Projects per year
Personal profile
Expertise
neuropharmacology
Expertise
neurosciences
Expertise
pharmacology
Expertise
Ilse Smolders (PhD in Pharmaceutical Sciences, full professor, ‘gewoon hoogleraar’) is attached to the VUB Faculty of Medicine and Pharmacy. Being a Pharmacist, she has huge interest in pharmacology and drug discovery, and her main teaching duties are situated within that field of expertise. She is responsible for teaching courses to Medical, Biomedical, Pharmacy and Psychology students. She is head of the Laboratory of Pharmaceutical Chemistry, Drug Analysis and Drug Information, and chair of the Department of Pharmaceutical Sciences. The research expertise of Ilse Smolders lies in the domain of neuroscience and pharmacology. She has expertise with rodent models of seizures, epilepsy, and epilepsy co-morbidities such as cognitive decline, anxiety and depression, as well as with in vivo monitoring of neurotransmitters, gliotransmitters and neuropeptides, ex vivo analysis of rodent brain, slice electrophysiology, and more recently, in vitro culture models. Available techniques in the lab are telemetry-based 24h-electroencephalographic (EEG) monitoring for rodents, and a wide range of behavioral paradigms for measuring epilepsy-related behavior, cognitive decline, locomotor, anxiety and depressive-like behaviors in rodents. In vivo microdialysis in rodents is used, and miniaturized analytical developments for targeted analysis of the dialysates are always ongoing and optimised. Novel state-of-the art technologies such as chemogenetics, optogenetics and untargeted metabolomics were recently introduced in the team.
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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HERC56: Intravital imaging as tool to bridge the gap between macroscopic in vivo imaging and microscopic tissue analysis
Hernot, S., Staels, W., Hellemans, K., Smolders, I., Rooman, I., Devoogdt, N., Menu, E., De Bundel, D., Breckpot, K., De Leu, N., Movahedi, K., D'Huyvetter, M. & De Kock, J.
1/05/22 → 30/04/26
Project: Fundamental
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OZR3913: Cofinancing OZR FWO Hercules MZW - High-parametric single-cell protein profiling in intact tissues
Movahedi, K., van Grunsven, L., Rooman, I., Van Ginderachter, J., Smolders, I., Neyns, B., Vanhaecke, T., Laoui, D., Breckpot, K., De Veirman, K., Stijlemans, B., Van Schependom, J., Magez, S., Goyvaerts, C., De Kock, J., De Leu, N., Massie, A., Hellemans, K., Spits, C., De Bundel, D., De Trez, C., Hernot, S., Van Dooren, S., Aerts, J., Staels, W. & Tuyaerts, S.
25/02/22 → 25/02/26
Project: Fundamental
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FWOTM1061: Chemogenetic modulation of CX3CR1+ cells in a mouse model of drug-resistant limbic epilepsy.
1/11/21 → 31/10/23
Project: Fundamental
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OZR3528: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UAntwerpen, NOUS Amber
5/03/20 → 4/03/24
Project: Fundamental
Research output
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Assessment of gliotransmitter concentrations upon chemogenetic modulation of astroglia in mouse hippocampus
Nestor, L., Sahu, S., De Bundel, D., Van Eeckhaut, A. & Smolders, I., 9 May 2022, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid
Custers, M-L., Nestor, L., De Bundel, D., Van Eeckhaut, A. & Smolders, I., 13 May 2022, In: Pharmaceutics. 14, 5, 20 p., 1051.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)17 Downloads (Pure) -
Does cannabidiol fail to suppress spontaneous seizures in the intrahippocampal kainic acid mouse model of mesial temporal lobe epilepsy?
Bournons, S., Sahu, S., De Smet, G., De Bundel, D. & Smolders, I., Jul 2022, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Ex Vivo Feedback Control of Neurotransmission Using a Photocaged Adenosine A1 Receptor Agonist
Craey, E., Hulpia, F., Spanoghe, J., Manzella, S., Larsen, L. E., Sprengers, M., De Bundel, D., Smolders, I., Carrette, E., Delbeke, J., Vonck, K., Boon, P., Van Calenbergh, S., Wadman, W. J. & Raedt, R., 10 Aug 2022, In: International Journal of Molecular Sciences. 23, 16, 12 p., 8887.Research output: Contribution to journal › Article › peer-review
Open Access -
Higher susceptibility to 6 Hz corneal kindling and lower responsiveness to antiseizure drugs in mouse models of Alzheimer's disease
Vande Vyver, M., Barker-Haliski, M., Aourz, N., Nagels, G., Bjerke, M., Engelborghs, S., De Bundel, D. & Smolders, I., Oct 2022, In: Epilepsia. 63, 10, p. 2703-2715 13 p.Research output: Contribution to journal › Article › peer-review
Prizes
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Bursary Award 6th European Congress on Epileptology Vienna
Smolders, Ilse (Recipient), 2004
Prize: Prize (including medals and awards)
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Galenusprijs voor Farmacologie
Smolders, Ilse (Recipient), 2001
Prize: Prize (including medals and awards)
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Laureate of the Prize of the Second Section 2002-2004
Smolders, Ilse (Recipient), 2005
Prize: Prize (including medals and awards)
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Project grant Wetenschappelijk Fonds Willy Gepts (WFWG)
Custers, Marie-Laure (Recipient), Van Eeckhaut, Ann (Recipient) & Smolders, Ilse (Recipient), 1 Dec 2021
Prize: Prize (including medals and awards)
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Activities
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Department of Bio-engineering Sciences (Organisational unit)
Eveline Peeters (Chair), Janine Brunner (Jury), Ilse Smolders (Jury), Steffen Jung (Jury), Diego Gomez-Nicola (Jury), Kiavash Movahedi (Supervisor) & Jo Van Ginderachter (Supervisor)
8 Jun 2022Activity: Membership › Member of PhD committee
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DA-PBA 2022: 12th International Symposium on Drug Analysis & 32nd International Symposium on Pharmaceutical and Biomedical Analysis
Marie-Laure Custers (Speaker), Maria Bjerke (Contributor), Ann Van Eeckhaut (Contributor) & Ilse Smolders (Contributor)
13 Sep 2022Activity: Talk or presentation › Talk or presentation at a conference
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Scientific Research Section
Marie-Laure Custers (Speaker), Maria Bjerke (Contributor), Ann Van Eeckhaut (Contributor) & Ilse Smolders (Contributor)
24 Sep 2021Activity: Talk or presentation › Talk or presentation at a conference
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PhD day C4N
Marie-Laure Custers (Speaker), Maria Bjerke (Contributor), Ann Van Eeckhaut (Contributor) & Ilse Smolders (Contributor)
16 Dec 2021Activity: Talk or presentation › Talk or presentation at a conference
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Chemogenetic modulation of CX3CR1+ cells in a mouse model of drug-resistant limbic epilepsy.
Jo Bossuyt (Participant) & Ilse Smolders (Supervisor)
1 Nov 2021 → 31 Oct 2025Activity: Other › Written proposal
Press / Media
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Expert neurofarmacologie omtrent de vergiftiging van een kleuter met een overdosis van een antipsychoticum
13/11/08
1 Media contribution
Press/Media: Other
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Radio interview als expert neurofarmacologie ivm het misbruik van Rilatine® bij scholieren
28/05/08
1 Media contribution
Press/Media: Other
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Interview voor het televisiejournaal ivm het misbruik van Rilatine® bij scholieren
28/05/08
1 Media contribution
Press/Media: Other
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Gast van HKH prinses Astrid naar aanleiding van de prijsuitreikingen Geneeskundige Stichting Koningin Elisabeth
22/05/07
1 Media contribution
Press/Media: Other
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Radio interview omtrent de neurobiologie van het reward circuit
3/08/06
1 Media contribution
Press/Media: Other
Thesis
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Analysis of glutamate transporter expression in post mortem tissue of depressed patients
Author: Rubbens, N., Demuyser, T., Massie, A., Smolders, I. & Caveliers, V., 2016Supervisor: Demuyser, T. (Promotor)
Student thesis: Master's Thesis
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Determination of the plasma stability of neuromedin U analogues
Author: Santon, S., Smolders, I., Van Eeckhaut, A. & Caveliers, V., 2016Supervisor: De Prins, A. (Promotor)
Student thesis: Master's Thesis
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Evaluation of the convulsant liability and antiepileptic properties of antidepressant
Author: Vermoesen, K., Clinckers, R., Massie, A., Smolders, I., Rombaut, B., Vinken, M., Voskuyl, R. & Raedt, R., 29 May 2012Supervisor: Clinckers, R. (Promotor), Massie, A. (Co-promotor), Smolders, I. (External person) (Co-promotor), Rombaut, B. (Jury), Vinken, M. (Jury), Voskuyl, R. (External person) (Jury) & Raedt, R. (External person) (Jury)
Student thesis: Doctoral Thesis
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Ghrelin receptor involvement in fear extinction
Author: De Bundel, D., De Heyn, S. & Smolders, I. J., 2015Student thesis: Master's Thesis
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Het gebruik van microdialyse voor de bepaling van de plasma-eiwitbinding van farmaca
Author: Smolders, I. J. & Sarre, S., 1992Supervisor: Sarre, S. (Promotor)
Student thesis: Master's Thesis