Projects per year
Personal profile
Expertise
PhD student with a focus on cell-based cancer (immuno)therapy and targeted cancer imagig. Experienced in nanobody generation, protein expression and purification, (in vivo) molecular nuclear imaging, flow cytometry, radioactive labelings, surface plasmon resonance, cell culture, subcloning and cell-based assays.
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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FWOSB58: Development of a NanoCAR-T cell approach for the treatment of multiple myeloma
Hanssens, H., Devoogdt, N., De Veirman, K. & Breckpot, K.
1/01/19 → 31/12/23
Project: Fundamental
Research output
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Anti-Idiotypic VHHs and VHH-CAR-T Cells to Tackle Multiple Myeloma: Different Applications Call for Different Antigen-Binding Moieties
Hanssens, H., Meeus, F., Gesquiere, E. L., Puttemans, J., Vlaeminck, Y. D., Veirman, K. D., Breckpot, K. & Devoogdt, N., 22 May 2024, In: International Journal of Molecular Sciences. 25, 11, 16 p., 5634.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Optimizing CAR-T cell therapy for multiple myeloma by exploiting the advantageous properties of VHH antigen-binding domains
Hanssens, H., 2024, 189 p.Research output: Thesis › PhD Thesis
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Scrutiny of chimeric antigen receptor activation by the extracellular domain: experience with single domain antibodies targeting multiple myeloma cells highlights the need for case-by-case optimization
Hanssens, H., Meeus, F., De Vlaeminck, Y., Lecocq, Q., Puttemans, J., Debie, P., De Groof, T. W. M., Goyvaerts, C., De Veirman, K., Breckpot, K. & Devoogdt, N., 2024, In: Frontiers in Immunology. 15, 15 p., 1389018.Research output: Contribution to journal › Article › peer-review
Open Access -
Emerging applications of nanobodies in cancer therapy
Awad, R. M., Meeus, F., Ceuppens, H., Ertveldt, T., Hanssens, H., Lecocq, Q., Mateusiak, L., Zeven, K., Valenta, H., De Groof, T. W. M., De Vlaeminck, Y., Krasniqi, A., De Veirman, K., Goyvaerts, C., D'Huyvetter, M., Hernot, S., Devoogdt, N. & Breckpot, K., 2022, In: International review of cell and molecular biology. 369, p. 143-199 57 p.Research output: Contribution to journal › Scientific review › peer-review
Open AccessFile14 Citations (Scopus)430 Downloads (Pure) -
The antigen-binding moiety in the driver's seat of CARs
Hanssens, H., Meeus, F., De Veirman, K., Breckpot, K. & Devoogdt, N., Jan 2022, In: Medicinal Research Reviews. 42, 1, p. 306-342 37 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)48 Downloads (Pure)
Prizes
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Development of a nanoCAR-T cell approach for the treatment of multiple myeloma
Hanssens, Heleen (Recipient), Devoogdt, Nick (Recipient), De Veirman, Kim (Recipient) & Breckpot, Karine (Recipient), 15 Dec 2021
Prize: Fellowship awarded competitively
Activities
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LSM-PhD Day 2023
Niels Vandewalle (Organiser), Heleen Hanssens (Organiser), Hamide Yildirim (Organiser), Arne Wyns (Organiser), Lien Ann Van Hemelrijck (Organiser), Catharina Muylaert (Organiser), Charlotte Janssens (Organiser), Michiel De Coster (Organiser), Laura De Pauw (Organiser) & Océane Vanonckelen (Organiser)
28 Mar 2023Activity: Participating in or organising an event › Participation in conference
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Charity Quiz PhD United 2023
Niels Vandewalle (Organiser), Febe Geirnaert (Organiser), Arne Wyns (Organiser), Catharina Muylaert (Organiser), Jarne Walckiers (Organiser), Milan Lobo (Organiser), Océane Vanonckelen (Organiser), Lien Ann Van Hemelrijck (Organiser), Jente Van Campenhout (Organiser), Melissa Van der Vliet (Organiser), Heleen Hanssens (Organiser), Charlotte Janssens (Organiser), Michiel De Coster (Organiser), Jan-Lars Van den Bossche (Organiser) & Katarina Coolens (Organiser)
14 Dec 2023Activity: Participating in or organising an event › Participating in or organizing a school event
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WFWG 2021: Development of a nanoCAR-T cell approach for the treatment of multiple myeloma
Heleen Hanssens (Organiser)
1 Jan 2022 → 1 Jan 2026Activity: Other › Written proposal
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Granted Project Scientific Fund Willy Gepts: Development of a nanoCAR-T cell approach for the treatment of multiple myeloma
Heleen Hanssens (Supervisor), Nick Devoogdt (Supervisor) & Karine Breckpot (Supervisor)
1 Jan 2022 → 1 Jan 2026Activity: Other
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EHA-EBMT 3rd European CAR T-Cell Meeting
Heleen Hanssens (Participant)
4 Feb 2021 → 6 Feb 2021Activity: Participating in or organising an event › Participation in conference
Thesis
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Development of a NanoCAR approach for the treatment of multiple myeloma
Author: Devoogdt, N., Breckpot, K., De Veirman, K. & Hanssens, H., 2022Student thesis: Doctoral Thesis
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Generation and validation of nanobodies targeting brain tumors with aberrant expression of epidermal growth factor receptor and human epidermal growth factor receptor 2
Author: Hanssens, H., Devoogdt, N., Muyldermans, S. & Puttemans, J., 13 Sep 2018Supervisor: Puttemans, J. (Advisor)
Student thesis: Master's Thesis