, K. & Spits, C., 5 Jul 2019, In : bio-protocol. 9, 13, 7 p., e3283.Research output: Contribution to journal › Article
Activities
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Differences in the landscape of mitochondrial DNA variants between ART and spontaneously conceived individuals links to maternal infertility and low birth weight
Joke Mertens (Speaker), Filippo Zambelli (Contributor), Florence Belva (Contributor), Aafke PA van Montfoort (Contributor), Edouard Couvreu De Deckersberg (Contributor), Mary-Louise Bonduelle (Contributor), Katrien Stouffs (Contributor), Sara Seneca (Contributor), Hilde Van De Velde (Contributor), Christophe Blockeel (Contributor), Karen Sermon (Contributor), Claudia Spits (Contributor)5 Jul 2020 → 8 Jul 2020Activity: Talk or presentation › Talk or presentation at a conference
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Maternally inherited differences in mitochondrial DNA genotype between ART and spontaneously conceived individuals are aggravated by controlled ovarian stimulation and link to low birth weight
Joke Mertens (Speaker), Florence Belva (Contributor), Aafke PA van Montfoort (Contributor), Filippo Zambelli (Contributor), Edouard Couvreu De Deckersberg (Contributor), Mary-Louise Bonduelle (Contributor), Herman Tournaye (Contributor), Katrien Stouffs (Contributor), Sara Seneca (Contributor), Kurt Barbé (Contributor), Hubert J M Smeets (Contributor), Hilde Van De Velde (Contributor), Karen Sermon (Contributor), Christophe Blockeel (Contributor), Claudia Spits (Contributor)28 Nov 2020Activity: Talk or presentation › Talk or presentation at a conference
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Mitochondrial DNA mosaicism in early human development
Joke Mertens (Speaker), Marius Regin (Contributor), Neelke De Munck (Contributor), Hilde Van De Velde (Contributor), Karen Sermon (Contributor), Claudia Spits (Contributor)25 Jun 2019Activity: Talk or presentation › Talk or presentation at a conference
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Mitochondrial DNA mosaicism in early human development
Joke Mertens (Speaker), Marius Regin (Contributor), Neelke De Munck (Contributor), Hilde Van De Velde (Contributor), Karen Sermon (Contributor), Christophe Blockeel (Contributor), Claudia Spits (Contributor)22 Nov 2019 → 23 Nov 2019Activity: Talk or presentation › Talk or presentation at a conference
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Increased heteroplasmic load of coding mitochondrial DNA variants in tissues from ART children
Joke Mertens (Speaker), Filippo Zambelli (Contributor), Florence Belva (Contributor), Aafke PA van Montfoort (Contributor), Mary-Louise Bonduelle (Contributor), Sara Seneca (Contributor), Karen Sermon (Contributor), Claudia Spits (Contributor)3 Jul 2018Activity: Talk or presentation › Talk or presentation at a conference
Press / Media
Thesis
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(R)evolution in preimplantation genetic diagnosis : development and clinical application of different approaches to preimplantation genetic diagnosis for monogenic disorders.
Author: Spits, C., Liebaers, I., Sermon, K., De Rycke, M., Van Schravendijk, C., Van Der Auwera, B., Geraedts, J., Harper, J., Santalo Pedro, J., De Paepe, A., Legius, E. & Timmerman, V., 4 Dec 2006Supervisor: Liebaers, I. (Promotor), Sermon, K. (Co-promotor), De Rycke, M. (Co-promotor), Van Schravendijk, C. (Jury), Van Der Auwera, B. (Jury), Geraedts, J. (External person) (Jury), Harper, J. (External person) (Jury), Santalo Pedro, J. (External person) (Jury), De Paepe, A. (External person) (Jury), Legius, E. (External person) (Jury) & Timmerman, V. (External person) (Jury)
Student thesis: Doctoral Thesis
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Analysis of mitochondrial DNA variants in ART and spontaneously conceived individuals
Author: Rhioui, K., Mertens, J. & Spits, C., 6 Sep 2018Supervisor: Spits, C. (Promotor)
Student thesis: Master's Thesis
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Characterisation of the molecular causes and selective advantages of chromosome abnormalities in human embryonic stem cells
Author: Nguyen Thi, H., Sermon, K. & Spits, C., 2 Sep 2010Supervisor: Sermon, K. (Promotor) & Spits, C. (Advisor)
Student thesis: Master's Thesis
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Chromosomal abnormalities in human preimplantation development
Author: Mertzanidou, A., Spits, C., Sermon, K., Van Schravendijk, C., Breckpot, K., De Rycke, M., Verpoest, W., Wells, D. & Debrock, S., 29 Apr 2015Supervisor: Sermon, K. (Promotor), Spits, C. (Promotor), Van Schravendijk, C. (Jury), Breckpot, K. (Jury), De Rycke, M. (Jury), Verpoest, W. (Jury), Wells, D. (External person) (Jury) & Debrock, S. (External person) (Jury)
Student thesis: Doctoral Thesis
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DNA damage in hESC cultured on feeder-free conditions: the impact of cell density
Author: Ivanna, I., Spits, C. & Jacobs, K., 3 Sep 2014Supervisor: Spits, C. (Promotor) & Jacobs, K. (Co-promotor)
Student thesis: Master's Thesis