Research output per year
Research output per year
Research output
Search results
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2024
Abstract 3378: Acinar cell susceptibility for tumor development in the pancreas: Targeting the critical regulators for therapy
Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., 15 Mar 2024, In: Cancer Research. 84, 6_supplement, 1 p., 3378.Research output: Contribution to journal › Meeting abstract (Journal)
Open Access -
Acinar cell susceptibility for tumor development in the pancreas: targeting the critical regulators for therapy
Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., Apr 2024, (Accepted/In press).Research output: Unpublished contribution to conference › Poster
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Spatial transcriptomic analysis of human Pancreatic Basal Cells reveals PTGES as a potential target for the Basal-Like subtype of Pancreatic Ductal Adenocarcinoma.
Van den Bossche, J-L., Van der Vliet, M., Coolens, K., Michiels, E., Houbracken, I., Baldan, J. & Rooman, I., 18 Apr 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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Spatial transcriptomic and single cell sequencing data reveals PTGES as a conserved potential therapeutic target for basal cells in pancreatic cancer.
Van der Vliet, M., Van den Bossche, J-L., Coolens, K., Van Lint, S., Michiels, E., Houbracken, I., Baldan, J. & Rooman, I., Oct 2024, (Unpublished).Research output: Unpublished contribution to conference › Poster
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2023
Do cancer centres and palliative care wards routinely measure patients’ quality of life? An international cross-sectional survey
Miranda, R., Raemdonck, E., Deliens, L., Kaasa, S., Zimmermann, C., Rodin, G., Robijn, L., Lundeby, T., Houbracken, I. & Beernaert, K., 31 Jul 2023, In: Supportive Care in Cancer. 31, 8, 9 p., 499.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)14 Downloads (Pure) -
Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress
Pan, Z., Van den Bossche, J-L., Rodriguez-Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., 21 Aug 2023, In: Cell & Death Disease. 14, 8, 10 p., 536.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)26 Downloads (Pure) -
System xc- (xCT) prevents ferroptosis in pancreatic acinar cells as a first step in acinar-to-ductal metaplasia
Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., Nov 2023, (Unpublished).Research output: Unpublished contribution to conference › Poster
File108 Downloads (Pure) -
2022
Do Cancer Centres Routinely Assess Patients' Quality of Life- And if So, How and for What Purpose?: A Cross-Sectional Study in the Cancer Centre Network of the European Palliative Care Research Centre
Miranda, R., Deliens, L., Kaasa, S., Zimmermann, C., Rodin, G., Lundeby, T., Robijn, L., Houbracken, I. & Beernaert, K., 1 Jul 2022, In: Palliative Medicine. 36, 1, p. 47-48 2 p.Research output: Contribution to journal › Meeting abstract (Journal)
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2021
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Kurokawa, M., Goyama, S., Bouwens, L., Jacquemin, P., Houbracken, I. & Rooman, I., Sep 2021, In: Cell Death and Differentiation. 28, 9, p. 2601-2615 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)79 Downloads (Pure) -
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Kurokawa, M., Goyama, S., Bouwens, L., Jacquemin, P., Houbracken, I. & Rooman, I., 21 Mar 2021, Biorxiv, 40 p.Research output: Working paper › Preprint
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On the origin of pancreatic cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
Backx, E., Coolens, K., Van den Bossche, J-L., Houbracken, I., Espinet, E. & Rooman, I., 4 Dec 2021, In: Cellular and molecular gastroenterology and hepatology. 13, 4, p. 1243-1253 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)326 Downloads (Pure) -
2020
Inflammation enables pancreatic acinar cells to overcome resistance to oncogenic Kras by increasing its expression and plasma membrane localization.
Assi, M. N., Lodewyckx, J-N., Achouri, Y., Gerard, C., Dauguet, N., Houbracken, I., Heremans, Y., Tyteca, D., Rooman, I., Bouwens, L., Lemaigre, F. & Jacquemin, P., May 2020, In: MOLECULAR CANCER RESEARCH. 18, 5, p. 36-36Research output: Contribution to journal › Meeting abstract (Journal)
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MECOM Permits Pancreatic Acinar Cell Dedifferentiation Avoiding Cell Death Under Stress Conditions
Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Bouwens, L., Kurokawa, M., Goyama, S., Jacquemin, P., Houbracken, I. & Rooman, I., Nov 2020, In: Pancreas. 49, 10, p. 1399-1400Research output: Contribution to journal › Meeting abstract (Journal)
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2019
Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture
Baldan, J., Houbracken, I., Rooman, I. & Bouwens, L., 11 Mar 2019, In: Scientific Reports - Nature. 9, 1, p. 1-12 12 p., 4040.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)42 Downloads (Pure) -
Human pancreatic acinar cell plasticity – potential for endocrine neogenesis?
Baldan, J., Houbracken, I., Rooman, I. & Bouwens, L., 1 Apr 2019.Research output: Unpublished contribution to conference › Poster
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2018
Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells
Houbracken, I. & Bouwens, L., 26 Oct 2018, • Poster presentation at Annual meeting of the Belgian Society for Stem Cell Research, Leuven, Belgium. p. 99-99 1 p. 83Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
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Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells
Houbracken, I. & Bouwens, L., 6 Oct 2018, oral presentation Post-EASD workshop "The Beta Cell in Health, Disease and after Therapy". p. O16-O16 1 p.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
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Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells
Houbracken, I. & Bouwens, L., 4 Jun 2018.Research output: Unpublished contribution to conference › Poster
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Discovery analysis of cancer-relevant genes uniquely expressed in dedifferentiated human acinar cells and not in duct cells
Backx, E., Wauters, E., Van Bulck, M., Baldan, J., Ling, Z., Bouwens, L., Jacquemin, P., Houbracken, I. & Rooman, I., 18 Jun 2018, In: Pancreatology. 18, 4, p. 122-123Research output: Contribution to journal › Meeting abstract (Journal)
7 Citations (Scopus) -
Human pancreatic acinar dedifferentiation towards an embryonic progenitor-like state in 3D suspension culture.
Baldan, J., Houbracken, I., Rooman, I. & Bouwens, L., 4 Jun 2018.Research output: Unpublished contribution to conference › Poster
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Human pancreatic adult acinar cells dedifferentiate towards an embryonic progenitor-like state in 3D suspension culture
Baldan, J., Houbracken, I., Rooman, I. & Bouwens, L., 26 Oct 2018.Research output: Unpublished contribution to conference › Poster
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2017
Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells
Houbracken, I. & Bouwens, L., 14 Sep 2017.Research output: Unpublished contribution to conference › Poster
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Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells
Houbracken, I. & Bouwens, L., 3 Oct 2017, In: Scientific Reports - Nature. 7, 1, 10 p., 12643.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)304 Downloads (Pure) -
Nieuwvorming van insuline-producerende bètacellen in muis en mens
Houbracken, I., Baldan, J. & Bouwens, L., Oct 2017, Poster presentatie Event 75 jaar Diabetes Liga, Antwerpen, België. p. 18-19Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
Open Access -
2016
Acinar phenotype is preserved in human exocrine pancreas cells cultured at low temperature: implications for lineage-tracing of beta cell neogenesis
Mfopou Kunjom, J., Houbracken, I., Wauters, E., Mathijs, I., Song, I., Himpe, E., Baldan, J., Heimberg, H. & Bouwens, L., 2016, In: Bioscience Reports. 36, 3, p. 1-15 15 p., e00329.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)362 Downloads (Pure) -
Neonatal beta cell but not acinar cell neogenesis evidenced by lineage tracing
Houbracken, I. & Bouwens, L., 9 Dec 2016.Research output: Unpublished contribution to conference › Poster
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Neonatal beta cell but not acinar cell neogenesis evidenced by lineage tracing
Houbracken, I. & Bouwens, L., 16 Sep 2016, Poster presentation at Islet Study Group annual meeting ISG 2016, Garmisch-Partenkirchen, Germany. p. 28-29 2 p.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
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Neonatal beta cell but not acinar cell neogenesis evidenced by lineage tracing
Houbracken, I. & Bouwens, L., 18 Aug 2016, In: Diabetologia. 59, S1, p. S25-S25 1 p., 47.Research output: Contribution to journal › Meeting abstract (Journal)
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2015
Neonatal beta cell neogenesis evidenced by lineage tracing
Houbracken, I. & Bouwens, L., 8 Oct 2015, Poster presentation at Islet Cell Plasticity in Diabetes Therapy conference, Copenhagen, Denmark. p. 62-62 1 p.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
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2014
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.
Laoui, D., Van Overmeire, E., Di Conza, G., Aldeni, C., Keirsse, J., Morias, Y., Movahedi, K., Houbracken, I., Schouppe, E., Elkrim, Y., Karroum, O., Jordan, B., Carmeliet, P., Gysemans, C., De Baetselier, P., Mazzone, M. & Van Ginderachter, J., 1 Jan 2014, In: Cancer Research. 74, 1, p. 24-30 7 p.Research output: Contribution to journal › Article › peer-review
338 Citations (Scopus) -
2013
Direct evidence for new formation of beta cells in the pancreas during the first weeks of life: Neonatal beta cell neogenesis evidenced by lineage tracing
Houbracken, I. & Bouwens, L., 17 Dec 2013.Research output: Unpublished contribution to conference › Poster
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Neonatal beta cell neogenesis evidenced by lineage tracing
Houbracken, I. & Bouwens, L., 27 Sep 2013, Poster presentation EASD Islet Study Group annual meeting ISG2013: Beta cell regeneration and genome regulation. p. 90-90 1 p.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
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Progenitors of islet cells
Houbracken, I., Mfopou Kunjom, J. & Bouwens, L., 2013, Stem cells handbook. Sell, S. (ed.). New York: Humana Press, p. 271-281 11 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research
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Suppression of epithelial to mesenchymal transitioning (EMT) enhances ex vivo reprogramming of human exocrine pancreatic tissue towards functional insulin producing β-like cells
Lima, M. J., Muir, K., Docherty, H., Drummond, R., Mcgowan, N., Forbes, S., Heremans, Y., Houbracken, I., Ross, J., Ravassard, P., Heimberg, H., Casey, J. & Docherty, K., Aug 2013, In: Diabetes. 62, 8, p. 2821-2833 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Citations (Scopus)329 Downloads (Pure) -
The use of stem cells for pancreatic regeneration in diabetes mellitus: equally contributing authors
Bouwens, L., Houbracken, I. & Mfopou Kunjom, J., 2013, In: Nature Reviews Endocrinology. 9, p. 598-606 9 p.Research output: Contribution to journal › Article › peer-review
78 Citations (Scopus) -
2012
Gene delivery to pancreatic exocrine cells in vivo and in vitro
Houbracken, I., Baeyens, L., Ravassard, P., Heimberg, H. & Bouwens, L., 2012, In: BMC Biotechnology. 12, 12, 13 p., 74.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)226 Downloads (Pure) -
Gene delivery to pancreatic exocrine cells in vivo and in vitro
Houbracken, I., Baeyens, L., Ravassard, P., Heimberg, H. & Bouwens, L., 2012, In: BMC Biotechnology. 12, 12 p., 74.Research output: Contribution to journal › Article › peer-review
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Genetic lineage tracing of beta cell neogenesis
Mathijs, I., Houbracken, I. & Bouwens, L., 2012, Animal models in diabetes research. Joost, H., Al-hasani, H. & Schürmann, A. (eds.). Humana Press, Springer, p. 317-322 6 p. (Methods in Molecular Biology; vol. 933).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review
3 Citations (Scopus) -
Lineage tracing of pancreatic stem cells and beta cell regeneration
Houbracken, I., Mathijs, I. & Bouwens, L., 2012, Animal models in diabetes research. Joost, H., Al-hasani, H. & Schürmann, A. (eds.). Humana Press, p. 303-315 13 p. (Methods in molecular biology; vol. 933).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review
3 Citations (Scopus) -
Nanobody-based targeting of the Macrophage Mannose Receptor for effective in vivo imaging of tumor-associated macrophages.
Movahedi, K., Schoonooghe, S., Laoui, D., Houbracken, I., Waelput, W., Breckpot, K., Bouwens, L., Lahoutte, T., De Baetselier, P., Raes, G., Devoogdt, N. & Van Ginderachter, J., 15 Aug 2012, In: Cancer Research. 72, p. 4165-4177 13 p.Research output: Contribution to journal › Article › peer-review
269 Citations (Scopus) -
2011
Lineage tracing evidence for in vitro acinar to duct cell transdifferentiation in human pancreas
Houbracken, I., De Waele, E., Lardon, J., Ling, Z., Heimberg, H., Rooman, I. & Bouwens, L., 5 Apr 2011, Poster presentation PhD Day - Research Unlimited Brussels 2011.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
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Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas
Houbracken, I., De Waele, E., Lardon, J., Ling, Z., Heimberg, H., Rooman, I. & Bouwens, L., 23 Oct 2011, Poster presentation at BetaCell Workshop 2011: Programming beta cell development, impairment and regeneration, Helsingor, Denmark.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
119 Citations (Scopus) -
Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas: shared first authorship
Houbracken, I., De Waele, E., Lardon, J., Ling, Z., Heimberg, H., Rooman, I. & Bouwens, L., 2011, In: GASTROENTEROLOGY. 141, p. 731-741 11 p.Research output: Contribution to journal › Article › peer-review
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Lineage tracing of pancreatic exocrine cell plasticity
Houbracken, I., 19 Sep 2011, Brussels: VUB Press. 199 p.Research output: Book/Report › Book › Research
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Mechanisms of beta cell regeneration after injury
Bouwens, L., Baeyens, L., Song, I., Mathijs, I. & Houbracken, I., 23 Oct 2011, Oral presentation at BetaCell Workshop 2011: Programming beta cell development, impairment and regeneration, Helsingor, Denmark.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
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Plasticity of human pancreas: transdifferentiation of acinar to duct cells
De Waele, E., Houbracken, I., Lardon, J., Ling, Z., Heimberg, H., Rooman, I. & Bouwens, L., 23 Oct 2011, Poster presentation at BetaCell Workshop 2011: Programming beta cell development, impairment and regeneration, Helsingor, Denmark.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
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2010
Evidence for in vitro acinar-to-ductal transdifferentiation of human pancreas
Houbracken, I., De Waele, E., Lardon, J., Ling, Z., Heimberg, H. & Bouwens, L., 21 Jan 2010, Poster presentation BetaCellTherapy workshop Brussels 2010.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
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The quest for tissue stem cells in the pancreas and other organs, and their application in beta-cell replacement
Houbracken, I. & Bouwens, L., 2010, In: The Review of Diabetic Studies. 7, p. 112-123 12 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
2009
Analysis of the plasticity of HNF1b-expressing cells in the embryonic and adult pancreas
Solar, M., Martin, M., De Medts42996, N., Houbracken, I., Carcalda, C., Maestro, M. A., Grau, V., Xu, X., Heimberg, H., Bouwens, L. & Ferrer, J., 26 Feb 2009, Poster and oral presentation Beta cell differentiation and regeneration workshop, Peebles, Scotland 2009.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research
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Gene delivery to pancreatic exocrine cells in vivo and in vitro
Houbracken, I., Baeyens, L., Ravassard, P. & Heimberg, H., 26 Feb 2009, Poster presentation Beta cell differentiation and regeneration workshop, Peebles, Scotland 2009.Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book) › Research