Research output per year
Research output per year
Personal profile
Expertise
After I obtained my Master degree at Vrije Universiteit Brussels, faculty Medicine & Pharmacy, I was selected as a PhD candidate at the lab of Molecular Oncology under supervision of Prof. Dr. Ilse Rooman. Here I finished my master thesis, which was focused on pancreatic acinar dedifferentiation. Currently, I perform a PhD study aiming to establish patient-derived organoids as a reliable and efficient model to study fundamental biology of pancreatic cancer. Extensive tissue characterization and sequencing methods clarify whether these models are suitable to ensure patient identity.
My PhD project is sponsored by Innoser NV - a biomedical CRO service - located both in Belgium and The Netherlands. I am working on their PDXO project aiming to develop an innovative platform to test oncological drugs in a preclinical setting.
Education/Academic qualification
Pancreatic cancer, Masters degree, Vrije Universiteit Brussel
Award Date: 30 Jun 2019
External positions
Employee, Innoser NV
1 Sep 2019 → …Fingerprint
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Research output
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Multicellular Modelling of Difficult-To-Treat Gastrointestinal Cancers: Current Possibilities and Challenges
Hakuno, S., Michiels, E., Kuhlemaijer, E., Rooman, I., Hawinkels, L. JAC. & Slingerland, M., 15 Mar 2022, In: International Journal of Molecular Sciences. 23, 6, 15 p., 3147.Research output: Contribution to journal › Scientific review › peer-review
Open AccessFile45 Downloads (Pure) -
Spatial heterogeneity of mutant KRAS expression in the context of pancreatic cancer subtypes
Michiels, E., Messaoudi, N., Rooman, I., Giron, P., Olsen, C., Lefesvre, P. & Frederix, K., 29 Sep 2022.Research output: Unpublished contribution to conference › Poster
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Spatial heterogeneity of mutant KRAS expression in the context of pancreatic cancer subtypes
Michiels, E., Rooman, I., Messaoudi, N., Giron, P., Olsen, C., Frederix, K. & Lefesvre, P., 6 Nov 2022.Research output: Unpublished contribution to conference › Poster
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MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Kurokawa, M., Goyama, S., Bouwens, L., Jacquemin, P., Houbracken, I. & Rooman, I., Sep 2021, In: Cell Death and Differentiation. 28, 9, p. 2601-2615 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)68 Downloads (Pure) -
Setting up a PDXO platform for pancreatic cancer with spatial omics characterization
Michiels, E. & Rooman, I., 5 Oct 2021.Research output: Unpublished contribution to conference › Poster
Prizes
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Best oral presentation award: In situ detection of KRAS(G12D) mutations in the spatial context of pancreatic cancer subtypes
Michiels, Ellis (Recipient), 11 Oct 2022
Prize: Prize (including medals and awards)
Activities
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High resolution and quantitative intra-ductal spatial analysis reveals phenotypic and functional diversification in pancreatic cancer
Ellis Michiels (Speaker), Ilse Rooman (Contributor), Nouredin Messaoudi (Contributor), Hediel Madhloum (Contributor), Silke Christophe Van Lint (Contributor), Philippe Giron (Contributor), Catharina Olsen (Contributor), Nelson Dusetti (Contributor) & Jean-Luc Van Laethem (Contributor)
30 Apr 2023Activity: Talk or presentation › Talk or presentation at a conference
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Spatial profiling reveals phenotypic diversification at single pancreatic tumor duct level
Ellis Michiels (Speaker) & Ilse Rooman (Speaker)
22 Dec 2022Activity: Talk or presentation › Talk or presentation at a conference
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Charity Quiz PhD United
Ellis Michiels (Organiser), Margo Willems (Organiser) & Niels Vandewalle (Organiser)
14 Dec 2022Activity: Participating in or organising an event › Participating in or organizing a school event
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Doctoral Derby: The pre-selection trajectory
Ellis Michiels (Participant)
1 Mar 2022 → 31 Mar 2022Activity: Participating in or organising an event › Participating in or organizing a public lecture/debate
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In situ detection of KRAS(G12D) mutations in the spatial context of pancreatic cancer subtypes
Ellis Michiels (Speaker), Ilse Rooman (Contributor), Nouredin Messaoudi (Contributor), Catharina Olsen (Contributor), Philippe Giron (Contributor), Pierre Lefesvre (Contributor) & Kim Frederix (Contributor)
8 Oct 2022 → 11 Oct 2022Activity: Talk or presentation › Talk or presentation at a conference
Press/Media
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Setting up a PDXO platform of pancreatic cancer with spatial-omics characterization
27/09/21
1 Media contribution
Press/Media: Public Engagement Activities
Thesis
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MECOM as a transcriptional regulator of pancreatic acinar dedifferentiation
Author: Michiels, E., 30 Jun 2019Supervisor: Rooman, I. (Promotor)
Student thesis: Master's Thesis