Projects per year
Personal profile
Expertise
My research is situated within the domain of immune therapy. The nature of the research is situated between fundamental (“blue sky”) and strategic basic research, which is the ideal situation for valorization of fundamental research results in an early stage. The research entails different priorities of the VRWI transition area Health- and Wellbeing: personalized therapy with new markers, cell- and immune therapy. The focus is on the development of novel virotherapies (oncolytic viruses) for the treatment of cancer. Cancer immune therapy has experienced a tremendous boost during the last years, especially thanks to the success of the checkpoint inhibitors, antibodies that are aimed at reactivating the immune system against cancer. Despite this success, still a large number of patients do not respond to this therapy. Our approach, whereby viruses are used that are specifically aimed at cancer cells, uses the strength of viruses to activate the immune system, which can in turn recognize and remove cancer cells, without the need for identification of tumor-specific antigens (in vivovaccination). These viruses can easily be modified by inserting genes that further enhance the immune system.
Another research direction that is being explored is the development of novel immune therapies against HIV. Thanks to the development of novel anti-retroviral drugs HIV infection can be kept under control. However, these drugs are not curative and the patient is obliged to take this therapy life-long in order to avoid that the virus reemerges. There are however indications that the immune system can suppress the virus for prolonged periods of time, even in the absence of antiretroviral therapy. For this reason, we try to find ways to boost the immune system in such a way that the patient is taken off therapy for prolonged periods of time, or that he or she can eventually perhaps live without any anti-retroviral therapy.
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Network
Projects
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OZR3633: OZR Back-up mandate: Nanoparticle-encapsulated self-replicating mRNA-based vaccination as a novel therapeutic approach against HIV
1/11/20 → 31/10/21
Project: Fundamental
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OZR3586: Financiering FWO Hercules: SPIDER-FLOW: State-of-the-art high-Parameter Immunology and DEvelopmental biology Research FLOW cytometer
Van Ginderachter, J., Messens, J., Raes, G., Devoogdt, N., Magez, S., Leyns, L., Aerts, J., Movahedi, K., De Trez, C. & Laoui, D.
1/05/20 → 30/04/24
Project: Fundamental
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FWOAL974: Development of a novel nanoparticle formulation for mRNA based therapeutic vaccination
1/01/20 → 31/12/23
Project: Fundamental
Research output
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Layer-by-Layer technique as a versatile tool for gene delivery applications
Linnik, D. S., Tarakanchikova, Y. V., Zyuzin, M. V., Lepik, K. V., Aerts, J. L., Sukhorukov, G. & Timin, A. S., 18 Feb 2021, In : Expert Opinion on Drug Delivery. p. 1-19 19 p.Research output: Contribution to journal › Article
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Off the beaten path: Novel mRNA-nanoformulations for therapeutic vaccination against HIV
D'haese, S., Lacroix, C., Garcia, F., Plana, M., Ruta, S., Vanham, G., Verrier, B. & Aerts, J. L., 10 Feb 2021, In : Journal of Controlled Release. 330, p. 1016-1033 18 p.Research output: Contribution to journal › Article
1 Citation (Scopus) -
Lemierre's syndrome in adulthood, a case report and systematic review
Moretti, M., De Geyter, D., Goethals, L., Allard, S. D. & Aerts, J., 3 Mar 2020, In : Acta Clinica Belgica. 2020, p. 1-11 11 p.Research output: Contribution to journal › Article
3 Citations (Scopus) -
Neuroprotection by Insulin-like Growth Factor-1 in Rats with Ischemic Stroke is Associated with Microglial Changes and a Reduction in Neuroinflammation
Serhan, A., Aerts, J. L., Boddeke, E. W. G. M. & Kooijman, R., 1 Feb 2020, In : Neuroscience. 426, p. 101-114 14 p.Research output: Contribution to journal › Article
5 Citations (Scopus) -
Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on-going viral transcription
Pannus, P., Rutsaert, S., De Wit, S., Allard, S. D., Vanham, G., Cole, B., Nescoi, C., Aerts, J., De Spiegelaere, W., Tsoumanis, A., Couttenye, M-M., Herssens, N., De Scheerder, M-A., Vandekerckhove, L. & Florence, E., Feb 2020, In : Journal of the International AIDS Society. 23, 2, e25453.Research output: Contribution to journal › Article
5 Citations (Scopus)
Activities
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EU4HIV CURE symposium 2020
Thessa Laeremans (Participant), Sigrid D'Haese (Participant), Jonathan Inez G Aernout (Participant), Kurt Barbé (Participant), Guido Vanham (Participant), Joeri Aerts (Participant), Sabine Allard (Participant)9 Jan 2020 → 10 Jan 2020Activity: Participating in or organising an event › Participation in conference
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Unknown (External organisation)
Joeri Aerts (Member)2009Activity: Membership › Membership of external research organisation
Thesis
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A scavenger hunt towards a better understanding of the involvement of ghrelin receptor signaling in emotion regulation
Author: Pierre, A., De Bundel, D., Smolders, I., beckers, T., Mangelings, D., De Kock, J., Aerts, J., Singewald, N. & Dickson , S., 5 Feb 2020Supervisor: De Bundel, D. (Promotor), Smolders, I. (Co-promotor), beckers, T. (External person) (Co-promotor), Mangelings, D. (Jury), De Kock, J. (Jury), Aerts, J. (Jury), Singewald, N. (External person) (Jury) & Dickson , S. (External person) (Jury)
Student thesis: Doctoral Thesis
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Characterization of cancer stem cells in a syngeneic mouse model
Author: Van Der Jeught, K., Aerts, J. & Thielemans, K., 15 Jun 2012Supervisor: Aerts, J. (Promotor) & Thielemans, K. (Promotor)
Student thesis: Master's Thesis
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Combination therapy for a durable tumor rejection
Author: Bialkowski, L., 16 Jan 2018Supervisor: Thielemans, K. (Promotor), Aerts, J. (Co-promotor), Demanet, C. (Jury), De Greve, J. (Jury), Devoogdt, N. (Jury), van der Burg, S. H. (External person) (Jury), Moser, M. (External person) (Jury) & Sanders, N. (External person) (Jury)
Student thesis: Doctoral Thesis
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DC vaccines knock your SOX off. Induction of anti-tumor immunity.
Author: Bialkowski, L., Thielemans, K., Aerts, J. & Piotr, T., 22 Sep 2011Supervisor: Thielemans, K. (Promotor), Aerts, J. (Co-promotor) & Piotr, T. (External person) (Co-promotor)
Student thesis: Master's Thesis
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Development of a differentiated hepatic in vitro system for long-term pharmaco-toxicological studies based on (epi)genetic modification of primary hepatocytes
Author: Ramboer, E., 15 Oct 2015Supervisor: Vinken, M. (Promotor), Vanhaecke, T. (Promotor), Rogiers, V. (Promotor), Smolders, I. (Jury), Van Grunsven, L. A. (Jury), Aerts, J. (Jury), Vandenbroucke, R. (External person) (Jury) & Annaert, P. (External person) (Jury)
Student thesis: Doctoral Thesis