Projects per year
Personal profile
Expertise
Last years, the Steyaert lab pioneered the use of nanobodies for chaperone-assisted X-ray crystallography (www.steyaertlab.eu), aiming at the highest hanging fruits of structural biology including membrane proteins, amyloidogenic proteins, and now also (transient) multiprotein complexes. The elucidation of the first GPCR structures in the agonist-bound active state demonstrate the power of Nanobodies to stabilize G protein coupled receptor conformational states including transmembrane signalling complexes. Recent work focusses on exploiting the conformational complexity of therapeutic targets for Nanobody-enabled drug discovery.
Appart of his research activities, Jan Steyaert is also a serial entrepreneur. He is a co-founder of Ablynx (now a Sanofi company) and Biotalys and more recently he founded ConfoTherapeutics, three succesful biotech spin-offs that valorize a unique class of single domain antibodies (Nanobodies) derived from camelids.
External positions
Director, Flanders Institute for Biotechnology
15 Dec 2016 → …
Founder & Senior advisor, Confo Therapeutics
15 May 2015 → …
Francqui Research Professor, FRANCQUI Stichting
1 Jan 2015 → 1 Dec 2017
Fingerprint
Dive into the research topics where Jan Steyaert is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
FWOSBO79: SBO: Learning enhanced product developability design rules of nanobody-containing protein formats.
Steyaert, J. (Administrative Promotor)
1/10/26 → 30/09/30
Project: Applied
-
FWOSB198: Expanding the Nanobody Toolbox: Computational and Experimental Methods for Fusing Nanobodies with Other Proteins
Kocev, A. (Mandate), Vranken, W. (Administrative Promotor) & Steyaert, J. (CoI (Co-Promotor))
1/11/25 → 31/10/29
Project: Fundamental
-
IOFPOC67: IOF PoC “Positive allosteric modulators of receptor tyrosine kinases with ligand specificity and spatiotemporal precision as a new therapeutic strategy..”
Steyaert, J. (Administrative Promotor)
1/07/25 → 31/01/27
Project: Applied
-
IOF3034: Nanotools - From Nanobodies to new materials for Biotechnology and Health
Steyaert, J. (Administrative Promotor), Remaut, H. K. (CoI (Co-Promotor)), Efremov, R. (CoI (Co-Promotor)), Vorobieva, A. A. (CoI (Co-Promotor)), Van Molle, I. (Mandate) & Pardon, E. (CoI (Co-Promotor))
1/01/25 → 31/12/29
Project: Applied
-
OZR4377: Prijs Van Geen 2024
Steyaert, J. (Administrative Promotor)
4/09/24 → 4/09/27
Project: Fundamental
-
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
Uchański, T., Masiulis, S., Fischer, B., Kalichuk, V., López-Sánchez, U., Zarkadas, E., Weckener, M., Sente, A., Ward, P., Wohlkönig, A., Zögg, T., Remaut, H., Naismith, J. H., Nury, H., Vranken, W., Aricescu, A. R., Pardon, E. & Steyaert, J., Jan 2021, In: Nature Methods. 18, 1, p. 60-68 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile118 Citations (Scopus)731 Downloads (Pure) -
Nanobodies to study protein conformational states
Uchański, T., Pardon, E. & Steyaert, J., Feb 2020, In: Current Opinion in Structural Biology. 60, p. 117-123 7 p.Research output: Contribution to journal › Scientific review › peer-review
80 Citations (Scopus) -
The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier
Ruprecht, J. J., King, M. S., Zögg, T., Aleksandrova, A. A., Pardon, E., Crichton, P. G., Steyaert, J. & Kunji, E. R. S., 24 Jan 2019, In: Cell. 176, 3, p. 435-447.e15 13 p.Research output: Contribution to journal › Article › peer-review
Open Access280 Citations (Scopus) -
Structure of a nanobody-stabilized active state of the b2 adrenoceptor
Rasmussen, S. G. F., Choi, H.-J., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. M., Thian, F. S., Kobilka, T. S., Schnapp, A., Konetzki, I., Sunahara, R. K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I. & Kobilka, B. K., 13 Apr 2011, In: Nature. 469, 7329, p. 175-180 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1529 Citations (Scopus)859 Downloads (Pure) -
Crystal structure of the β2 adrenergic receptor–Gs protein complex
Rasmussen, S. G. F., Devree, B. T., Zou, Y., Kruse, A., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., Mathiesen, J. M., Shah, S. T. A., Lyons, J. A., Martin, C., Steyaert, J., Skiniotis, G., Weis, W. I., Sunahara, R. K. & Kobilka, B. K., 29 Sept 2011, In: Nature. 477, p. 549-555 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2725 Citations (Scopus)1967 Downloads (Pure)
Prizes
-
2022 Jacob and Louise Gabbay Award in Biotechnology and Medicine - 25000$
Steyaert, J. (Recipient), 27 Oct 2022
Prize: Prize (including medals and awards)
-
-
-
-
Activities
-
42d FEBS Congress
Steyaert, J. (Invited speaker)
11 Sept 2017Activity: Talk or presentation › Talk or presentation at a conference
-
Lezing voor Internationalisation@Home
Steyaert, J. (Speaker)
2 May 2017Activity: Talk or presentation › Talk at an external academic organisation
-
Invited seminar at the University of Ljubljana
Steyaert, J. (Speaker)
15 Feb 2017Activity: Talk or presentation › Talk at an external academic organisation
-
EU project 731005 - INSTRUCT-ULTRA
Steyaert, J. (Organiser)
22 Feb 2017 → 23 Feb 2017Activity: Participating in or organising an event › Participation in workshop, seminar
-
Invited seminar at the Vienna Biocenter
Steyaert, J. (Speaker)
12 Jan 2017Activity: Talk or presentation › Talk at an external academic organisation
Press/Media
-
-
This scientific ‘power couple’ has one of the largest publishing networks in biology
7/05/20
1 Media contribution
Press/Media: Research
Thesis
-
Trivalent Nb430 and homologous Nanobodies inhibit glutamine uptake via ASCT2 transporter in cancer
Carballo Salazar, V. J. ((PhD) Student), Steyaert, J. (Promotor), Kalichuk, V. (Co-promotor), Pardon, E. (Co-promotor), Vincke, C. (Jury) & Messens, J. (Jury), 2025Student thesis: Master's Thesis