Projects per year
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Collaborations and top research areas from the last five years
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VLAIM5: Innovation mandate Spin-off: EVOZymes Development Platform
Neuckermans, J., De Kock, J. & Vanhaecke, T.
1/08/23 → 31/07/25
Project: Applied
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FWOAL1003: TALENT: Engineering human tyrosine ammonia lyase (TAL) enzymes to treat inborn errors of tyrosine metabolism
1/01/21 → 31/12/24
Project: Fundamental
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OZR3588: Financiering FWO hercules: ERA platform: Extended RNA Analysis platform - version 2.0
Rooman, I., Bouwens, L., Heimberg, H., Neyns, B., Vranken, W., Vanhaecke, T., Massie, A., van Grunsven, L., De Bruyne, E., De Bundel, D., Forsyth, R., Breckpot, K., Van Dooren, S., De Kock, J., Njemini, R. & Laoui, D.
1/05/20 → 30/04/24
Project: Fundamental
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IOF3013: GEAR: Brussels Liver Research to Valorisation Alliance (B-Liver): Valorisation of VUB’s liver cell biology and toxicology expertise via a consortium focused on liver therapeutics, patient and consumer safety.
Vanhaecke, T., van Grunsven, L., De Kock, J., Vinken, M. & Reynaert, H.
1/01/20 → 31/12/24
Project: Applied
Research output
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Development of a robust high-throughput screenings system for the evaluation of tyrosine ammonia lyases in the context of inborn errors of tyrosine metabolism
Nulmans, I., Laga, C. A., Salvi, N. S., Desmet, L., Lequeue, S., Neuckermans, J. & De Kock, J., 19 Sep 2023.Research output: Unpublished contribution to conference › Poster
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Genetically engineering human skin-derived precursor cells into functional hepatocyte-like cells as a novel liver-based in vitro model.
Stinckens, M., Rombaut, M., Gatzios, A., Rodrigues, R., Vanhaecke, T. & De Kock, J., 19 Sep 2023.Research output: Unpublished contribution to conference › Poster
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Hereditary Tyrosinemia Type 1 Mice under Continuous Nitisinone Treatment Display Remnants of an Uncorrected Liver Disease Phenotype
Neuckermans, J., Lequeue, S., Claes, P., Heymans, A., Hughes, J. H., Colemonts-Vroninks, H., Marcélis, L., Casimir, G., Goyens, P., Martens, G. A., Gallagher, J. A., Vanhaecke, T., Bou-Gharios, G. & De Kock, J., 11 Mar 2023, In: Genes. 14, 3, 15 p., 693.Research output: Contribution to journal › Article › peer-review
Open Access -
Human skin stem cell-derived hepatic cells as in vitro drug discovery model for insulin-driven de novo lipogenesis
Buyl, K., Vrints, M., Fernando, R., Desmae, T., Van Eeckhoutte, T., Jans, M., Van Der Schueren, J., Boeckmans, J., Rodrigues, R. M., De Boe, V., Rogiers, V., De Kock, J., Beirinckx, F. & Vanhaecke, T., 15 Oct 2023, In: European Journal of Pharmacology. 957, 175989.Research output: Contribution to journal › Article › peer-review
Open Access -
Human skin stem cell-derived hepatic cells with genetic predisposition for liver fat accumulation mimic susceptibility to develop metabolic dysfunction-associated fatty liver disease
Gatzios, A., Rodrigues, R., De Kock, J., Rombaut, M., De Win, D., Rogiers, V., Boeckmans, J. & Vanhaecke, T., Jun 2023, Abstract Book of EASL Congress 2023: 21-24 June 2023, Vienna, Austria. Elsevier, Vol. 78(S1). p. S775-S776 2 p. WED-465. (Poster presentations; vol. 78(S1)).Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book)
Open AccessFile4 Downloads (Pure)
Prizes
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33. Forschungspreises zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
De Kock, Joery (Recipient), Marcelino Rodrigues, Robim (Recipient), Vanhaecke, Tamara (Recipient) & Rogiers, Vera (Recipient), 2014
Prize: Prize (including medals and awards)
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FixAKUre: High-throughput screening of a chemical compound library with the aim to identify restabilizing compounds for homogentisate 1,2-dioxygenase enzyme variants in the context of rare disease alkaptonuria
De Kock, Joery (Recipient) & Lequeue, Sien (Recipient), 2022
Prize: Prize (including medals and awards)
Activities
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The Innovation Centre 3Rs (IC-3Rs) in Belgium
Mieke Van Mulders (Invited speaker), Birgit Mertens (Contributor), Robim Marcelino Rodrigues (Contributor), Joery De Kock (Contributor), Tamara Vanhaecke (Contributor) & Vera Rogiers (Contributor)
28 Sep 2022Activity: Talk or presentation › Talk or presentation at a conference
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Human hepatic in vitro models identify ANGPTL4, PDK4 and PLIN2 as potential pro-steatogenic mediators induced by elafibranor
Joost Boeckmans (Speaker), Alexandra Gatzios (Contributor), Anja Heymans (Contributor), Matthias Rombaut (Contributor), Vera Rogiers (Contributor), Joery De Kock (Contributor), Tamara Vanhaecke (Contributor) & Robim Marcelino Rodrigues (Contributor)
9 Jun 2022Activity: Talk or presentation › Talk or presentation at a conference
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Resmetirom reduces lipid load, restores THRB expression and prevents cell damage in a human stem cell based in vitro MAFLD model.
Alexandra Gatzios (Speaker), Robim Marcelino Rodrigues (Contributor), Joery De Kock (Contributor), Anouk Verhoeven (Contributor), Sara Sepehri (Contributor), Karolien Buyl (Contributor), Matthias Rombaut (Contributor), Vera Rogiers (Contributor), Joost Boeckmans (Contributor) & Tamara Vanhaecke (Contributor)
10 Jun 2022Activity: Talk or presentation › Talk or presentation at a conference
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Reaching beyond the limits of nature to cure inherited metabolic disorders of the liver
Joery De Kock (Speaker)
2020Activity: Talk or presentation › Talk or presentation at a conference
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A human hepatocyte-like cell based In Vitro model for hepatic insulin-driven De Novo Lipogenesis
Karolien Buyl (Speaker), Martine Vrints (Speaker), Ruani Fernando (Speaker), Thomas Van Eeckhoute (Speaker), Mia Jans (Speaker), Joost Boeckmans (Speaker), Robim Marcelino Rodrigues (Speaker), Vera Rogiers (Speaker), Jan Van Der Schueren (Speaker), Joery De Kock (Speaker), Tamara Vanhaecke (Speaker) & Filip Beirinckx (Speaker)
2020 → …Activity: Talk or presentation › Talk or presentation at a workshop/seminar
Thesis
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Bepaling van de specifieke activiteit van cyclotron geproduceerd F18-fluoride en F18-gemerkt radiofarmacon
Author: Deprez, M., Caveliers, V., Blykers, A., De Kock, J. & Vander Heyden, Y., 10 Jun 2015Student thesis: Master's Thesis
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Evaluatie van de efficiëntie van CRE mRNA-geïnduceerde recombinase in humane huidafgeleide mesenchymale stamcellen.
Author: Rombaut, M., Vanhaecke, T., De Kock, J. & Neuckermans, J., 2018Supervisor: Vanhaecke, T. (Promotor)
Student thesis: Master's Thesis
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Karakterisatie op proteïnen-niveau van het differentiatieproces van ratepitheelcellen van biliaire oorsprong naar hepatische cellen
Author: De Kock, J., Rogiers, V., Vanhaecke, T. & Snykers, S., 2006Supervisor: Rogiers, V. (Promotor), Vanhaecke, T. (Co-promotor) & Snykers, S. (Co-promotor)
Student thesis: Master's Thesis
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NIR Imaging of HER2-positive breast cancer lesions using a site-specific fluorescently labeled nanobody
Author: Maldeghem, F., Hernot, S., Caveliers, V., De Bundel, D. & De Kock, J., 28 Jan 2016Supervisor: Hernot, S. (Promotor) & Caveliers, V. (Co-promotor)
Student thesis: Master's Thesis
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Optimalisatie van immunohistochemische kleuringen voor het myeline basisch proteïne (MBP) en het gliale fibrillatie zure eiwit (GFAP) in FAH5981SB muizen en hun genottypering
Author: Walgraeve, J. K., De Kock, J., Hernot, S. & Vanhaecke, T., 13 Jun 2018Supervisor: Vanhaecke, T. (Promotor)
Student thesis: Master's Thesis