Projects per year
Personal profile
Expertise
Joke Mertens graduated as a master in the Biomedical Sciences at the Vrije Universiteit Brussel in 2017. She performed her master thesis in the REGE lab under supervision of Prof. Claudia Spits and became a PhD student in August 2017. She works on the MitoART project which aims at investigating mitochondrial DNA changes in oocytes, embryos and children born after assisted reproductive technologies.
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Projects
- 1 Finished
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OZR3296: Do mitochondrial DNA mutations play a role in the outcome of assisted reproduction technologies?
1/10/18 → 30/09/19
Project: Fundamental
Research output
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Detection of Heteroplasmic Variants in the Mitochondrial Genome through Massive Parallel Sequencing
Mertens, J., Zambelli, F., Daneels, D., Caljon, B., Sermon, K. & Spits, C., 5 Jul 2019, In : bio-protocol. 9, 13, 7 p., e3283.Research output: Contribution to journal › Article
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Increased heteroplasmic load of coding mitochondrial DNA variants in tissues from ART children
Mertens, J., Zambelli, F., Belva, F., Van Montfoort, A., Bonduelle, M., Seneca, S., Sermon, K. & Spits, C., Jul 2018, In : Human Reproduction. 33, p. 80-81 2 p.Research output: Contribution to journal › Meeting abstract (Journal)
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Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells
Zambelli, F., Mertens, J., Dziedzicka, D., Sterckx, J., Markouli, C., Keller, A., Tropel, P., Jung, L., Viville, S., Van de Velde, H., Geens, M., Seneca, S., Sermon, K. & Spits, C., 10 Jul 2018, In : Stem Cell Reports. 11, 1, p. 102-114 13 p.Research output: Contribution to journal › Article
3 Citations (Scopus) -
Accurate and comprehensive analysis of single nucleotide variants and large deletions of the human mitochondrial genome in DNA and single cells
Zambelli, F., Vancampenhout, K., Daneels, D., Brown, D., Mertens, J., Van Dooren, S., Caljon, B., Gianaroli, L., Sermon, K., Voet, T., Seneca, S. & Spits, C., 1 Nov 2017, In : European Journal of Human Genetics. 25, 11, p. 1229-1236 8 p.Research output: Contribution to journal › Article
4 Citations (Scopus) -
Comparative analysis of mitochondrial DNA variants in hiPSC and hESC through massive parallel sequencing
Zambelli, F., Barbé, L., Mertens, J., Tropel, P., Jung, L., Viville, S., Geens, M., Sermon, K. & Spits, C., 14 Jun 2017.Research output: Unpublished contribution to conference › Poster
Prizes
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BSRM Award Winner 2020
Joke Mertens (Recipient), 28 Nov 2020
Prize: Prize (including medals and awards)
Activities
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LSM PhD day 2021
Joke Mertens (Participant)30 Mar 2021Activity: Participating in or organising an event › Participation in workshop, seminar
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PRISM workshop (individual exercise)
Joke Mertens (Participant)1 Jan 2021 → 31 Jan 2021Activity: Participating in or organising an event › Participation in workshop, seminar
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Turning the Tables: Advanced Negotiation Skills
Joke Mertens (Participant)23 Mar 2021Activity: Participating in or organising an event › Participation in workshop, seminar
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Differences in the landscape of mitochondrial DNA variants between ART and spontaneously conceived individuals links to maternal infertility and low birth weight
Joke Mertens (Speaker), Filippo Zambelli (Contributor), Florence Belva (Contributor), Aafke PA van Montfoort (Contributor), Edouard Couvreu De Deckersberg (Contributor), Mary-Louise Bonduelle (Contributor), Katrien Stouffs (Contributor), Sara Seneca (Contributor), Hilde Van De Velde (Contributor), Christophe Blockeel (Contributor), Karen Sermon (Contributor), Claudia Spits (Contributor)5 Jul 2020 → 8 Jul 2020Activity: Talk or presentation › Talk or presentation at a conference
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Maternally inherited differences in mitochondrial DNA genotype between ART and spontaneously conceived individuals are aggravated by controlled ovarian stimulation and link to low birth weight
Joke Mertens (Speaker), Florence Belva (Contributor), Aafke PA van Montfoort (Contributor), Filippo Zambelli (Contributor), Edouard Couvreu De Deckersberg (Contributor), Mary-Louise Bonduelle (Contributor), Herman Tournaye (Contributor), Katrien Stouffs (Contributor), Sara Seneca (Contributor), Kurt Barbé (Contributor), Hubert J M Smeets (Contributor), Hilde Van De Velde (Contributor), Karen Sermon (Contributor), Christophe Blockeel (Contributor), Claudia Spits (Contributor)28 Nov 2020Activity: Talk or presentation › Talk or presentation at a conference
Thesis
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Analysis of mitochondrial DNA variants in ART and spontaneously conceived individuals
Author: Rhioui, K., Mertens, J. & Spits, C., 6 Sep 2018Supervisor: Spits, C. (Promotor)
Student thesis: Master's Thesis
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Maternal Inheritance as a Possible Origin of the Increased mtDNA Mutation Load in Children born after Assisted Reproductive Technologies
Author: Bossuyt, J., Mertens, J. & Spits, C., 18 Jun 2020Supervisor: Spits, C. (Promotor)
Student thesis: Master's Thesis
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Mitochondrial DNA Variants in Early Development and ART
Author: Mertens, J., Zambelli, F. & Spits, C., 30 Jun 2017Supervisor: Spits, C. (Promotor)
Student thesis: Master's Thesis
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Single-Cell Analysis to Unravel Somatic Mosaicism of Mitochondrial DNA Variants
Author: Krupińska, P. K., Mertens, J. & Spits, C., 4 Sep 2019Supervisor: Spits, C. (Promotor)
Student thesis: Master's Thesis
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SNP Analyse in het FSH-Receptor gen van Patïenten met een Optimale en Suboptimale Opbrengst na Controlled Ovarian Stimulation
Author: Duque, G., Mertens, J. & Spits, C., 26 Jun 2018Supervisor: Spits, C. (Promotor)
Student thesis: Master's Thesis