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Dive into the research topics where Jone Paesmans is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Projects
- 1 Finished
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Ontrafeling van de structuur en functie van de synaptische eiwitten TBC1D24 en Synaptojanin1 en hun rol in neurologische aandoeningen
Paesmans, J., 2021Research output: Thesis › PhD Thesis
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Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies
Leemans, M., Galicia, C., Deyaert, E., Daems, E., Krause, L., Paesmans, J., Pardon, E., Steyaert, J., Kortholt, A., Sobott, F., Klostermeier, D. & Versees, W., 17 Apr 2020, In: Biochemical Journal. 477, 7, p. 1203-1218 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)42 Downloads (Pure) -
A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations
Paesmans, J., Martin, E., Deckers, B., Berghmans, M., Sethi, R., Loeys, Y., Pardon, E., Steyaert, J., Verstreken, P., Galicia, C. & Versées, W., 22 Dec 2020, In: eLife. 9, p. 1-27 27 p., e64922.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)80 Downloads (Pure) -
Compounds for treatment of intractable epilepsy and doors syndrome
Verstreken, P., Lüthy, K., Versées, W., Fischer, B. & Paesmans, J., 2019, Patent No. EP3503880Research output: Patent
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TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model
Lüthy, K., Mei, D., Fischer, B., De Fusco, M., Swerts, J., Paesmans, J., Parrini, E., Lubarr, N., Meijer, I. A., Mackenzie, K. M., Lee, W-T., Cittaro, D., Aridon, P., Schoovaerts, N., Versées, W., Verstreken, P., Casari, G. & Guerrini, R., 1 Aug 2019, In: Brain. 142, 8, p. 2319-2335 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)73 Downloads (Pure)
Datasets
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Crystal structure of the 5-phosphatase domain of Synaptojanin1 in complex with a nanobody
Paesmans, J. (Creator), Versées, W. (Supervisor), Galicia Diaz Santana, C. (Creator) & Martin, E. (Creator), Protein Data Bank in Europe, 30 Dec 2020
DOI: 10.2210/pdb7A0V/pdb
Dataset
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Crystal structure of the 5-phosphatase domain of Synaptojanin1 bound to its substrate diC8-PI(3,4,5)P3 in complex with a nanobody.
Paesmans, J. (Creator), Versées, W. (Supervisor), Galicia Diaz Santana, C. (Creator) & Martin, E. (Creator), Protein Data Bank in Europe, 30 Dec 2020
DOI: 10.2210/pdb7A17/pdb
Dataset
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Crystal structure of the TLDc domain of Skywalker/TBC1D24 from Drosophila melanogaster
Versées, W. (Project Leader), Fischer, B. (Creator) & Paesmans, J. (Researcher), Protein Data Bank in Europe, 17 Jul 2019
DOI: 10.2210/pdb6R82/pdb
Dataset
Activities
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Science on the road
Jone Paesmans (Speaker)
14 Feb 2020Activity: Talk or presentation › Talk at a school event
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Science on the road
Jone Paesmans (Speaker)
13 Feb 2020Activity: Talk or presentation › Talk at a school event
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Science on the road
Jone Paesmans (Speaker)
11 Jan 2019Activity: Talk or presentation › Talk at a school event
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Science on the road
Jone Paesmans (Speaker)
8 Feb 2019Activity: Talk or presentation › Talk at a school event
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Science day
Jone Paesmans (Speaker)
25 Nov 2018Activity: Talk or presentation › Talk at a festival/exhibition
Thesis
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Karakterisering van domein- en conformatie-specifieke Nanobodies gericht tegen een bacterieel homoloog van het LRRK2-eiwit
Author: Paesmans, J., 30 Jun 2014Supervisor: Versees, W. (Promotor), Steyaert, J. (Co-promotor), Muyldermans, S. (Jury) & Vanderheyden, P. (Jury)
Student thesis: Master's Thesis
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Unraveling the structure and function of the synaptic proteins TBC1D24 and Synaptojanin1 and their role in neurological disorders
Author: Paesmans, J., Versées, W., Ballet, S., Brunner, J., Smolders, I., Greggio, E. & Ismail, S., 29 Jun 2021Student thesis: Doctoral Thesis