Projects per year
Personal profile
Expertise
Prof. I. Rooman has a main interest and expertise in pancreatic cell biology and pancreatic cancer, in particular tumour development, cell plasticity and regeneration.
Ilse Rooman was educated at the Vrije Universiteit Brussel (VUB), where she obtained her PhD in 2002, studying cellular plasticity in the pancreatic organ. Within the same research area, she also completed two postdoctoral research projects, one of which at the Institut Municipal d'Investigació Mèdica in Spain. In 2011, she was appointed as a group leader at the Garvan Institute of Medical Research in Australia. Most of her basic research was devoted at finding new genes and pathways that are aberrantly expressed in pancreatic tumour development (hypothesis driven approach and unbiased integrative –omics analyses). Prof. Rooman and her team established powerful models to analyse the initiation of pancreatic cancer, and its relation with pancreatitis. The research has a strong translational focus and aims for early detection, biomarker discovery and development of therapeutic and prevention strategies. In 2016 she returned to Belgium and took the position of Program Manager for Pancreatic Cancer at the Anticancer Fund, managing preclinical and clinical research projects. She was granted an Odysseus fellowship from the Fund for Scientific Research (FWO) to build a research team at the VUB.
Apart from the aforementioned Odysseus grant, Prof. Rooman has had prestigious fellowships and funding from the Fund for Scientific Research Flanders, the European Union - Marie Curie Program, the Francqui Foundation, the Cancer Institute New South Wales and the National Health & Medical Research Council Australia. She makes regular contributions to peer review of manuscripts and serves on several grant/fellowship review panels.
External positions
Program Director (Pancreatic Cancer), Anticancer Fund (Strombeek-Bever)
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Network
Projects
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VOPPU95: VOPPU95 - Prijs Kankeronderzoek 2020 - Elyne Backx
Rooman, I., Houbracken, I. & Backx, E.
1/02/21 → 31/07/21
Project: Fundamental
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VOPPU95: VOPPU95 - Prijs Kankeronderzoek 2020 - Mathias Van Bulck
1/01/21 → 30/06/21
Project: Fundamental
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FWOTM1010: Characterization of a novel cell population in the pancreas expressing the stem cell marker ΔNp63.
1/11/20 → 31/10/22
Project: Fundamental
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OZR3588: Financiering FWO hercules: ERA platform: Extended RNA Analysis platform - version 2.0
Rooman, I., Bouwens, L., Heimberg, H., Neyns, B., Vranken, W., Vanhaecke, T., Massie, A., van Grunsven, L., De Bruyne, E., De Bundel, D., Forsyth, R., Breckpot, K., Van Dooren, S., De Kock, J., Njemini, R. & Laoui, D.
1/05/20 → 30/04/24
Project: Fundamental
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SRP65: SRP-Groeifinanciering: Molecular Portrait of Pancreatic Tumours: Veni, vidi, vici
1/03/19 → 29/02/24
Project: Fundamental
Research output
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Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin
Espinet, E., Gu, Z., Imbusch, C. D., Giese, N. A., Buscher, M., Safavi, M., Weisenburger, S., Klein, C., Vogel, V., Falcone, M., Insua-Rodriguez, J., Reitberger, M., Thiel, V., Kossi, S. O., Muckenhuber, A., Sarai, K., Lee, A. Y., Backx, E., Zarei, S., Gaida, M. M. & 18 others, , Mar 2021, In : Cancer discovery. 11, 3, p. 638-659 22 p.Research output: Contribution to journal › Article
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Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
Glasgow Precision Oncology Laboratory, & Rooman, I., Jan 2021, In : Gastroenterology. 160, 1, p. 362-377.e13 16 p.Research output: Contribution to journal › Article
4 Citations (Scopus) -
HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
Glasgow Precision Oncology Laboratory, Brunton, H., Caligiuri, G., Cunningham, R., Upstill-Goddard, R., Bailey, U-M., Garner, I. M., Nourse, C., Dreyer, S., Jones, M., Moran-Jones, K., Wright, D. W., Paulus-Hock, V., Nixon, C., Thomson, G., Jamieson, N. B., McGregor, G. A., Evers, L., McKay, C. J., Gulati, A. & 25 others, , 12 May 2020, In : Cell Reports. 31, 6, 28 p., 107625.Research output: Contribution to journal › Article
8 Citations (Scopus) -
Inflammation enables pancreatic acinar cells to overcome resistance to oncogenic Kras by increasing its expression and plasma membrane localization.
Assi, M. N., Lodewyckx, J-N., Achouri, Y., Gerard, C., Dauguet, N., Houbracken, I., Heremans, Y., Tyteca, D., Rooman, I., Bouwens, L., Lemaigre, F. & Jacquemin, P., May 2020, In : MOLECULAR CANCER RESEARCH. 18, 5, p. 36-36Research output: Contribution to journal › Meeting abstract (Journal)
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Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice
Chellakkan Selvanesan, B., Meena, K., Beck, A., Meheus, L., Lara, O., Rooman, I. & Gravekamp, C., 5 Nov 2020, In : Journal for immunotherapy of cancer. 8, 2, 14 p., e001250.Research output: Contribution to journal › Article
Open AccessFile8 Downloads (Pure)
Prizes
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Ishango-prize for young scientists
Ilse Rooman (Recipient), 2003
Prize: Prize (including medals and awards)
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Posterprize Belgian Society of Cellbiology
Ilse Rooman (Recipient), 1996
Prize: Prize (including medals and awards)
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Prize of the Fund Dr. Karel-Lodewijk Verleysen
Ilse Rooman (Recipient), 2002
Prize: Prize (including medals and awards)
Activities
- 1 Research and Teaching at External Organisation
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Characterisation of exocrine cells from adult rodent pancreas and their phenotypic plasticity in pancreatic pathology and regeneration
Ilse Rooman (Member)1 Nov 2005 → 31 Oct 2007Activity: Other › Research and Teaching at External Organisation
Thesis
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Cell-Autonomous Role of ROBO2 in Pancreatic and Lung Cancer
Author: Lapaille, D., 2020Supervisor: Rooman, I. (Promotor), Noeparast, M. (Co-promotor) & Houbracken, I. (Advisor)
Student thesis: Master's Thesis
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Exosomal Communication in Multiple Myeloma-Friend or Foe-
Author: Faict, S., Menu, E., Vanderkerken, K., Schots, R., Jernberg-Wiklund, H., De Wever, O., van Grunsven, L. A., Rooman, I. & Breckpot, K., 23 Sep 2019Supervisor: Menu, E. (Promotor), Vanderkerken, K. (Promotor), Schots, R. (External person) (Promotor), Jerneberg-Wiklund, H. (External person) (Jury), De Wever, O. (External person) (Jury), van Grunsven, L. (Jury), Rooman, I. (Jury) & Breckpot, K. (Jury)
Student thesis: Doctoral Thesis
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Formation of a functional Beta Cell Mass by microencapsulated prenatal procine islet cells
Author: De Mesmaeker, I., Keymeulen, B., Pipeleers, D., Dupont, A., Rooman, I., Smolders, I., Piemonti, L. & Ysebaert, D., 16 Jul 2020Supervisor: Keymeulen, B. (Promotor), Pipeleers, D. (Promotor), Dupont, A. (Jury), Rooman, I. (Jury), Smolders, I. (Jury), Piemonti , L. (External person) (Jury) & Ysebaert, D. (External person) (Jury)
Student thesis: Doctoral Thesis
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Gene regulation by lentiviral vectors and epigenetic modifications in multiple myeloma
Author: Bos, T., Vanderkerken, K., Van Schravendijk, C., Rooman, I., Heimberg, H., van Grunsven, L. A., Öberg, F. & Baekelandt, V., 21 Dec 2010Supervisor: Vanderkerken, K. (Promotor), Van Schravendijk, C. (Jury), Rooman, I. (Jury), Heimberg, H. (Jury), Van Grunsven, L. A. (Jury), Öberg, F. (External person) (Jury) & Baekelandt, V. (External person) (Jury)
Student thesis: Doctoral Thesis
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Immunosenescence, pre-frailty and impact of exercise in older persons.
Author: Cao Dinh, H., Njemini, R., Bautmans, I., Maggio, M., Chainiaux, F., Rooman, I., Demanet, C. & Beckwée, D., 11 Sep 2018Supervisor: Njemini, R. (Promotor), Bautmans, I. (Co-promotor), Maggio, M. (External person) (Jury), Chainiaux, F. (External person) (Jury), Rooman, I. (Jury), Demanet, C. (Jury) & Beckwee, D. (Jury)
Student thesis: Doctoral Thesis