Projects per year
Personal profile
Expertise
(i) glucose sensing system in alpha- and beta cells, (ii) transcription factors that support the phenotype of beta cells and control reprogramming of non-beta cells of the endocrine pancreas, (iii) development of experimental models to study beta cell neogenesis by differentiation from stem/progenitor cells and by proliferation of preexisting and newly formed beta cells.
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Collaborations and top research areas from the last five years
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FWOTM1142: Deciphering the involvement of iron metabolism in beta cell differentiation, maturation, and function.
Staels, W. (Administrative Promotor), De Leu, N. (Co-Promotor), Heimberg, H. (Co-Promotor) & Van Mulders, A. (Mandate)
1/11/22 → 31/10/26
Project: Fundamental
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GIFTFD19: Bankgiftovereenkomst: schenking onderzoek "Signals to preserve the functional beta cell mass in diabetes"
Heimberg, H. (Administrative Promotor)
28/11/19 → …
Project: Applied
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OZR2723: ULB-VUB Joint Research Group: Brussels Diabetes Research Pole - BDRP
Heimberg, H. (Administrative Promotor), Devoogdt, N. (Collaborator) & Cnop, M. (Co-Promotor)
5/11/14 → 2/10/28
Project: Fundamental
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AII43: Statement of intent for the SPEED BCBC Collaborative Bridging Project (CBP): Secreted Proteins from Endothelal cells for Endocrine Development (SPEED)
Heimberg, H. (Administrative Promotor)
7/10/08 → …
Project: Fundamental
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ADSI146: Internal regularisation.
Heimberg, H. (Administrative Promotor)
14/09/07 → …
Project: Fundamental
Research output
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Transient ER stress cell-autonomously promotes beta cell cycling in mice
Bourgeois, S., Van Mulders, A., Heremans, Y., Leuckx, G., Willems, L., Coenen, S., Degroote, L., Pierreux, J., Kancheva, D., Scheyltjens, I., Movahedi, K., Carlotti, F., de Koning, E., Yi, X., Vinci, C., Tong, Y., Cnop, M., Heimberg, H., De Leu, N. & Staels, W., May 2026, In: Diabetologia. 69, 5, p. 1265-1281 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)4 Downloads (Pure) -
ER stress relief drives ß-cell proliferation
Bourgeois, S., Staels, W., Van Mulders, A., Willems, L., Coenen, S., Degroote, L., Pierreux, J., Leuckx, G., Heremans, Y., De Leu, N., Heimberg, H., Cnop, M., Ye, X., Movahedi, K., Kancheva, D., Scheyltjens, I., de, K. E. & Carlotti, F., 16 Nov 2024, p. 316. 317 p.Research output: Unpublished contribution to conference › Unpublished abstract
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ER stress relief drives ß-cell proliferation
Bourgeois, S., Van Mulders, A., Leuckx, G., Heremans, Y., Willems, L., Coenen, S., Degroote, L., Pierreux, J., Kancheva, D., Scheyltjens, I., Movahedi, K., Carlotti, F., de Koning , E., Yi, X., Vinci, C., Tong, Y., Cnop, M., Heimberg, H., De Leu, N. & Staels, W., Sept 2024, Biorxiv, 34 p.Research output: Working paper › Preprint
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ER stress relief drives β-cell proliferation
Bourgeois, S., Staels, W., Van Mulders, A., Willems, L., Coenen, S., Degroote, L., Pierreux, J., Leuckx, G., Heremans, Y., De Leu, N., Heimberg, H., Cnop, M., Yi, X., Movahedi, K., Kancheva, D., Scheyltjens, I., de Koning, E. & Carlotti, F., Oct 2024, In: Hormone Research in Paediatrics. 97, p. 316-317 2 p.Research output: Contribution to journal › Meeting abstract (Journal)
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Correction: Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas (Cell Stem Cell (2021) 28(11) (2000–2008.e4), (S1934590921003404), (10.1016/j.stem.2021.08.003))
Gribben, C., Lambert, C., Messal, H. A., Hubber, E.-L., Rackham, C., Evans, I., Heimberg, H., Jones, P., Sancho, R. & Behrens, A., 6 Apr 2023, In: Cell Stem Cell. 30, 4, p. 498-499 2 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)79 Downloads (Pure)
Prizes
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Belgian Endocrine Society Annual Lecture Award
Heimberg, H. (Recipient), 2002
Prize: Prize (including medals and awards)
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EASD/Eli Lilly Research Fellowship in Diabetes and Metabolism
Heimberg, H. (Recipient), 2001
Prize: Prize (including medals and awards)
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Fulbright-Hays Award for Research
Heimberg, H. (Recipient), 1994
Prize: Prize (including medals and awards)
Activities
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Phd defence of Wissal Allaoui "Shedding light on the expression and function of neuromedin U in the brain" (Event)
Vander Heyden, Y. (Jury), De Kock, J. (Jury), Heimberg, H. (Jury), Beets, I. (Jury) & Seuntjens, E. (Jury)
7 Sept 2023Activity: Membership › Member of PhD committee
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A novel basal DeltaNP63 (P40)-expressing pancreatic cell type undergoes expansion and reorganization in chronic pancreatitis
Rooman, I. (Speaker), Martens, S. (Contributor), Van Bulck, M. (Contributor), Coolens, K. (Contributor), Esni, F. (Contributor), Leuckx, G. (Contributor), Heimberg, H. (Contributor), Bouwens, L. (Contributor), Jacquemin, P. (Contributor), Spagnoli, F. (Contributor), Real, F. X. (Contributor), in 't Veld, P. (Contributor) & Lesfevre, P. (Contributor)
11 Oct 2020Activity: Talk or presentation › Talk or presentation at a conference
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Stamcellen als therapie voor diabetes
Heimberg, H. (Participant)
Sept 2010Activity: Participating in or organising an event › Participating in or organizing a public lecture/debate
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Invited chair and organizer of the scientific program of the 15th EASD Oxford Hagedorn Workshop
Heimberg, H. (Organiser)
Aug 2010Activity: Participating in or organising an event › Participation in workshop, seminar
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Diabetes genezen met stamcellen
Heimberg, H. (Participant)
Apr 2010Activity: Participating in or organising an event › Participating in or organizing a public lecture/debate
Thesis
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Endothelial cells in beta cell generation and protection
Salinno, C. ((PhD) Student), Heimberg, H. (Promotor), De Leu, N. (Advisor) & De Groef, S. (Advisor), De Leu, N. (Advisor), 2015Student thesis: Master's Thesis
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Generation of ligand activated sentinels embedded in Rosa26 to study intercellular signaling in ES cells and mice”
Gustavsen, C. R. ((PhD) Student), Serup, P. (Promotor), Nielsen, J. H. (Co-promotor) & Heimberg, H. (Jury), Aug 2014Student thesis: Doctoral Thesis
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Genetische tracering van pancreatische transdifferentiatie
Houbracken, I. ((PhD) Student), Heimberg, H. (Co-promotor) & Bouwens, L. (Promotor), Bouwens, L. (Promotor) & Heimberg, H. (Co-promotor), 28 Jun 2005Student thesis: Master's Thesis
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Human Pancreatic Acinar Cell Plasticity.
Baldan, J. ((PhD) Student), Arnes, L. (Jury), Jacquemin, P. (Jury), Spits, C. (Jury), Heimberg, H. (Jury), Sermon, K. (Jury) & Bouwens, L. (Promotor), Arne, L. (Jury), Jacquemin, P. (Jury), Spits, C. (Jury), Heimberg, H. (Jury), Segers, K. (Jury) & Bouwens, L. (Promotor), 28 Sept 2020Student thesis: Doctoral Thesis
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Identification des gènes cibles du facteur de transcription Neurogenin 3 et étude de leur fonction au cours du développement pancréatique
Soyer, J. ((PhD) Student), Mellitzer, G. (Promotor) & Heimberg, H. (Jury), Oct 2009Student thesis: Doctoral Thesis