Projects per year
Personal profile
Expertise
Elke De Bruyne completed a masters degree in Biomedical Sciences at the Vrije Universiteit Brussel (VUB). After obtaining her masters degree, she started her scientific career as a PhD student at the Department of Hematology and Immunology (HEIM) at VUB (Prof. Ben Van Camp and Prof. Karin Vanderkerken). The topic of her PhD was the role of endothelial cells in bone marrow microenvironment-induced modulation of gene-expression of multiple myeloma cells. After obtaining a post-doctoral fellowship of the FWO-Vlaanderen, she remained member of the HEIM lab and became principal investigator for the study on epigenetics in MM focusing on the epigenetic regulation of malignant plasma cells within the supportive bone marrow and the therapeutic and diagnostic potential of broad acting epigenetic modulating agents (e.g. pan-HDACi and DNMTi) in MM.
Currently, she holds a faculty position and supervises a growing team of researchers focussing on epigenetic modifiers and their role in drug resistance in MM and cancer in general. Besides this topic, she is also involved in research projects aiming to explore the therapeutic potential of targeting mitotic exit in combination with standard of care agents for high grade B cell malignancies. Since 2015, she is a member of the scientific committee ‘KomOpTegenKanker’ (expert panel). In 2017, she also became a member of the OPINNO steering committee (flanders.bio)
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FWOSB137: The role of the epiplayer RBBP4 in malignant progression and relapse in multiple myeloma
De Bruyne, E. & Van Hemelrijck, L. A.
1/11/22 → 31/10/26
Project: Fundamental
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ANI302: ExoRAS: a novel, exosome-based K/N-RAS-targeting tool to overcome drug resistance in multiple myeloma
1/10/21 → 30/09/25
Project: Fundamental
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OZR3740: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - KU Leuven, DE COSTER Michiel
22/10/20 → 21/10/24
Project: Fundamental
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OZR3588: Financiering FWO hercules: ERA platform: Extended RNA Analysis platform - version 2.0
Rooman, I., Bouwens, L., Heimberg, H., Neyns, B., Vranken, W., Vanhaecke, T., Massie, A., van Grunsven, L., De Bruyne, E., De Bundel, D., Forsyth, R., Breckpot, K., Van Dooren, S., De Kock, J., Njemini, R. & Laoui, D.
1/05/20 → 30/04/24
Project: Fundamental
Research output
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Aberrant DNA methylation in multiple myeloma: A major obstacle or an opportunity?
Muylaert, C., Van Hemelrijck, L. A., Maes, A., De Veirman, K., Menu, E., Vanderkerken, K. & De Bruyne, E., 18 Aug 2022, In: Frontiers in Oncology. 12, 24 p., 979569.Research output: Contribution to journal › Article › peer-review
Open Access -
Dendritic Cell-Based Immunotherapy in Multiple Myeloma: Challenges, Opportunities, and Future Directions
Verheye, E., Melgar, J. B., Deschoemaeker, S., Raes, G., Maes, A., De Bruyne, E., Menu, E., Vanderkerken, K., Laoui, D. & De Veirman, K., 14 Jan 2022, In: International Journal of Molecular Sciences. 23, 2, 904.Research output: Contribution to journal › Scientific review › peer-review
Open Access6 Citations (Scopus) -
Inhibition of the Protein Arginine Methyltransferase PRMT5 in High-Risk Multiple Myeloma as a Novel Treatment Approach
Vlummens, P., Verhulst, S., De Veirman, K., Maes, A., Menu, E., Moreaux, J., De Bruyne, E., Hose, D., Vanderkerken, K. & Maes, K., 8 Jun 2022, In: Frontiers in cell and developmental biology. 10, 879057.Research output: Contribution to journal › Article › peer-review
Open Access -
Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma
Oudaert, I., Van der Vreken, A., Maes, A., De Bruyne, E., De Veirman, K., Vanderkerken, K. & Menu, E., 1 Sep 2022, In: Experimental Hematology and Oncology. 11, 1, 19 p., 49.Research output: Contribution to journal › Article › peer-review
Open Access -
Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis
Oudaert, I., Satilmis, H., Vlummens, P., De Brouwer, W., Maes, A., Hose, D., De Bruyne, E., Ghesquière, B., Vanderkerken, K., De Veirman, K. & Menu, E., 1 Feb 2022, In: Journal of Experimental & Clinical Cancer Research. 41, 1, p. 45 17 p., 45.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus)
Prizes
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Abstract Achievement Award
De Bruyne, Elke (Recipient), 7 Dec 2012
Prize: Prize (including medals and awards)
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Brian D. Novis Junior Research Award
De Bruyne, Elke (Recipient), 1 Jan 2014
Prize: Prize (including medals and awards)
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Fund Catherina Weekers- King Baudouin Foundation
De Bruyne, Elke (Recipient), 26 Nov 2009
Prize: Prize (including medals and awards)
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Activities
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Research Foundation - Flanders (External organisation)
Elke De Bruyne (Reviewer)
2020 → …Activity: Membership › Membership of peer-review panel or committee
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G9a/GLP targeting blocks myeloma cell growth and survival by suppressing mTOR- and Myc-signaling
Elke De Bruyne (Speaker)
13 Jun 2019Activity: Talk or presentation › Talk or presentation at a conference
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MCL1 Inhibitors in Multiple Myeloma
Kim De Veirman (Contributor), Karin Vanderkerken (Speaker), Elke De Bruyne (Contributor) & Eline Menu (Contributor)
13 Nov 2019Activity: Talk or presentation › Talk or presentation at a conference
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European Hematology Association (External organisation)
Elke De Bruyne (Member)
2019 → …Activity: Membership › Membership of external research organisation
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JoPCaRS for Joined Preclinical Cancer Research Seminars
Cleo Goyvaerts (Chair) & Elke De Bruyne (Chair)
2018 → …Activity: Participating in or organising an event › Participating in or organizing an event at an external academic organisation
Thesis
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Role of endothelial cells in bone marrow microenvironment-induced modulation of the gene expression of multiple myeloma cells’
Author: De Bruyne, E., Vanderkerken, K., Van Riet, I., De Grève, J., Van Ginderachter, J., van Grunsven, L. A., Croucher, P. I., Offner, F. & Van de Velde, A., 28 Jan 2010Supervisor: Vanderkerken, K. (Promotor), Van Riet, I. (Co-promotor), De Greve, J. (Jury), Van Ginderachter, J. (Jury), Van Grunsven, L. A. (Jury), Croucher, P. I. (External person) (Jury), Offner, F. (External person) (Jury) & Van De Velde, A. (External person) (Jury)
Student thesis: Doctoral Thesis