Projects per year
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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FWOSB55: A roadmap to the safe introduction of hESC in the clinic: the case of genetic mosaicism in hESC-derived retinal cells
Couvreu De Deckersberg, E. (Mandate), Spits, C. (Administrative Promotor) & Sermon, K. (Co-Promotor)
1/01/19 → 31/12/22
Project: Fundamental
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GAIN OF CHROMOSOME 20Q11.21 PROMOTES GROWTH ADVANTAGE DURING NEUROECTODERMAL DIFFERENTIATION AND DRIVES LINEAGE MIS-SPECIFICATION THROUGH BCL2L1–ID1 COOPERATION
Krivec, N., Lei, Y., Couvreu De Deckersberg, E., Duong, M. C., Huyghebaert, A., Verhulst, S., van Grunsven, L. A., Sermon, K., Al Delbany, D. & Spits, C., 28 Nov 2025, (Unpublished). 1 p.Research output: Unpublished contribution to conference › Poster
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hPSC WITH A GAIN OF 1q OR 20q11.21 RETAIN THEIR GROWTH ADVANTAGE DURING NEUROECTODERM DIFFERENTIATION AND MIS-SPECIFY TOWARDS NON-NEURAL LINEAGES
Krivec, N., Lei, Y., Couvreu De Deckersberg, E., Verhulst, S., van Grunsven, L. A., Sermon, K., Al Delbany, D. & Spits, C., 12 Jun 2025. 1 p.Research output: Unpublished contribution to conference › Poster
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Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells
lei, Y., Duong, C. M., Krivec, N., Janssens, C., Regin, M., Huyghebaert, A., Deckersberg, E. C. D., Sermon, K., Delbany, D. A. & Spits, C., 5 Feb 2025, In: Cell Proliferation. 58, 11, 12 p., e13813.Research output: Contribution to journal › Article › peer-review
Open Access -
The interplay between mitochondrial DNA genotypes, female infertility, ovarian response and mutagenesis in oocytes
Van Der Kelen, A., Li Piani, L., Mertens, J., Regin, M., Couvreu De Deckersberg, E., Van De Velde, H., Sermon, K., Tournaye, H., Verpoest, W., Hes, F. J., Blockeel, C. & Spits, C., 2025, In: Human reproduction open. 2025, 1, 13 p., hoae074.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight
Spits, C., Mertens, J., Belva, F., van Montfoort, A. P., Regin, M., Zambelli, F., Seneca, S., Couvreu De Deckersberg, E., Bonduelle, M.-L., Tournaye, H., Stouffs, K., Barbé, K., Smeets, B., Van De Velde, H., Sermon, K. & Blockeel, C., 9 Feb 2024, In: Nature Communications. 15, 1, p. 1232 16 p., 1232 .Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)51 Downloads (Pure)
Datasets
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Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
Spits, C. (Creator), Krivec, N. (Creator), Al Delbany, D. (Creator), Regin, M. (Creator), Lei, Y. (Creator), Sermon, K. (Creator), Couvreu De Deckersberg, E. (Creator), van Grunsven, L. (Creator) & Verhulst, S. (Creator), VUB Institutional Data Repository, 9 May 2025
Dataset
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Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells
Spits, C. (Creator), Lei, Y. (Creator), Regin, M. (Creator), Krivec, N. (Creator), Huyghebaert, A. (Creator), Couvreu De Deckersberg, E. (Creator), Sermon, K. (Creator), Al Delbany, D. (Creator), Duong, C. M. (Creator) & Janssens, C. (Creator), VUB Institutional Data Repository, 10 Oct 2025
Dataset
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SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss (OPEN)
Spits, C. (Creator), Lei, Y. (Creator), Al Delbany, D. (Creator), Krivec, N. (Creator), Regin, M. (Creator), Couvreu De Deckersberg, E. (Creator), Janssens, C. (Creator), Ghosh, M. (Creator) & Sermon, K. (Creator), VUB Institutional Data Repository, 10 Oct 2025
Dataset
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SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss (RESTRICTED)
Spits, C. (Creator), Lei, Y. (Creator), Al Delbany, D. (Creator), Krivec, N. (Creator), Regin, M. (Creator), Couvreu De Deckersberg, E. (Creator), Janssens, C. (Creator), Ghosh, M. (Creator) & Sermon, K. (Creator), VUB Institutional Data Repository, 10 Oct 2025
Dataset
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Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos
Spits, C. (Creator), Regin, M. (Creator), Lei, Y. (Creator), Couvreu De Deckersberg, E. (Creator), Janssens, C. (Creator), Huyghebaert, A. (Creator), Guns, Y. (Creator), Verheyen, G. (Creator), Van De Velde, H. (Creator) & Sermon, K. (Creator), VUB Institutional Data Repository, 10 Oct 2025
Dataset
Activities
- 6 Talk or presentation at a conference
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Maternally inherited differences in mitochondrial DNA genotype between ART and spontaneously conceived individuals associate with low birthweight
Mertens, J. (Speaker), Belva, F. (Contributor), van Montfoort, A. P. (Contributor), Zambelli, F. (Contributor), Seneca, S. (Contributor), Couvreu De Deckersberg, E. (Contributor), Bonduelle, M.-L. (Contributor), Tournaye, H. (Contributor), Stouffs, K. (Contributor), Barbé, K. (Contributor), Smeets, H. J. M. (Contributor), Van De Velde, H. (Contributor), Sermon, K. (Contributor), Blockeel, C. (Contributor) & Spits, C. (Contributor)
30 Jun 2021Activity: Talk or presentation › Talk or presentation at a conference
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Mitochondrial DNA mosaicism in early human development
Mertens, J. (Speaker), Regin, M. (Contributor), De Munck, N. (Contributor), Couvreu De Deckersberg, E. (Contributor), Blockeel, C. (Contributor), Tournaye, H. (Contributor), Van De Velde, H. (Contributor), Sermon, K. (Contributor) & Spits, C. (Contributor)
17 Sept 2021Activity: Talk or presentation › Talk or presentation at a conference
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Aneuploidy induces proteotoxic stress and autophagy-mediated apoptosis in human preimplantation embryos
Regin, M. (Speaker), Couvreu De Deckersberg, E. (Contributor), Guns, Y. (Contributor), Verdyck, P. (Contributor), Verheyen, G. (Contributor), Van De Velde, H. (Contributor), Spits, C. (Contributor) & Sermon, K. (Contributor)
1 Jul 2021Activity: Talk or presentation › Talk or presentation at a conference
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Aneuploidy induces proteotoxic stress and autophagy-mediated apoptosis in human preimplantation embryos
Regin, M. (Speaker), Lei, Y. (Contributor), Couvreu De Deckersberg, E. (Contributor), Guns, Y. (Contributor), Verdyck, P. (Contributor), Verheyen, G. (Contributor), Van De Velde, H. (Contributor), Spits, C. (Contributor) & Sermon, K. (Contributor)
26 Nov 2021 → 27 Nov 2021Activity: Talk or presentation › Talk or presentation at a conference
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Maternally inherited differences in mitochondrial DNA genotype between ART and spontaneously conceived individuals are aggravated by controlled ovarian stimulation and link to low birth weight
Mertens, J. (Speaker), Belva, F. (Contributor), van Montfoort, A. P. (Contributor), Zambelli, F. (Contributor), Couvreu De Deckersberg, E. (Contributor), Bonduelle, M.-L. (Contributor), Tournaye, H. (Contributor), Stouffs, K. (Contributor), Seneca, S. (Contributor), Barbé, K. (Contributor), Smeets, H. J. M. (Contributor), Van De Velde, H. (Contributor), Sermon, K. (Contributor), Blockeel, C. (Contributor) & Spits, C. (Contributor)
28 Nov 2020Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Impact of recurrent chromosome abnormalities on the transcriptome of human embryonic stem cells.
Couvreu De Deckersberg, E. ((PhD) Student) & Spits, C. (Promotor), Spits, C. (Promotor), 2018Student thesis: Master's Thesis