Projects per year
Personal profile
Expertise
After I obtained my Master degree at Vrije Universiteit Brussels, faculty Medicine & Pharmacy, I was selected as a PhD candidate at the lab of Molecular Oncology under supervision of Prof. Dr. Ilse Rooman. Here I finished my master thesis, which was focused on pancreatic acinar dedifferentiation. Currently, I perform a PhD study aiming to establish patient-derived organoids as a reliable and efficient model to study fundamental biology of pancreatic cancer. Extensive tissue characterization and sequencing methods clarify whether these models are suitable to ensure patient identity.
My PhD project is sponsored by Innoser NV - a biomedical CRO service - located both in Belgium and The Netherlands. I am working on their PDXO project aiming to develop an innovative platform to test oncological drugs in a preclinical setting.
Education/Academic qualification
Pancreatic cancer, Masters degree, Vrije Universiteit Brussel
Award Date: 30 Jun 2019
External positions
Employee, Innoser NV
1 Sep 2019 → …
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Collaborations and top research areas from the last five years
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Projects
- 1 Finished
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ANI356: Spatial mapping of pancreatic cancer subtypes and their microenvironmental niches
1/11/23 → 31/10/24
Project: Fundamental
Research output
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Spatial subtyping of pancreatic cancer
Michiels, E., 2025, 108 p.Research output: Thesis › PhD Thesis
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High-resolution and quantitative spatial analysis reveal intra-ductal phenotypic and functional diversification in pancreatic cancer
Michiels, E., Madhloum, H., Van Lint, S., Messaoudi, N., Kunda, R., Martens, S., Giron, P., Olsen, C., Lefesvre, P., Dusetti, N., El Mohajer, L., Tomasini, R., Hawinkels, L. J., Ahsayni, F., Nicolle, R., Arsenijevic, T., Bouchart, C., Van Laethem, J-L. & Rooman, I., Jan 2024, In: Journal of pathology. 262, 1, p. 76-89 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)33 Downloads (Pure) -
Spatial Characterization of B7H3 Expression in PDAC reveals increased Expression in Basal-like Tumor Ducts and αSMA-positive Stromal Cells
De Man, V., Michiels, E., Messaoudi, N., Olsen, C., Giron, P. & Rooman, I., 18 Apr 2024.Research output: Unpublished contribution to conference › Poster
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Spatial Characterization of CD276 (B7H3) Expression in PDAC reveals increased Expression in Basal-like Tumor Ducts and αSMA-positive Stromal Cells
De Man, V., Michiels, E., Messaoudi, N., Olsen, C., Giron, P. & Rooman, I., 23 Oct 2024.Research output: Unpublished contribution to conference › Poster
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Spatial transcriptomic analysis of human Pancreatic Basal Cells reveals PTGES as a potential target for the Basal-Like subtype of Pancreatic Ductal Adenocarcinoma.
Van den Bossche, J-L., Van der Vliet, M., Coolens, K., Michiels, E., Houbracken, I., Baldan, J. & Rooman, I., 18 Apr 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
Datasets
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Dataset for 'High-resolution and quantitative spatial analysis reveal intra-ductal phenotypic and functional diversification in pancreatic cancer'
Michiels, E. (Creator) & Rooman, I. (Creator), VUB Institutional Data Repository, 19 Mar 2025
Dataset
Prizes
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Best oral presentation award: In situ detection of KRAS(G12D) mutations in the spatial context of pancreatic cancer subtypes
Michiels, Ellis (Recipient), 11 Oct 2022
Prize: Prize (including medals and awards)
Activities
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A newly identified basal-luminal stratification of human pancreatic ducts is differentially recapitulated in pancreatic cancers
Jan-Lars Van den Bossche (Speaker), Melissa Van der Vliet (Contributor), Ellis Michiels (Contributor), Oier Azurmendi Senar (Contributor), Zeynep Hazal Madran (Contributor), Silke Van Lint (Contributor), Katarina Coolens (Speaker), Montserrat Nacher (Contributor), Tatjana Arsenijevic (Contributor), Pierre Lefesvre (Contributor), Meritxell Rovira (Contributor), Eduard Montanya (Contributor), Jean-Luc Van Laethem (Contributor), Jonathan Baldan (Contributor), Isabelle Houbracken (Contributor) & Ilse Rooman (Contributor)
23 Oct 2024Activity: Talk or presentation › Talk or presentation at a conference
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High resolution and quantitative intra-ductal spatial analysis reveals phenotypic and functional diversification in pancreatic cancer
Ellis Michiels (Speaker), Ilse Rooman (Contributor), Nouredin Messaoudi (Contributor), Hediel Madhloum (Contributor), Silke Christophe Van Lint (Contributor), Philippe Giron (Contributor), Catharina Olsen (Contributor), Nelson Dusetti (Contributor) & Jean-Luc Van Laethem (Contributor)
30 Apr 2023Activity: Talk or presentation › Talk or presentation at a conference
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In situ detection of KRAS(G12D) mutations in the spatial context of pancreatic cancer subtypes
Ellis Michiels (Speaker), Ilse Rooman (Contributor), Nouredin Messaoudi (Contributor), Catharina Olsen (Contributor), Philippe Giron (Contributor), Pierre Lefesvre (Contributor) & Kim Frederix (Contributor)
8 Oct 2022 → 11 Oct 2022Activity: Talk or presentation › Talk or presentation at a conference
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Charity Quiz PhD United
Ellis Michiels (Chair)
3 Mar 2022Activity: Participating in or organising an event › Participating in or organizing a school event
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Spatial profiling reveals phenotypic diversification at single pancreatic tumor duct level
Ellis Michiels (Speaker) & Ilse Rooman (Speaker)
22 Dec 2022Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
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Setting up a PDXO platform of pancreatic cancer with spatial-omics characterization
27/09/21
1 Media contribution
Press/Media: Public Engagement Activities
Thesis
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MECOM as a transcriptional regulator of pancreatic acinar dedifferentiation
Author: Michiels, E., 30 Jun 2019Supervisor: Rooman, I. (Promotor)
Student thesis: Master's Thesis