Projects per year
Personal profile
Expertise
PhD student with a focus on cell-based cancer (immuno)therapy and targeted cancer imagig. Experienced in nanobody generation, protein expression and purification, (in vivo) molecular nuclear imaging, flow cytometry, radioactive labelings, surface plasmon resonance, cell culture, subcloning and cell-based assays.
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Collaborations and top research areas from the last five years
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Projects
- 1 Active
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FWOSB58: Development of a NanoCAR-T cell approach for the treatment of multiple myeloma
Hanssens, H., Devoogdt, N., De Veirman, K. & Breckpot, K.
1/01/19 → 31/12/23
Project: Fundamental
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Emerging applications of nanobodies in cancer therapy
Awad, R. M., Meeus, F., Ceuppens, H., Ertveldt, T., Hanssens, H., Lecocq, Q., Mateusiak, L., Zeven, K., Valenta, H., De Groof, T. W. M., De Vlaeminck, Y., Krasniqi, A., De Veirman, K., Goyvaerts, C., D'Huyvetter, M., Hernot, S., Devoogdt, N. & Breckpot, K., 2022, In: International review of cell and molecular biology. 369, p. 143-199 57 p.Research output: Contribution to journal › Scientific review › peer-review
Open AccessFile7 Citations (Scopus)218 Downloads (Pure) -
The antigen-binding moiety in the driver's seat of CARs
Hanssens, H., Meeus, F., De Veirman, K., Breckpot, K. & Devoogdt, N., Jan 2022, In: Medicinal Research Reviews. 42, 1, p. 306-342 37 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)18 Downloads (Pure) -
The road to personalized myeloma medicine: Patient-specific single-domain antibodies for anti-idiotypic radionuclide therapy
Puttemans, J., Stijlemans, B., Keyaerts, M., Vander Meeren, S., Renmans, W., Fostier, K., Debie, P., Hanssens, H., Rodak, M., Pruszynski, M., De Veirman, K., Vanderkerken, K., Lahoutte, T., Morgenstern, A., Bruchertseifer, F., Devoogdt, N. & D'Huyvetter, M., Jan 2022, In: Molecular Cancer Therapeutics. 21, 1, p. 159-169 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)87 Downloads (Pure) -
CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma
De Veirman, K., Puttemans, J., Krasniqi, A., Ertveldt, T., Hanssens, H., Romao, E., Hose, D., Goyvaert, C., Vlummens, P., Muyldermans, S., Breckpot, K., Bruchertseifer, F., Morgenstern, A., D'Huyvetter, M. & Devoogdt, N., 2021, In: Oncoimmunology. 10, 1, 11 p., 2000699.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality
Baudhuin, H., Puttemans, J., Hanssens, H., Vanwolleghem, P., Hernot, S., Raes, G., Xavier, C., Lahoutte, T. & Debie, P., May 2021, In: Pharmaceuticals. 14, 5, 19 p., 407.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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Development of a nanoCAR-T cell approach for the treatment of multiple myeloma
Hanssens, Heleen (Recipient), Devoogdt, Nick (Recipient), De Veirman, Kim (Recipient) & Breckpot, Karine (Recipient), 15 Dec 2021
Prize: Fellowship awarded competitively
Activities
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LSM-PhD Day 2023
Niels Vandewalle (Organiser), Heleen Hanssens (Organiser), Hamide Yildirim (Organiser), Arne Wyns (Organiser), Lien Ann Van Hemelrijck (Organiser), Catharina Muylaert (Organiser), Charlotte Janssens (Organiser), Michiel De Coster (Organiser) & Laura De Pauw (Organiser)
28 Mar 2023Activity: Participating in or organising an event › Participation in conference
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WFWG 2021: Development of a nanoCAR-T cell approach for the treatment of multiple myeloma
Heleen Hanssens (Organiser)
1 Jan 2022 → 1 Jan 2026Activity: Other › Written proposal
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Granted Project Scientific Fund Willy Gepts: Development of a nanoCAR-T cell approach for the treatment of multiple myeloma
Heleen Hanssens (Supervisor), Nick Devoogdt (Supervisor) & Karine Breckpot (Supervisor)
1 Jan 2022 → 1 Jan 2026Activity: Other
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EHA-EBMT 3rd European CAR T-Cell Meeting
Heleen Hanssens (Participant)
4 Feb 2021 → 6 Feb 2021Activity: Participating in or organising an event › Participation in conference
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VUB Phd Day 2021
Heleen Hanssens (Chair)
27 May 2021Activity: Participating in or organising an event › Participating in or organizing a public lecture/debate
Thesis
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Development of a NanoCAR approach for the treatment of multiple myeloma
Author: Devoogdt, N., Breckpot, K., De Veirman, K. & Hanssens, H., 2022Student thesis: Doctoral Thesis
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Generation and validation of nanobodies targeting brain tumors with aberrant expression of epidermal growth factor receptor and human epidermal growth factor receptor 2
Author: Hanssens, H., Devoogdt, N., Muyldermans, S. & Puttemans, J., 13 Sep 2018Supervisor: Puttemans, J. (Advisor)
Student thesis: Master's Thesis