Projects per year
Personal profile
Expertise
neuropharmacology
Expertise
neurosciences
Expertise
pharmacology
Expertise
Ilse Smolders (PhD in Pharmaceutical Sciences, full professor, ‘gewoon hoogleraar’) is attached to the VUB Faculty of Medicine and Pharmacy. Being a Pharmacist, she has huge interest in pharmacology and drug discovery, and her main teaching duties are situated within that field of expertise. She is responsible for teaching courses to Medical, Biomedical, Pharmacy and Psychology students. She is head of the Laboratory of Pharmaceutical Chemistry, Drug Analysis and Drug Information, and chair of the Department of Pharmaceutical Sciences. The research expertise of Ilse Smolders lies in the domain of neuroscience and pharmacology. She has expertise with rodent models of seizures, epilepsy, and epilepsy co-morbidities such as cognitive decline, anxiety and depression, as well as with in vivo monitoring of neurotransmitters, gliotransmitters and neuropeptides, ex vivo analysis of rodent brain, slice electrophysiology, and more recently, in vitro culture models. Available techniques in the lab are telemetry-based 24h-electroencephalographic (EEG) monitoring for rodents, and a wide range of behavioral paradigms for measuring epilepsy-related behavior, cognitive decline, locomotor, anxiety and depressive-like behaviors in rodents. In vivo microdialysis in rodents is used, and miniaturized analytical developments for targeted analysis of the dialysates are always ongoing and optimised. Novel state-of-the art technologies such as chemogenetics, optogenetics and untargeted metabolomics were recently introduced in the team.
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OZR3629: OZR Back-up mandate: Subclinical epileptiform activity and melatonin disruptions in the Alzheimer's disease continuum.
1/11/20 → 31/10/21
Project: Fundamental
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OZR3528: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UAntwerpen, NOUS Amber
5/03/20 → 4/03/24
Project: Fundamental
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FWOTM971: Photopharmacology as novel treatment option for refractory focal epilepsies
Smolders, I., De Bundel, D. & Bournons, S.
1/11/19 → 31/10/21
Project: Fundamental
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FWOAL927: Can antiepileptogenic treatments slow down the progression of Alzheimer's disease?
Smolders, I., Engelborghs, S. & Versijpt, J.
1/01/19 → 31/12/22
Project: Fundamental
Research output
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Activation of DREADDed astrocytes attenuates pharmacoresistant spontaneous seizures in a chronic epilepsy model
Smolders, I., Van den Herrewegen, Y., Sahu, S., Nestor, L. & De Bundel, D., Jul 2021, In : Glia. 69, p. E285-E285Research output: Contribution to journal › Meeting abstract (Journal)
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Applicability of cerebral open flow microperfusion and microdialysis to quantify a brain-penetrating nanobody in mice
Custers, M-L., Wouters, Y., Jaspers, T., Bundel, D. D., Dewilde, M., Eeckhaut, A. V. & Smolders, I., Sep 2021, In : Analytica Chimica Acta. 1178, 338803.Research output: Contribution to journal › Article
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Effects of repeated anodal transcranial direct current stimulation on auditory fear extinction in C57BL/6J mice
Van Schuerbeek, A., Vanderhasselt, M-A., Baeken, C., Pierre, A., Smolders, I., Van Waes, V. & De Bundel, D., 1 Mar 2021, In : Brain Stimulation. 14, 2, p. 250-260 11 p.Research output: Contribution to journal › Article
Open AccessFile1 Citation (Scopus)45 Downloads (Pure) -
Ghrelin receptor agonism protects neurons and astrocytes from excitotoxicity: looking for possible mechanisms-of-action.
Buckinx, A., Bossuyt, J., Legroux, F., De Bundel, D., Kooijman, R. & Smolders, I., Jul 2021, In : Glia. 69, p. E342-E343Research output: Contribution to journal › Meeting abstract (Journal)
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Melatonin levels in the Alzheimer's disease continuum: a systematic review.
Nous, A., Engelborghs, S. & Smolders, I., 23 Feb 2021, In : Alzheimer's Research & Therapy. 13, 1, 12 p., 52.Research output: Contribution to journal › Scientific review
Open AccessFile2 Citations (Scopus)1 Downloads (Pure)
Prizes
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Bursary Award 6th European Congress on Epileptology Vienna
Ilse Smolders (Recipient), 2004
Prize: Prize (including medals and awards)
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Galenusprijs voor Farmacologie
Ilse Smolders (Recipient), 2001
Prize: Prize (including medals and awards)
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Laureate of the Prize of the Second Section 2002-2004
Ilse Smolders (Recipient), 2005
Prize: Prize (including medals and awards)
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Activities
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Targeted metabolomics of the brain – the quest for sensitivity, selectivity and throughput.
Ann Van Eeckhaut (Invited speaker), Jana Bongaerts (Contributor), Marie-Laure Custers (Contributor), Liam Nestor (Contributor), Anouk Pierre (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor)29 Jan 2020 → 31 Jan 2020Activity: Talk or presentation › Talk or presentation at a conference
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The synthetic ghrelin receptor agonist MK0677 increases mesolimbic/mesocortical dopamine release following local administration in the ventral tegmental area without affecting anxiety or cued fear extinction
Anouk Pierre (Speaker), Andries Van Schuerbeek (Speaker), Wissal Allaoui (Speaker), Eva-Maria Fritz (Contributor), Nicolas Singewald (Contributor), tom beckers (Contributor), Ann Van Eeckhaut (Speaker), Ilse Smolders (Speaker), Dimitri De Bundel (Speaker)21 May 2019Activity: Talk or presentation › Talk or presentation at a conference
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CHEMOGENETIC MODULATION OF ASTROCYTES IN A MODEL FOR TEMPORAL LOBE EPILEPSY
Yana Van Den Herrewegen (Presenter), An Buckinx (Contributor), Ann Van Eeckhaut (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor)20 May 2019Activity: Talk or presentation › Talk or presentation at a conference
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CE-MS-based profiling of cationic plasma metabolomics from a mouse model for acute epileptic seizures.
Karen Segers (Speaker), W. Zhang (Contributor), Debby Mangelings (Contributor), T. Hankemeier (Contributor), Dimitri De Bundel (Contributor), Yvan Vander Heyden (Contributor), Ilse Smolders (Contributor), Rawi Ramautar (Contributor), Ann Van Eeckhaut (Contributor)20 May 2019Activity: Talk or presentation › Talk or presentation at a conference
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Comparison of Unispray and Electropspray for the ionization of neuropeptides.
Jana Bongaerts (Speaker), Yannick Van Wanseele (Contributor), Laurence Van Oudenhove (Contributor), Karen Segers (Contributor), Marijn Van Hulle (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor), Debby Mangelings (Contributor), Yvan Vander Heyden (Contributor), Ann Van Eeckhaut (Contributor)20 May 2019Activity: Talk or presentation › Talk or presentation at a conference
Press / Media
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Expert neurofarmacologie omtrent de vergiftiging van een kleuter met een overdosis van een antipsychoticum
13/11/08
1 Media contribution
Press/Media: Other
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Interview voor het televisiejournaal ivm het misbruik van Rilatine® bij scholieren
28/05/08
1 Media contribution
Press/Media: Other
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Radio interview als expert neurofarmacologie ivm het misbruik van Rilatine® bij scholieren
28/05/08
1 Media contribution
Press/Media: Other
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Gast van HKH prinses Astrid naar aanleiding van de prijsuitreikingen Geneeskundige Stichting Koningin Elisabeth
22/05/07
1 Media contribution
Press/Media: Other
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Radio interview omtrent de neurobiologie van het reward circuit
3/08/06
1 Media contribution
Press/Media: Other
Thesis
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Additie van inuline in de voeding: Effecten op de serotonine- en dopaminevrijgave in de hippocampus van de rat
Author: Grauwels, K., Michotte, Y. & Smolders, I. J., 1998Supervisor: Michotte, Y. (Promotor) & Smolders, I. (Co-promotor)
Student thesis: Master's Thesis
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Alternative approaches to build quantitative structure-retention relationships
Author: Put, R., Vander Heyden, Y., Vanhaecke, T., Foriers, A., Smolders, I. J., Adams, E. & Kaliszan, R., 17 Sep 2008Supervisor: Vander Heyden, Y. (Promotor), Vanhaecke, T. (Jury), Foriers, A. (Jury), Smolders, I. (Jury), Adams, E. (External person) (Jury) & Kaliszan, R. (External person) (Jury)
Student thesis: Doctoral Thesis
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Alternative replication systems for picornaviridae: development and use.
Author: Franco, D., Rombaut, B., Vander Heyden, Y., Wimmer, E., Michiels, T., Paul, A., Melchers, W., Smolders, I. J. & Vrijsen, R., 2005Supervisor: Rombaut, B. (Promotor), Vander Heyden, Y. (Jury), Smolders, I. (Jury), Vrijsen, R. (Jury), Michiels, T. (External person) (Jury), Melchers, W. (External person) (Jury), Wimmer, E. (External person) (Co-promotor) & Paul, A. (External person) (Co-promotor)
Student thesis: Doctoral Thesis
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Analysis of glutamate transporter expression in post mortem tissue of depressed patients
Author: Rubbens, N., Demuyser, T., Massie, A., Smolders, I. & Caveliers, V., 2016Supervisor: Demuyser, T. (Promotor)
Student thesis: Master's Thesis
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Antipicornaviral compounds: modes of action, use as research tools and as vaccine stabilisers
Author: Verheyden, B., Rombaut, B., Verbeke, J., Vanden Berghe, D., Van Acker, K., Smolders, I. J. & Vrijsen, R., 1 Jun 2006Supervisor: Rombaut, B. (Promotor), Verbeke, J. (Jury), Smolders, I. (Jury), Vrijsen, R. (Jury), Vanden Berghe, D. (External person) (Jury) & Van Acker, K. (External person) (Jury)
Student thesis: Doctoral Thesis