Projects per year
Personal profile
Expertise
Dimitri De Bundel is a lecturer to the Faculty of Medicine and Pharmacy. He graduated as a Pharmacist (summa cum laude, 2004) and obtained a PhD in Pharmaceutical Sciences (2009). During his PhD he gained expertise in in vivo neurochemistry methods and behavioural analysis. During a postdoctoral research stays in Karolinska Institutet (Sweden, 2009-2011) and Institut Génomique Fonctionelle (France, 2011-2014) he further developed his expertise in techniques for studying the neurobiological basis for cognitive function and mood regulation. He is now a principal investigator at VUB (since 2014) where he is investigating neurotransmitter and neuropeptide systems involved in memory and mood dysfunction. His core expertise lies in behavioural analysis and targeted pharmacological manipulation of brain transmitter systems in neurological and psychiatric disorders.
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Projects
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OZR3588: Financiering FWO hercules: ERA platform: Extended RNA Analysis platform - version 2.0
Rooman, I., Bouwens, L., Heimberg, H., Neyns, B., Vranken, W., Vanhaecke, T., Massie, A., van Grunsven, L., De Bruyne, E., De Bundel, D., Forsyth, R., Breckpot, K., Van Dooren, S., De Kock, J., Njemini, R. & Laoui, D.
1/05/20 → 30/04/24
Project: Fundamental
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ANI246: Application of transcranial alternating current stimulation to improve remyelination
Van Schependom, J., De Bundel, D., Nagels, G. & Stiens, J.
1/01/20 → 31/12/21
Project: Fundamental
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FWOTM971: Photopharmacology as novel treatment option for refractory focal epilepsies
Smolders, I., De Bundel, D. & Bournons, S.
1/11/19 → 31/10/21
Project: Fundamental
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FWOAL912: Photoswitchable cannabinoids for precision treatment of refractory focal epileptic seizures
1/01/19 → 31/12/22
Project: Fundamental
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FWOTM907: Investigation of the disease modification potential of early life prolonged antiepileptogenic treatments in established Alzheimer's disease mouse models.
Smolders, I., Vande Vyver, M., De Bundel, D. & Nagels, G.
1/10/18 → 30/09/22
Project: Fundamental
Research output
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Effects of repeated anodal transcranial direct current stimulation on auditory fear extinction in C57BL/6J mice
Van Schuerbeek, A., Vanderhasselt, M-A., Baeken, C., Pierre, A., Smolders, I., Van Waes, V. & De Bundel, D., 1 Mar 2021, In : Brain Stimulation. 14, 2, p. 250-260 11 p.Research output: Contribution to journal › Article
Open AccessFile -
"+ Flash presentation" A comparative study of Unispray and Electrospray for the ionization of neuropeptides in LC-MS/MS.
Bongaerts, J., Van Wanseele, Y., Van Oudenhove, L., Segers, K., Van Hulle, M., De Bundel, D., Smolders, I., Mangelings, D., Vander Heyden, Y. & Van Eeckhaut, A., 2020.Research output: Unpublished contribution to conference › Poster
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A comparative study of UniSpray and electrospray sources for the ionization of neuropeptides in liquid chromatography tandem mass spectrometry.
Bongaerts, J., Segers, K., Van Oudenhove, L., Van Wanseele, Y., Van Hulle, M., De Bundel, D., Mangelings, D., Smolders, I., Vander Heyden, Y. & Van Eeckhaut, A., 27 Sep 2020, In : Journal of Chromatography. A. 1628, 461462.Research output: Contribution to journal › Article
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Apparent reconsolidation interference without generalized amnesia
Alfei, J. M., De Gruy, H., De Bundel, D., Luyten, L. & Beckers, T., 11 Nov 2020, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry. p. 110161 110161.Research output: Contribution to journal › Article
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CE-MS metabolic profiling of volume-restricted plasma samples from an acute mouse model for epileptic seizures to discover potentially involved metabolomic features.
Segers, K., Zhang, W., Aourz, N., Bongaerts, J., Declerck, S., Mangelings, D., Hankemeier, T., De Bundel, D., Vander Heyden, Y., Smolders, I., Ramautar, R. & Van Eeckhaut, A., 1 Sep 2020, In : Talanta. 217, 121107.Research output: Contribution to journal › Article
1 Citation (Scopus)
Prizes
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Hugo d'Haenen Award
Dimitri De Bundel (Recipient), 2 Oct 2015
Prize: Prize (including medals and awards)
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Les Grandes Avancées en Biologie-Santé du Pôle RABELAIS 2017
Dimitri De Bundel (Recipient), 4 May 2017
Prize: Prize (including medals and awards)
Activities
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Targeted metabolomics of the brain – the quest for sensitivity, selectivity and throughput.
Ann Van Eeckhaut (Invited speaker), Jana Bongaerts (Contributor), Marie-Laure Custers (Contributor), Liam Nestor (Contributor), Anouk Pierre (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor)29 Jan 2020 → 31 Jan 2020Activity: Talk or presentation › Talk or presentation at a conference
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Comparison of Unispray and Electropspray for the ionization of neuropeptides.
Jana Bongaerts (Speaker), Yannick Van Wanseele (Contributor), Laurence Van Oudenhove (Contributor), Karen Segers (Contributor), Marijn Van Hulle (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor), Debby Mangelings (Contributor), Yvan Vander Heyden (Contributor), Ann Van Eeckhaut (Contributor)20 May 2019Activity: Talk or presentation › Talk or presentation at a conference
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The synthetic ghrelin receptor agonist MK0677 increases mesolimbic/mesocortical dopamine release following local administration in the ventral tegmental area without affecting anxiety or cued fear extinction
Anouk Pierre (Speaker), Andries Van Schuerbeek (Speaker), Wissal Allaoui (Speaker), Eva-Maria Fritz (Contributor), Nicolas Singewald (Contributor), tom beckers (Contributor), Ann Van Eeckhaut (Speaker), Ilse Smolders (Speaker), Dimitri De Bundel (Speaker)21 May 2019Activity: Talk or presentation › Talk or presentation at a conference
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CE-MS-based profiling of cationic plasma metabolomics from a mouse model for acute epileptic seizures.
Karen Segers (Speaker), W. Zhang (Contributor), Debby Mangelings (Contributor), T. Hankemeier (Contributor), Dimitri De Bundel (Contributor), Yvan Vander Heyden (Contributor), Ilse Smolders (Contributor), Rawi Ramautar (Contributor), Ann Van Eeckhaut (Contributor)20 May 2019Activity: Talk or presentation › Talk or presentation at a conference
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CHEMOGENETIC MODULATION OF ASTROCYTES IN A MODEL FOR TEMPORAL LOBE EPILEPSY
Yana Van Den Herrewegen (Presenter), An Buckinx (Contributor), Ann Van Eeckhaut (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor)20 May 2019Activity: Talk or presentation › Talk or presentation at a conference
Press / Media
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Une horloge biologique perturbée : facteur de risque pour des troubles de l’anxiété
8/11/13
1 item of Media coverage
Press/Media: Research
Thesis
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A scavenger hunt towards a better understanding of the involvement of ghrelin receptor signaling in emotion regulation
Author: Pierre, A., De Bundel, D., Smolders, I., beckers, T., Mangelings, D., De Kock, J., Aerts, J., Singewald, N. & Dickson , S., 5 Feb 2020Supervisor: De Bundel, D. (Promotor), Smolders, I. (Co-promotor), beckers, T. (External person) (Co-promotor), Mangelings, D. (Jury), De Kock, J. (Jury), Aerts, J. (Jury), Singewald, N. (External person) (Jury) & Dickson , S. (External person) (Jury)
Student thesis: Doctoral Thesis
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Astrocytic endothelin-1 and cerebral hypoperfusion in multiple sclerosis
Author: Hostenbach, S., Kooijman, R., D'Haeseleer, M., De Keyser, J., De Bundel, D., Versijpt, J., Bissay, V., Van Eeckhaut, A., Hupperts, R. & Hellings, N., 16 Jul 2020Supervisor: Kooijman, R. (Promotor), D'Haeseleer, M. (Promotor), De Keyser, J. (Promotor), De Bundel, D. (Jury), Versijpt, J. (Jury), Van Eeckhaut, A. (Jury), Bissay, V. (Jury), Hupperts, R. (External person) (Jury) & Niels, H. (External person) (Jury)
Student thesis: Doctoral Thesis
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Characterization and reprogramming of umbilical cord-derived mesenchymal stromal cells towards the hepatic lineage
Author: Buyl, K., De Kock, J., Vanhaecke, T., Rogiers, V., De Bundel, D., Hernot, S., Vinken, M., Roskams, T., Najimi, M. & Castell, J., 28 Feb 2017Supervisor: De Kock, J. (Promotor), Vanhaecke, T. (Promotor), Rogiers, V. (Promotor), De Bundel, D. (Jury), Vinken, M. (Jury), Hernot, S. (Jury), Najimi, M. (External person) (Jury), Roskams, T. (External person) (Jury) & Castell, J. V. (External person) (Jury)
Student thesis: Doctoral Thesis
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Cognitive impairment in rodent model of Parkinson's disease
Author: Moons, G., 2016Supervisor: Deroost, N. (Promotor), Massie, A. (Promotor), Kerckhofs, E. (Promotor) & De Bundel, D. (Promotor)
Student thesis: Master's Thesis
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Development and biological evaluation of neuromedin U analogs as tools for functional elucidation: focus on stress-related disorders
Author: De Prins, A., Smolders, I., Ballet, S., Van Eeckhaut, A., De Bundel, D., Caveliers, V., Mangelings, D., Tourwe, D., Vinken, M., Simonin, F. & Van Calenbergh, S., 12 Dec 2018Supervisor: Smolders, I. (Promotor), Ballet, S. (Promotor), Van Eeckhaut, A. (Co-promotor), De Bundel, D. (Co-promotor), Caveliers, V. (Co-promotor), Mangelings, D. (Jury), Tourwe, D. (Jury), Vinken, M. (Jury), Simonin, F. (External person) (Jury) & Van Calenbergh, S. (External person) (Jury)
Student thesis: Doctoral Thesis