Projects per year
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Dive into the research topics where Claudia Spits is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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BASGO23: OZR Basisfinanciering voor Grote Onderzoeksgroepen - GRAD
1/01/24 → 31/12/29
Project: Fundamental
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OZRMETH9: The Genetic Component to Infertility and Early Developmental Failure
1/01/23 → 31/12/29
Project: Fundamental
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FWOAL1071: Liver and brain organoids to model human pluripotent stem cell tumorigenesis
1/01/23 → 31/12/26
Project: Fundamental
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FWOAL1040: The impact of chromosomal abnormalities in hPSC-derived retinal pigmented epithelial cells
1/01/22 → 31/12/25
Project: Fundamental
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A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy
Benvenisty, N., Draper, J. S., Gokhale, P. J., Healy, L. E., Hewitt, Z., Hursh, D., Hodgson, A., Ludwig, T., Mah, N., McClelland, S., Mennecozzi, M., Merkle, F. T., Mountford, J. C., Pera, M. F., Prigione, A., Rodriguez, T., Rossi, A., Rouhani, F., Saeb-Parsy, K., Selfa Aspiroz, L., & 4 others, 3 Apr 2025, In: Cell Stem Cell. 32, 4, p. 508-512 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)4 Downloads (Pure) -
A novel liver organoid model using directed mutagenesis to study the oncogenic potential of human pluripotent stem cell-derived hepatocytes
Huyghebaert, A., Al Delbany, D., Krivec, N., van Grunsven, L. A. & Spits, C., 11 Apr 2025, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells
lei, Y., Duong, C. M., Krivec, N., Janssens, C., Regin, M., Huyghebaert, A., Deckersberg, E. C. D., Sermon, K., Delbany, D. A. & Spits, C., 5 Feb 2025, In: Cell Proliferation. 12 p., e13813.Research output: Contribution to journal › Article › peer-review
Open Access -
The interplay between mitochondrial DNA genotypes, female infertility, ovarian response and mutagenesis in oocytes
Van Der Kelen, A., Li Piani, L., Mertens, J., Regin, M., Couvreu De Deckersberg, E., Van De Velde, H., Sermon, K., Tournaye, H., Verpoest, W., Hes, F. J., Blockeel, C. & Spits, C., 2025, In: Human reproduction open. 2025, 1, 13 p., hoae074.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Aneuploidy as a first genetic hit that enhances the tumorigenic capacity of differentiated human pluripotent stem cells.
Al Delbany, D., Myrthe Mampay , Adhithya Narayanan Srinivasan, Krivec, N., Huyghebaert, A., Lei, Y., Sermon, K., Movahedi, K. & Spits, C., 29 Nov 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
Datasets
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Modeling of myogenesis using human embryonic stem cells reveals myotonic dystrophy type 1 specific misregulated cellular processes
Spits, C. (Creator), Gene Expression Omnibus (GEO), 2022
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE160916
Dataset
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Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research
Spits, C. (Creator), OSF, 14 Nov 2024
Dataset
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SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss
Spits, C. (Creator) & Lei, Y. (Creator), Open Science Framework, 2024
Dataset
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Gain of 1q confers an MDM4 - driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
Spits, C. (Creator), Krivec, N. (Creator) & Verloes, A. (Creator), Open Science Framework, 15 Sept 2023
Dataset
Activities
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Regulators of cell fate decisions in human pre-implantation embryos (Event)
Luc Leyns (Jury), Marius Regin (Presenter), Karen Sermon (Supervisor) & Claudia Spits (Supervisor)
28 Mar 2024Activity: Membership › Member of PhD committee
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KU Leuven (External organisation)
Johan De Mey (Chair), Eveline Peeters (Member), Gerard Clarke (Member), Joost Smolders (Member), Joao Sabino (Member), Claudia Spits (Member), Marie Beatrice D'Hooghe (Supervisor), Jeroen Raes (Supervisor) & Lindsay Devolder (Supervisor)
21 Nov 2022Activity: Membership › Member of PhD committee
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Aneuploidy induces proteotoxic stress and autophagy-mediated apoptosis in human preimplantation embryos
Marius Regin (Speaker), Edouard Couvreu De Deckersberg (Contributor), Yves Guns (Contributor), Pieter Verdyck (Contributor), Greta Verheyen (Contributor), Hilde Van De Velde (Contributor), Claudia Spits (Contributor) & Karen Sermon (Contributor)
1 Jul 2021Activity: Talk or presentation › Talk or presentation at a conference
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Shifting the context of differentiation: chromosomal abnormalities in pluripotent stem cells (Event)
Luc Leyns (Jury), Alexander Scott Keller (Presenter), Claudia Spits (Supervisor) & Mieke Geens (Supervisor)
14 Jul 2021Activity: Membership › Member of PhD committee
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Aneuploidy induces proteotoxic stress and autophagy-mediated apoptosis in human preimplantation embryos
Marius Regin (Speaker), Yingnan Lei (Contributor), Edouard Couvreu De Deckersberg (Contributor), Yves Guns (Contributor), Pieter Verdyck (Contributor), Greta Verheyen (Contributor), Hilde Van De Velde (Contributor), Claudia Spits (Contributor) & Karen Sermon (Contributor)
26 Nov 2021 → 27 Nov 2021Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
Thesis
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(R)evolution in preimplantation genetic diagnosis : development and clinical application of different approaches to preimplantation genetic diagnosis for monogenic disorders.
Author: Spits, C., Liebaers, I., Sermon, K., De Rycke, M., Van Schravendijk, C., Van Der Auwera, B., Geraedts, J., Harper, J., Santalo Pedro, J., De Paepe, A., Legius, E. & Timmerman, V., 4 Dec 2006Supervisor: Liebaers, I. (Promotor), Sermon, K. (Co-promotor), De Rycke, M. (Co-promotor), Van Schravendijk, C. (Jury), Van Der Auwera, B. (Jury), Geraedts, J. (External person) (Jury), Harper, J. C. (External person) (Jury), Santalo Pedro, J. (External person) (Jury), De Paepe, A. (External person) (Jury), Legius, E. (External person) (Jury) & Timmerman, V. (External person) (Jury)
Student thesis: Doctoral Thesis