Projects per year
Personal profile
Expertise
I am a PhD student currently employed at the Laboratory for Molecular and Cellular Therapy (LMCT, VUB). I have obtained a Master degree in Biomedical Sciences at the Vrije Universiteit Brussel. My PhD project is a joint project between the LMCT and ICMI research groups in which I will focus on the development of an in vivo nanoCAR-T cell therapy.
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Dive into the research topics where Fien Meeus is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Projects
- 3 Finished
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ANI395: CARGO: advancing chimeric antigen receptor T cell therapy using nanobodydisplaying lentiviral vectors
Devoogdt, N. (Administrative Promotor) & Meeus, F. (CoI (Co-Promotor))
1/11/24 → 31/10/25
Project: Fundamental
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IOFPOC42: IOF PoC “MOTIF: MOdification of T cells In situ for altered Functionality”
Devoogdt, N. (Administrative Promotor), Breckpot, K. (Co-Promotor), Meeus, F. (Collaborator), De Groof, T. (Collaborator) & De Vlaeminck, Y. (Collaborator)
1/01/21 → 31/12/22
Project: Applied
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FWOSB101: CARGO: advancing chimeric antigen receptor T cell therapy using nanobody-displaying lentiviral vectors
Meeus, F. (Administrative Promotor) & Breckpot, K. (Administrative Promotor)
1/11/20 → 31/10/24
Project: Fundamental
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Hypoxia promotes BCMA loss and a suppressive secretome thereby hindering CAR T cell therapy in multiple myeloma
Tu, C., Van der Vreken, A., Meeus, F., van den Broecke, L., Brons, J., De Veirman, K., Vanderkerken, K., De Bruyne, E., Breckpot, K. & Menu, E., Dec 2026, In: Experimental Hematology and Oncology. 15, 1, 6 p., 1.Research output: Contribution to journal › Article › peer-review
Open Access -
B7-H3 nanobody-based CAR T cells control multiple myeloma growth, while dual BCMA/B7-H3 CAR T cells overcome antigen escape
van der Vreken, A., Meeus, F., Tu, C., van den Broecke, L., Raimondi, V., Vescovini, R., Hanssens, H., Watté, F., Autaers, D., Aragon, M., Billiau, J., De Veirman, K., Vanderkerken, K., De Vlaeminck, Y., Franceschini, L., Lee, H., Neri, P., De Bruyne, E., Storti, P. & Giuliani, N. & 2 others, , 14 Nov 2025, In: Journal of Hematology & Oncology. 18, 17 p., 103.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Design and Preclinical Validation of an Anti-B7-H3-Specific Radiotracer: A Non-Invasive Imaging Tool to Guide B7-H3-Targeted Therapies
Funeh, C. N., Meeus, F., De Groof, T., D'Huyvetter, M. & Devoogdt, N., 30 Sept 2025, In: Pharmaceuticals. 18, 10, 20 p., 1477.Research output: Contribution to journal › Article › peer-review
Open Access -
Preclinical development and selection of nanobody-based CAR-T cells targeting HER2-positive solid tumors
Meeus, F., Van der Vreken, A., Autaers, D., De Groof, T. W. M., Esprit, A., Franceschini, L., Parone, P., Goyvaerts, C., De Vlaeminck, Y., Devoogdt, N. & Breckpot, K., 18 Dec 2025, In: Molecular therapy. Oncology. 33, 4, 16 p., 201088.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Transforming CAR-based therapy using innovative technology platforms
Meeus, F., Bertazzon, G., Autaers, D., Camphyn, E., Franceschini, L. & Breckpot, K., 4 Nov 2025, p. 1. 1 p.Research output: Unpublished contribution to conference › Poster
File3 Downloads (Pure)
Datasets
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Dataset of Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT
De Groof, T. (Creator), Zeven, K. (Creator), Ceuppens, H. (Creator), Awad, R. M. (Creator), Ertveldt, T. (Creator), de Mey, W. (Creator), Meeus, F. (Creator), Raes, G. (Creator), Breckpot, K. (Creator) & Devoogdt, N. (Creator), Zenodo, 24 Mar 2025
Dataset
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B7-H3-targeting nanobody-based CAR-T cells
Breckpot, K. (Creator) & Meeus, F. (Creator), VUB Institutional Data Repository, 20 Jan 2025
Dataset
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HER2-targeting nanobody-based CAR-T cells
Breckpot, K. (Creator) & Meeus, F. (Creator), VUB Institutional Data Repository, 8 Jan 2026
Dataset
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Hypoxia promotes BCMA loss and a suppressive secretome thereby hindering CAR T cell therapy in multiple myeloma
Menu, E. (Creator), Van der Vreken, A. (Creator), Tu, C. (Creator), De Bruyne, E. (Creator), van den Broecke, L. (Creator), Meeus, F. (Creator), Brons, J. (Creator), De Veirman, K. (Creator), Vanderkerken, K. (Creator) & Breckpot, K. (Creator), Gene Expression Omnibus (GEO), 11 Sept 2025
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307311
Dataset
Activities
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Development of an in vitro hot tumor model for immunotherapeutic drug screening
Awad, R. M. (Presenter), Meeus, F. (Contributor), De Vlaeminck, Y. (Contributor), Devoogdt, N. (Contributor) & Breckpot, K. (Contributor)
21 Sept 2022Activity: Talk or presentation › Talk or presentation at a conference
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2021-80
Devoogdt, N. (Supervisor), De Groof, T. (Contributor), Meeus, F. (Contributor), Breckpot, K. (Contributor) & De Vlaeminck, Y. (Contributor)
2021 → …Activity: Other
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WDGO1870: Research And Collaboration Agreement : Development of a nanobody-displaying lentiviral vector platform for in vivo T-Cell modification
Meeus, F. (Contributor)
18 Jun 2021 → 17 Jun 2024Activity: Consultancy › Joint or sponsored appointments or secondments with industry and commerce
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Human relevant models for drug research and development
Meeus, F. (Speaker), Awad, R. M. (Contributor), Devoogdt, N. (Contributor), Tuyaerts, S. (Contributor), Goyvaerts, C. (Contributor), De Vlaeminck, Y. (Contributor), Neyns, B. (Contributor) & Breckpot, K. (Contributor)
8 Oct 2021Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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FWO-SB fellowship: CARGO: advancing chimeric antigen receptor T cell therapy using nanobody-displaying lentiviral vectors.
Meeus, F. (Participant) & Meeus, F. (Contributor)
1 Nov 2020 → 31 Oct 2024Activity: Other › Written proposal
Press/Media
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Betaalbare kankerimmunotherapie
Breckpot, K., Devoogdt, N., De Vlaeminck, Y. & Meeus, F.
8/02/22
1 item of Media coverage
Press/Media: Research
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VUB-onderzoek naar gedeeltelijk falen immuuntherapie
Breckpot, K., Meeus, F. & De Vlaeminck, Y.
3/02/22
1 Media contribution
Press/Media: Research
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VUB-onderzoekers en start-up Esobiotec streven naar betaalbare kankerimmunotherapie
Breckpot, K., Devoogdt, N., De Vlaeminck, Y. & Meeus, F.
31/01/22
1 Media contribution
Press/Media: Research
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VUB-onderzoekers en start-up Esobiotec willen kankerimmunotherapie betaalbaarder maken
Breckpot, K., Devoogdt, N., Meeus, F. & De Vlaeminck, Y.
31/01/22
1 item of Media coverage
Press/Media: Research
Thesis
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Assessment of antigen-binding domain parameters important for adequate CAR-T-cell activation: evaluating different SLAMF7-targeting nanobodies.
Meeus, F. ((PhD) Student), Hanssens, H. ((PhD) Student), De Veirman, K. (Co-promotor) & Devoogdt, N. (Promotor), Hanssens, H. (Advisor), 19 Jun 2020Student thesis: Master's Thesis