Research output per year
Research output per year
Research output
- 1 - 50 out of 123 results
Search results
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2024
Abstract 3378: Acinar cell susceptibility for tumor development in the pancreas: Targeting the critical regulators for therapy
Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., 15 Mar 2024, In: Cancer Research. 84, 6_supplement, 1 p., 3378.Research output: Contribution to journal › Meeting abstract (Journal)
Open Access -
Acinar cell susceptibility for tumor development in the pancreas: targeting the critical regulators for therapy
Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., Apr 2024, (Accepted/In press).Research output: Unpublished contribution to conference › Poster
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Characterization of the long-term effects of lethal total body irradiation followed by bone marrow transplantation on the brain of C57BL/6 mice
Janssen, P., De Pauw, L., Mambretti, M., Lara, O., Walckiers, J., Mackens, L., Rooman, I., Guillaume, B., De Ridder, M., Ates, G. & Massie, A., 3 Mar 2024, In: International Journal of Radiation Biology. 100, 3, p. 385-398 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Downloads (Pure) -
Compartmentalized role of xCT in supporting pancreatic tumor growth, inflammation and mood disturbance in mice
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Walckiers, J., Pan, Z., Beckers, P., Espinet, E., Sato, H., De Ridder, M., Marks, D. L., Barbé, K., Aerts, J., Hermans, E., Rooman, I. & Massie, A., May 2024, In: Brain, Behavior, and Immunity. 118, p. 275-286 12 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
High-resolution and quantitative spatial analysis reveal intra-ductal phenotypic and functional diversification in pancreatic cancer
Michiels, E., Madhloum, H., Van Lint, S., Messaoudi, N., Kunda, R., Martens, S., Giron, P., Olsen, C., Lefesvre, P., Dusetti, N., El Mohajer, L., Tomasini, R., Hawinkels, L. J., Ahsayni, F., Nicolle, R., Arsenijevic, T., Bouchart, C., Van Laethem, J-L. & Rooman, I., Jan 2024, In: Journal of pathology. 262, 1, p. 76-89 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)20 Downloads (Pure) -
ROBO1 Drives Gemcitabine Resistance in Pancreatic Cancer
Mader, S., Rooman, I., Rodriguez Aznar, E., Soubeyran, P., Dusetti, N. & Bousquet Vaysse, C., 17 Jun 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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ROBO1 Drives Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma
Mader, S., Soubeyran, P., Dusetti, N., Bousquet Vaysse, C., Rodriguez Aznar, E. & Rooman, I., 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Spatial Characterization of B7H3 Expression in PDAC reveals increased Expression in Basal-like Tumor Ducts and αSMA-positive Stromal Cells
De Man, V., Michiels, E., Messaoudi, N., Olsen, C., Giron, P. & Rooman, I., 18 Apr 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Spatial transcriptomic analysis reveals PTGES as a conserved potential therapeutic target for basal cells in Pancreatic Ductal Adenocarcinoma.
Van der Vliet, M., Van den Bossche, J-L. & Rooman, I., 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Spatial transcriptomic and single cell sequencing data reveals PTGES as a conserved potential therapeutic target for basal cells in pancreatic cancer.
Van der Vliet, M. & Rooman, I., 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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2023
Axon guidance genes control hepatic artery development
Gannoun, L., De Schrevel, C., Belle, M., Dauguet, N., Achouri, Y., Loriot, A., Vanderaa, C., Cordi, S., Dili, A., Heremans, Y., Rooman, I., Leclercq, I. A., Jacquemin, P., Gatto, L. & Lemaigre, F. P., 15 Aug 2023, In: Development. 150, 16, 15 p., dev201642.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)3 Downloads (Pure) -
Heterotopia of salivary gland tissue in the pancreas
Martens, S., Coolens, K., Olsen, C., Lefesvre, P. & Rooman, I., Dec 2023, In: Diagnostic pathology. 18, 1, 6 p., 98.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)26 Downloads (Pure) -
Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress
Pan, Z., Van den Bossche, J-L., Rodriguez-Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., 21 Aug 2023, In: Cell & Death Disease. 14, 8, 10 p., 536.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)21 Downloads (Pure) -
Systemic deletion of xCT in mice attenuates peripheral inflammation and inflammation-related mood disturbances in a pancreatic cancer model
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Sato, H., De Ridder, M., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 6 Jun 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Systemic deletion of xCT in mice attenuates peripheral inflammation and inflammation-related mood disturbances in a pancreatic cancer model
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Sato, H., De Ridder, M., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 21 Apr 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
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System xc- (xCT) prevents ferroptosis in pancreatic acinar cells as a first step in acinar-to-ductal metaplasia
Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., Nov 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
File60 Downloads (Pure) -
System xc- prevents ferroptosis in pancreatic acinar cells as a first step in acinar-to-ductal metaplasia
Pan, Z. & Rooman, I., Apr 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Tackling pancreatic cancer from different angles: compartmentalized role of xCT in supporting tumor growth and inflammation-related comorbidities in mice
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Walckiers, J., Pan, Z., Beckers, P., Espinet, E., Sato, H., De Ridder, M., Marks, D. L., Barbé, K., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 13 Nov 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
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2022
Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease
Martens, S., Coolens, K., Van Bulck, M., Arsenijevic, T., Casamitjana, J., Fernandez Ruiz, A., El Kaoutari, A., Martinez de Villareal, J., Madhloum, H., Esni, F., Heremans, Y., Leuckx, G., Heimberg, H., Bouwens, L., Jacquemin, P., De Paep, D. L., In't Veld, P., D'Haene, N., Bouchart, C., Dusetti, N. & 6 others, , 1 Oct 2022, In: Gut. 71, 10, p. 2030-2042 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)32 Downloads (Pure) -
Multicellular Modelling of Difficult-To-Treat Gastrointestinal Cancers: Current Possibilities and Challenges
Hakuno, S., Michiels, E., Kuhlemaijer, E., Rooman, I., Hawinkels, L. JAC. & Slingerland, M., 15 Mar 2022, In: International Journal of Molecular Sciences. 23, 6, 15 p., 3147.Research output: Contribution to journal › Scientific review › peer-review
Open AccessFile7 Citations (Scopus)66 Downloads (Pure) -
Spatial heterogeneity of mutant KRAS expression in the context of pancreatic cancer subtypes
Michiels, E., Messaoudi, N., Rooman, I., Giron, P., Olsen, C., Lefesvre, P. & Frederix, K., 29 Sep 2022.Research output: Unpublished contribution to conference › Poster
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Spatial heterogeneity of mutant KRAS expression in the context of pancreatic cancer subtypes
Michiels, E., Rooman, I., Messaoudi, N., Giron, P., Olsen, C., Frederix, K. & Lefesvre, P., 6 Nov 2022.Research output: Unpublished contribution to conference › Poster
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Spatial Heterogeneity of Mutant KRAS Expression in the Context of Pancreatic Cancer Subtypes
Rooman, I., 5 Nov 2022.Research output: Unpublished contribution to conference › Poster
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Targeting system xc- in a mouse pancreatic cancer model reduces tumor growth, neuroinflammation and mood disturbances
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Njemini, R., Sato, H., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 9 May 2022, Targeting system xc- in a mouse pancreatic cancer model reduces tumor growth, neuroinflammation and mood disturbances.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
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Targeting system xc- in a mouse pancreatic cancer model reduces tumor growth, neuroinflammation and mood disturbances
Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Njemini, R., Sato, H., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 9 May 2022, (Unpublished).Research output: Unpublished contribution to conference › Poster
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2021
Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin
Espinet, E., Gu, Z., Imbusch, C. D., Giese, N. A., Buscher, M., Safavi, M., Weisenburger, S., Klein, C., Vogel, V., Falcone, M., Insua-Rodriguez, J., Reitberger, M., Thiel, V., Kossi, S. O., Muckenhuber, A., Sarai, K., Lee, A. Y., Backx, E., Zarei, S., Gaida, M. M. & 18 others, , Mar 2021, In: Cancer discovery. 11, 3, p. 638-659 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile66 Citations (Scopus)122 Downloads (Pure) -
Cystine-glutamate antiporter deletion accelerates motor recovery and improves histological outcomes following spinal cord injury in mice
Sprimont, L., Janssen, P., De Swert, K., Van Bulck, M., Rooman, I., Gilloteaux, J., Massie, A. & Nicaise, C., 9 Jun 2021, In: Scientific Reports. 11, 1, 15 p., 12227.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)52 Downloads (Pure) -
Discovery and 3D imaging of deltaNp63-expressing cells in the human pancreatic duct that share characteristics with an aggressive molecular subtype of pancreatic cancer: poster and video abstract
Rooman, I., 5 May 2021.Research output: Unpublished contribution to conference › Poster
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Discovery and 3D imaging of deltaNp63-expressing cells in the human pancreatic duct that share characteristics with the aggressive molecular subtype of pancreatic cancer: Poster Discussion Session for Top Abstracts
Rooman, I., 9 Jun 2021.Research output: Unpublished contribution to conference › Poster
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Exploring new uses for existing drugs: innovative mechanisms to fund independent clinical research
Verbaanderd, C., Rooman, I. & Huys, I., 4 May 2021, In: Trials. 22, 1, 13 p., 322.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)43 Downloads (Pure) -
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Kurokawa, M., Goyama, S., Bouwens, L., Jacquemin, P., Houbracken, I. & Rooman, I., Sep 2021, In: Cell Death and Differentiation. 28, 9, p. 2601-2615 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)70 Downloads (Pure) -
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Kurokawa, M., Goyama, S., Bouwens, L., Jacquemin, P., Houbracken, I. & Rooman, I., 21 Mar 2021, Biorxiv, 40 p.Research output: Working paper › Preprint
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On the origin of pancreatic cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
Backx, E., Coolens, K., Van den Bossche, J-L., Houbracken, I., Espinet, E. & Rooman, I., 4 Dec 2021, In: Cellular and molecular gastroenterology and hepatology. 13, 4, p. 1243-1253 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)231 Downloads (Pure) -
Robo1 supports actin rich structures in pancreatic tumor cells with particular effects on Rhoa activity at adherens junctions
Sklyarova, T. & Rooman, I., Oct 2021, In: United European Gastroenterology Journal. 9, p. 108-109 2 p.Research output: Contribution to journal › Meeting abstract (Journal)
Open AccessFile64 Downloads (Pure) -
Setting up a PDXO platform for pancreatic cancer with spatial omics characterization
Michiels, E. & Rooman, I., 5 Oct 2021.Research output: Unpublished contribution to conference › Poster
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Setting up a PDXO platform of pancreatic cancer with spatial-omics characterization
Michiels, E., Rooman, I. & Heremans, Y., 27 May 2021.Research output: Unpublished contribution to conference › Poster
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Setting up a PDXO platform of pancreatic cancer with spatial-omics characterization
Michiels, E., Rooman, I. & Heremans, Y., 10 Jun 2021.Research output: Unpublished contribution to conference › Poster
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Setting up a PDXO platform of pancreatic cancer with spatial-omics characterization
Michiels, E. & Rooman, I., 21 Sep 2021.Research output: Unpublished contribution to conference › Poster
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Setting up a PDXO platform of pancreatic cancer with spatial-omics characterization
Michiels, E., Heremans, Y. & Rooman, I., 29 Jun 2021.Research output: Unpublished contribution to conference › Poster
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Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
Glasgow Precision Oncology Laboratory, & Rooman, I., Jan 2021, In: Gastroenterology. 160, 1, p. 362-377.e13 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile77 Citations (Scopus)52 Downloads (Pure) -
2020
A novel basal DeltaNP63 (P40)-expressing pancreatic cell type undergoes expansion and reorganization in chronic pancreatitis
Martens, S., Van Bulck, M., Coolens, K., Esni, F., Leuckx, G., Heimberg, H., Bouwens, L., Jacquemin, P., Spagnoli, F., Real, F. X., in 't Veld, P., Lesfevre, P. & Rooman, I., Oct 2020, In: United European Gastroenterology Journal. 8, p. 123-124 2 p.Research output: Contribution to journal › Meeting abstract (Journal)
Open AccessFile198 Downloads (Pure) -
Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease
Martens, S., Bulck, M. V., Coolens, K., Madhloum, H., Esni, F., Leuckx, G., Heimberg, H., Bouwens, L., Jacquemin, P., Veld, P. I., Lefesvre, P., Real, F. X., Rovira, M. & Rooman, I., 20 Aug 2020, 13 p.Research output: Other contribution
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HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
Glasgow Precision Oncology Laboratory, Brunton, H., Caligiuri, G., Cunningham, R., Upstill-Goddard, R., Bailey, U-M., Garner, I. M., Nourse, C., Dreyer, S., Jones, M., Moran-Jones, K., Wright, D. W., Paulus-Hock, V., Nixon, C., Thomson, G., Jamieson, N. B., McGregor, G. A., Evers, L., McKay, C. J., Gulati, A. & 25 others, , 12 May 2020, In: Cell Reports. 31, 6, 28 p., 107625.Research output: Contribution to journal › Article › peer-review
Open AccessFile81 Citations (Scopus)98 Downloads (Pure) -
Inflammation enables pancreatic acinar cells to overcome resistance to oncogenic Kras by increasing its expression and plasma membrane localization.
Assi, M. N., Lodewyckx, J-N., Achouri, Y., Gerard, C., Dauguet, N., Houbracken, I., Heremans, Y., Tyteca, D., Rooman, I., Bouwens, L., Lemaigre, F. & Jacquemin, P., May 2020, In: MOLECULAR CANCER RESEARCH. 18, 5, p. 36-36Research output: Contribution to journal › Meeting abstract (Journal)
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MECOM Permits Pancreatic Acinar Cell Dedifferentiation Avoiding Cell Death Under Stress Conditions
Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Bouwens, L., Kurokawa, M., Goyama, S., Jacquemin, P., Houbracken, I. & Rooman, I., Nov 2020, In: Pancreas. 49, 10, p. 1399-1400Research output: Contribution to journal › Meeting abstract (Journal)
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Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice
Chellakkan Selvanesan, B., Meena, K., Beck, A., Meheus, L., Lara, O., Rooman, I. & Gravekamp, C., 5 Nov 2020, In: Journal for immunotherapy of cancer. 8, 2, 14 p., e001250.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)106 Downloads (Pure) -
On-Label or Off-Label? Overcoming Regulatory and Financial Barriers to Bring Repurposed Medicines to Cancer Patients
Verbaanderd, C., Rooman, I., Meheus, L. & Huys, I., 1 Jan 2020, In: Frontiers in Pharmacology. 10, 01664.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)81 Downloads (Pure) -
Pan-cancer analysis of whole genomes
ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Feb 2020, In: Nature. 578, 7793, p. 82-93 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1699 Citations (Scopus)23 Downloads (Pure) -
Pancreatic resection with perioperative drug repurposing of propranolol and etodolac: trial protocol of the phase-II randomised placebo controlled PROSPER trial
Hüttner, F. J., Rooman, I., Bouche, G., Knebel, P., Hüsing, J., Mihaljevic, A. L., Hackert, T., Strobel, O., Büchler, M. W. & Diener, M. K., 30 Sep 2020, In: BMJ Open. 10, 9, e040406.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)26 Downloads (Pure) -
Pragmatic subtyping of pancreatic ductal adenocarcinoma with markers and histological features
Martens, S., Lefesvre, P., Arsenijevic, T., Bouchart, C., Puleo, F., Van Laethem, J-L. & Rooman, I., 7 Feb 2020.Research output: Unpublished contribution to conference › Poster