Projects per year
Personal profile
Expertise
Prof. I. Rooman has a main interest and expertise in pancreatic cell biology and pancreatic cancer, in particular tumour development, cell plasticity and regeneration.
Ilse Rooman was educated at the Vrije Universiteit Brussel (VUB), where she obtained her PhD in 2002, studying cellular plasticity in the pancreatic organ. Within the same research area, she also completed two postdoctoral research projects, one of which at the Institut Municipal d'Investigació Mèdica in Spain. In 2011, she was appointed as a group leader at the Garvan Institute of Medical Research in Australia. Most of her basic research was devoted at finding new genes and pathways that are aberrantly expressed in pancreatic tumour development (hypothesis driven approach and unbiased integrative –omics analyses). Prof. Rooman and her team established powerful models to analyse the initiation of pancreatic cancer, and its relation with pancreatitis. The research has a strong translational focus and aims for early detection, biomarker discovery and development of therapeutic and prevention strategies. In 2016 she returned to Belgium and took the position of Program Manager for Pancreatic Cancer at the Anticancer Fund, managing preclinical and clinical research projects. She was granted an Odysseus fellowship from the Fund for Scientific Research (FWO) to build a research team at the VUB.
Apart from the aforementioned Odysseus grant, Prof. Rooman has had prestigious fellowships and funding from the Fund for Scientific Research Flanders, the European Union - Marie Curie Program, the Francqui Foundation, the Cancer Institute New South Wales and the National Health & Medical Research Council Australia. She makes regular contributions to peer review of manuscripts and serves on several grant/fellowship review panels.
External positions
Program Director (Pancreatic Cancer), Anticancer Fund (Strombeek-Bever)
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Collaborations and top research areas from the last five years
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ANI342: InterCePPT: Interfere with Cellular Positioning in the Pancreatic Tumor
1/01/23 → 31/12/26
Project: Fundamental
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FWOTM1141: Spatial positioning in pancreatic tumors: mapping and deconstructing the underlying SLIT-ROBO pathway
Rooman, I., Rodriguez Aznar, E. & Madhloum, H.
1/11/22 → 31/10/26
Project: Fundamental
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FWOAL1065: Next generation cancer immunotherapy: Targeting the tumor microenvironment.
15/10/22 → 14/10/25
Project: Fundamental
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FWOAL1044: Study of pancreatic exocrine cell plasticity and its footprints in molecular subtypes of pancreatic cancer
1/01/22 → 31/12/25
Project: Fundamental
Research output
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Axon guidance genes control hepatic artery development
Gannoun, L., De Schrevel, C., Belle, M., Dauguet, N., Achouri, Y., Loriot, A., Vanderaa, C., Cordi, S., Dili, A., Heremans, Y., Rooman, I., Leclercq, I. A., Jacquemin, P., Gatto, L. & Lemaigre, F. P., 15 Aug 2023, In: Development. 150, 16, 15 p., dev201642.Research output: Contribution to journal › Article › peer-review
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Heterotopia of salivary gland tissue in the pancreas
Martens, S., Coolens, K., Olsen, C., Lefesvre, P. & Rooman, I., Dec 2023, In: Diagnostic pathology. 18, 1, 6 p., 98.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress
Pan, Z., Van den Bossche, J-L., Rodriguez-Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., 21 Aug 2023, In: Cell & Death Disease. 14, 8, 10 p., 536.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease
Martens, S., Coolens, K., Van Bulck, M., Arsenijevic, T., Casamitjana, J., Fernandez Ruiz, A., El Kaoutari, A., Martinez de Villareal, J., Madhloum, H., Esni, F., Heremans, Y., Leuckx, G., Heimberg, H., Bouwens, L., Jacquemin, P., De Paep, D. L., In't Veld, P., D'Haene, N., Bouchart, C., Dusetti, N. & 6 others, , 1 Oct 2022, In: Gut. 71, 10, p. 2030-2042 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)22 Downloads (Pure) -
Multicellular Modelling of Difficult-To-Treat Gastrointestinal Cancers: Current Possibilities and Challenges
Hakuno, S., Michiels, E., Kuhlemaijer, E., Rooman, I., Hawinkels, L. JAC. & Slingerland, M., 15 Mar 2022, In: International Journal of Molecular Sciences. 23, 6, 15 p., 3147.Research output: Contribution to journal › Scientific review › peer-review
Open AccessFile1 Citation (Scopus)28 Downloads (Pure)
Prizes
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EASD-Bayer Travel Fellowship
Rooman, Ilse (Recipient), 1996
Prize: Prize (including medals and awards)
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Ishango-prize for young scientists
Rooman, Ilse (Recipient), 2003
Prize: Prize (including medals and awards)
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Posterprize Belgian Society of Cellbiology
Rooman, Ilse (Recipient), 1996
Prize: Prize (including medals and awards)
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Prize of the Fund Dr. Karel-Lodewijk Verleysen
Rooman, Ilse (Recipient), 2002
Prize: Prize (including medals and awards)
Activities
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Visual and Spatial Tissue Analysis (VSTA) At Your Service
Ilse Rooman (Speaker)
21 Mar 2023Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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High resolution in situ analysis reveals phenotypic and functional diversification within single pancreatic tumour ducts
Ilse Rooman (Speaker)
29 Mar 2023Activity: Talk or presentation › Talk or presentation at a conference
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Invited Lecture: Pancreatic cancer and its origin: a masked ball of exocrine cells
Ilse Rooman (Speaker)
10 Mar 2023Activity: Talk or presentation › Talk or presentation at a conference
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Pancreatic cancer origin and plasticity, a “masked ball” of exocrine cells
Ilse Rooman (Speaker)
23 Jun 2023Activity: Talk or presentation › Talk or presentation at a workshop/seminar
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High resolution and quantitative intra-ductal spatial analysis reveals phenotypic and functional diversification in pancreatic cancer
Ellis Michiels (Speaker), Ilse Rooman (Contributor), Nouredin Messaoudi (Contributor), Hediel Madhloum (Contributor), Silke Christophe Van Lint (Contributor), Philippe Giron (Contributor), Catharina Olsen (Contributor), Nelson Dusetti (Contributor) & Jean-Luc Van Laethem (Contributor)
30 Apr 2023Activity: Talk or presentation › Talk or presentation at a conference