Projects per year
Personal profile
Expertise
MD PhD with expertise in deep phenotyping using various OMICS tools (genomics, transcriptomics, metabolomics, proteomics) for cell biology and IVD applications.
MD with specific expertise in: (i) biochemical diagnosis of inborn errors of metabolism using chromatographic techniques; (ii) molecular diagnostics: genomic analysis of solid and hematological tumors using DNA/RNA sequencing and qPCR and prenatal diagnosis using genome wide NIPT; (iii) clinical validation of bioinformatic pipelines.
Researcher with specific expertise in (i) beta cell therapy in type 1 diabetes & deep phenotyping of pancreatic beta cells in vitro; (ii) cell biology of beta cell death & differentiation; (iii) metabolomic profiling of extreme metabolic phenotypes using high-resolution metabolimics on Waters VION IMS QTOF; (iv) biomarker identification and prototype assay development (high-sensitivity immunoassays for protein biomarkers and targeted PCR for DNA or microRNA markers); (v) integrated profiling of pathogenic variants in tumors.
Senior lecturer at Vrije Universiteit Brussel (Course: Integrative physiology and systems biology, 3rd bachelor medical school)
Independent consultant at AZ Delta general hospital.
External positions
Head of Molecular Diagnostics, AZ Delta, Department of Laboratory Medicine
1 Sep 2016 → …Fingerprint
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Projects
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AIIFUND37: Medical Grant agreement SOBI:High-Resolution Metabolomics of the NTBC-primed HT1 metabolism
8/10/18 → …
Project: Fundamental
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HERC36: advanced Metabolomics Platform consisting of two complementary LC-MS/MS analyzers
Martens, G., Van Eeckhaut, A., Smolders, I., De Bundel, D., De Kock, J., Rogiers, V., Marcelino Rodrigues, R., Menu, E., Vander Heyden, Y., van Grunsven, L., Mortier, A., Vanhaecke, T. & Mangelings, D.
1/05/16 → 30/04/20
Project: Applied
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IWT703: Circulating nucleic acids as high-sensitivity biomarkers for occult beta cell destruction in type 1 diabetes
1/01/15 → 31/12/18
Project: Fundamental
Research output
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Belgian rare diseases plan in clinical pathology: identification of key biochemical diagnostic tests and establishment of reference laboratories and financing conditions
Advisory Board of the Action 1 of the Belgian National Plan for Rare Diseases, 17 Feb 2021, In : Orphanet Journal of Rare Diseases. 16, 1, 16 p., 89.Research output: Contribution to journal › Article
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Oxidative Stress, Glutathione Metabolism, and Liver Regeneration Pathways Are Activated in Hereditary Tyrosinemia Type 1 Mice upon Short-Term Nitisinone Discontinuation
Colemonts-Vroninks, H., Neuckermans, J., Marcelis, L., Claes, P., Branson, S., Casimir, G., Goyens, P., Martens, G. A., Vanhaecke, T. & De Kock, J., Jan 2021, In : Genes. 12, 1, p. 1-16 16 p., 3.Research output: Contribution to journal › Article
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Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality
De Smet, D., De Smet, K., Herroelen, P., Gryspeerdt, S. & Martens, G. A., 11 Feb 2021, In : American Journal of Clinical Pathology. 155, 3, p. 381-388 8 p.Research output: Contribution to journal › Article
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Diagnostic Performance of Chest CT for SARS-CoV-2 Infection in Individuals with or without COVID-19 Symptoms
De Smet, K., De Smet, D., Ryckaert, T., Laridon, E., Heremans, B., Vandenbulcke, R., Demedts, I., Bouckaert, B., Gryspeerdt, S. & Martens, G. A., 10 Aug 2020, In : Radiology. 298, 1, p. E30-E37 8 p.Research output: Contribution to journal › Article
2 Citations (Scopus) -
Humoral Immune Response to SARS-CoV-2
Herroelen, P. H., Martens, G. A., De Smet, D., Swaerts, K. & Decavele, A-S., 2020, In : American Journal of Clinical Pathology. 154, 5, p. 610-619 10 p.Research output: Contribution to journal › Article
5 Citations (Scopus)
Prizes
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Senior Clinical Investigator Grant Research Foundation Flanders (FWO)
Geert Martens (Recipient), 2011
Prize: Prize (including medals and awards)
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Activities
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Society for the Study of Inborn Errors of Metabolism (SSIEM) (External organisation)
Geert Martens (Member)2012 → 2016Activity: Membership › Membership of public/government advisory/policy group or panel
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European Association for the Study of Diabetes (EASD) (External organisation)
Geert Martens (Member)2012 → 2016Activity: Membership › Membership of external research organisation
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Erfelijke Stofwisselingsziekten Nederland (External organisation)
Geert Martens (Member)2012Activity: Membership › Membership of external research organisation
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Annual Symposium Belgische Vereniging voor Klinische Biologie en Klinische Chemie
Geert Martens (Participant)16 Oct 2010Activity: Participating in or organising an event › Participation in workshop, seminar
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Unknown (External organisation)
Geert Martens (Member)2007 → …Activity: Membership › Membership of external research organisation
Thesis
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A search for markers that label progenitor cells in adult pancreas
Author: Marien, K., Heimberg, H., Martens, G. & Bonne, S., 2010Supervisor: Heimberg, H. (Promotor), Martens, G. (Advisor) & Bonne, S. (Advisor)
Student thesis: Master's Thesis
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Circulerend miR-375 als biomerker voor beta cel destructie in type 1 diabetes.
Author: Vandervore, L. & Roels, S., 2015Supervisor: Martens, G. (Promotor)
Student thesis: Master's Thesis
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Development of advanced immunoassays for subpicomolar detection of plasma GAD65 as biomarker of beta cell destruction
Author: Costa, O., Martens, G., Gorus, F., Schots, H., Dupont, A., Jacobs-Tulleneers-Thevissen, D., Lampasona, V. & Lapauw, B., 22 Feb 2017Supervisor: Martens, G. (Promotor), Gorus, F. (Promotor), Schots, R. (External person) (Jury), Dupont, A. (Jury), Lampasona, V. (External person) (Jury), Lapauw, B. (External person) (Jury) & Jacobs-Tulleneers-Thevissen, D. (Jury)
Student thesis: Doctoral Thesis
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Diagnostisch gebruik van microRNA-375 als ultragevoelige biomerker voor de occulte ß-cel destructie in een preklinisch diermodel van type 1 diabetes.
Author: Philips, K., Roels, S. & Caveliers, V., 2016Supervisor: Martens, G. (Promotor)
Student thesis: Master's Thesis
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Discovery of novel biomarkers for real-time detection of beta cell injury
Author: Jiang, L., Martens, G., Lahoutte, T., Hinke, S., Vandekerckhove, J., Bossuyt, X., Delvaux, G. & In 'T Veld, P., 25 Mar 2013Supervisor: Martens, G. (Promotor), Lahoutte, T. (Jury), Delvaux, G. (Jury), In 'T Veld, P. (Jury), Hinke, S. (External person) (Jury), Vandekerckhove, J. (External person) (Jury) & Bossuyt, X. (External person) (Jury)
Student thesis: Doctoral Thesis