Projects per year
Personal profile
Expertise
- Analysis of minor and trace elements in various matrices (biological material, foodstuff) using XRF, NAA, PIXE. Qualitative and quantitative analysis of radioactive contaminations with alpha, beta or gamma emitters. Absolute efficiency calibration of scintillation and proportional flow-through detectors for gaseous beta-emitters. Various qualitative and quantitative chemical analysis using HPLC, GCMS, IR and UV spectrometry. Irradiation of small laboratory animals and objects with calibrated gama sources. Irradiations with charged particle beams (protons, alpha, deuterons). Study and automatisation of separation and purification techniques for radioisotopes.
- Development of radioactive molecules for molecular imaging and radionuclide therapy. Synthesis of precursor molecules. Optimization of the Radiosynthesis Methods with Radiohalogens (123I,131I,125I18F) and Radiometals (111In 3+,201Tl 3+,99mTc(III) and (V), 99mTc1+ - tricarbonyl). New radioiodination and radiobromination procedures applied in radiopharmaceutical industry (patent). Development of new radioactive compounds for diagnosis with SPECT and PET (brain receptors, brain tumors, tumours of periphery )( 4 patents). In vitro evaluation in cell models (over)expressing transporters and/or receptors. In vivo evaluation in rodent models (nude mice with tumours, rats with or without tumours) by means of (animal) SPECT and PET and dissection. European Project ( with Organic Chemistry VUBrussel, PSI Switserland, FZRossendorf Germany, Democritos Center Athene) on Radiometallo- chelated (111In, 201Tl, 99mTc,..) peptides as potential tumor tracers. Eureka project with University Zurich and Mallinckrodt Medi
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Dive into the research topics where John Mertens is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
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OZR1715: Development of positron emission tomography technologies for cancer diagnosis and new drugs development
Tavernier, S., Bossuyt, A., Bruyndonckx, P., Defrise, M. & Mertens, J.
1/01/08 → 31/12/08
Project: Fundamental
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FWOAL281: Development of L-and D- 18F-alkyl - phenylalanine and 18F-leucine analogues as tumor-specific PET tracers.
1/01/04 → 31/12/07
Project: Fundamental
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ADSI15: Interne overschrijving voor uitbetaling doctoraatsbeurs.
1/01/04 → 31/12/04
Project: Fundamental
Research output
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Establishment of a Kinetic Model for the Intramolecular Catalyzed Hydrolysis of [18 F]- Benzylfluoride Containing Amino Acid Analoques by Linking Experimental and DFT Studies
Kersemans, K., Sablon, N., Geerlings, P. & Mertens, J., 2012, In : Intern. J. Chem. Kin.. 44, p. 705 1 p.Research output: Contribution to journal › Article
2 Citations (Scopus) -
Mechanistic approach of the difference in hydrolysis rate between the 2- and 4-isomers of no-carrier added [18F] fluoromethyl-L-phenylalanine
Kersemans, K., Mertens, J., De Proft, F. & Geerlings, P., 2011, In : Journal of Labelled Compounds and Radiopharmaceuticals. 54, p. 220 1 p.Research output: Contribution to journal › Article
3 Citations (Scopus) -
Mechanistic approach of the difference in non-enzymatic hydrolysis rate between the L and D enantiomers of no-carrier added 2-[18F] fluoromethyl-phenylalanine
Kersemans, K., Mertens, J., De Proft, F. & Geerlings, P., 2011, In : Journal of Labelled Compounds and Radiopharmaceuticals. 54, p. 80 1 p.Research output: Contribution to journal › Article
2 Citations (Scopus) -
The impact of HF-rTMS treatment on serotonin(2A) receptors in unipolar melancholic depression
Baeken, C., De Raedt, R., Bossuyt, A., Vanhove, C., Mertens, J., Dobbeleir, A., Blanckaert, P. & Goethals, L., Apr 2011, In : Brain Stimulation. 4, p. 104-111 8 p.Research output: Contribution to journal › Article
56 Citations (Scopus) -
The impact of HF-rTMS treatment on Serotonin 2A receptors in unipolar melancholic depression
Baeken, C., De Raedt, R., Bossuyt, A., Van Hove, C., Mertens, J., Dobbeleir, A., Blanckaert, P. & Goethals, I., 2011, In : Brain Stimul. 4, 2, p. 104-111 8 p.Research output: Contribution to journal › Article
Prizes
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Prijs Stas van de Belgische Academie Wetenschappen
John Mertens (Recipient), 1997
Prize: Prize (including medals and awards)
Activities
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Unknown (External organisation)
John Mertens (Member)1 Jan 2004 → 31 Dec 2007Activity: Membership › Membership of external research organisation
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Unknown (External organisation)
John Mertens (Member)1 Jan 2004 → 30 Sep 2006Activity: Membership › Membership of external research organisation
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Unknown (External organisation)
John Mertens (Member)1 Jan 2004 → 31 Dec 2007Activity: Membership › Membership of external research organisation
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University of Zurich (External organisation)
John Mertens (Member)1 Jan 2003 → …Activity: Membership › Membership of external research organisation
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European Association for Nuclear Medicine (External organisation)
John Mertens (Member)1 Jan 2002 → 31 Dec 2002Activity: Membership › Membership of external research organisation
Thesis
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"Development of new radiofluorinated methylphenylalanine analoques for tumour imaging with PET".
Author: Kersemans, K., Geerlings, P. & Mertens, J., 21 Jan 2011Supervisor: Geerlings, P. (Promotor) & Mertens, J. (Co-promotor)
Student thesis: Doctoral Thesis
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Human biodistribution studies: acritical step int he clinical evaluation of new radiopharmaceutical drugs
Author: Caveliers, V., Bossuyt, A., Michotte, Y., Smolders, I. J., Vander Heyden, Y., Thornback, J., Mertens, J., Slegers, G. & Foriers, A., 19 Mar 2003Supervisor: Bossuyt, A. (Promotor), Michotte, Y. (Co-promotor), Smolders, I. (Jury), Vander Heyden, Y. (Jury), Mertens, J. (Jury), Foriers, A. (Jury), Thornback, J. (External person) (Jury) & Slegers, G. (External person) (Jury)
Student thesis: Doctoral Thesis
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Human biodistribution studies: a critical step in the clinical evaluation of radiopharmaceutical drugs.
Author: Caveliers, V., Bossuyt, A., Foriers, A., Michotte, Y., Thornback, J., Slegers, G., Mertens, J., Smolders, I. J. & Vander Heyden, Y., 2006Supervisor: Bossuyt, A. (Promotor), Foriers, A. (Jury), Michotte, Y. (Co-promotor), Mertens, J. (Jury), Smolders, I. (Jury), Vander Heyden, Y. (Jury), Thornback, J. (External person) (Jury) & Slegers, G. (External person) (Jury)
Student thesis: Doctoral Thesis
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In Vivo Bioluminescentie in de studie van het potentieel radiotherapeutisch effect van 131I-2-Iodo-D-phenylalanine in de tumormuis
Author: Wimana, L., Mertens, J. & Lahoutte, T., 27 Jun 2008Supervisor: Mertens, J. (Promotor) & Lahoutte, T. (Co-promotor)
Student thesis: Master-after-master
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Radioiodinated D aromatic amino acid analogues as potential cancer theragnostics
Author: Bauwens, M., Mertens, J., Lahoutte, T., Van Schravendijk, C., Everaert, H., Neyns, B., Smolders, I., De Jong, M., De Vos, F. & Verbruggen, A., 5 Mar 2009Supervisor: Mertens, J. (Promotor), Lahoutte, T. (Co-promotor), Van Schravendijk, C. (Jury), Everaert, H. (Jury), Neyns, B. (Jury), Smolders, I. (Jury), De Jong, M. (External person) (Jury), De Vos, F. (External person) (Jury) & Verbruggen, A. (External person) (Jury)
Student thesis: Doctoral Thesis