Projects per year
Personal profile
Expertise
Last years, the Steyaert lab pioneered the use of nanobodies for chaperone-assisted X-ray crystallography (www.steyaertlab.eu), aiming at the highest hanging fruits of structural biology including membrane proteins, amyloidogenic proteins, and now also (transient) multiprotein complexes. The elucidation of the first GPCR structures in the agonist-bound active state demonstrate the power of Nanobodies to stabilize G protein coupled receptor conformational states including transmembrane signalling complexes. Recent work focusses on exploiting the conformational complexity of therapeutic targets for Nanobody-enabled drug discovery.
Appart of his research activities, Jan Steyaert is also a serial entrepreneur. He is a co-founder of Ablynx (now a Sanofi company) and Biotalys and more recently he founded ConfoTherapeutics, three succesful biotech spin-offs that valorize a unique class of single domain antibodies (Nanobodies) derived from camelids.
External positions
Director, Flanders Institute for Biotechnology
15 Dec 2016 → …
Founder & Senior advisor, Confo Therapeutics
15 May 2015 → …
Francqui Research Professor, FRANCQUI Stichting
1 Jan 2015 → 1 Dec 2017
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Collaborations and top research areas from the last five years
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OZR4290: Financiering MZW OZR: High-resolution low-cost 100 kV electron cryogenic microscope for near-atomic protein structure determination
Efremov, R., Messens, J., Vorobieva, A. A., Remaut, H. K., Van der Henst, C., Steyaert, J., Versées, W., Loris, R. & Brunner, J.
24/04/24 → 24/04/28
Project: Fundamental
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OZRMETH10: Nanobodies for structural biology, molecular pharmacology and drug discovery
1/03/24 → 28/02/31
Project: Fundamental
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BASGO32: OZR Basisfinanciering voor Grote Onderzoeksgroepen - SBB
1/01/24 → 31/12/25
Project: Fundamental
Research output
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Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
Uchański, T., Masiulis, S., Fischer, B., Kalichuk, V., López-Sánchez, U., Zarkadas, E., Weckener, M., Sente, A., Ward, P., Wohlkönig, A., Zögg, T., Remaut, H., Naismith, J. H., Nury, H., Vranken, W., Aricescu, A. R., Pardon, E. & Steyaert, J., Jan 2021, In: Nature Methods. 18, 1, p. 60-68 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile79 Citations (Scopus)359 Downloads (Pure) -
Nanobodies to study protein conformational states
Uchański, T., Pardon, E. & Steyaert, J., Feb 2020, In: Current Opinion in Structural Biology. 60, p. 117-123 7 p.Research output: Contribution to journal › Scientific review › peer-review
65 Citations (Scopus) -
The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier
Ruprecht, J. J., King, M. S., Zögg, T., Aleksandrova, A. A., Pardon, E., Crichton, P. G., Steyaert, J. & Kunji, E. R. S., 24 Jan 2019, In: Cell. 176, 3, p. 435-447.e15 13 p.Research output: Contribution to journal › Article › peer-review
Open Access214 Citations (Scopus) -
Structure of a nanobody-stabilized active state of the b2 adrenoceptor
Rasmussen, S. G. F., Choi, H-J., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. M., Thian, F. S., Kobilka, T. S., Schnapp, A., Konetzki, I., Sunahara, R. K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I. & Kobilka, B. K., 13 Apr 2011, In: Nature. 469, 7329, p. 175-180 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1421 Citations (Scopus)692 Downloads (Pure) -
Crystal structure of the β2 adrenergic receptor–Gs protein complex
Rasmussen, S. G. F., Devree, B. T., Zou, Y., Kruse, A., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., Mathiesen, J. M., Shah, S. T. A., Lyons, J. A., Martin, C., Steyaert, J., Skiniotis, G., Weis, W. I., Sunahara, R. K. & Kobilka, B. K., 29 Sep 2011, In: Nature. 477, p. 549-555 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2534 Citations (Scopus)1581 Downloads (Pure)
Prizes
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2022 Jacob and Louise Gabbay Award in Biotechnology and Medicine - 25000$
Steyaert, Jan (Recipient), 27 Oct 2022
Prize: Prize (including medals and awards)
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Activities
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EU project 731005 - INSTRUCT-ULTRA
Jan Steyaert (Organiser)
22 Feb 2017 → 23 Feb 2017Activity: Participating in or organising an event › Participation in workshop, seminar
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42d FEBS Congress
Jan Steyaert (Invited speaker)
11 Sep 2017Activity: Talk or presentation › Talk or presentation at a conference
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Invited seminar at the Vienna Biocenter
Jan Steyaert (Speaker)
12 Jan 2017Activity: Talk or presentation › Talk at an external academic organisation
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Lezing voor Internationalisation@Home
Jan Steyaert (Speaker)
2 May 2017Activity: Talk or presentation › Talk at an external academic organisation
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Invited seminar at the University of Ljubljana
Jan Steyaert (Speaker)
15 Feb 2017Activity: Talk or presentation › Talk at an external academic organisation
Press/Media
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This scientific ‘power couple’ has one of the largest publishing networks in biology
7/05/20
1 Media contribution
Press/Media: Research